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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

Cited: 0 times

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Clinical Research: From Case Reports to International Multicenter Clinical Trials.

Simon Finfer, Deborah Cook, Flavia R Machado, Anders Perner,

Crit Care Med (Critical care medicine)
[2021, 49(11):1866-1882]

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Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial.

Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Murillo S C Assunção, Ary Serpa-Neto, Jorge L R Paranhos, José Andrade, Michele M G Godoy, Edson Romano, Felipe Dal Pizzol, Emerson B Silva, Miqueias M L Silva, Miriam C V Machado, Luiz Marcelo S Malbouisson, Airton L O Manoel, Marlus M Thompson, Lanese M Figueiredo, Rafael M Soares, Tamiris A Miranda, Lucas M de Lima, Eliana V Santucci, Thiago D Corrêa, Luciano C P Azevedo, John A Kellum, Lucas P Damiani, Nilton B Silva, Alexandre B Cavalcanti, ,

<h4>Importance</h4>Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different infusion rates during fluid challenges for important outcomes such as mortality.<h4>Objective</h4>To determine the effect of a slower infusion rate vs control infusion rate ... Read more >>

JAMA (JAMA)
[2021, 326(9):830-838]

Cited: 0 times

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Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial.

Fernando G Zampieri, Flávia R Machado, Rodrigo S Biondi, Flávio G R Freitas, Viviane C Veiga, Rodrigo C Figueiredo, Wilson J Lovato, Cristina P Amêndola, Ary Serpa-Neto, Jorge L R Paranhos, Marco A V Guedes, Eraldo A Lúcio, Lúcio C Oliveira-Júnior, Thiago C Lisboa, Fábio H Lacerda, Israel S Maia, Cintia M C Grion, Murillo S C Assunção, Airton L O Manoel, João M Silva-Junior, Péricles Duarte, Rafael M Soares, Tamiris A Miranda, Lucas M de Lima, Rodrigo M Gurgel, Denise M Paisani, Thiago D Corrêa, Luciano C P Azevedo, John A Kellum, Lucas P Damiani, Nilton Brandão da Silva, Alexandre B Cavalcanti, ,

<h4>Importance</h4>Intravenous fluids are used for almost all intensive care unit (ICU) patients. Clinical and laboratory studies have questioned whether specific fluid types result in improved outcomes, including mortality and acute kidney injury.<h4>Objective</h4>To determine the effect of a balanced solution vs saline solution (0.9% sodium chloride) on 90-day survival in critically ... Read more >>

JAMA (JAMA)
[2021, :]

Cited: 0 times

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.

, Manu Shankar-Hari, Claire L Vale, Peter J Godolphin, David Fisher, Julian P T Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S Benbenishty, Lindsay R Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L De Buyser, Lennie P G Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C Gordon, Richard Haynes, Olivier Hermine, Peter W Horby, Nora K Horick, Kuldeep Kumar, Bart N Lambrecht, Martin J Landray, Lorna Leal, David J Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini V Mohan, Michael C Nivens, Jarmo Oksi, Jose A Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet V Ramanan, Philippe Ravaud, Pankti D Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H Stone, Garth W Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E Westerweel, Srinivas Murthy, Janet V Diaz, John C Marshall, Jonathan A C Sterne,

<h4>Importance</h4>Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.<h4>Objective</h4>To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.<h4>Data sources</h4>Trials were identified through systematic searches of electronic ... Read more >>

JAMA (JAMA)
[2021, 326(6):499-518]

Cited: 11 times

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The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.

Mark E Nunnally, Ricard Ferrer, Greg S Martin, Ignacio Martin-Loeches, Flavia R Machado, Daniel De Backer, Craig M Coopersmith, Clifford S Deutschman, ,

<h4>Objective</h4>To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.<h4>Design</h4>As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):34]

Cited: 1 time

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Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.

Renato D Lopes, Pedro Gabriel Melo de Barros E Silva, Remo H M Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, Alexandre B Cavalcanti, Regis G Rosa, Luciano C P Azevedo, Viviane C Veiga, Flávia R Machado, Luiz Eduardo Ritt, Priscilla de Aquino Martins, John H Alexander, Alvaro Avezum, Otavio Berwanger, ,

<h4>Background</h4>Observational studies have suggested a higher risk of thrombotic events in patients with coronavirus disease 2019 (COVID-19). Moreover, elevated D-dimer levels have been identified as an important prognostic marker in COVID-19 directly associated with disease severity and progression. Prophylactic anticoagulation for hospitalized COVID-19 patients might not be enough to prevent ... Read more >>

Am Heart J (American heart journal)
[2021, 238:1-11]

Cited: 4 times

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 6 times

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Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial.

