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Author Firas Kobeissy

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SARS-CoV-2 involvement in central nervous system tissue damage.

Muhammad Ali Haidar, Zaynab Shakkour, Mohammad Amine Reslan, Nadine Al-Haj, Perla Chamoun, Karl Habashy, Hasan Kaafarani, Shima Shahjouei, Sarah H Farran, Abdullah Shaito, Esber S Saba, Bassam Badran, Mirna Sabra, Firas Kobeissy, Maya Bizri,

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1228-1239]

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Blood-based traumatic brain injury biomarkers - Clinical utilities and regulatory pathways in the United States, Europe and Canada.

Kevin K Wang, Jennifer C Munoz Pareja, Stefania Mondello, Ramon Diaz-Arrastia, Cheryl Wellington, Kimbra Kenney, Ava M Puccio, Jamie Hutchison, Nicole McKinnon, David O Okonkwo, Zhihui Yang, Firas Kobeissy, J Adrian Tyndall, András Büki, Endre Czeiter, Maria C Pareja Zabala, Nithya Gandham, Rebecca Berman, ,

<h4>Introduction</h4>Traumatic brain injury (TBI) is a major global health issue, resulting in debilitating consequences to families, communities, and health-care systems. Prior research has found that biomarkers aid in the pathophysiological characterization and diagnosis of TBI. Significantly, the FDA has recently cleared both a bench-top assay and a rapid point-of-care assays ... Read more >>

Expert Rev Mol Diagn (Expert review of molecular diagnostics)
[2021, :1-19]

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Correction to: Elevation of Pro‑inflammatory and Anti‑inflammatory Cytokines in Rat Serum after Acute Methamphetamine Treatment and Traumatic Brain Injury.

Firas H Kobeissy, Zaynab Shakkour, Samer El Hayek, Wael Mohamed, Mark S Gold, Kevin K W Wang,

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, :]

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Delayed-Onset Neuropathological Complications From a Foramen Magnum and Occipital Crest Focused Traumatic Brain Injury of the Vietnam War and Other Conflicts: Part I, Case Report.

Frederick M Burkle, Kevin S Hadley, Leah L Ridge, Jan K Herman, Firas H Kobeissy,

<h4>Introduction</h4>The diagnosis of traumatic brain injuries is typically based on hemispheric blasts resulting in degrees of unconsciousness and associated cerebral injuries. This case report describes a Vietnam War era setting in which a traumatic blast wave struck the posterior cranium in the region of the foramen magnum, occipital crest, and ... Read more >>

Mil Med (Military medicine)
[2021, :]

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Elevation of Pro-inflammatory and Anti-inflammatory Cytokines in Rat Serum after Acute Methamphetamine Treatment and Traumatic Brain Injury.

Firas H Kobeissy, Zaynab Shakkour, Samer El Hayek, Wael Mohamed, Mark S Gold, Kevin K W Wang,

The use of methamphetamine (METH) is a growing worldwide epidemic that bears grave societal implications. METH is known to exert its neurotoxic effects on the dopaminergic and serotonergic systems of the brain. In addition to this classical studied mechanism of damage, findings from our laboratory and others have shown that ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, :]

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Delayed-Onset Neuropathological Complications From a Foramen Magnum and Occipital Crest Focused TBI of the Vietnam War and Other Conflicts: Part III, Critique of Existing TBI Criteria and Their Operational Controversies.

Frederick M Burkle, Kevin S Hadley, Leah L Ridge, Jan K Herman, Firas H Kobeissy,

<h4>Introduction</h4>In this report, we discuss the controversy of the diverse traumatic brain injury (TBI) categorization and taxonomy and the need to develop a new multidimensional and multidisciplinary categorization system that can be an aid in improved diagnostic and prognostic outcomes. Of interest, the heterogeneity of TBI marks the major obstacle ... Read more >>

Mil Med (Military medicine)
[2021, :]

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Delayed-Onset Neuropathological Complications From a Foramen Magnum and Occipital Crest-Focused Traumatic Brain Injury of the Vietnam War and Other Conflicts: Part II, Research Analysis.

Frederick M Burkle, Kevin S Hadley, Leah L Ridge, Jan K Herman, Firas H Kobeissy,

<h4>Introduction</h4>Much of the research impacting diagnosis, outcome, and treatment of traumatic brain injuries (TBIs) has favored time of consciousness criteria indicative of hemispheric blast focus alone. However, recent animal-based research has widely expanded the diagnostic knowledge base and potential treatment options.<h4>Methods</h4>Recent animal-based research findings of foramen magnum and occipital crest-focused ... Read more >>

Mil Med (Military medicine)
[2021, :]

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Surfaceome Proteomic of Glioblastoma Revealed Potential Targets for Immunotherapy.

