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Author Flavia R Machado

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Hierarchical endpoint analysis using win ratio in critical care: An exploration using the balanced solutions in intensive care study (BaSICS).

Fernando G Zampieri, Lucas P Damiani, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Ary Serpa-Neto, Airton L O Manoel, Tamiris A Miranda, Thiago D Corrêa, Luciano C P Azevedo, Nilton B Silva, Flavia R Machado, Alexandre B Cavalcanti, ,

<h4>Purpose</h4>To reanalyze the results of the Balanced Solutions in Intensive Care Study (BaSICS) through hierarchical endpoint analysis with win ratio.<h4>Methods</h4>All patients with full data in BaSICS trial were elected for the analysis. BaSICS compared balanced solutions (Plasma Lye 148) versus 0.9% saline in critically ill patients requiring fluid challenge. The ... Read more >>

J Crit Care (Journal of critical care)
[2022, 71:154113]

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Association between Type of Fluid Received Prior to Enrollment, Type of Admission, and Effect of Balanced Crystalloid in Critically Ill Adults: A Secondary Exploratory Analysis of the BaSICS Clinical Trial.

Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Ary Serpa-Neto, Jorge L R Paranhos, Eraldo A Lúcio, Lúcio C Oliveira-Júnior, Thiago C Lisboa, Fábio H Lacerda, Israel S Maia, Cintia M C Grion, Murillo S C Assunção, Airton L O Manoel, Thiago D Corrêa, Marco Antonio V A Guedes, Luciano C P Azevedo, Tamiris A Miranda, Lucas P Damiani, Nilton Brandão da Silva, Alexandre B Cavalcanti,

<b>Rationale:</b> The effects of balanced crystalloid versus saline on clinical outcomes for ICU patients may be modified by the type of fluid that patients received for initial resuscitation and by the type of admission. <b>Objectives:</b> To assess whether the results of a randomized controlled trial could be affected by fluid ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2022, 205(12):1419-1428]

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