Viviane C Veiga, João A G G Prats, Danielle L C Farias, Regis G Rosa, Leticia K Dourado, Fernando G Zampieri, Flávia R Machado, Renato D Lopes, Otavio Berwanger, Luciano C P Azevedo, Álvaro Avezum, Thiago C Lisboa, Salomón S O Rojas, Juliana C Coelho, Rodrigo T Leite, Júlio C Carvalho, Luis E C Andrade, Alex F Sandes, Maria C T Pintão, Claudio G Castro, Sueli V Santos, Thiago M L de Almeida, André N Costa, Otávio C E Gebara, Flávio G Rezende de Freitas, Eduardo S Pacheco, David J B Machado, Josiane Martin, Fábio G Conceição, Suellen R R Siqueira, Lucas P Damiani, Luciana M Ishihara, Daniel Schneider, Denise de Souza, Alexandre B Cavalcanti, Phillip Scheinberg, ,

<h4>Objective</h4>To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19).<h4>Design</h4>Randomised, open label trial.<h4>Setting</h4>Nine hospitals in Brazil, 8 May to 17 July 2020.<h4>Participants</h4>Adults with confirmed covid-19 who were receiving supplemental oxygen or mechanical ventilation and had abnormal levels of at least two serum biomarkers ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 372:n84]

Cited: 86 times

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How the COVID-19 pandemic will change the future of critical care.

Yaseen M Arabi, Elie Azoulay, Hasan M Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D Gomersall, Peter Horby, Nicole P Juffermans, Jozef Kesecioglu, Ruth M Kleinpell, Flavia R Machado, Greg S Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-François Timsit, Jean-Louis Vincent, Giuseppe Citerio,

Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical care surge response must be nested within the overall care delivery model. The COVID-19 pandemic has highlighted key elements ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(3):282-291]

Cited: 7 times

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Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.

Bruno M Tomazini, Israel S Maia, Alexandre B Cavalcanti, Otavio Berwanger, Regis G Rosa, Viviane C Veiga, Alvaro Avezum, Renato D Lopes, Flavia R Bueno, Maria Vitoria A O Silva, Franca P Baldassare, Eduardo L V Costa, Ricardo A B Moura, Michele O Honorato, Andre N Costa, Lucas P Damiani, Thiago Lisboa, Letícia Kawano-Dourado, Fernando G Zampieri, Guilherme B Olivato, Cassia Righy, Cristina P Amendola, Roberta M L Roepke, Daniela H M Freitas, Daniel N Forte, Flávio G R Freitas, Caio C F Fernandes, Livia M G Melro, Gedealvares F S Junior, Douglas Costa Morais, Stevin Zung, Flávia R Machado, Luciano C P Azevedo, ,

<h4>Importance</h4>Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients.<h4>Objective</h4>To determine whether intravenous dexamethasone increases the number of ventilator-free days among patients with COVID-19-associated ARDS.<h4>Design, setting, and participants</h4>Multicenter, randomized, ... Read more >>

JAMA (JAMA)
[2020, 324(13):1307-1316]

Cited: 246 times

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Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit. CRITIC Pilot Randomized Controlled Trial.

Fernando G Zampieri, Neymar Elias de Oliveira, Antonio Paulo Nassar, Airton Leonardo de Oliveira Manoel, Cintia Grion, Fábio H Lacerda, Israel Maia, Marlus Thompson, Thiago Simões Giancursi, Priscilla de Aquino Martins, Thiago Lisboa, Tamiris Abait, Lucas P Damiani, Flávia R Machado, Alexandre B Cavalcanti, ,

<b>Rationale:</b> Coated devices may reduce biofilm formation and reduce the occurrence of device-related infections in critically ill patients. A bundle of coated devices (an endotracheal tube [ETT], central venous catheter [CVC], and urinary catheter [UC]) simultaneously inserted may optimize benefits of coated devices in patients with the most severe illness.<b>Objectives:</b> ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(10):1257-1263]

Cited: 1 time

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Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial.

