Full Text Journal Articles by
Author Francesca Guerrieri


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Structural Variations of Vaginal and Endometrial Microbiota: Hints on Female Infertility.

Lucia Riganelli, Valerio Iebba, Mariagrazia Piccioni, Isabella Illuminati, Giulia Bonfiglio, Bruna Neroni, Ludovica Calvo, Antonella Gagliardi, Massimo Levrero, Lucia Merlino, Marianna Mariani, Oriana Capri, Daniela Pietrangeli, Serena Schippa, Francesca Guerrieri,

Microbiota are microorganismal communities colonizing human tissues exposed to the external environment, including the urogenital tract. The bacterial composition of the vaginal microbiota has been established and is partially related to obstetric outcome, while the uterine microbiota, considered to be a sterile environment for years, is now the focus of ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:350]

Cited: 0 times

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Nasal Microbiota in RSV Bronchiolitis.

Serena Schippa, Antonella Frassanito, Massimiliano Marazzato, Raffaella Nenna, Laura Petrarca, Bruna Neroni, Giulia Bonfiglio, Francesca Guerrieri, Federica Frasca, Giuseppe Oliveto, Alessandra Pierangeli, Fabio Midulla,

Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and the severity may be influenced by the bacterial ecosystem. Our aim was to analyze the nasal microbiota from 48 infants affected by bronchiolitis from RSV virus and 28 infants with bronchiolitis but negative for the virus. Results showed a ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(5):]

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Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription.

Debora Salerno, Letizia Chiodo, Vincenzo Alfano, Oceane Floriot, Grazia Cottone, Alexia Paturel, Matteo Pallocca, Marie-Laure Plissonnier, Safaa Jeddari, Laura Belloni, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri,

OBJECTIVE:The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN:We explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA ... Read more >>

Gut (Gut)
[2020, :]

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The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.

Federica Laudisi, Davide Di Fusco, Vincenzo Dinallo, Carmine Stolfi, Antonio Di Grazia, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Claudia Alteri, Francesca Guerrieri, Maria Mavilio, Francesca Ceccherini-Silberstein, Massimo Federici, Thomas Thornton MacDonald, Ivan Monteleone, Giovanni Monteleone,

BACKGROUND & AIMS:Food additives, such as emulsifiers, stabilizers, or bulking agents, are present in the Western diet and their consumption is increasing. However, little is known about their potential effects on intestinal homeostasis. In this study we examined the effect of some of these food additives on gut inflammation. METHODS:Mice ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2019, 7(2):457-473]

Cited: 9 times

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Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Laura Belloni, Silvia Di Cocco, Francesca Guerrieri, Abigail D G Nunn, Silvia Piconese, Debora Salerno, Barbara Testoni, Claudio Pulito, Federica Mori, Matteo Pallocca, Andrea Sacconi, Elisa Vivoli, Fabio Marra, Sabrina Strano, Giovanni Blandino, Massimo Levrero, Natalia Pediconi,

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13638]

Cited: 2 times

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Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy.

Valerio Iebba, Francesca Guerrieri, Vincenza Di Gregorio, Massimo Levrero, Antonella Gagliardi, Floriana Santangelo, Anatoly P Sobolev, Simone Circi, Valerio Giannelli, Luisa Mannina, Serena Schippa, Manuela Merli,

In liver cirrhosis (LC), impaired intestinal functions lead to dysbiosis and possible bacterial translocation (BT). Bacteria or their byproducts within the bloodstream can thus play a role in systemic inflammation and hepatic encephalopathy (HE). We combined 16S sequencing, NMR metabolomics and network analysis to describe the interrelationships of members of ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):8210]

Cited: 10 times

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Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.