Mélanie Rose, Tristan Cardon, Soulaimane Aboulouard, Nawale Hajjaji, Firas Kobeissy, Marie Duhamel, Isabelle Fournier, Michel Salzet,

Glioblastoma (GBM) is the most common and devastating malignant brain tumor in adults. The mortality rate is very high despite different treatments. New therapeutic targets are therefore highly needed. Cell-surface proteins represent attractive targets due to their accessibility, their involvement in essential signaling pathways, and their dysregulated expression in cancer. ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:746168]

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Microvascular imaging ultrasound (MicroV) and power Doppler vascularization analysis in a pediatric population with early scrotal pain onset.

Carmela Visalli, Sergio Lucio Vinci, Stefania Mondello, Firas Kobeissy, Ignazio Salamone, Alessandra Coglitore, Renato Trimarchi, Agostino Tessitore, Pietro Impellizzeri, Enricomaria Mormina,

<h4>Introduction</h4>The power Doppler is a useful tool in the evaluation of pediatric acute scrotal pain. Nonetheless, it may have some inherent limitations in scrotal vascularization analysis, potentially causing unnecessary surgery. The microvascular imaging ultrasound (MicroV) is an innovative Doppler technique able to improve the detection of very low flow. This ... Read more >>

Jpn J Radiol (Japanese journal of radiology)
[2021, :]

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Long-term cognitive deficits after traumatic brain injury associated with microglia activation.

Esber S Saba, Mona Karout, Leila Nasrallah, Firas Kobeissy, Hala Darwish, Samia J Khoury,

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases of the central nervous system. We hypothesize that microglia may play a beneficial or detrimental role in TBI depending on their state of activation and duration. In this study, ... Read more >>

Clin Immunol (Clinical immunology (Orlando, Fla.))
[2021, 230:108815]

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MS-based glycomics and glycoproteomics methods enabling isomeric characterization.

Wenjing Peng, Cristian D Gutierrez Reyes, Sakshi Gautam, Aiying Yu, Byeong Gwan Cho, Mona Goli, Kaitlyn Donohoo, Stefania Mondello, Firas Kobeissy, Yehia Mechref,

Glycosylation is one of the most significant and abundant posttranslational modifications in mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell communication, immune cell trafficking, and protein stability. Also, aberrant glycosylation has been associated with various diseases such as diabetes, Alzheimer's disease, inflammation, immune deficiencies, congenital ... Read more >>

Mass Spectrom Rev (Mass spectrometry reviews)
[2021, :]

Cited: 1 time

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Involvement of T-type calcium channels in the mechanism of low dose morphine-induced hyperalgesia in adult male rats.

Elham Abbasloo, Farzaneh Abdollahi, Arezoo Saberi, Saeed Esmaeili-Mahani, Ayat Kaeidi, Fereshteh Akhlaghinasab, Vahid Sheibani, Theresa Currier Thomas, Firas Hosni Kobeissy, Shahrbanoo Oryan,

It has been shown that systemic and local administration of ultra-low dose morphine induced a hyperalgesic response via mu-opioid receptors. However, its exact mechanism(s) has not fully been clarified. It is documented that mu-opioid receptors functionally couple to T-type voltage dependent Ca<sup>+2</sup> channels. Here, we investigated the role of T-type ... Read more >>

Neuropeptides (Neuropeptides)
[2021, 90:102185]

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Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications.

Khalil Mallah, Kazem Zibara, Coline Kerbaj, Ali Eid, Nour Khoshman, Zahraa Ousseily, Abir Kobeissy, Tristan Cardon, Dasa Cizkova, Firas Kobeissy, Isabelle Fournier, Michel Salzet,

Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation as well as military-related practices. This type of central nervous system trauma is known ... Read more >>

Mass Spectrom Rev (Mass spectrometry reviews)
[2021, :]

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Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2.

Mohammad Tarek, Hana Abdelzaher, Firas Kobeissy, Hassan A N El-Fawal, Mohammed M Salama, Anwar Abdelnaser,

The virus responsible for the COVID-19 global health crisis, SARS-CoV-2, has been shown to utilize the ACE2 protein as an entry point to its target cells. The virus has been shown to rely on the actions of TMPRSS2 (a serine protease), as well as FURIN (a peptidase), for the critical ... Read more >>

Genes (Basel) (Genes)
[2021, 12(7):]

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Potentiating Hemorrhage in a Periadolescent Rat Model of Closed-Head Traumatic Brain Injury Worsens Hyperexcitability but Not Behavioral Deficits.