Remo H M Furtado, Otavio Berwanger, Henrique A Fonseca, Thiago D Corrêa, Leonardo R Ferraz, Maura G Lapa, Fernando G Zampieri, Viviane C Veiga, Luciano C P Azevedo, Regis G Rosa, Renato D Lopes, Alvaro Avezum, Airton L O Manoel, Felipe M T Piza, Priscilla A Martins, Thiago C Lisboa, Adriano J Pereira, Guilherme B Olivato, Vicente C S Dantas, Eveline P Milan, Otavio C E Gebara, Roberto B Amazonas, Monalisa B Oliveira, Ronaldo V P Soares, Diogo D F Moia, Luciana P A Piano, Kleber Castilho, Roberta G R A P Momesso, Guilherme P P Schettino, Luiz Vicente Rizzo, Ary Serpa Neto, Flávia R Machado, Alexandre B Cavalcanti, ,

<h4>Background</h4>The efficacy and safety of azithromycin in the treatment of COVID-19 remain uncertain. We assessed whether adding azithromycin to standard of care, which included hydroxychloroquine, would improve clinical outcomes of patients admitted to the hospital with severe COVID-19.<h4>Methods</h4>We did an open-label, randomised clinical trial at 57 centres in Brazil. We ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10256):959-967]

Cited: 87 times

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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.

, Jonathan A C Sterne, Srinivas Murthy, Janet V Diaz, Arthur S Slutsky, Jesús Villar, Derek C Angus, Djillali Annane, Luciano Cesar Pontes Azevedo, Otavio Berwanger, Alexandre B Cavalcanti, Pierre-Francois Dequin, Bin Du, Jonathan Emberson, David Fisher, Bruno Giraudeau, Anthony C Gordon, Anders Granholm, Cameron Green, Richard Haynes, Nicholas Heming, Julian P T Higgins, Peter Horby, Peter Jüni, Martin J Landray, Amelie Le Gouge, Marie Leclerc, Wei Shen Lim, Flávia R Machado, Colin McArthur, Ferhat Meziani, Morten Hylander Møller, Anders Perner, Marie Warrer Petersen, Jelena Savovic, Bruno Tomazini, Viviane C Veiga, Steve Webb, John C Marshall,

<h4>Importance</h4>Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.<h4>Objective</h4>To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.<h4>Design, setting, and ... Read more >>

JAMA (JAMA)
[2020, 324(13):1330-1341]

Cited: 468 times

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An international comparison of the cost of fluid resuscitation therapies.

Colman Taylor, Li Yang, Simon Finfer, Flavia R Machado, An YouZhong, Laurent Billot, Frank Bloos, Fernando Bozza, Alexandre Biasi Cavalcanti, Maryam Correa, Bin Du, Peter B Hjortrup, Lauralyn McIntyre, Manoj Saxena, Frédérique Schortgen, Nicola R Watts, John Myburgh, Kelly Thompson, Naomi E Hammond, ,

<h4>Objective</h4>Fluid resuscitation is a ubiquitous intervention in the management of patients treated in the intensive care unit, which has implications for intensive care unit resourcing and budgets. Our objective was to calculate the relative cost of resuscitation fluids in several countries to inform future economic evaluations.<h4>Methods</h4>We collected site-level data regarding ... Read more >>

Aust Crit Care (Australian critical care : official journal of the Confederation of Australian Critical Care Nurses)
[2021, 34(1):23-32]

Cited: 1 time

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Reply to Topeli et al. and to Akinosoglou et al.

Luciano C P Azevedo, Alexandre B Cavalcanti, Flavia R Machado,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(1):154]

Cited: 0 times

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Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19.

