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Author Fernando Holguin

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The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations.

Anastasia Ivanova, Elliot Israel, Lisa M LaVange, Michael C Peters, Loren C Denlinger, Wendy C Moore, Leonard B Bacharier, M Alison Marquis, Nathan M Gotman, Michael R Kosorok, Chalmer Tomlinson, David T Mauger, Steve N Georas, Rosalind J Wright, Patricia Noel, Gary L Rosner, Praveen Akuthota, Dean Billheimer, Eugene R Bleecker, Juan Carlos Cardet, Mario Castro, Emily A DiMango, Serpil C Erzurum, John V Fahy, Merritt L Fajt, Benjamin M Gaston, Fernando Holguin, Sonia Jain, Nicholas J Kenyon, Jerry A Krishnan, Monica Kraft, Rajesh Kumar, Mark C Liu, Ngoc P Ly, James N Moy, Wanda Phipatanakul, Kristie Ross, Lewis J Smith, Stanley J Szefler, W Gerald Teague, Michael E Wechsler, Sally E Wenzel, Steven R White,

The Precision Interventions for Severe and/or Exacerbation-prone Asthma (PrecISE) study is an adaptive platform trial designed to investigate novel interventions to severe asthma. The study is conducted under a master protocol and utilizes a crossover design with each participant receiving up to five interventions and at least one placebo. Treatment ... Read more >>

J Biopharm Stat (Journal of biopharmaceutical statistics)
[2020, :1-12]

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Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor?

Richard Broadhurst, Ryan Peterson, Juan P Wisnivesky, Alex Federman, Shanta M Zimmer, Sunita Sharma, Michael Wechsler, Fernando Holguin,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, :]

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Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations.

Meghan D Althoff, Fernando Holguin, Fan Yang, Gary K Grunwald, Marc Moss, R William Vandivier, P Michael Ho, Tyree H Kiser, Ellen L Burnham,

RATIONALE:Non-invasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma. OBJECTIVE:To assess the association between non-invasive ventilation and subsequent need for invasive mechanical ventilation and in-hospital mortality among patients admitted with asthma exacerbation to ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, :]

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Management of Severe Asthma Beyond the Guidelines.

Anne E Reihman, Fernando Holguin, Sunita Sharma,

PURPOSE OF REVIEW:Asthma is one of the most common chronic respiratory diseases worldwide, yet only a small percentage of patients are categorized as having severe disease. Severe asthmatics, however, are responsible for the largest burden of healthcare costs and lost productivity. Several recent guidelines have addressed disease pathogenesis and treatment ... Read more >>

Curr Allergy Asthma Rep (Current allergy and asthma reports)
[2020, 20(9):47]

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Oxidative stress and obesity-related asthma.

Hartmut Grasemann, Fernando Holguin,

Obesity is an asthma comorbidity associated with poor control, increased exacerbation risk and reduced response to inhaled and systemic corticosteroids. It affects children and adults differentially. In those with early onset asthma, it associated with increased eosinophilic inflammation, whereas in late onset, it correlates with lower nitric oxide (NO) and ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, :]

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Parkin, an E3 ubiquitin ligase, enhances airway mitochondrial DNA release and inflammation.

Kris Genelyn Dimasuay, Niccolette Schaunaman, Richard J Martin, Nicole Pavelka, Christena Kolakowski, Roberta A Gottlieb, Fernando Holguin, Hong Wei Chu,

INTRODUCTION:Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the involvement of Parkin in promoting inflammation. In the present study, we determined if Parkin regulates airway mitochondrial DNA (mtDNA) release and inflammatory responses to type 2 ... Read more >>

Thorax (Thorax)
[2020, 75(9):717-724]

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Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes.

Anne M Fitzpatrick, Leonard B Bacharier, Daniel J Jackson, Stanley J Szefler, Avraham Beigelman, Michael Cabana, Ronina Covar, Theresa Guilbert, Fernando Holguin, Robert F Lemanske, Fernando D Martinez, Wayne Morgan, Wanda Phipatanakul, Jacqueline A Pongracic, Hengameh H Raissy, Robert S Zeiger, David T Mauger,

BACKGROUND:Compared with adults, phenotypic characterization of children with asthma is still limited and it remains difficult to predict which children with asthma are at highest risk for poor outcomes. OBJECTIVE:To identify latent classes in a large population of treatment-adherent children with mild to moderate asthma enrolled in clinical trials and ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, 8(8):2617-2627.e4]

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Sex Hormones and Asthma.

