Full Text Journal Articles by
Author Fernanda F Cruz

Advertisement

Find full text journal articles






Immunomodulators in anesthesia.

Fernanda F Cruz, Patricia R M Rocco, Paolo Pelosi,

<h4>Purpose of review</h4>Anesthetics are known to have immunomodulatory effects. These can be detrimental, inducing immunosuppression and facilitating the development of opportunistic infections, especially when used at high doses, for prolonged periods, or in patients with preexisting immune deficiency; or beneficial, modulating the inflammatory response, particularly in critical illness and systemic ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):357-363]

Cited: 0 times

View full text PDF listing >>



Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia.

Raquel F de Magalhães, Daniela G Cruz, Mariana A Antunes, Marcos V de S Fernandes, Milena V Oliveira, Cassia L Braga, Joshua Satalin, Penny Andrews, Nader Habashi, Gary Nieman, Cassiano F Gonçalves de-Albuquerque, Adriana R Silva, Roseli V Ribeiro, Vera L Capelozzi, Fernanda F Cruz, Cynthia Dos S Samary, Patricia R M Rocco, Pedro L Silva,

<h4>Objectives</h4>We hypothesized that a time-controlled adaptive ventilation strategy would open and stabilize alveoli by controlling inspiratory and expiratory duration. Time-controlled adaptive ventilation was compared with volume-controlled ventilation at the same levels of mean airway pressure and positive end-release pressure (time-controlled adaptive ventilation)/positive end-expiratory pressure (volume-controlled ventilation) in a Pseudomonas aeruginosa-induced ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(1):140-150]

Cited: 0 times

View full text PDF listing >>



Advertisement

Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial.

Patricia R M Rocco, Pedro L Silva, Fernanda F Cruz, Marco Antonio C M Junior, Paulo F G M M Tierno, Marcos A Moura, Luís Frederico G De Oliveira, Cristiano C Lima, Ezequiel A Dos Santos, Walter F Junior, Ana Paula S M Fernandes, Kleber G Franchini, Erick Magri, Nara F de Moraes, José Mário J Gonçalves, Melanie N Carbonieri, Ivonise S Dos Santos, Natália F Paes, Paula V M Maciel, Raissa P Rocha, Alex F de Carvalho, Pedro Augusto Alves, José Luiz P Modena, Artur T Cordeiro, Daniela B B Trivella, Rafael E Marques, Ronir R Luiz, Paolo Pelosi, Jose Roberto Lapa E Silva, ,

Nitazoxanide is widely available and exerts broad-spectrum antiviral activity <i>in vitro</i> However, there is no evidence of its impact on SARS-CoV-2 infection.In a multicenter, randomised, double-blind, placebo-controlled trial, adult patients presenting up to 3 days after onset of Covid-19 symptoms (dry cough, fever, and/or fatigue) were enrolled. After confirmation of SARS-CoV2 ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

Cited: 8 times

View full text PDF listing >>



Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.

Soraia C Abreu, Thomas H Hampton, Evan Hoffman, Jacob Dearborn, Alix Ashare, Karatatiwant Singh Sidhu, Dwight E Matthews, David H McKenna, Eyal Amiel, Jayita Barua, Anna Krasnodembskaya, Karen English, Bernard Mahon, Claudia Dos Santos, Fernanda F Cruz, Daniel C Chambers, Kathleen D Liu, Michael A Matthay, Robert A Cramer, Bruce A Stanton, Patricia R M Rocco, Matthew J Wargo, Daniel J Weiss, Sara Rolandsson Enes,

Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 319(6):L908-L925]

Cited: 0 times

View full text PDF listing >>



Iso-Oncotic Albumin Mitigates Brain and Kidney Injury in Experimental Focal Ischemic Stroke.

Renata de S Mendes, Gloria Martins, Milena V Oliveira, Nazareth N Rocha, Fernanda F Cruz, Mariana A Antunes, Soraia C Abreu, Adriana L Silva, Christina Takiya, Pedro M Pimentel-Coelho, Chiara Robba, Rosália Mendez-Otero, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

<b>Background:</b> There is widespread debate regarding the use of albumin in ischemic stroke. We tested the hypothesis that an iso-oncotic solution of albumin (5%), administered earlier after acute ischemic stroke (3 h), could provide neuroprotection without causing kidney damage, compared to a hyper-oncotic albumin (20%) and saline. <b>Objective:</b> To compare ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:1001]

Cited: 0 times

View full text PDF listing >>



Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma.