Alexandre B Cavalcanti, Fernando G Zampieri, Regis G Rosa, Luciano C P Azevedo, Viviane C Veiga, Alvaro Avezum, Lucas P Damiani, Aline Marcadenti, Letícia Kawano-Dourado, Thiago Lisboa, Debora L M Junqueira, Pedro G M de Barros E Silva, Lucas Tramujas, Erlon O Abreu-Silva, Ligia N Laranjeira, Aline T Soares, Leandro S Echenique, Adriano J Pereira, Flávio G R Freitas, Otávio C E Gebara, Vicente C S Dantas, Remo H M Furtado, Eveline P Milan, Nicole A Golin, Fábio F Cardoso, Israel S Maia, Conrado R Hoffmann Filho, Adrian P M Kormann, Roberto B Amazonas, Monalisa F Bocchi de Oliveira, Ary Serpa-Neto, Maicon Falavigna, Renato D Lopes, Flávia R Machado, Otavio Berwanger, ,

<h4>Background</h4>Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.<h4>Methods</h4>We conducted a multicenter, randomized, open-label, three-group, controlled trial involving hospitalized patients with suspected or confirmed Covid-19 who were receiving either no supplemental oxygen or ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(21):2041-2052]

Cited: 343 times

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Predictive Accuracy of the Quick Sepsis-related Organ Failure Assessment Score in Brazil. A Prospective Multicenter Study.

Flavia R Machado, Alexandre B Cavalcanti, Mariana B Monteiro, Juliana L Sousa, Aline Bossa, Antonio T Bafi, Felipe Dal-Pizzol, Flavio G R Freitas, Thiago Lisboa, Glauco A Westphal, Andre M Japiassu, Luciano C P Azevedo, ,

Rationale: Although proposed as a clinical prompt to sepsis based on predictive validity for mortality, the Quick Sepsis-related Organ Failure Assessment (qSOFA) score is often used as a screening tool, which requires high sensitivity.Objectives: To assess the predictive accuracy of qSOFA for mortality in Brazil, focusing on sensitivity.Methods: We prospectively ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(7):789-798]

Cited: 10 times

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Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial

Alexandre Cavalcanti, Fernando Zampieri, Luciani CP Azevedo, Regis Rosa, Alvaro Avezum, Viviane Veiga, Renato Lopes, Leticia Kawano-Dourado, Lucas Damiani, Adriano Pereira, Ary Serpa Neto, Remo Furtado, Bruno Tomazini, Fernando Bozza, Israel Maia, Maicon Falavigna, Thiago Lisboa, Henrique Fonseca, Flavia Machado, Otavio Berwanger, ,

<h4>Introduction: </h4> Hydroxychloroquine and its combination with azithromycin have been suggested to improve viral clearance in patients with COVID-19, but its effect on clinical outcomes remains uncertain. Methods and analysis: We describe the rationale and design of an open-label pragmatic multicentre randomised (concealed) clinical trial of 7 days of hydroxychloroquine ... Read more >>

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Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.

Jean-Louis Vincent, Yasser Sakr, Mervyn Singer, Ignacio Martin-Loeches, Flavia R Machado, John C Marshall, Simon Finfer, Paolo Pelosi, Luca Brazzi, Dita Aditianingsih, Jean-François Timsit, Bin Du, Xavier Wittebole, Jan Máca, Santhana Kannan, Luis A Gorordo-Delsol, Jan J De Waele, Yatin Mehta, Marc J M Bonten, Ashish K Khanna, Marin Kollef, Mariesa Human, Derek C Angus, ,

<h4>Importance</h4>Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about the types of infections, causative pathogens, and outcomes can aid the development of policies for prevention, diagnosis, treatment, and resource allocation and may assist in the design of interventional studies.<h4>Objective</h4>To provide information about the prevalence and ... Read more >>

JAMA (JAMA)
[2020, 323(15):1478-1487]

Cited: 37 times

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Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017.