Fernando Holguin,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(2):127-128]

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T2-"Low" Asthma: Overview and Management Strategies.

Anne M Fitzpatrick, Bradley E Chipps, Fernando Holguin, Prescott G Woodruff,

Although the term "asthma" has been applied to all patients with airway lability and variable chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular features that may warrant different treatment approaches are well recognized. Patients with type 2 (T2)-"high" asthma are characterized by upregulation of T2 immune ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, 8(2):452-463]

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Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline.

Fernando Holguin, Juan Carlos Cardet, Kian Fan Chung, Sarah Diver, Diogenes S Ferreira, Anne Fitzpatrick, Mina Gaga, Liz Kellermeyer, Sandhya Khurana, Shandra Knight, Vanessa M McDonald, Rebecca L Morgan, Victor E Ortega, David Rigau, Padmaja Subbarao, Thomy Tonia, Ian M Adcock, Eugene R Bleecker, Chris Brightling, Louis-Philippe Boulet, Michael Cabana, Mario Castro, Pascal Chanez, Adnan Custovic, Ratko Djukanovic, Urs Frey, Betty Frankemölle, Peter Gibson, Dominique Hamerlijnck, Nizar Jarjour, Satoshi Konno, Huahao Shen, Cathy Vitary, Andy Bush,

This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the European Respiratory Society/American Thoracic Society Task Force's questions. The evidence was appraised using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach and ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(1):]

Cited: 7 times

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Contemporary management techniques of asthma in obese patients.

Meghan Althoff, Fernando Holguin,

Introduction: Obesity-associated asthma represents a heterogeneous group of clinical phenotypes, including an adult-onset phenotype. These patients often have difficult to control symptoms and often are less likely to respond to conventional asthma therapies.Areas covered: This review covers the effects of lifestyle interventions, including diet and weight loss, effect asthma outcomes ... Read more >>

Expert Rev Respir Med (Expert review of respiratory medicine)
[2020, 14(3):249-257]

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L-Citrulline increases nitric oxide and improves control in obese asthmatics.

Fernando Holguin, Hartmut Grasemann, Sunita Sharma, Daniel Winnica, Karen Wasil, Vong Smith, Margaret H Cruse, Nancy Perez, Erika Coleman, Timothy J Scialla, Loretta G Que,

BACKGROUNDThe airways of obese asthmatics have been shown to be NO deficient, and this contributes to airway dysfunction and reduced response to inhaled corticosteroids. In cultured airway epithelial cells, L-citrulline, a precursor of L-arginine recycling and NO formation, has been shown to prevent asymmetric dimethyl arginine-mediated (ADMA-mediated) NO synthase (NOS2) ... Read more >>

JCI Insight (JCI insight)
[2019, 4(24):]

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Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

Michael E Wechsler, Stanley J Szefler, Victor E Ortega, Jacqueline A Pongracic, Vernon Chinchilli, John J Lima, Jerry A Krishnan, Susan J Kunselman, David Mauger, Eugene R Bleecker, Leonard B Bacharier, Avraham Beigelman, Mindy Benson, Kathryn V Blake, Michael D Cabana, Juan-Carlos Cardet, Mario Castro, James F Chmiel, Ronina Covar, Loren Denlinger, Emily DiMango, Anne M Fitzpatrick, Deborah Gentile, Nicole Grossman, Fernando Holguin, Daniel J Jackson, Harsha Kumar, Monica Kraft, Craig F LaForce, Jason Lang, Stephen C Lazarus, Robert F Lemanske, Dayna Long, Njira Lugogo, Fernando Martinez, Deborah A Meyers, Wendy C Moore, James Moy, Edward Naureckas, J Tod Olin, Stephen P Peters, Wanda Phipatanakul, Loretta Que, Hengameh Raissy, Rachel G Robison, Kristie Ross, William Sheehan, Lewis J Smith, Julian Solway, Christine A Sorkness, Lisa Sullivan-Vedder, Sally Wenzel, Steven White, Elliot Israel, ,

BACKGROUND:Morbidity from asthma is disproportionately higher among black patients than among white patients, and black patients constitute the minority of participants in trials informing treatment. Data indicate that patients with inadequately controlled asthma benefit more from addition of a long-acting beta-agonist (LABA) than from increased glucocorticoids; however, these data may ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(13):1227-1239]

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Disulfide disruption reverses mucus dysfunction in allergic airway disease

Leslie Morgan, Siddharth Shenoy, Dorota Raclawska, Nkechinyere Emezienna, Vanessa Richardson, Naoko Hara, Anna Harder, Hassan El-Batal, Chelsea Magin, Diane Grove Villalon, Gregg Duncan, Justin Hanes, Jung Soo Suk, David Thornton, Fernando Holguin, William Janssen, William Thelin, Christopher Evans,

Airway mucus is essential for healthy lung defense 1 , but excessive mucus in asthma obstructs airflow, leading to severe and potentially fatal outcomes 2–5 . Current asthma therapies reduce allergic inflammation and relax airway smooth muscle, but treatments are often inadequate due to their minimal effects on mucus obstruction ... Read more >>

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Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.

