Full Text Journal Articles by
Author Fouad A Zouein

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Insights into the modulation of the interferon response and NAD+ in the context of COVID-19.

Nada J Habeichi, Cynthia Tannous, Andriy Yabluchanskiy, Raffaele Altara, Mathias Mericskay, George W Booz, Fouad A Zouein,

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in dramatic worldwide mortality. Along with developing vaccines, the medical profession is exploring new strategies to curb this pandemic. A better understanding of the molecular consequences of SARS-CoV-2 cellular infection could lead to more effective and ... Read more >>

Int Rev Immunol (International reviews of immunology)
[2021, :1-11]

Cited: 1 time

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Potential Biomarkers in Atrial Fibrillation: Insight Into Their Clinical Significance.

Khalil Charafeddine, Patrick Zakka, Bassel Bou Dargham, Farah Abdulhai, Katerina Zakka, Fouad A Zouein, Marwan Refaat,

<h4>Abstract</h4>In risk-stratifying patients with atrial fibrillation (AF), physicians rely heavily on clinical parameters that provide risk scores and determine treatment strategies. There has been increasing research on potential biomarkers in the blood that could more accurately determine both risk of complications in AF and risk of incidence of AF. This ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2021, 78(2):184-191]

Cited: 0 times

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Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate.

George W Booz, Gaelle P Massoud, Raffaele Altara, Fouad A Zouein,

Fetal exposure to an unfavorable intrauterine environment programs an individual to have a greater susceptibility later in life to non-communicable diseases, such as coronary heart disease, but the molecular processes are poorly understood. An article in Clinical Science recently reported novel details on the effects of maternal nutrient reduction (MNR) ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2021, 135(14):1767-1772]

Cited: 0 times

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Distorted assessment of left atrial size by echocardiography in patients with increased aortic root diameter.

Abdullah Kaplan, Raffaele Altara, Marco Manca, Hacı Murat Gunes, Alessandro Cataliotti, George W Booz, Fouad A Zouein,

<h4>Background</h4>Left atrial (LA) size is frequently assessed by posterior-anterior linear measurement of LA (LAD P-A) in the parasternal long axis to expedite examination. Aging, changes in body surface area, and several cardiovascular pathologies can affect aortic root (AoR) size, thereby affecting LA anatomical shape. We hypothesized that AoR dilatation influences ... Read more >>

Egypt Heart J (The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology)
[2021, 73(1):55]

Cited: 0 times

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Transforming iodoquinol into broad spectrum anti-tumor leads: Repurposing to modulate redox homeostasis.

Ibrahim Chaaban, Haidy Hafez, Ibrahim AlZaim, Cynthia Tannous, Hanan Ragab, Aly Hazzaa, Salma Ketat, Asser Ghoneim, Mohamed Katary, Mohammad M Abd-Alhaseeb, Fouad A Zouein, Amgad Albohy, Ahmed Noby Amer, Ahmed F El-Yazbi, Ahmed S F Belal,

We managed to repurpose the old drug iodoquinol to a series of novel anticancer 7-iodo-quinoline-5,8-diones. Twelve compounds were identified as inhibitors of moderate to high potency on an inhouse MCF-7 cell line, of which 2 compounds (5 and 6) were capable of reducing NAD level in MCF-7 cells in concentrations ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 113:105035]

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Cannabinoids and myocardial ischemia: Novel insights, updated mechanisms, and implications for myocardial infarction.

Karim Seif El-Dahan, Dima Machtoub, Gaelle Massoud, Suzanne A Nasser, Bassam Hamam, Firas Kobeissy, Fouad A Zouein, Ali H Eid,

Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects as compared to other illicit drugs; however, growing evidence clearly indicates that cannabis is associated with considerable adverse ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, :]

Cited: 0 times

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The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?

Fouad A Zouein, Raffaele Altara, Gaelle P Massoud, George W Booz,

<h4>Abstract</h4>An ongoing issue in cardiac pharmacology is whether angiotensin II has direct growth promoting effects on the heart via the angiotensin II type 1 (AT1) receptor. This question has relevance for whether angiotensin-converting enzyme inhibitors and AT1 receptor blockers offer additional benefit in preventing adverse cardiac remodeling in hypertension. In ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2021, 77(5):531-535]

Cited: 0 times

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Beat-to-beat blood pressure variability: an early predictor of disease and cardiovascular risk.

Nour-Mounira Z Bakkar, Ahmed F El-Yazbi, Fouad A Zouein, Souha A Fares,

Blood pressure (BP) varies on the long, short and very-short term. Owing to the hidden physiological and pathological information present in BP time-series, increasing interest has been given to the study of continuous, beat-to-beat BP variability (BPV) using invasive and noninvasive methods. Different linear and nonlinear parameters of variability are ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(5):830-845]

Cited: 1 time

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Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction.

