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Author Firas Petros

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Predictive model for systemic recurrence following cisplatin-based neoadjuvant chemotherapy and radical nephroureterectomy for high risk upper tract urothelial carcinoma.

Rashed A Ghandour, Yuval Freifeld, Joseph Cheaib, Nirmish Singla, Xiaosong Meng, Alexander Kenigsberg, Aditya Bagrodia, Solomon Woldu, Jean Hoffman-Censits, Dmitry Enikeev, Leonid Rapoport, Firas G Petros, Jay D Raman, Philip M Pierorazio, Surena F Matin, Vitaly Margulis,

<h4>Introduction</h4>Neoadjuvant chemotherapy (NAC) is increasingly used prior to radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Systemic recurrence (SR) carries a dismal prognosis. We sought to determine risk factors associated with SR in this setting.<h4>Methods</h4>We evaluated a multi-center database of patients with UTUC who received cisplatin-based NAC before RNU. ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Urine versus stent cultures and clinical UTIs.

Bijan Salari, Muhamad Khalid, Samuel Ivan, Obinna Ekwenna, Firas Petros, Barbara Saltzman, Puneet Sindhwani,

<h4>Purpose</h4>Current American Urological Association guidelines recommend pre-operative antimicrobial therapy based on prior urine cultures (UC); however, the role of stent culture (SC) in urologic practice is unclear. We examined whether UC and SC differed at the time of stent removal, as well as the association, microbiology, and timing of subsequent ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, :]

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The Emerging Role of Poly (ADP-Ribose) Polymerase Inhibitors as Effective Therapeutic Agents in Renal Cell Carcinoma.

Jerred P Pletcher, Sayani Bhattacharjee, Jonathan P Doan, Rebecca Wynn, Puneet Sindhwani, Nagalakshmi Nadiminty, Firas G Petros,

Renal cell carcinoma (RCC) is the sixth most common cancer in the US. However, no significant changes in management have occurred since the tyrosine kinase era until the recent breakthrough with checkpoint inhibitors. Therefore, the need for more therapeutic options is paramount. Our objective was to determine whether PARP inhibition ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:681441]

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Expression Analysis of Same-Patient Metachronous and Synchronous Upper Tract and Bladder Urothelial Carcinoma.

Firas G Petros, Woonyoung Choi, Yuan Qi, Tyler Moss, Roger Li, Xiaoping Su, Charles C Guo, Bogdan Czerniak, Colin Dinney, David J McConkey, Surena F Matin,

<h4>Purpose</h4>We compared upper tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) in same-patient metachronous UTUC and synchronous UTUC and BUC using next-generation sequencing.<h4>Materials and methods</h4>Consecutive untreated same-patient samples of UTUC and BUC were macrodissected from unstained formalin-fixed, paraffin-embedded slides after quality control. Samples were divided into 4 groups: 1) ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001788]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Long-Term Outcomes of Whole Gland Salvage Cryotherapy for Locally Recurrent Prostate Cancer following Radiation Therapy: A Combined Analysis of Two Centers.

Joseph L Chin, Arnon Lavi, Michael J Metcalfe, Khuram Siddiqui, Malcolm Dewar, Firas G Petros, Roger Li, Graciela M Nogueras González, Xuemei Wang, Shiva M Nair, John F Ward, Louis Pisters,

<h4>Purpose</h4>Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose of this study is to determine long-term outcomes following salvage cryotherapy for RRPca.<h4>Materials and methods</h4>Patients undergoing salvage cryotherapy for biopsy-proven, ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001831]

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Plasmacytoid variant of urothelial carcinoma of the bladder manifesting as bilateral ureteral and small bowel obstruction.

Alex Carsel, Chris Levy, Ashwin M Raghavan, Jorge A Ortiz, Puneet Sindhwani, Firas G Petros,

Plasmacytoid urothelial carcinoma (PUC) is a rare variant of bladder cancer characterized by distinct histopathology and advanced stage at diagnosis. Multimodal treatment is usually indicated. We present a case of PUC causing bilateral ureteral obstruction with subsequent renal failure followed shortly by malignant small bowel obstruction, demonstrating the need for ... Read more >>

Urol Case Rep (Urology case reports)
[2020, 33:101415]

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Comparative effectiveness of neoadjuvant chemotherapy in bladder and upper urinary tract urothelial carcinoma.