Fabio S Aguiar, André S Melo, Ana Maria S Araújo, Alexandre P Cardoso, Sergio Augusto L de Souza, Miquéias Lopes-Pacheco, Fernanda F Cruz, Debora G Xisto, Karina D Asensi, Lanuza Faccioli, Anna Beatriz S Salgado, Maria Carolina P P Landesmann, Regina C S Goldenberg, Bianca Gutfilen, Marcelo M Morales, Patricia R M Rocco, Jose R Lapa E Silva,

BACKGROUND:Despite recent advances in understanding its pathophysiology and development of novel therapies, asthma remains a serious public health issue worldwide. Combination therapy with inhaled corticosteroids and long-acting β2-adrenoceptor agonists results in disease control for many patients, but those who exhibit severe asthma are often unresponsive to conventional treatment, experiencing worse ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):167]

Cited: 2 times

View full text PDF listing >>



Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19.

Maroun Khoury, Jimena Cuenca, Fernanda F Cruz, Fernando E Figueroa, Patricia R M Rocco, Daniel J Weiss,

The severe respiratory consequences of the coronavirus disease 2019 (COVID-19) pandemic have prompted urgent need for novel therapies. Cell-based approaches, primarily using mesenchymal stem (stromal) cells (MSCs), have demonstrated safety and possible efficacy in patients with acute respiratory distress syndrome (ARDS), although they are not yet well studied in respiratory ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 55(6):]

Cited: 62 times

View full text PDF listing >>



Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma.

Ligia L Castro, Jamil Z Kitoko, Debora G Xisto, Priscilla C Olsen, Herbert L M Guedes, Marcelo M Morales, Miquéias Lopes-Pacheco, Fernanda F Cruz, Patricia R M Rocco,

In experimental house dust mite (HDM)-induced allergic asthma, therapeutic administration of a single dose of adipose tissue-derived mesenchymal stromal cells (MSCs) ameliorates lung inflammation but is unable to reverse remodeling. We hypothesized that multiple doses of MSCs might exert better therapeutic effects by reducing lung inflammation and remodeling but might ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2020, 9(2):250-260]

Cited: 8 times

View full text PDF listing >>



Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury.

Renata de S Mendes, Milena V Oliveira, Gisele A Padilha, Nazareth N Rocha, Cintia L Santos, Ligia A Maia, Marcos V de S Fernandes, Fernanda F Cruz, Priscilla C Olsen, Vera L Capelozzi, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

<h4>Background</h4>Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung injury, recent studies have shown that human albumin may lead to kidney damage proportional to albumin concentration. In this context, we compared the effects of ... Read more >>

Respir Res (Respiratory research)
[2019, 20(1):155]

Cited: 2 times

View full text PDF listing >>



Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury.

Lígia de A Maia, Fernanda F Cruz, Milena V de Oliveira, Cynthia S Samary, Marcos Vinicius de S Fernandes, Stefano de A A Trivelin, Nazareth de N Rocha, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L Silva, Patricia R M Rocco,

Obese patients are at higher risk of developing acute respiratory distress syndrome (ARDS); however, their survival rates are also higher compared to those of similarly ill non-obese patients. We hypothesized that obesity would not only prevent lung inflammation, but also reduce remodeling in moderate endotoxin-induced acute lung injury (ALI). Obesity ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1215]

Cited: 7 times

View full text PDF listing >>



Gradually Increasing Tidal Volume May Mitigate Experimental Lung Injury in Rats.

Nathane S Felix, Cynthia S Samary, Fernanda F Cruz, Nazareth N Rocha, Marcos V S Fernandes, Joana A Machado, Rebecca L Bose-Madureira, Vera L Capelozzi, Paolo Pelosi, Pedro L Silva, John J Marini, Patricia R M Rocco,

<h4>Background</h4>This study hypothesized that, in experimental mild acute respiratory distress syndrome, lung damage caused by high tidal volume (VT) could be attenuated if VT increased slowly enough to progressively reduce mechanical heterogeneity and to allow the epithelial and endothelial cells, as well as the extracellular matrix of the lung to ... Read more >>

Anesthesiology (Anesthesiology)
[2019, 130(5):767-777]

Cited: 5 times

View full text PDF listing >>



Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema.

Hananda A Poggio, Mariana A Antunes, Nazareth N Rocha, Jamil Z Kitoko, Marcelo M Morales, Priscilla C Olsen, Miquéias Lopes-Pacheco, Fernanda F Cruz, Patricia R M Rocco,

<h4>Background</h4>A single administration of mesenchymal stromal cells (MSCs) has been shown to reduce lung inflammation in experimental elastase-induced emphysema; however, effects were limited in terms of lung-tissue repair and cardiac function improvement. We hypothesized that two doses of MSCs could induce further lung and cardiovascular repair by mitigating inflammation and ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2018, 9(1):296]

Cited: 9 times

View full text PDF listing >>



Effects of static magnetic fields on natural or magnetized mesenchymal stromal cells: Repercussions for magnetic targeting.