Michael Frisk, Christopher Le, Xin Shen, Åsmund T Røe, Yufeng Hou, Ornella Manfra, Gustavo J J Silva, Isabelle van Hout, Einar S Norden, J Magnus Aronsen, Martin Laasmaa, Emil K S Espe, Fouad A Zouein, Regis R Lambert, Christen P Dahl, Ivar Sjaastad, Ida G Lunde, Sean Coffey, Alessandro Cataliotti, Lars Gullestad, Theis Tønnessen, Peter P Jones, Raffaele Altara, William E Louch,

<h4>Background</h4>Whereas heart failure with reduced ejection fraction (HFrEF) is associated with ventricular dilation and markedly reduced systolic function, heart failure with preserved ejection fraction (HFpEF) patients exhibit concentric hypertrophy and diastolic dysfunction. Impaired cardiomyocyte Ca<sup>2+</sup> homeostasis in HFrEF has been linked to disruption of membrane invaginations called t-tubules, but it ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(4):405-419]

Cited: 2 times

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Advances in Cardiovascular Biomarker Discovery.

Crystal M Ghantous, Layla Kamareddine, Rima Farhat, Fouad A Zouein, Stefania Mondello, Firas Kobeissy, Asad Zeidan,

Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart failure and stroke. Identifying novel and early stage biomarkers of hypertension and other cardiovascular diseases is of paramount importance in predicting ... Read more >>

Biomedicines (Biomedicines)
[2020, 8(12):]

Cited: 2 times

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Science unites a troubled world: Lessons from the pandemic.

George W Booz, Fouad A Zouein,

European Journal of Pharmacology has published a special issue entitled Therapeutic targets and pharmacological treatment of COVID-19 that contains more than 30 manuscripts. Scientists from around the world contributed both review articles and original manuscripts that are remarkable in their diversity. Each contribution offers a unique perspective on the current ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2021, 890:173696]

Cited: 0 times

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Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases.

Cynthia Tannous, George W Booz, Raffaele Altara, Dina H Muhieddine, Mathias Mericskay, Marwan M Refaat, Fouad A Zouein,

Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor that plays crucial roles in several cellular processes. NAD can be synthesized de novo starting with tryptophan, or from salvage pathways starting with NAD precursors like nicotinic acid (NA), nicotinamide (NAM) or nicotinamide riboside (NR), referred to as niacin/B<sub>3</sub> vitamins, arising from ... Read more >>

Acta Physiol (Oxf) (Acta physiologica (Oxford, England))
[2021, 231(3):e13551]

Cited: 3 times

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Worsening baroreflex sensitivity on progression to type 2 diabetes: localized vs. systemic inflammation and role of antidiabetic therapy.

Nour-Mounira Z Bakkar, Nahed Mougharbil, Ali Mroueh, Abdullah Kaplan, Ali H Eid, Souha Fares, Fouad A Zouein, Ahmed F El-Yazbi,

Cardiac autonomic neuropathy (CAN) is an early cardiovascular manifestation of type 2 diabetes (T2D) that constitutes an independent risk factor for cardiovascular mortality and morbidity. Nevertheless, its underlying pathophysiology remains poorly understood. We recently showed that localized perivascular adipose tissue (PVAT) inflammation underlies the incidence of parasympathetic CAN in prediabetes. ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2020, 319(5):E835-E851]

Cited: 2 times

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Macrophage responses associated with COVID-19: A pharmacological perspective.

George W Booz, Raffaele Altara, Ali H Eid, Zena Wehbe, Souha Fares, Hassan Zaraket, Nada J Habeichi, Fouad A Zouein,

COVID-19 has caused worldwide death and economic destruction. The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great morbidity and mortality in vulnerable populations. At present, scientists are exploring various approaches to curb this pandemic and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 887:173547]

Cited: 11 times

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Untangling the Interplay Between Mitochondrial Fission and NF-κB Signaling in Endothelial Inflammation.

Raffaele Altara, Fouad A Zouein, George W Booz,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 76(1):23-25]

Cited: 0 times

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IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture.

Rana Ghali, Nada J Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W Booz, Ziad Mallat, Fouad A Zouein,

Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin (IL)-33 (IL-33) is a cytokine present in most cardiac cells and is secreted on necrosis where it acts as a functional ligand for the ST2 receptor. Although IL-33/ST2 axis is protective against various forms of cardiovascular diseases, some studies ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2020, 134(11):1191-1218]

Cited: 1 time

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Targeting mitochondria to protect the heart: a matter of balance?

