Full Text Journal Articles by
Author Frances Tong

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High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue.

Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W Shannon Dillmore, Rainer Blaesius,

Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigations are still limited by the precision of analysis methods and access to relevant tissue ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238594]

Cited: 0 times

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Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

[This corrects the article DOI: 10.18632/oncotarget.26911.]. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(49):5119]

Cited: 0 times

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Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not well defined. We compare 12 human clinical BE and adjacent normal squamous epithelium biopsies using single cell immunophenotyping by ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(38):3592-3604]

Cited: 3 times

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Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue.

Eileen Snowden, Warren Porter, Friedrich Hahn, Mitchell Ferguson, Frances Tong, Joel S Parker, Aaron Middlebrook, Smita Ghanekar, W Shannon Dillmore, Rainer Blaesius,

Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the number of cells which can be assessed or are very resource ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2017, 15(4):429-438]

Cited: 4 times

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Subtype and pathway specific responses to anticancer compounds in breast cancer.

Laura M Heiser, Anguraj Sadanandam, Wen-Lin Kuo, Stephen C Benz, Theodore C Goldstein, Sam Ng, William J Gibb, Nicholas J Wang, Safiyyah Ziyad, Frances Tong, Nora Bayani, Zhi Hu, Jessica I Billig, Andrea Dueregger, Sophia Lewis, Lakshmi Jakkula, James E Korkola, Steffen Durinck, François Pepin, Yinghui Guan, Elizabeth Purdom, Pierre Neuvial, Henrik Bengtsson, Kenneth W Wood, Peter G Smith, Lyubomir T Vassilev, Bryan T Hennessy, Joel Greshock, Kurtis E Bachman, Mary Ann Hardwicke, John W Park, Laurence J Marton, Denise M Wolf, Eric A Collisson, Richard M Neve, Gordon B Mills, Terence P Speed, Heidi S Feiler, Richard F Wooster, David Haussler, Joshua M Stuart, Joe W Gray, Paul T Spellman,

Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2012, 109(8):2724-2729]

Cited: 243 times

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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Richard M Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong, Terry Speed, Paul T Spellman, Sandy DeVries, Anna Lapuk, Nick J Wang, Wen-Lin Kuo, Jackie L Stilwell, Daniel Pinkel, Donna G Albertson, Frederic M Waldman, Frank McCormick, Robert B Dickson, Michael D Johnson, Marc Lippman, Stephen Ethier, Adi Gazdar, Joe W Gray,

Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer ... Read more >>

Cancer Cell (Cancer cell)
[2006, 10(6):515-527]

Cited: 1758 times

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Pharmacodynamic monitoring of BAY 43-9006 (Sorafenib) in phase I clinical trials involving solid tumor and AML/MDS patients, using flow cytometry to monitor activation of the ERK pathway in peripheral blood cells.

Frances K Tong, Sue Chow, David Hedley,

BACKGROUND: We previously reported a flow cytometry technique to monitor pharmacodynamic effects of the raf kinase inhibitor BAY 43-9006 based on the ability of phorbol ester (PMA) to phosphorylate extracellular-regulated kinase (ERK) in peripheral blood (Chow et al., Cytometry 2001;46:72-78). In this article, we describe its application to phase I ... Read more >>

Cytometry B Clin Cytom (Cytometry. Part B, Clinical cytometry)
[2006, 70(3):107-114]

Cited: 27 times

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NKIAMRE, a novel conserved CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases.

Karen W L Yee, Susan J Moore, Michael Midmer, Brent W Zanke, Frances Tong, David Hedley, Mark D Minden,

We report the cloning of the NKIAMRE gene located on human chromosome 5q31.1. It encodes a novel 52kDa Cdc2-related kinase with a 1.5kb open reading frame. Like MAP kinases, NKIAMRE contains a Thr-X-Tyr (TXY) motif in the activation loop domain. Similar to cdks, NKIAMRE contains the putative negative regulatory Ser14 ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2003, 308(4):784-792]

Cited: 14 times

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High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes.

Elena Allen, Steve Horvath, Frances Tong, Peter Kraft, Elizabeth Spiteri, Arthur D Riggs, York Marahrens,

Genes subject to monoallelic expression are expressed from only one of the two alleles either selected at random (random monoallelic genes) or in a parent-of-origin specific manner (imprinted genes). Because high densities of long interspersed nuclear element (LINE)-1 transposon sequence have been implicated in X-inactivation, we asked whether monoallelically expressed ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2003, 100(17):9940-9945]

Cited: 80 times

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Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand.

Ivan Bosanac, Jean-René Alattia, Tapas K Mal, Jenny Chan, Susanna Talarico, Frances K Tong, Kit I Tong, Fumio Yoshikawa, Teiichi Furuichi, Miwako Iwai, Takayuki Michikawa, Katsuhiko Mikoshiba, Mitsuhiko Ikura,

In a variety of cells, the Ca2+ signalling process is mediated by the endoplasmic-reticulum-membrane-associated Ca2+ release channel, inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Being ubiquitous and present in organisms ranging from humans to Caenorhabditis elegans, InsP3R has a vital role in the control of cellular and physiological processes as diverse as ... Read more >>

Nature (Nature)
[2002, 420(6916):696-700]

Cited: 170 times

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