Luisa H A Silva, Sueli M Silva, Emilia C D Lima, Renata C Silva, Daniel J Weiss, Marcelo M Morales, Fernanda F Cruz, Patricia R M Rocco,

The magnetic targeting (MT) technique improves delivery of mesenchymal stromal cells (MSCs) to target sites. However, the moderate-intensity static magnetic fields (SMF) used for MT may exert adverse effects on MSCs. Thus, we aimed to evaluate the effects of SMF on MSCs in vitro. Cells were initially magnetized using citrate-coated ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2018, 14(7):2075-2085]

Cited: 4 times

View full text PDF listing >>



hMSCs as an alternative therapeutic option for asthma with neutrophil mediated inflammation.

Fernanda F Cruz, Patricia R M Rocco, Daniel J Weiss,

Exp Mol Med (Experimental & molecular medicine)
[2018, 50(6):1-2]

Cited: 0 times

View full text PDF listing >>



Impact of different intratracheal flows during lung decellularization on extracellular matrix composition and mechanics.

Mariana Alves Bellezzia, Fernanda F Cruz, Vanessa Martins, Lígia Lins de Castro, Miquéias Lopes-Pacheco, Eduardo Prata Vilanova, Paulo A Mourão, Patricia Rm Rocco, Pedro L Silva,

<h4>Aim</h4>To evaluate different intratracheal flow rates on extracellular matrix content and lung mechanics in an established lung decellularization protocol.<h4>Materials & methods</h4>Healthy mice were used: 15 for decellularization and five to serve as controls. Fluids were instilled at 5, 10 and 20 ml/min flow rates through tracheal cannula and right ventricular cavity (0.5 ml/min) ... Read more >>

Regen Med (Regenerative medicine)
[2018, 13(5):519-530]

Cited: 0 times

View full text PDF listing >>



Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases.

Luisa H A Silva, Mariana A Antunes, Claudia C Dos Santos, Daniel J Weiss, Fernanda F Cruz, Patricia R M Rocco,

Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in clinical trials, to date, few studies have shown evidence of MSC efficacy in respiratory ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2018, 9(1):45]

Cited: 32 times

View full text PDF listing >>



Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome.

Johnatas D Silva, Miquéias Lopes-Pacheco, Ana H R Paz, Fernanda F Cruz, Elga B Melo, Milena V de Oliveira, Débora G Xisto, Vera L Capelozzi, Marcelo M Morales, Paolo Pelosi, Elizabeth Cirne-Lima, Patricia R M Rocco,

OBJECTIVES:Mesenchymal stem cells-based therapies have shown promising effects in experimental acute respiratory distress syndrome. Different mesenchymal stem cells sources may result in diverse effects in respiratory diseases; however, there is no information regarding the best source of mesenchymal stem cells to treat pulmonary acute respiratory distress syndrome. We tested the ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(2):e132-e140]

Cited: 23 times

View full text PDF listing >>



Stem-cell extracellular vesicles and lung repair.

Fernanda F Cruz, Patricia R M Rocco,

Four out of the ten leading causes of morbidity and mortality worldwide are lung diseases. Despite advances in comprehending the pathophysiological mechanisms involved in these disorders, for several respiratory diseases, there is still no effective treatment able to stop their natural history or reverse the morphological and functional damage they ... Read more >>

Stem Cell Investig (Stem cell investigation)
[2017, 4:78]

Cited: 6 times

View full text PDF listing >>



Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension.

Lucas de Mendonça, Nathane S Felix, Natália G Blanco, Jaqueline S Da Silva, Tatiana P Ferreira, Soraia C Abreu, Fernanda F Cruz, Nazareth Rocha, Patrícia M Silva, Vanessa Martins, Vera L Capelozzi, Gizele Zapata-Sudo, Patricia R M Rocco, Pedro L Silva,

<h4>Background</h4>Experimental research has reported beneficial effects of mesenchymal stromal cell (MSC) therapy in pulmonary arterial hypertension (PAH). However, these studies either were based on prophylactic protocols or assessed basic remodeling features without evaluating possible mechanisms. We analyzed the effects of MSC therapy on lung vascular remodeling and hemodynamics and its ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2017, 8(1):220]

Cited: 16 times

View full text PDF listing >>



Sevoflurane, Compared With Isoflurane, Minimizes Lung Damage in Pulmonary but Not in Extrapulmonary Acute Respiratory Distress Syndrome in Rats.

