Full Text Journal Articles by
Author Florian Hitzenbichler

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Adherence to STIKO recommendations in patients with pulmonary disease in southeast Germany.

Arno Mohr, Annelie Plentz, Anna Sieroslawski, Fabian Pezenburg, Myriam Koch, Stilla Bauernfeind, Michael Pfeifer, Bernd Salzberger, Florian Hitzenbichler,

<h4>Background</h4>Vaccinations are among the most effective preventative healthcare measures. The aim of this cross-sectional study was to evaluate the adherence of adults with pre-existing pulmonary conditions to the national vaccination schedule and to identify reasons for poor adherence.<h4>Methods</h4>All patients with an appointment at Donaustauf hospital between October 2019 and April ... Read more >>

Infection (Infection)
[2021, :]

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Letter in response to article in journal of infection: "The microbiology of chronic osteomyelitis: Changes over ten years".

Nike Walter, Susanne Baertl, Ulrike Engelstaedter, Martin Ehrenschwender, Florian Hitzenbichler, Volker Alt, Markus Rupp,

J Infect (The Journal of infection)
[2021, :]

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Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2

Stilla Bauernfeind, Bernd Salzberger, Florian Hitzenbichler, Karolina Scigala, Sebastian Einhauser, Ralf Wagner, André Gessner, Josef Koestler, David Peterhoff,

It is not clear whether there is an association between adverse reactions and immune response after vaccination. Seven hundred and thirty-five vaccinees from our University Medical Center vaccination clinic provided information about sex, age and adverse reactions after first and second vaccination with BNT162b2. Adverse reactions were categorized into three ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(10):]

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[Update on: SARS-CoV-2/COVID-19-epidemiology and prevention].

Bernd Salzberger, Felix Buder, Benedikt Lampl, Boris Ehrenstein, Florian Hitzenbichler, Stilla Bauernfeind, Thomas Holzmann, Barbara Schmidt, Frank Hanses,

Nephrologe (Der nephrologe)
[2021, :1-4]

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Is There a Difference in Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Fracture-Related Infection and Periprosthetic Joint Infection? A Retrospective Comparative Study.

Markus Rupp, Susanne Baertl, Nike Walter, Florian Hitzenbichler, Martin Ehrenschwender, Volker Alt,

This study aims to investigate (1) microbial patterns in fracture-related infections (FRIs) in comparison to microbiological patterns of periprosthetic joint infections (PJIs), (2) the identification of effective empiric antibiotic therapy for FRIs and PJIs and (3) analysis of difficult-to-treat (DTT) pathogens. Patients treated for FRIs or PJIs from 2017 to ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(8):]

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Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.

Kerstin Renner, Tobias Schwittay, Sophia Chaabane, Johanna Gottschling, Christine Müller, Charlotte Tiefenböck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Saidou Balam, Maximilian V Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orsó, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, André Gessner, Bernd Salzberger, Matthias Mack,

Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3006]

Cited: 1 time

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Brief report: attitudes towards Covid-19 vaccination among hospital employees in a tertiary care university hospital in Germany in December 2020.

Stilla Bauernfeind, Florian Hitzenbichler, Gunnar Huppertz, Florian Zeman, Michael Koller, Barbara Schmidt, Annelie Plentz, Markus Bauswein, Arno Mohr, Bernd Salzberger,

Coronavirus disease 2019 (Covid-19) vaccination is essential to fight the pandemic. Health care workers (HCWs) are prioritized to get vaccinated, yet uptake of recommended vaccinations is known to be low in this group. In a tertiary care university hospital with a high number of Covid-19 patients in intensive care, 59.5% ... Read more >>

Infection (Infection)
[2021, :]

Cited: 3 times

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[Hygiene in ENT examination: Fluorescence study with overview of current recommendations].

Christian Rohrmeier, Wulf Schneider-Brachert, Thomas Kühnel, Florian Hitzenbichler, Thomas Holzmann, Christopher Bohr,

Increasing normative demands on patient safety and quality assurance measures, but also the problem of multi-resistant germs and pathogens with a high potential for infection, increase the need for hygienically correct work.In this study, hygienically relevant potential sources of contamination in ENT examinations were to be identified and possible improvement ... Read more >>

Laryngorhinootologie (Laryngo- rhino- otologie)
[2021, 100(6):434-442]

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[Cervicofacial actinomycosis].