David D'Andrea, Surena Matin, Peter C Black, Firas G Petros, Homayoun Zargar, Colin P Dinney, Michael S Cookson, Wassim Kassouf, Marc A Dall'Era, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeffrey M Holzbeierlein, Trinity J Bivalacqua, Srikala S Sridhar, Scott North, Daniel A Barocas, Yair Lotan, Andrew J Stephenson, Bas W van Rhijn, Philippe E Spiess, Siamak Daneshmand, Shahrokh F Shariat,

<h4>Objective</h4>To assess the differential response to neoadjuvant chemotherapy (NAC) in patients with urothelial carcinoma of the bladder (UCB) compared to upper tract urothelial carcioma (UTUC) treated with radical surgery.<h4>Patients and methods</h4>Data from 1299 patients with UCB and 276 with UTUC were obtained from multicentric collaborations. The association of disease location ... Read more >>

BJU Int (BJU international)
[2021, 127(5):528-537]

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Comparison of the Comprehensive Complication Index and Clavien-Dindo systems in predicting perioperative outcomes following radical nephroureterectomy.

Scott Geiger, Neil Kocher, Dan Illinsky, Evanguelos Xylinas, Peter Chang, Lauren Dewey, Andrew A Wagner, Firas Petros, Surena F Matin, Conrad Tobert, Chad Tracy, Pierre-Marie Patard, Mathieu Roumiguie, Leonardo Lima Monteiro, Wassim Kassouf, Jay D Raman,

<h4>Background</h4>Complications can occur following radical nephroureterectomy (RNU) in 20-40% of patients. The Comprehensive Complication Index (CCI) is an alternative grading system to the Clavien-Dindo (CD) grading system that aggregates all complications experienced by a patient on a continuous (as opposed to categorical) scale. We investigate whether the cumulative nature of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1780-1785]

Cited: 1 time

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Epidemiology, clinical presentation, and evaluation of upper-tract urothelial carcinoma.

Firas G Petros,

An overview of epidemiological pattern of upper tract urothelial carcinoma (UTUC), including outcome of UTUC over past decades as well as factors responsible for observed epidemiological changes was performed. Gender and racial disparities influencing incidence of UTUC were reviewed. The incidence of multifocal urothelial carcinoma and relation of UTUC to ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1794-1798]

Cited: 1 time

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Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy.

Yuval Freifeld, Rashed Ghandour, Nirmish Singla, Solomon Woldu, Aditya Bagrodia, Yair Lotan, Leonid M Rapoport, Magomet Gazimiev, Karen Delafuente, Rohan Kulangara, Haley Robyak, Firas G Petros, Jay D Raman, Surena F Matin, Vitaly Margulis,

<h4>Purpose</h4>Single, postoperative instillation of prophylactic intravesical chemotherapy (pIVC) is effective in reducing bladder cancer recurrences following radical nephroureterectomy (RNU). Despite high level evidence, pIVC is underutilized. Intraoperative pIVC (I-pIVC) may be easier and safer to implement than postoperative pIVC (P-pIVC). We aimed to evaluate the efficacy of I-pIVC during RNU.<h4>Materials ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(9):737.e11-737.e16]

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Impact of Sex on Response to Neoadjuvant Chemotherapy in Patients with Upper-tract Urothelial Cancer.

David D'Andrea, Beat Foerster, Surena F Matin, Ja H Ku, Tim Muilwijk, Leonardo L Monteiro, Ross Liao, Firas G Petros, Philippe E Spiess, Trinity J Bivalacqua, Kees Hendricksen, Bas W G van Rhijn, Ahmad Shabsigh, Alberto Briganti, Steven Joniau, Wassim Kassouf, Phillip M Pierorazio, Vitaly Margulis, Andrea Necchi, Shahrokh F Shariat, ,

Eur Urol Open Sci (European urology open science)
[2020, 19:16-19]

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Pathologic stage as a surrogate for oncologic outcomes after receipt of neoadjuvant chemotherapy for high-grade upper tract urothelial carcinoma.