Fouad A Zouein, George W Booz,

Mitochondria are dynamic, undergoing both fission and fusion. Evidence indicates that a balance between these two processes is necessary to maintain a healthy state. With ischemia/reperfusion (I/R) of the heart, fission is enhanced and is associated with mitochondrial swelling, depolarization, and production of reactive oxygen species (ROS), as well as ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2020, 134(7):885-888]

Cited: 2 times

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Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage.

Raffaele Altara, Gustavo J J da Silva, Michael Frisk, Francesco Spelta, Fouad A Zouein, William E Louch, George W Booz, Alessandro Cataliotti,

Cardiac hypertrophy and renal damage associated with hypertension are independent predictors of morbidity and mortality. In a model of hypertensive heart disease and renal damage, we tested the actions of continuous administration of Vastiras, a novel compound derived from the linear fragment of ANP (atrial natriuretic peptide), namely pro-ANP<sub>31-67</sub>, on ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 75(5):1195-1204]

Cited: 3 times

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Spatiotemporal Dynamics of Immune Cells in Early Left Ventricular Remodeling After Acute Myocardial Infarction in Mice.

Anthony T Bejjani, Sally A Saab, Dina H Muhieddine, Nada J Habeichi, George W Booz, Fouad A Zouein,

Myocardial infarction remains a leading cause of morbidity and death. Insufficient delivery of oxygen to the myocardium sets into play a complicated process of repair that involves the temporal recruitment of different immune cells so as to remove debris and necrotic cells expeditiously and to form effective scar tissue. Clearly ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 75(2):112-122]

Cited: 0 times

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Gender-biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females.

Abdullah Kaplan, Emna Abidi, Nada J Habeichi, Rana Ghali, Hiam Alawasi, Christina Fakih, Kazem Zibara, Firas Kobeissy, Ahmad Husari, George W Booz, Fouad A Zouein,

Multiple clinical studies documented renal damage in chronic cigarette smokers (CS) irrespective of their age and gender. Premenopausal female smokers are known to exert a certain cardiovascular and renal protection with undefined mechanisms. Given the multiple demographic variables within clinical studies, this experimental study was designed to be the first ... Read more >>

Physiol Rep (Physiological reports)
[2020, 8(2):e14339]

Cited: 1 time

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Tobacco cigarette smoking exacerbates aortic calcification in an early stage of myocardial infarction in a female mouse model.

Sara Zalghout, Abdullah Kaplan, Emna Abidi, Ghewa A El-Achkar, Wared Nour-Eldine, Asmaa A Khalil, Firas Kobeissy, Ahmad Husari, Aida Habib, Fouad A Zouein, Eva Hamade,

Despite increased social awareness, marketing restraints, tobacco taxation, and available smoking cessation rehab programs, active and passive smoking remain a worldwide challenging epidemic and a key risk factor for cardiovascular diseases development. Although cardiovascular (CV) protection is more pronounced in women than in men due to estrogenic effects, tobacco cigarette ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2020, 235(2):1568-1575]

Cited: 1 time

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STAT3 and Endothelial Cell-Cardiomyocyte Dialog in Cardiac Remodeling.

Fouad A Zouein, George W Booz, Raffaele Altara,

This article presents an overview of the central role of STAT3 in the crosstalk between endothelial cells and cardiac myocytes in the heart. Endothelial cell STAT3 has a key role in inflammation that underlies cardiovascular disease and impacts on cardiac structure and function. STAT3 in endothelial cells contributes to adverse ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2019, 6:50]

Cited: 3 times

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An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology.

Ali Nehme, Fouad A Zouein, Zeinab Deris Zayeri, Kazem Zibara,

In its classical view, the renin angiotensin system (RAS) was defined as an endocrinesystem involved in blood pressure regulation and body electrolyte balance. However, the emergingconcept of tissue RAS, along with the discovery of new RAS components, increased thephysiological and clinical relevance of the system. Indeed, RAS has been shown ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2019, 6(2):]

Cited: 57 times

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MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.

Hassan Dehaini, Hussein Awada, Ahmed El-Yazbi, Fouad A Zouein, Khodr Issa, Assaad A Eid, Maryam Ibrahim, Adnan Badran, Elias Baydoun, Gianfranco Pintus, Ali H Eid,

<h4>Background</h4>Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed ... Read more >>

Cells (Cells)
[2019, 8(2):]

Cited: 12 times

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Cerebral blood flow alteration following acute myocardial infarction in mice.

Abdullah Kaplan, Andriy Yabluchanskiy, Rana Ghali, Raffaele Altara, George W Booz, Fouad A Zouein,

Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain ageing and Alzheimer's disease (AD) development. Although clinical heart failure can emerge several years following acute myocardial infarction (AMI), the impact of AMI on cerebral blood flow (CBF) at ... Read more >>

Biosci Rep (Bioscience reports)
[2018, 38(5):]

Cited: 2 times

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