Anja Maria Brosig, Florian Hitzenbichler, Benjamin Ernst, Josef Köstler, Christopher Bohr, Julian Künzel,

Actinomycosis is an infectious disease caused by gram-positive, facultative anaerobic bacteria, which in most cases manifests itself in the cervicofacial area and often has a dentogenic focus. The clinical presentation ranges from acute abscess to chronically fistulating soft tissue processes. Early diagnosis and an appropriate therapeutic approach including a combination ... Read more >>

Laryngorhinootologie (Laryngo- rhino- otologie)
[2021, :]

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Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2.

Florian Hitzenbichler, Stilla Bauernfeind, Bernd Salzberger, Barbara Schmidt, Jürgen J Wenzel,

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA is detected by reverse-transcription quantitative real-time PCR (RT-qPCR) from respiratory specimens. This study compares throat washings (TW), nasopharyngeal swabs (NS) and oropharyngeal swabs (OS). A total of 102 samples from 34 adult patients with confirmed SARS-CoV-2 infection were analysed by RT-qPCR with ... Read more >>

Viruses (Viruses)
[2021, 13(4):]

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Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients.

Selina Schießer, Florian Hitzenbichler, Martin G Kees, Alexander Kratzer, Matthias Lubnow, Bernd Salzberger, Frieder Kees, Christoph Dorn,

<h4>Background</h4>The antibacterial effect of antibiotics is linked to the free drug concentration. This study investigated the applicability of an ultrafiltration method to determine free plasma concentrations of beta-lactam antibiotics in ICU patients.<h4>Methods</h4>Eligible patients included adult ICU patients treated with ceftazidime (CAZ), meropenem (MEM), piperacillin (PIP)/tazobactam (TAZ), or flucloxacillin (FXN) by ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2021, 43(2):264-270]

Cited: 1 time

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Cardiopulmonary exercise pattern in patients with persistent dyspnoea after recovery from COVID-19.

Arno Mohr, Laura Dannerbeck, Tobias J Lange, Michael Pfeifer, Stefan Blaas, Bernd Salzberger, Florian Hitzenbichler, Myriam Koch,

Cause and mechanisms of persistent dyspnoea after recovery from COVID-19 are not well described. The objective is to describe causal factors for persistent dyspnoea in patients after COVID-19. We examined patients reporting dyspnoea after recovery from COVID-19 by cardiopulmonary exercise testing. After exclusion of patients with pre-existing lung diseases, ten ... Read more >>

Multidiscip Respir Med (Multidisciplinary respiratory medicine)
[2021, 16(1):732]

Cited: 5 times

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[SARS-CoV-2/COVID-19-epidemiology and prevention].

Bernd Salzberger, Felix Buder, Benedikt Lampl, Boris Ehrenstein, Florian Hitzenbichler, Thomas Holzmann, Barbara Schmidt, Frank Hanses,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally since December 2019. A first wave is visible up to the end of June 2020 in many regions. This article presents a review of the current knowledge on the epidemiology and prevention. The SARS-CoV‑2 predominantly replicates in the upper and ... Read more >>

Nephrologe (Der nephrologe)
[2020, :1-7]

Cited: 2 times

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Comment on "Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples".

Uwe Liebchen, Christoph Dorn, Martin Kees, Selina Schiesser, Florian Hitzenbichler, Frieder Kees, Michael Paal,

Ther Drug Monit (Therapeutic drug monitoring)
[2020, 42(6):909-910]

Cited: 3 times

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Diagnostic value of FDG PET/CT imaging in patients with surgically managed infective endocarditis: results of a retrospective analysis at a tertiary center.

Sabine Julia Maria Sag, Karin Menhart, Jirka Grosse, Florian Hitzenbichler, Frank Hanses, Arno Mohr, Bernd Salzberger, Matthäus Zerdzitzki, Michael Hilker, Leopold Rupprecht, Dirk Hellwig, Christof Schmid, Lars Siegfried Maier, Can Martin Sag,

<h4>Background</h4>We assessed the diagnostic value of FDG PET/CT in a real-world cohort of patients with surgically managed infective endocarditis (IE).<h4>Methods</h4>We performed a retrospective analysis of all patients hospitalized in a tertiary IE referral medical center from January 2014 to October 2018 fulfilling the following criteria: ICD-10 code for IE and ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2020, :]

Cited: 1 time

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Use of Pneumococcal and influenza vaccine in patients with COPD, asthma bronchiale and interstitial lung diseases in south east Germany.