Dounya Jalloul, Helene Hajjar, Rita Asdikian, Mariam Maawie, Leila Nasrallah, Yasser Medlej, Mouhamad Darwich, Nabil Karnib, Nada Lawand, Ronza Abdel Rassoul, Kevin K W Wang, Firas Kobeissy, Hala Darwish, Makram Obeid,

Post-traumatic epilepsy (PTE) and neurocognitive deficits are devastating sequelae of head injuries that are common in adolescents. Investigating desperately needed treatments is hindered by the difficulties in inducing PTE in rodents and the lack of established immature rat models of pediatric PTE. Hemorrhage is a significant risk factor for PTE, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(12):]

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On-tissue spatially resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape.

Stacy Alyse Malaker, Jusal Quanico, Antonella Raffo-Romero, Firas Kobeissy, Soulaimane Aboulouard, Dominique Tierny, Carolyn Ruth Bertozzi, Isabelle Fournier, Michel Salzet,

Here, we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of matrix-assisted laser desorption ionization (MALDI) N-glycan mass spectrometry imaging (MSI) and spatially resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuAc2 was predominantly ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2021, :]

Cited: 1 time

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Long-Term Cognitive Deficits After Traumatic Brain Injury Associated With Microglia Activation

Esber Saba, Mona Karout, Leila Nasralla, Firas Kobeissy, Hala Darwish, Samia Khoury,

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries, and based on the severity of the injury, it may result in chronic neurologic and cognitive deficits. Microglia play an essential role in homeostasis and diseases of the central nervous system. We hypothesize that microglia may play a ... Read more >>

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Sweat metabolome and proteome: Recent trends in analytical advances and potential biological functions.

Ahmed Serag, Zaynab Shakkour, Abdulsalam M Halboup, Firas Kobeissy, Mohamed A Farag,

Metabolome and proteome profiling of biofluids, e.g., urine, plasma, has generated vast and ever-increasing amounts of knowledge over the last few decades. Paradoxically, omics analyses of sweat, one of the most readily available human biofluids, have lagged behind. This review capitalizes on the current knowledge and state of the art ... Read more >>

J Proteomics (Journal of proteomics)
[2021, 246:104310]

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Meningioma genomics: a therapeutic challenge for clinicians.

Charbel Moussalem, Elie Massaad, Georges B Minassian, Louna Ftouni, Shadi Bsat, Mohamad N El Houshiemy, Safwan Alomari, Rana Sarieddine, Firas Kobeissy, Ibrahim Omeis,

Meningiomas are amongst the most commonly encountered intracranial tumors. The majority of these tumors arise intracranially, and the remaining incidents occur along the spinal cord. Meningiomas tend to grow gradually, with many tumors arising in inaccessible locations. Such sporadic behavior poses a therapeutic challenge to clinicians, causing incomplete tumor resections ... Read more >>

J Integr Neurosci (Journal of integrative neuroscience)
[2021, 20(2):463-469]

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National trauma and substance use disorders: A slippery slope in Lebanon.

Maya Bizri, Samer El Hayek, Hadi Beaini, Firas Kobeissy, Farid Talih,

Lebanon, a small middle-income nation in western Asia, has been crippled by decades of political turmoil and armed conflict. A "quadruple crisis" hit the country over the past years, starting with the protracted humanitarian Syrian refugee crisis, followed by a severe socioeconomic collapse, the global COVID-19 pandemic, and lastly the ... Read more >>

Subst Abus (Substance abuse)
[2021, 42(3):264-265]

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Cannabinoids and myocardial ischemia: Novel insights, updated mechanisms, and implications for myocardial infarction.

Karim Seif El-Dahan, Dima Machtoub, Gaelle Massoud, Suzanne A Nasser, Bassam Hamam, Firas Kobeissy, Fouad A Zouein, Ali H Eid,

Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects as compared to other illicit drugs; however, growing evidence clearly indicates that cannabis is associated with considerable adverse ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, :]

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C-Reactive Protein for Prediction or Early Detection of Pre-Eclampsia: A Systematic Review.