Nirmish Singla, Alana Christie, Yuval Freifeld, Rashed A Ghandour, Solomon L Woldu, Timothy N Clinton, Firas G Petros, Haley Robyak, Hsin-Chih Yeh, Dong Fang, Dmitry Enikeev, Aditya Bagrodia, Arthur I Sagalowsky, Yair Lotan, Jay D Raman, Surena F Matin, Vitaly Margulis,

<h4>Objective</h4>Whether pathologic stage at radical nephroureterectomy (RNU) can serve as an appropriate surrogate for oncologic outcomes in patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) treated with neoadjuvant chemotherapy (NAC) is not defined. We sought to determine whether patients who achieve pathologically non-muscle-invasive (ypT0, ypTa, ypT1, ypTis) HG UTUC ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(12):933.e7-933.e12]

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 2 times

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Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma.

Yuval Freifeld, Rashed Ghandour, Nirmish Singla, Solomon Woldu, Timothy Clinton, Rohan Kulangara, Aditya Bagrodia, Surena F Matin, Firas G Petros, Jay D Raman, Haley Robyak, Jingsheng Yan, Hong Zhu, Leonid Rapoport, Yair Lotan, Vitaly Margulis,

<h4>Purpose</h4>To identify preoperative risk factors for disease recurrence, following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), and to create a predictive nomogram.<h4>Materials and methods</h4>Based on a multicenter database, we identified patients who underwent RNU due to high grade UTUC. Urothelial carcinoma of the bladder or contralateral UTUC was ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(10):758-764]

Cited: 2 times

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Robotic Postchemotherapy Retroperitoneal Lymph Node Dissection for Testicular Cancer.

Roger Li, Jonathan J Duplisea, Firas G Petros, Graciela M Nogueras González, Shi-Ming Tu, Jose A Karam, Tam T Huynh, John F Ward,

<h4>Background</h4>Postchemotherapy retroperitoneal lymph node dissection (pcRPLND) is mandated in patients with nonseminomatous germ cell tumor found to have residual masses after chemotherapy. Performed via the open approach, pcRPLND can incur significant perioperative morbidity.<h4>Objective</h4>To demonstrate the feasibility of robotic pcRPLND (r-pcRPLND) and provide evidence for its selection criteria.<h4>Design, setting, and participants</h4>A ... Read more >>

Eur Urol Oncol (European urology oncology)
[2019, :]

Cited: 5 times

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The role of metastatic burden in cytoreductive/consolidative radical cystectomy.

Roger Li, Janet E Baack Kukreja, Mohamed A Seif, Firas G Petros, Matthew T Campbell, Justin V Nguyen, Graciela M Nogueras González, Ashish M Kamat, Louis L Pisters, Colin P Dinney, Neema Navai,

<h4>Purpose</h4>To describe our institutional experience with cytoreductive/consolidative radical cystectomy (CCRC) for metastatic urothelial carcinoma (UC) and to investigate clinicopathologic features predicting prolonged cancer specific survival (CSS) following CCRC.<h4>Methods</h4>We performed IRB-approved review of our cystectomy database, and identified 43 patients with metastatic UC who underwent CCRC. Baseline demographics, chemotherapy regimen, clinicopathologic ... Read more >>

World J Urol (World journal of urology)
[2019, 37(12):2691-2698]

Cited: 2 times

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Outcomes of nonmetastatic micropapillary variant upper tract urothelial carcinoma.

Jonathan J Duplisea, Firas G Petros, Roger Li, Bryan Fellman, Charles C Guo, Bogdan A Czerniak, Arlene O Siefker-Radtke, John C Araujo, Colin P N Dinney, Surena F Matin,

<h4>Purpose</h4>Micropapillary variant upper tract urothelial cancer (MP-UTUC) is a rare malignancy with little known regarding its clinical course and/or optimal treatment. In this case series, we describe patient characteristics, surgical treatment, oncologic outcomes, and response to perioperative chemotherapy.<h4>Materials and methods</h4>We conducted a review to identify patients with MP-UTUC treated at ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(6):354.e19-354.e26]

Cited: 0 times

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Preoperative multiplex nomogram for prediction of high-risk nonorgan-confined upper-tract urothelial carcinoma.