Nicole L Grossman, Victor E Ortega, Tonya S King, Eugene R Bleecker, Elizabeth A Ampleford, Leonard B Bacharier, Michael D Cabana, Juan C Cardet, Tara F Carr, Mario Castro, Loren C Denlinger, Joshua L Denson, Nicolas Fandino, Anne M Fitzpatrick, Gregory A Hawkins, Fernando Holguin, Jerry A Krishnan, Stephen C Lazarus, Sharmilee M Nyenhuis, Wanda Phipatanakul, Sima K Ramratnam, Sally Wenzel, Stephen P Peters, Deborah A Meyers, Michael E Wechsler, Elliot Israel,

BACKGROUND:Minority groups of African descent experience disproportionately greater asthma morbidity compared with other racial groups, suggesting that genetic variation from a common ancestry could influence exacerbation risk. OBJECTIVE:We evaluated clinical trial measures in the context of self-reported race and genetic ancestry to identify risk factors for asthma exacerbations. METHODS:One thousand ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(6):1524-1533]

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Reply.

Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A Boushey, Mario Castro, Vernon M Chinchilli, Christopher D Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F Lemanske, Njira Lugogo, Dave Mauger, Wendy C Moore, James Moy, Victor E Ortega, Stephen P Peters, Lewis J Smith, Julian Solway, Christine A Sorkness, Kaharu Sumino, Michael E Wechsler, Sally Wenzel, Elliot Israel, ,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(3):873-874]

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Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.

Stephen C Lazarus, Jerry A Krishnan, Tonya S King, Jason E Lang, Kathryn V Blake, Ronina Covar, Njira Lugogo, Sally Wenzel, Vernon M Chinchilli, David T Mauger, Anne-Marie Dyer, Homer A Boushey, John V Fahy, Prescott G Woodruff, Leonard B Bacharier, Michael D Cabana, Juan C Cardet, Mario Castro, James Chmiel, Loren Denlinger, Emily DiMango, Anne M Fitzpatrick, Deborah Gentile, Annette Hastie, Fernando Holguin, Elliot Israel, Daniel Jackson, Monica Kraft, Craig LaForce, Robert F Lemanske, Fernando D Martinez, Wendy Moore, Wayne J Morgan, James N Moy, Ross Myers, Stephen P Peters, Wanda Phipatanakul, Jacqueline A Pongracic, Loretta Que, Kristie Ross, Lewis Smith, Stanley J Szefler, Michael E Wechsler, Christine A Sorkness, ,

BACKGROUND:In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown. METHODS:In this 42-week, double-blind, crossover trial, we assigned 295 patients who were at least 12 years of age and who had mild, ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 380(21):2009-2019]

Cited: 6 times

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The impact of bariatric surgery on asthma control differs among obese individuals with reported prior or current asthma, with or without metabolic syndrome.

Erick Forno, Peng Zhang, Mehdi Nouraie, Anita Courcoulas, James E Mitchell, Bruce M Wolfe, Gladys Strain, Saurabh Khandelwal, Fernando Holguin,

BACKGROUND:Both obesity and the metabolic syndrome have been independently associated with increased asthma morbidity. However, it is unclear whether metabolic syndrome limits the beneficial effects of weight loss on asthma. OBJECTIVES:To evaluate whether bariatric weight loss is associated with improved asthma control, and whether this association varies by metabolic syndrome ... Read more >>

PLoS ONE (PloS one)
[2019, 14(4):e0214730]

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Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.

Daniel Winnica, Catherine Corey, Steven Mullett, Michael Reynolds, Gabrielle Hill, Stacy Wendell, Loretta Que, Fernando Holguin, Sruti Shiva,

Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more severe and less responsive to treatment in obese subjects. While alterations in mitochondrial function and redox signaling have been implicated in asthma pathogenesis, it is unclear whether these mechanisms differ in lean versus obese asthmatics. In addition, we previously demonstrated ... Read more >>

Antioxid. Redox Signal. (Antioxidants & redox signaling)
[2019, 31(10):673-686]

Cited: 5 times

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Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation.