Arno Mohr, Annelie Plentz, Anna Sieroslawski, Fabian Pezenburg, Michael Pfeifer, Bernd Salzberger, Florian Hitzenbichler,

<h4>Introduction</h4>The aim of this study was to analyse use of and adherence to influenza and pneumococcal vaccination in high-risk patients with chronic pulmonary disease.<h4>Methods</h4>The study was initiated at the Centre of Pneumology in Donaustauf, Germany. All patients with asthma bronchiale (AB), chronic obstructive pulmonary disease (COPD) and interstitial lung disease ... Read more >>

Respir Med (Respiratory medicine)
[2020, 174:106207]

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T cell anergy in COVID-19 reflects virus persistence and poor outcomes

Kerstin Renner, Christine Müller, Charlotte Tiefenböck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Maximilian Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orso, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, Andre Gessner, Bernd Salzberger, Matthias Mack,

Coronavirus disease 2019 (COVID-19) can lead to severe pneumonia and hyperinflammation. So far, insufficient or excessive T cell responses were described in patients. We applied novel approaches to analyze T cell reactivity and showed that T anergy is already present in non-ventilated COVID-19 patients, very pronounced in ventilated patients, strongly ... Read more >>

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Epidemiology of SARS-CoV-2.

Bernd Salzberger, Felix Buder, Benedikt Lampl, Boris Ehrenstein, Florian Hitzenbichler, Thomas Holzmann, Barbara Schmidt, Frank Hanses,

<h4>Purpose</h4>SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features.<h4>Methods</h4>Non-systematic review.<h4>Results</h4>SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infected subjects. The consensus estimate for the basis reproduction number (R<sub>0</sub>) is between ... Read more >>

Infection (Infection)
[2021, 49(2):233-239]

Cited: 20 times

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Candida Endocarditis in Patients with Candidemia: A Single-Center Experience of 14 Cases.

Florian Hitzenbichler, Tobias Joha, Michaela Simon, Jirka Grosse, Karin Menhart, Dirk Hellwig, Daniele Camboni, Sabine Sag, Can Martin Sag, Frank Hanses, Bernd Salzberger, Arno Mohr,

A retrospective, single-center analysis of 14 cases of Candida endocarditis (from 355 candidemia cases during the years 2012-2019) revealed a high in-hospital mortality (57.1%), a high proportion of healthcare-associated infections (13/14) and a high treatment preference for echinocandins. Transthoracic echocardiography and <sup>18</sup>F-FDG PET/CT had a sensitivity of 54.5% and 57.1%, ... Read more >>

Mycopathologia (Mycopathologia)
[2020, 185(6):1057-1067]

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Dalbavancin as long-term suppressive therapy for patients with Gram-positive bacteremia due to an intravascular source-a series of four cases.

Florian Hitzenbichler, Arno Mohr, Daniele Camboni, Michaela Simon, Bernd Salzberger, Frank Hanses,

We present four cases with Gram-positive bacteremia (pathogens: MRSA n = 1, Enterococcus spp. n = 3) due to an intravascular source (left ventricular assist device: n = 2, transfemoral aortic valve implantation n = 1, prosthetic aortic valve: n = 1) where no curative treatment was available. These patients received indefinite, chronic suppressive (palliative) therapy with dalbavancin (500 mg weekly ... Read more >>

Infection (Infection)
[2021, 49(1):181-186]

Cited: 3 times

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Metabolic stress and disease-stage specific basigin expression of peripheral blood immune cell subsets in COVID-19 patients

Peter Siska, Katrin Singer, Jana Klitzke, Nathalie Kauer, Sonja-Maria Decking, Christina Bruss, Carina Matos, Kristina Kolodova, Alice Peuker, Gabriele Schönhammer, Johanna Raithel, Dirk Lunz, Bernhard Graf, Florian Geismann, Matthias Lubnow, Matthias Mack, Peter Hau, Christopher Bohr, Ralph Burkhardt, Andre Gessner, Bernd Salzberger, Frank Hanses, Florian Hitzenbichler, Daniel Heudobler, Florian Lüke, Tobias Pukrop, Wolfgang Herr, Daniel Wolff, Hendrik Poeck, Christoph Brochhausen, Petra Hoffmann, Michael Rehli, Marina Kreutz, Kathrin Renner,

