Full Text Journal Articles by
Author Florian Maurer

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Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak

Maxime Godfroid, Tal Dagan, Matthias Merker, Thomas Kohl, Roland Diel, Florian Maurer, Stefan Niemann, Anne Kupczok,

Abstract In genome evolution, genetic variants are the source of diversity, which natural selection acts upon. Treatment of human tuberculosis (TB) induces a strong selection pressure for the emergence of antibiotic resistance in the infecting Mycobacterium tuberculosis (MTB) strains. MTB evolution in response to treatment has been intensively studied and ... Read more >>

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[Antibiotic Stewardship in Community-Acquired Pneumonia].

Fabian Leo, Miriam Songa Stegemann, Florian Maurer,

Antibiotic stewardship (ABS) denotes structured and continuous measures to improve the quality of prescribing anti-infectives. The aim is to achieve optimal treatment results and to minimize undesirable effects, especially the emergence of antibiotic resistance. This review summarizes the most important ABS principles based on recently published studies with implications for ... Read more >>

Dtsch. Med. Wochenschr. (Deutsche medizinische Wochenschrift (1946))
[2020, 145(6):383-392]

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Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.

Matthias Merker, Thomas A Kohl, Ivan Barilar, Sönke Andres, Philip W Fowler, Erja Chryssanthou, Kristian Ängeby, Pontus Jureen, Danesh Moradigaravand, Julian Parkhill, Sharon J Peacock, Thomas Schön, Florian P Maurer, Timothy Walker, Claudio Köser, Stefan Niemann,

BACKGROUND:A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). METHODS:We investigated mutations in 92 genes implicated in resistance to 21 anti-tuberculosis drugs using the genomes ... Read more >>

Genome Med (Genome medicine)
[2020, 12(1):27]

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Comparative analysis of phenotypic and genotypic antibiotic susceptibility patterns in Mycobacterium avium complex.

Nils Wetzstein, Thomas A Kohl, Sönke Andres, Tilman G Schultze, Ari Geil, Eunhee Kim, Teodora Biciusca, Christian Hügel, Michael Hogardt, Annette Lehn, Maria J G T Vehreschild, Timo Wolf, Stefan Niemann, Florian P Maurer, Thomas A Wichelhaus,

OBJECTIVE:Phenotypic (Sensititre Myco, pDST) and genotypic drug susceptibility testing (GenoType NTM DR, gDST) in M. avium complex (MAC) have become available as standardized assays, but comparable data is needed. This study aimed to investigate the phenotypic and genotypic drug susceptibility patterns in MAC clinical isolates. METHODS:Overall, 98 isolates from 85 ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 93:320-328]

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Bedaquiline-resistant Tuberculosis: Dark Clouds on the Horizon.

Sönke Andres, Matthias Merker, Jan Heyckendorf, Barbara Kalsdorf, Rudolf Rumetshofer, Alexander Indra, Sabine Hofmann-Thiel, Harald Hoffmann, Christoph Lange, Stefan Niemann, Florian P Maurer,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, :]

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Unravelling the Different Reaction Pathways for Low Temperature CO Oxidation on Pt/CeO2 and Pt/Al2O3 by Spatially Resolved Structure-Activity Correlations.

Andreas M Gänzler, Maria Casapu, Dmitry E Doronkin, Florian Maurer, Patrick Lott, Pieter Glatzel, Martin Votsmeier, Olaf Deutschmann, Jan-Dierk Grunwaldt,

Spatially resolved operando HERFD-XANES (high energy resolution fluorescence detected X-ray absorption near edge structure) complemented by CO concentration gradient profiles along the catalyst bed (SpaciPro) was used to identify the dominant reaction paths for the low and high temperature CO oxidation on Pt/CeO2 and Pt/Al2O3. At low temperatures, features associated ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2019, :7698-7705]

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Accuracy of whole-genome sequencing to determine recent tuberculosis transmission: an 11-year population-based study in Hamburg, Germany.

Roland Diel, Thomas A Kohl, Florian P Maurer, Matthias Merker, Karen Meywald Walter, Jörg Hannemann, Albert Nienhaus, Philip Supply, Stefan Niemann,

Eur. Respir. J. (The European respiratory journal)
[2019, 54(5):]

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Improving tuberculosis surveillance by detecting international transmission using publicly available whole-genome sequencing data

Andrea Sanchini, Christine Jandrasits, Julius Tembrockhaus, Thomas Andreas Kohl, Christian Utpatel, Florian Maurer, Stefan Niemann, Walter Haas, Bernhard Renard, Stefan Kröger,

Abstract Introduction Improving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR)-TB. The large amount of publicly available whole-genome sequencing (WGS) data for TB gives us the chance to re-use data and to perform additional analysis at a large scale. Aim We assessed the ... Read more >>

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[Tuberculosis].