Mariana N Araújo, Cíntia L Santos, Cynthia S Samary, Luciana B B Heil, Vinicius C M Cavalcanti, Fernanda F Cruz, Nathane S Felix, Johnatas D Silva, Marcelo M Morales, Paolo Pelosi, Fatima C Fernandes, Nivaldo R Villela, Pedro L Silva, Patricia R M Rocco,

<h4>Background</h4>Volatile anesthetics modulate inflammation in acute respiratory distress syndrome (ARDS). However, it is unclear whether they act differently depending on ARDS etiology. We hypothesized that the in vivo and in vitro effects of sevoflurane and isoflurane on lung damage would not differ in pulmonary (p) and extrapulmonary (exp) ARDS.<h4>Methods</h4>Twenty-four Wistar ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2017, 125(2):491-498]

Cited: 0 times

View full text PDF listing >>



Collection, processing and freezing of equine bone marrow cells.

Fernanda Z Bastos, Fernanda C M Barussi, Thasla F Santi, Bianca P Vieira, Alexandra C Senegaglia, Fernanda F Cruz, Pedro V Michelotto,

There is no consensus on aspects of equine bone marrow collection and processing. The study aimed to describe the collection of large volumes of bone marrow from horses of advanced age, with emphasis on bone marrow mononuclear cells (BMMCs) recovery and viability after cryopreservation. Fourteen horses, aged 3-24 years, were ... Read more >>

Cryobiology (Cryobiology)
[2017, 78:95-100]

Cited: 0 times

View full text PDF listing >>



Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model.

Ricardo Lima, Pedro L Silva, Vera L Capelozzi, Mariana G Oliveira, Maria Cristina E Santana, Fernanda F Cruz, Paolo Pelosi, Alberto Schanaider, Manu L N G Malbrain, Patricia R M Rocco,

<h4>Background</h4>Abdominal compartment syndrome (ACS) sometimes occurs in critically ill patients following damage control surgery. The purpose of the present study was to develop a model of ACS and to evaluate its pathologic impact on liver, kidney, and lung morphology.<h4>Methods</h4>Twenty Wistar rats (mass 300-350 g) were randomly divided into four groups: ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2017, 49(2):130-138]

Cited: 4 times

View full text PDF listing >>



Magnetic targeting as a strategy to enhance therapeutic effects of mesenchymal stromal cells.

Luisa H A Silva, Fernanda F Cruz, Marcelo M Morales, Daniel J Weiss, Patricia R M Rocco,

Mesenchymal stromal cells (MSCs) have been extensively investigated in the field of regenerative medicine. It is known that the success of MSC-based therapies depends primarily on effective cell delivery to the target site where they will secrete vesicles and soluble factors with immunomodulatory and potentially reparative properties. However, some lesions ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2017, 8(1):58]

Cited: 8 times

View full text PDF listing >>



Bone Marrow, Adipose, and Lung Tissue-Derived Murine Mesenchymal Stromal Cells Release Different Mediators and Differentially Affect Airway and Lung Parenchyma in Experimental Asthma.

Soraia C Abreu, Mariana A Antunes, Debora G Xisto, Fernanda F Cruz, Vivian C Branco, Elga Bandeira, Jamil Zola Kitoko, Almair F de Araújo, Ludmilla Dellatorre-Texeira, Priscilla C Olsen, Daniel J Weiss, Bruno L Diaz, Marcelo M Morales, Patricia R M Rocco,

Mesenchymal stromal cells (MSCs) from different sources have differential effects on lung injury. To compare the effects of murine MSCs from bone marrow (BM), adipose tissue (AD), and lung tissue (LUNG) on inflammatory and remodeling processes in experimental allergic asthma, female C57BL/6 mice were sensitized and challenged with ovalbumin (OVA) ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2017, 6(6):1557-1567]

Cited: 26 times

View full text PDF listing >>



Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema.

Isabela Henriques, Gisele A Padilha, Robert Huhle, Caio Wierzchon, Paulo J B Miranda, Isalira P Ramos, Nazareth Rocha, Fernanda F Cruz, Raquel S Santos, Milena V de Oliveira, Sergio A Souza, Regina C Goldenberg, Ronir R Luiz, Paolo Pelosi, Marcelo G de Abreu, Pedro L Silva, Patricia R M Rocco,

Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical ventilation strategies on ventilator-induced lung injury (VILI) in emphysema is poorly defined. New ventilator strategies should be developed to minimize VILI in emphysema. The present study was divided into ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:277]

Cited: 8 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2509 s