<h4>Summary</h4> Coronavirus disease 2019 (COVID-19) is driven by dysregulated immune responses yet the role of immunometabolism in COVID-19 pathogenesis remains unclear. By investigating 47 patients with confirmed SARS-CoV-2 infection and 16 uninfected controls, we found an immunometabolic dysregulation specific for patients with progressed disease that was reversible in the recovery ... Read more >>

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T cell anergy in COVID-19 reflects virus persistence and poor outcomes

Kerstin Renner, Christine Müller, Charlotte Tiefenböck, Jan-Niklas Salewski, Frederike Winter, Simone Buchtler, Maximilian Malfertheiner, Matthias Lubnow, Dirk Lunz, Bernhard Graf, Florian Hitzenbichler, Frank Hanses, Hendrik Poeck, Marina Kreutz, Evelyn Orsó, Ralph Burkhardt, Tanja Niedermair, Christoph Brochhausen, André Gessner, Bernd Salzberger, Matthias Mack,

Coronavirus disease 2019 (COVID-19) can lead to severe pneumonia and hyperinflammation. So far, insufficient or excessive T cell responses were described in patients. We applied novel approaches to analyze T cell reactivity and showed that T anergy is already present in non-ventilated COVID-19 patients, very pronounced in ventilated patients, strongly ... Read more >>

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A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2.

Maximilian J Gottsauner, Ioannis Michaelides, Barbara Schmidt, Konstantin J Scholz, Wolfgang Buchalla, Matthias Widbiller, Florian Hitzenbichler, Tobias Ettl, Torsten E Reichert, Christopher Bohr, Veronika Vielsmeier, Fabian Cieplik,

<h4>Objectives</h4>SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2020, 24(10):3707-3713]

Cited: 18 times

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A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization.

David Peterhoff, Vivian Glück, Matthias Vogel, Philipp Schuster, Anja Schütz, Philip Neubert, Veruschka Albert, Stefanie Frisch, Mara Kiessling, Philip Pervan, Maren Werner, Nicole Ritter, Leon Babl, Maria Deichner, Frank Hanses, Matthias Lubnow, Thomas Müller, Dirk Lunz, Florian Hitzenbichler, Franz Audebert, Viola Hähnel, Robert Offner, Martina Müller, Stephan Schmid, Ralph Burkhardt, Thomas Glück, Michael Koller, Hans Helmut Niller, Bernhard Graf, Bernd Salzberger, Jürgen J Wenzel, Jonathan Jantsch, André Gessner, Barbara Schmidt, Ralf Wagner,

<h4>Objective</h4>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic challenges national health systems and the global economy. Monitoring of infection rates and seroprevalence can guide public health measures to combat the pandemic. This depends on reliable tests on active and former infections. Here, we set out to develop and validate ... Read more >>

Infection (Infection)
[2021, 49(1):75-82]

Cited: 27 times

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Coronavirus disease 2019 induces multi-lineage, morphologic changes in peripheral blood cells.

Florian Lüke, Evelyn Orsó, Jana Kirsten, Hendrik Poeck, Matthias Grube, Daniel Wolff, Ralph Burkhardt, Dirk Lunz, Matthias Lubnow, Barbara Schmidt, Florian Hitzenbichler, Frank Hanses, Bernd Salzberger, Matthias Evert, Wolfgang Herr, Christoph Brochhausen, Tobias Pukrop, Albrecht Reichle, Daniel Heudobler,

The clinical course of coronavirus disease 2019 (COVID-19) varies from mild symptoms to acute respiratory distress syndrome, hyperinflammation, and coagulation disorder. The hematopoietic system plays a critical role in the observed hyperinflammation, particularly in severely ill patients. We conducted a prospective diagnostic study performing a blood differential analyzing morphologic changes ... Read more >>

EJHaem (EJHaem)
[2020, :]

Cited: 7 times

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