Juanita A Haagsma, Spencer L James, Chris D Castle, Zachary V Dingels, Jack T Fox, Erin B Hamilton, Zichen Liu, Lydia R Lucchesi, Nicholas L S Roberts, Dillon O Sylte, Oladimeji M Adebayo, Alireza Ahmadi, Muktar Beshir Ahmed, Miloud Taki Eddine Aichour, Fares Alahdab, Suliman A Alghnam, Syed Mohamed Aljunid, Rajaa M Al-Raddadi, Ubai Alsharif, Khalid Altirkawi, Mina Anjomshoa, Carl Abelardo T Antonio, Seth Christopher Yaw Appiah, Olatunde Aremu, Amit Arora, Hamid Asayesh, Reza Assadi, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Shivanthi Balalla, Amrit Banstola, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Masoud Behzadifar, Meysam Behzadifar, Corina Benjet, Derrick A Bennett, Isabela M Bensenor, Soumyadeep Bhaumik, Zulfiqar A Bhutta, Ali Bijani, Guilherme Borges, Rohan Borschmann, Dipan Bose, Soufiane Boufous, Alexandra Brazinova, Julio Cesar Campuzano Rincon, Rosario Cárdenas, Juan J Carrero, Félix Carvalho, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Jee-Young J Choi, Devasahayam J Christopher, Christopher Stephen Crowe, Koustuv Dalal, Ahmad Daryani, Dragos Virgil Davitoiu, Louisa Degenhardt, Diego De Leo, Jan-Walter De Neve, Kebede Deribe, Getenet Ayalew Dessie, Gabrielle Aline deVeber, Samath Dhamminda Dharmaratne, Linh Phuong Doan, Kate A Dolan, Tim Robert Driscoll, Manisha Dubey, Ziad El-Khatib, Christian Lycke Ellingsen, Maysaa El Sayed Zaki, Aman Yesuf Endries, Sharareh Eskandarieh, Andre Faro, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Richard Charles Franklin, Takeshi Fukumoto, Kebede Embaye Gezae, Tiffany K Gill, Alessandra C Goulart, Ayman Grada, Yuming Guo, Rahul Gupta, Hassan Haghparast Bidgoli, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R Hamadeh, Samer Hamidi, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Delia Hendrie, Andualem Henok, Martha Híjar, Michael K Hole, Enayatollah Homaie Rad, Naznin Hossain, Sorin Hostiuc, Guoqing Hu, Ehimario U Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Rebecca Q Ivers, Kathryn H Jacobsen, Nader Jahanmehr, Mihajlo Jakovljevic, Achala Upendra Jayatilleke, Ravi Prakash Jha, Jost B Jonas, Zahra Jorjoran Shushtari, Jacek Jerzy Jozwiak, Mikk Jürisson, Ali Kabir, Rizwan Kalani, Amir Kasaeian, Abraham Getachew Kelbore, Andre Pascal Kengne, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Ejaz Ahmad Khan, Abdullah T Khoja, Aliasghar A Kiadaliri, Young-Eun Kim, Daniel Kim, Adnan Kisa, Ai Koyanagi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ratilal Lalloo, Hilton Lam, Faris Hasan Lami, Van C Lansingh, Janet L Leasher, Shanshan Li, Shai Linn, Raimundas Lunevicius, Flavia R Machado, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Narayan Bahadur Mahotra, Marek Majdan, Azeem Majeed, Reza Malekzadeh, Manzoor Ahmad Malik, Deborah Carvalho Malta, Ana-Laura Manda, Mohammad Ali Mansournia, Benjamin Ballard Massenburg, Pallab K Maulik, Hailemariam Abiy Alemu Meheretu, Man Mohan Mehndiratta, Addisu Melese, Walter Mendoza, Melkamu Merid Mengesha, Tuomo J Meretoja, Atte Meretoja, Tomislav Mestrovic, Tomasz Miazgowski, Ted R Miller, G K Mini, Erkin M Mirrakhimov, Babak Moazen, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Shafiu Mohammed, Mariam Molokhia, Lorenzo Monasta, Stefania Mondello, Pablo A Montero-Zamora, Yoshan Moodley, Mahmood Moosazadeh, Ghobad Moradi, Maziar Moradi-Lakeh, Lidia Morawska, Ilais Moreno Velásquez, Shane Douglas Morrison, Marilita M Moschos, Seyyed Meysam Mousavi, Srinivas Murthy, Kamarul Imran Musa, Gurudatta Naik, Farid Najafi, Vinay Nangia, Bruno Ramos Nascimento, Duduzile Edith Ndwandwe, Ionut Negoi, Trang Huyen Nguyen, Son Hoang Nguyen, Long Hoang Nguyen, Huong Lan Thi Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Richard Ofori-Asenso, Felix Akpojene Ogbo, In-Hwan Oh, Olanrewaju Oladimeji, Andrew T Olagunju, Tinuke O Olagunju, Pedro R Olivares, Heather M Orpana, Stanislav S Otstavnov, Mahesh P A, Smita Pakhale, Eun-Kee Park, George C Patton, Konrad Pesudovs, Michael R Phillips, Suzanne Polinder, Swayam Prakash, Amir Radfar, Anwar Rafay, Alireza Rafiei, Siavash Rahimi, Vafa Rahimi-Movaghar, Muhammad Aziz Rahman, Rajesh Kumar Rai, Kiana Ramezanzadeh, Salman Rawaf, David Laith Rawaf, Andre M N Renzaho, Serge Resnikoff, Shahab Rezaeian, Leonardo Roever, Luca Ronfani, Gholamreza Roshandel, Yogesh Damodar Sabde, Basema Saddik, Payman Salamati, Yahya Salimi, Inbal Salz, Abdallah M Samy, Juan Sanabria, Lidia Sanchez Riera, Milena M Santric Milicevic, Maheswar Satpathy, Monika Sawhney, Susan M Sawyer, Sonia Saxena, Mete Saylan, Ione J C Schneider, David C Schwebel, Soraya Seedat, Sadaf G Sepanlou, Masood Ali Shaikh, Mehran Shams-Beyranvand, Morteza Shamsizadeh, Mahdi Sharif-Alhoseini, Aziz Sheikh, Jiabin Shen, Mika Shigematsu, Rahman Shiri, Ivy Shiue, João Pedro Silva, Jasvinder A Singh, Dhirendra Narain Sinha, Adauto Martins Soares Filho, Joan B Soriano, Sergey Soshnikov, Ireneous N Soyiri, Vladimir I Starodubov, Dan J Stein, Mark A Stokes, Mu'awiyyah Babale Sufiyan, Jacob E Sunshine, Bryan L Sykes, Rafael Tabarés-Seisdedos, Karen M Tabb, Arash Tehrani-Banihashemi, Gizachew Assefa Tessema, Jarnail Singh Thakur, Khanh Bao Tran, Bach Xuan Tran, Lorainne Tudor Car, Olalekan A Uthman, Benjamin S Chudi Uzochukwu, Pascual R Valdez, Elena Varavikova, Ana Maria Nogales Vasconcelos, Narayanaswamy Venketasubramanian, Francesco S Violante, Vasily Vlassov, Yasir Waheed, Yuan-Pang Wang, Tissa Wijeratne, Andrea Sylvia Winkler, Priyanka Yadav, Yuichiro Yano, Muluken Azage Yenesew, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mustafa Z Younis, Chuanhua Yu, Shamsa Zafar, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Yong Zhao, Sanjay Zodpey, Simon I Hay, Alan D Lopez, Ali H Mokdad, Theo Vos,