Xiuxia Zhou, Carol L Kinlough, Rebecca P Hughey, Mingzhu Jin, Hideki Inoue, Emily Etling, Brian D Modena, Naftali Kaminski, Eugene R Bleecker, Deborah A Meyers, Nizar N Jarjour, John B Trudeau, Fernando Holguin, Anuradha Ray, Sally E Wenzel,

Although type-2-induced (T2-induced) epithelial dysfunction is likely to profoundly alter epithelial differentiation and repair in asthma, the mechanisms for these effects are poorly understood. A role for specific mucins, heavily N-glycosylated epithelial glycoproteins, in orchestrating epithelial cell fate in response to T2 stimuli has not previously been investigated. Levels of ... Read more >>

JCI Insight (JCI insight)
[2019, 4(5):]

Cited: 1 time

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Idiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report.

Faiza Khalid, Fernando Holguin,

BACKGROUND Hypereosinophilic syndrome (HES) is defined as hypereosinophilia with eosinophil mediated organ damage or dysfunction, provided that other causes of organ damage have been excluded. CASE REPORT An 83-year-old female presented with worsening dyspnea for 3 weeks. She was initially diagnosed with bronchitis and prescribed oral antibiotics along with prednisone ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:381-384]

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Loss of bronchoprotection with ICS plus LABA treatment, β-receptor dynamics, and the effect of alendronate.

Juan Carlos Cardet, Xiaofeng Jiang, Quan Lu, Norma Gerard, Kristen McIntire, Homer A Boushey, Mario Castro, Vernon M Chinchilli, Christopher D Codispoti, Anne-Marie Dyer, Fernando Holguin, Monica Kraft, Stephen Lazarus, Robert F Lemanske, Njira Lugogo, Dave Mauger, Wendy C Moore, James Moy, Victor E Ortega, Stephen P Peters, Lewis J Smith, Julian Solway, Christine A Sorkness, Kaharu Sumino, Michael E Wechsler, Sally Wenzel, Elliot Israel, ,

BACKGROUND:Loss of bronchoprotection (LOBP) with a regularly used long-acting β2-adrenergic receptor agonist (LABA) is well documented. LOBP has been attributed to β2-adrenergic receptor (B2AR) downregulation, a process requiring farnesylation, which is inhibited by alendronate. OBJECTIVE:We sought to determine whether alendronate can reduce LABA-associated LOBP in inhaled corticosteroid (ICS)-treated patients. METHODS:We ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(2):416-425.e7]

Cited: 0 times

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Advocating for the Health Worker.

Melissa McDiarmid,

BACKGROUND:Health workers in both well-resourced and limited income settings face health threats from exposures encountered in their unique and complex work environment. Even before the 2014 Ebola outbreak, preventable harm was routinely felt by health workers, most visibly through the fatal collusion between the HIV/AIDS epidemic and tuberculosis (TB) infection ... Read more >>

Ann Glob Health (Annals of global health)
[2019, 85(1):]

Cited: 1 time

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Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children.

Theresa W Guilbert, Leonard B Bacharier, David T Mauger, Wanda Phipatanakul, Stanley J Szefler, Susan Boehmer, Avraham Beigelman, Anne M Fitzpatrick, Daniel J Jackson, Sachin N Baxi, Mindy Benson, Carey-Ann D Burnham, Michael D Cabana, Mario Castro, James F Chmiel, Ronina Covar, Michael Daines, Jonathan M Gaffin, Deborah A Gentile, Fernando Holguin, Elliot Israel, H William Kelly, Stephen C Lazarus, Robert F Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, J Tod Olin, Stephen P Peters, Jacqueline A Pongracic, Hengameh H Raissy, Kristie Ross, William J Sheehan, Christine Sorkness, W Gerald Teague, Shannon Thyne, Fernando D Martinez, ,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 143(5):1934-1937.e4]

Cited: 0 times

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Obesity Trends among Asthma Patients in the United States: A Population-based Study.

Maria Fernanda Lurbet, Belen Rojano, Stacey-Ann Whittaker Brown, Paula Busse, Fernando Holguin, Alex D Federman, Juan P Wisnivesky,

BACKGROUND:Obesity is strongly associated with worse asthma control and poorer quality of life. The current obesity epidemic has reached historically high levels, with an estimated prevalence rate of 37% in the general United States (US) population. However, less is known about trends in the prevalence of obesity among individuals with ... Read more >>

Ann Glob Health (Annals of global health)
[2019, 85(1):]

Cited: 0 times

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