Rola Hamadeh, Amani Mohsen, Firas Kobeissy, Ali Karouni, Hikmat Akoum,

<h4>Objective</h4>Pre-eclampsia (PE) is a serious disease of pregnancy and one of the major causes of morbidity and mortality for both the mother and baby. This systematic review aims to detect the role of high-sensitivity C-reactive protein (CRP) in the detection of PE.<h4>Methods</h4>Thirty-four articles published between 2001 and 2019 were included ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2021, 86(1-2):13-26]

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SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group.

Shima Shahjouei, Georgios Tsivgoulis, Ghasem Farahmand, Eric Koza, Ashkan Mowla, Alireza Vafaei Sadr, Arash Kia, Alaleh Vaghefi Far, Stefania Mondello, Achille Cernigliaro, Annemarei Ranta, Martin Punter, Faezeh Khodadadi, Soheil Naderi, Mirna Sabra, Mahtab Ramezani, Ali Amini Harandi, Oluwaseyi Olulana, Durgesh Chaudhary, Aicha Lyoubi, Bruce C V Campbell, Juan F Arenillas, Daniel Bock, Joan Montaner, Saeideh Aghayari Sheikh Neshin, Diana Aguiar de Sousa, Matthew S Tenser, Ana Aires, Mercedes de Lera Alfonso, Orkhan Alizada, Elsa Azevedo, Nitin Goyal, Zabihollah Babaeepour, Gelareh Banihashemi, Leo H Bonati, Carlo W Cereda, Jason J Chang, Miljenko Crnjakovic, Gian Marco De Marchis, Massimo Del Sette, Seyed Amir Ebrahimzadeh, Mehdi Farhoudi, Ilaria Gandoglia, Bruno Gonçalves, Christoph J Griessenauer, Mehmet Murat Hanci, Aristeidis H Katsanos, Christos Krogias, Ronen R Leker, Lev Lotman, Jeffrey Mai, Shailesh Male, Konark Malhotra, Branko Malojcic, Teresa Mesquita, Asadollah Mir Ghasemi, Hany Mohamed Aref, Zeinab Mohseni Afshar, Jusun Moon, Mika Niemelä, Behnam Rezai Jahromi, Lawrence Nolan, Abhi Pandhi, Jong-Ho Park, João Pedro Marto, Francisco Purroy, Sakineh Ranji-Burachaloo, Nuno Reis Carreira, Manuel Requena, Marta Rubiera, Seyed Aidin Sajedi, João Sargento-Freitas, Vijay K Sharma, Thorsten Steiner, Kristi Tempro, Guillaume Turc, Yasaman Ahmadzadeh, Mostafa Almasi-Dooghaee, Farhad Assarzadegan, Arefeh Babazadeh, Humain Baharvahdat, Fabricio Buchadid Cardoso, Apoorva Dev, Mohammad Ghorbani, Ava Hamidi, Zeynab Sadat Hasheminejad, Sahar Hojjat-Anasri Komachali, Fariborz Khorvash, Firas Kobeissy, Hamidreza Mirkarimi, Elahe Mohammadi-Vosough, Debdipto Misra, Ali Reza Noorian, Peyman Nowrouzi-Sohrabi, Sepideh Paybast, Leila Poorsaadat, Mehrdad Roozbeh, Behnam Sabayan, Saeideh Salehizadeh, Alia Saberi, Mercedeh Sepehrnia, Fahimeh Vahabizad, Thomas Alexandre Yasuda, Mojdeh Ghabaee, Nasrin Rahimian, Mohammad Hossein Harirchian, Afshin Borhani-Haghighi, Mahmoud Reza Azarpazhooh, Rohan Arora, Saeed Ansari, Venkatesh Avula, Jiang Li, Vida Abedi, Ramin Zand,

[Figure: see text]. ... Read more >>

Stroke (Stroke)
[2021, 52(5):e117-e130]

Cited: 3 times

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A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption

Mahmoud Mona, Zunnaira Abbasi, Firas Kobeissy, Abdulrahman Chahbandar, Roberta Pileggi,

External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection, inflammation, traumatic injuries, pressure, mechanical stimulations, neoplastic conditions, systemic disorders, or idiopathic causes. Often, if undiagnosed and untreated, ERR can lead to the loss of the tooth or multiple ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases.

Ali Dakroub, Suzanne A Nasser, Firas Kobeissy, Hadi M Yassine, Alexander Orekhov, Javad Sharifi-Rad, Rabah Iratni, Ahmed F El-Yazbi, Ali H Eid,

Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular inflammation, and atherosclerosis, all of which pose increased risks of cardiovascular events. In this context, increased levels of visfatin have been correlated with several upregulated pro-inflammatory ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, 236(9):6282-6296]

Cited: 1 time

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