<h4>Background</h4>The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted ... Read more >>

Inj Prev (Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention)
[2020, 26(Supp 1):i12-i26]

Cited: 5 times

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Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study.

Kristina E Rudd, Sarah Charlotte Johnson, Kareha M Agesa, Katya Anne Shackelford, Derrick Tsoi, Daniel Rhodes Kievlan, Danny V Colombara, Kevin S Ikuta, Niranjan Kissoon, Simon Finfer, Carolin Fleischmann-Struzek, Flavia R Machado, Konrad K Reinhart, Kathryn Rowan, Christopher W Seymour, R Scott Watson, T Eoin West, Fatima Marinho, Simon I Hay, Rafael Lozano, Alan D Lopez, Derek C Angus, Christopher J L Murray, Mohsen Naghavi,

<h4>Background</h4>Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the global burden of sepsis are limited. As a syndrome caused by underlying infection, sepsis is not part of standard Global Burden of Diseases, Injuries, ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10219):200-211]

Cited: 381 times

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Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice.

Hallie C Prescott, Theodore J Iwashyna, Bronagh Blackwood, Thierry Calandra, Linda L Chlan, Karen Choong, Bronwen Connolly, Paul Dark, Luigi Ferrucci, Simon Finfer, Timothy D Girard, Carol Hodgson, Ramona O Hopkins, Catherine L Hough, James C Jackson, Flavia R Machado, John C Marshall, Cheryl Misak, Dale M Needham, Pinaki Panigrahi, Konrad Reinhart, Sachin Yende, Ross Zafonte, Kathryn M Rowan, Derek C Angus,

An estimated 14.1 million patients survive sepsis each year. Many survivors experience poor long-term outcomes, including new or worsened neuropsychological impairment; physical disability; and vulnerability to further health deterioration, including recurrent infection, cardiovascular events, and acute renal failure. However, clinical trials and guidelines have focused on shorter-term survival, so there ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(8):972-981]

Cited: 14 times

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