Marion Darnaud, Alexandre Dos Santos, Patrick Gonzalez, Sandrine Augui, Claire Lacoste, Christophe Desterke, Gert De Hertogh, Emma Valentino, Emilie Braun, Jinzi Zheng, Raphael Boisgard, Christel Neut, Laurent Dubuquoy, Franck Chiappini, Didier Samuel, Patricia Lepage, Francesca Guerrieri, Joel Doré, Christian Bréchot, Nicolas Moniaux, Jamila Faivre,

Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and promotes development of inflammatory bowel diseases. We investigated whether transgenic (TG) expression of the human regenerating family member 3 alpha gene (REG3A) alters the fecal ... Read more >>

Gastroenterology (Gastroenterology)
[2018, 154(4):1009-1023.e14]

Cited: 20 times

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Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Gianna Aurora Palumbo, Cecilia Scisciani, Natalia Pediconi, Leonardo Lupacchini, Dulce Alfaiate, Francesca Guerrieri, Ludovica Calvo, Debora Salerno, Silvia Di Cocco, Massimo Levrero, Laura Belloni,

PLoS ONE (PloS one)
[2015, 10(12):e0145555]

Cited: 0 times

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TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.

Antonio Costanzo, Natalia Pediconi, Alessandra Narcisi, Francesca Guerrieri, Francesca Guerrieri, Laura Belloni, Francesca Fausti, Elisabetta Botti, Massimo Levrero,

TP53 belongs to a small gene family that includes, in mammals, two additional paralogs, TP63 and TP73. The p63 and p73 proteins are structurally and functionally similar to p53 and their activity as transcription factors is regulated by a wide repertoire of shared and unique post-translational modifications and interactions with ... Read more >>

FEBS Lett. (FEBS letters)
[2014, 588(16):2590-2599]

Cited: 15 times

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The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Isabella Massimi, Francesca Guerrieri, Francesca Guerrieri, Marialaura Petroni, Veronica Veschi, Silvia Truffa, Isabella Screpanti, Luigi Frati, Massimo Levrero, Alberto Gulino, Giuseppe Giannini,

Reactivation of the HMGA1 protoncogene is very frequent in human cancer, but still very little is known on the molecular mechanisms leading to this event. Prompted by the finding of putative E2F binding sites in the human HMGA1 promoter and by the frequent deregulation of the RB/E2F1 pathway in human ... Read more >>

Mol. Carcinog. (Molecular carcinogenesis)
[2013, 52(7):526-534]

Cited: 15 times

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Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways.

Cecilia Scisciani, Stefania Vossio, Francesca Guerrieri, Valeria Schinzari, Rossana De Iaco, Paolo D'Onorio de Meo, Melchiorre Cervello, Giuseppe Montalto, Teresa Pollicino, Giovanni Raimondo, Massimo Levrero, Natalia Pediconi,

BACKGROUND & AIMS: miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. METHODS: Mature miRNA expression was evaluated by a 2 step ... Read more >>

J. Hepatol. (Journal of hepatology)
[2012, 56(4):855-861]

Cited: 72 times

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Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.

Barbara Testoni, Christine Völlenkle, Francesca Guerrieri, Francesca Guerrieri, Sabine Gerbal-Chaloin, Giovanni Blandino, Massimo Levrero,

Signal transducer and activator of transcription 2 (STAT2), the critical component of type I interferons signaling, is a prototype latent cytoplasmic signal-dependent transcription factor. Activated tyrosine-phosphorylated STAT2 associates with STAT1 and IRF9 to bind the ISRE elements in the promoters of a subset of IFN-inducible genes (ISGs). In addition to ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2011, 286(23):20217-20227]

Cited: 28 times

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hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.

Natalia Pediconi, Francesca Guerrieri, Francesca Guerrieri, Stefania Vossio, Tiziana Bruno, Laura Belloni, Valeria Schinzari, Cecilia Scisciani, Maurizio Fanciulli, Massimo Levrero,

The NAD(+)-dependent histone deacetylase hSirT1 regulates cell survival and stress responses by inhibiting p53-, NF-kappaB-, and E2F1-dependent transcription. Here we show that the hSirT1/PCAF interaction controls the E2F1/p73 apoptotic pathway. hSirT1 represses E2F1-dependent P1p73 promoter activity in untreated cells and inhibits its activation in response to DNA damage. hSirT1, PCAF, ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2009, 29(8):1989-1998]

Cited: 37 times

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