Christoph Lange, Barbara Kalsdorf, Florian P Maurer, Jan Heyckendorf,

Tuberculosis is a bacterial infectious disease that is usually transmitted by inhalation of droplets containing the bacteria. The World Health Organization (WHO) estimates that approximately 10 million patients were newly diagnosed with tuberculosis in 2017. Rapid diagnosis relies on a combination of imaging and microbiological, molecular, and, rarely, immunological tests. Genotypic methods ... Read more >>

Internist (Berl) (Der Internist)
[2019, 60(11):1155-1175]

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Prevalence of and risk factors for anaemia in patients with advanced chronic liver disease.

Bernhard Scheiner, Georg Semmler, Florian Maurer, Philipp Schwabl, Theresa A Bucsics, Rafael Paternostro, David Bauer, Benedikt Simbrunner, Michael Trauner, Mattias Mandorfer, Thomas Reiberger,

BACKGROUND:Anaemia is common in advanced chronic liver disease (ACLD) as a result of various risk factors. AIMS & METHODS:We evaluated the prevalence and severity of anaemia as well as the impact of anaemia on clinical outcomes in consecutive patients with ACLD and portal hypertension. RESULTS:Among 494 patients, 324 (66%) patients ... Read more >>

Liver Int. (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(1):194-204]

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A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3.

Christian Dupont, Yushu Chen, Zhujun Xu, Françoise Roquet-Banères, Mickaël Blaise, Anne-Kathrin Witt, Faustine Dubar, Christophe Biot, Yann Guérardel, Florian P Maurer, Shu-Sin Chng, Laurent Kremer,

Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a major human pathogen, and current treatment options to combat this disease are under threat because of the emergence of multidrug-resistant and extensively drug-resistant tuberculosis. High-throughput whole-cell screening of an extensive compound library has recently identified a piperidinol-containing molecule, PIPD1, as a ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2019, 294(46):17512-17523]

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New World Health Organization Treatment Recommendations for Multidrug-Resistant Tuberculosis: Are We Well Enough Prepared?

Katharina Kranzer, Barbara Kalsdorf, Jan Heyckendorf, Sönke Andres, Matthias Merker, Sabine Hofmann-Thiel, Guido V Bloemberg, Harald Hoffmann, Stefan Niemann, Christoph Lange, Florian P Maurer,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(4):514-515]

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Same meat, different gravy: ignore the new names of mycobacteria.

Enrico Tortoli, Barbara A Brown-Elliott, James D Chalmers, Daniela M Cirillo, Charles L Daley, Stefan Emler, R Andres Floto, Maria J Garcia, Wouter Hoefsloot, Won-Jung Koh, Christoph Lange, Michael Loebinger, Florian P Maurer, Kozo Morimoto, Stefan Niemann, Elvira Richter, Christine Y Turenne, Ravikiran Vasireddy, Sruthi Vasireddy, Dirk Wagner, Richard J Wallace, Nancy Wengenack, Jakko van Ingen,

Eur. Respir. J. (The European respiratory journal)
[2019, 54(1):]

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Rifamycin derivatives active against pathogenic rapidly-growing mycobacteria.

Keith D Combrink, Andrea Ramirez Ramos, Stephanie Spring, Sebastian Schmidl, Kira Elizondo, Petronilo Morin, Bryant De Jesus, Florian P Maurer,

Infections due to rapidly growing mycobacteria (RGM), and in particular the RGM species Mycobacterium abscessus (Mab), are very difficult to treat and reports on novel therapeutic options are scarce. A hallmark of all pathogenic RGM species is their resistance to the four first-line drugs used to treat infections with Mycobacterium ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2019, 29(16):2112-2115]

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Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods.

Lucia Asar, Susanne Pfefferle, Marc Lütgehetmann, Armin Hoffmann, Juri Katchanov, Martin Aepfelbacher, Holger Rohde, Florian P Maurer,

OBJECTIVES:To determine the influence of local spread of clonal strains and testing of follow-up isolates on categorical (CA) and essential agreement rates (EA) of common colistin (COL) drug susceptibility testing methods with the broth microdilution (BMD) reference method. METHODS:COL MICs were determined for 178 bacterial isolates (Enterobacteriaceae, n = 97; ... Read more >>

PLoS ONE (PloS one)
[2019, 14(6):e0217468]

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Novel external quality assurance scheme for drug susceptibility testing of non-tuberculous mycobacteria: a multicentre pilot study.

Vladyslav Nikolayevskyy, Florian P Maurer, Yen Holicka, Lucy Taylor, Helen Liddy, Katharina Kranzer,

OBJECTIVES:Our aim was to conduct a multicentre study involving laboratories participating in the European TB Reference Laboratory Network aiming to develop a pilot external quality assessment (EQA) scheme for drug susceptibility testing (DST) of non-tuberculous mycobacteria (NTM). METHODS:The study comprised a survey using a structured questionnaire followed by a pilot ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2019, 74(5):1288-1294]

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'Those who cannot remember the past are condemned to repeat it': Drug-susceptibility testing for bedaquiline and delamanid.