Firas G Petros, Wei Qiao, Nirmish Singla, Timothy N Clinton, Haley Robyak, Jay D Raman, Vitaly Margulis, Surena F Matin,

<h4>Background</h4>Accurate risk stratification prior to radical nephroureterectomy remains a challenge with upper-tract urothelial carcinoma (UTUC). Herein, we generated an optimized preoperative tool predicting high-risk nonorgan-confined (NOC)-UTUC.<h4>Materials and methods</h4>Retrospective evaluation of 699 patients undergoing radical nephroureterectomy at 3 academic centers. Multiplex preoperative patient, imaging, endoscopic, and laboratory values were evaluated. Model ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):292.e1-292.e9]

Cited: 5 times

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Renal cell carcinoma and pathologic nodal disease: Implications for American Joint Committee on Cancer staging.

Kai-Jie Yu, Sarp K Keskin, Matthew A Meissner, Firas G Petros, Xuemei Wang, Leonardo D Borregales, Cindy Gu, Pheroze Tamboli, Surena F Matin, Christopher G Wood, Jose A Karam,

<h4>Background</h4>Lymph node (LN) metastases are associated with poor outcomes for patients with renal cell carcinoma (RCC). This study compared the survival outcomes of patients with stage III, node-positive disease (pT<sub>123</sub> N<sub>1</sub> M<sub>0</sub> ) and patients with stage III, node-negative disease (pT<sub>3</sub> N<sub>0</sub> M<sub>0</sub> ).<h4>Methods</h4>A database of 4652 patients with RCC ... Read more >>

Cancer (Cancer)
[2018, 124(20):4023-4031]

Cited: 5 times

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Conditional survival of patients with small renal masses undergoing active surveillance.

Firas G Petros, Aradhana M Venkatesan, Diana Kaya, Chaan S Ng, Bryan M Fellman, Jose A Karam, Christopher G Wood, Surena F Matin,

<h4>Objectives</h4>To determine conditional survival for patients with small renal masses (SRMs) undergoing active surveillance (AS).<h4>Materials and methods</h4>Patients were enrolled in a prospective AS protocol at our institution between May 2005 and January 2016. Patients with SRMs ≤4 cm with serial cross-sectional imaging available in-house for review were included. Overall survival ... Read more >>

BJU Int (BJU international)
[2019, 123(3):447-455]

Cited: 1 time

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Extended Pelvic Lymph Node Dissection in Bladder Cancer.

Roger Li, Firas G Petros, John W Davis,

INTRODUCTION:Radical cystectomy and extended pelvic lymph node dissection (ePLND) are the gold standard treatment for muscle-invasive bladder cancer and BCG unresponsive nonmuscle-invasive bladder cancer. In this article, we review the rationale for ePLND in the treatment of bladder cancer and the evidence supporting the equipoise between robot-assisted (RA) and open ... Read more >>

J Endourol (Journal of endourology)
[2018, 32(S1):S49-S54]

Cited: 1 time

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Intraoperative Conversion From Partial to Radical Nephrectomy: Incidence, Predictive Factors, and Outcomes.

Firas G Petros, Sarp K Keskin, Kai-Jie Yu, Roger Li, Michael J Metcalfe, Bryan M Fellman, Courtney M Chang, Cindy Gu, Pheroze Tamboli, Surena F Matin, Jose A Karam, Christopher G Wood,

OBJECTIVE:To evaluate preoperative and intraoperative predictors of conversion to radical nephrectomy (RN) in a cohort of patients undergoing a planned partial nephrectomy (PN) for renal cell carcinoma (RCC). METHODS:A single-center, retrospective review was conducted using our PN database that includes patients who were scheduled to undergo PN (regardless of the ... Read more >>

Urology (Urology)
[2018, 116:114-119]

Cited: 4 times

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Oncologic outcomes of patients with positive surgical margin after partial nephrectomy: a 25-year single institution experience.

Firas G Petros, Michael J Metcalfe, Kai-Jie Yu, Sarp K Keskin, Bryan M Fellman, Courtney M Chang, Cindy Gu, Pheroze Tamboli, Surena F Matin, Jose A Karam, Christopher G Wood,

<h4>Purpose</h4>To evaluate oncologic outcomes and management of patients with microscopic positive surgical margin (PSM) after partial nephrectomy (PN) for renal cell carcinoma (RCC).<h4>Methods</h4>We reviewed our database to identify patients who underwent PN between 1990 and 2015 for RCC and had PSM on final pathology. A 1:3 matching was performed to ... Read more >>

World J Urol (World journal of urology)
[2018, 36(7):1093-1101]

Cited: 6 times

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