Claudio U Köser, Florian P Maurer, Katharina Kranzer,

Despite being fundamental to all treatment decisions, the breakpoints that define susceptibility and resistance to conventional anti-tuberculosis (TB) drugs were traditionally defined based on expert opinion as opposed to modern microbiological principles. As a result, the breakpoints for several key drugs (i.e. amikacin, levofloxacin, and moxifloxacin) were too high, resulting ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2019, 80S:S32-S35]

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Carbapenem-resistant Gram-negative pathogens in a German university medical center: Prevalence, clinical implications and the role of novel β-lactam/β-lactamase inhibitor combinations.

Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer,

To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center.Retrospective analysis.Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized ... Read more >>

PLoS ONE (PloS one)
[2018, 13(4):e0195757]

Cited: 12 times

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Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis.

Christian H Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D'Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger, Christoph Schmaderer,

Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has been shown to cause severe hyperkalemia. The pathophysiology behind the rapid development of hyperkalemia is not well understood. We hypothesized that the hyperkalemia should be ... Read more >>

EJNMMI Res (EJNMMI research)
[2018, 8(1):17]

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ESGAP inventory of target indicators assessing antibiotic prescriptions: a cross-sectional survey.

Philip Howard, Benedikt Huttner, Bojana Beovic, Guillaume Beraud, Diamantis P Kofteridis, José Pano Pardo, Jeroen Schouten, Céline Pulcini, ,

Background:A variety of indicators is commonly used to monitor antibiotic prescriptions as part of national antimicrobial stewardship (AMS) programmes. Objectives:To make an inventory of indicators that assess antibiotic prescriptions and are linked to specific targets and incentives, at a national level. Methods:A cross-sectional survey (three-item questionnaire) was conducted in 2017 ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2017, 72(10):2910-2914]

Cited: 7 times

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Emergence of ceftazidime/avibactam non-susceptibility in an MDR Klebsiella pneumoniae isolate.

Anna Both, Henning Büttner, Jiabin Huang, Markus Perbandt, Cristina Belmar Campos, Martin Christner, Florian P Maurer, Stefan Kluge, Christina König, Martin Aepfelbacher, Dominic Wichmann, Holger Rohde,

Background:Avibactam is a novel broad-range β-lactamase inhibitor active against Ambler class A (including ESBL and KPC) and some Ambler class C and D (e.g. OXA-48) enzymes. We here report on the emergence of ceftazidime/avibactam resistance in clinical, multiresistant, OXA-48 and CTX-M-14-producing Klebsiella pneumoniae isolate DT12 during ceftazidime/avibactam treatment. Methods and ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2017, 72(9):2483-2488]

Cited: 16 times

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Advances in Rapid Identification and Susceptibility Testing of Bacteria in the Clinical Microbiology Laboratory: Implications for Patient Care and Antimicrobial Stewardship Programs.

Florian P Maurer, Martin Christner, Moritz Hentschke, Holger Rohde,

Early availability of information on bacterial pathogens and their antimicrobial susceptibility is of key importance for the management of infectious diseases patients. Currently, using traditional approaches, it usually takes at least 48 hours for identification and susceptibility testing of bacterial pathogens. Therefore, the slowness of diagnostic procedures drives prolongation of ... Read more >>

Infect Dis Rep (Infectious disease reports)
[2017, 9(1):6839]

Cited: 14 times

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Risk factors for excessively prolonged meropenem use in the intensive care setting: a case-contol study.

Juri Katchanov, Benno Kreuels, Florian P Maurer, Kai Wöstmann, Johannes Jochum, Christina König, Kariem Seoudy, Holger Rohde, Ansgar W Lohse, Dominic Wichmann, Michael Baehr, Camilla Rothe, Stefan Kluge,

Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and the general public. The aim of the study was to identify patients at risk for excessively prolonged carbapenem treatment in the ICU as a target for antimicrobial stewardship interventions.Case-control study in a network of 11 ICUs of a ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2017, 17(1):131]

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The Technical and Biological Reproducibility of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Based Typing: Employment of Bioinformatics in a Multicenter Study.

Michael Oberle, Nadia Wohlwend, Daniel Jonas, Florian P Maurer, Geraldine Jost, Sarah Tschudin-Sutter, Katleen Vranckx, Adrian Egli,

The technical, biological, and inter-center reproducibility of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI TOF MS) typing data has not yet been explored. The aim of this study is to compare typing data from multiple centers employing bioinformatics using bacterial strains from two past outbreaks and non-related strains.Participants ... Read more >>

PLoS ONE (PloS one)
[2016, 11(10):e0164260]

Cited: 5 times

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Standardization of Operator-Dependent Variables Affecting Precision and Accuracy of the Disk Diffusion Method for Antibiotic Susceptibility Testing.

Michael Hombach, Florian P Maurer, Tamara Pfiffner, Erik C Böttger, Reinhard Furrer,

Parameters like zone reading, inoculum density, and plate streaking influence the precision and accuracy of disk diffusion antibiotic susceptibility testing (AST). While improved reading precision has been demonstrated using automated imaging systems, standardization of the inoculum and of plate streaking have not been systematically investigated yet. This study analyzed whether ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2015, 53(12):3864-3869]

Cited: 5 times

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