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Comparisons of clinical phenotype, radiological and laboratory features, and therapy of neuromyelitis optica spectrum disorder by regions: update and challenges.

Caiyun Liu, Mingchao Shi, Mingqin Zhu, Fengna Chu, Tao Jin, Jie Zhu,

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) associated with autoantibody (ab) to aquaporin-4 (AQP4). There is obvious variation between regions and countries in the epidemiology, clinical features and management in NMOSD. Based on published population-based observation and cohort studies, the different ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2021, :102921]

Cited: 0 times

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Can Control Infections Slow Down the Progression of Alzheimer's Disease? Talking About the Role of Infections in Alzheimer's Disease.

Mingchao Shi, Chunrong Li, Xiaoping Tian, Fengna Chu, Jie Zhu,

Alzheimer's disease as the most common age-related dementia affects more than 40 million people in the world, representing a global public health priority. However, the pathogenesis of Alzheimer's disease (AD) is complex, and it remains unclear. Over the past decades, all efforts made in the treatments of AD, with targeting ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:685863]

Cited: 0 times

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Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type.

Donghui Shen, Fengna Chu, Yue Lang, Chao Zheng, Chunrong Li, Kangding Liu, Jie Zhu,

Guillain-Barré syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central role in its animal model, experimental autoimmune neuritis (EAN), which has been well accepted. Additionally, nuclear factor (NF)-κB inhibitors have been used to treat cancers and have shown beneficial ... Read more >>

Clin Exp Immunol (Clinical and experimental immunology)
[2021, 206(1):110-117]

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NF-κB inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type

Donghui Shen, Fengna Chu, Yue Lang, Chao Zheng, Chunrong Li, Xiangyu Zheng, Jie Zhu,

Guillain–Barre’ syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of peripheral nervous system (PNS). Macrophages playing a central role in its animal model, experimental autoimmune neuritis (EAN) has been well-accepted. Additionally, NF-κB inhibitors has been used to treat cancers and showed beneficial effects. Here we investigated the therapeutic ... Read more >>

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Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

Mingchao Shi, Fengna Chu, Xiaoping Tian, Qiaolifan Aerqin, Feiqi Zhu, Jie Zhu,

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the pathogenic factors unsuccessful over past decades. It has been evidenced that the innate immune is strongly implicated in the pathogenesis of AD. However, the role of adaptive ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420987224]

Cited: 1 time

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Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease.

Feiqi Zhu, Chunrong Li, Fengna Chu, Xiaoping Tian, Jie Zhu,

Alzheimer's disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:544235]

Cited: 7 times

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Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis.

Chao Zheng, Jingtao Chen, Fengna Chu, Jie Zhu, Tao Jin,

Multiple sclerosis (MS) is a neuro-autoimmune and neurodegenerative disorder leading to chronic inflammation, demyelination, axonal, and neuronal loss in the central nervous system (CNS). Despite intense research efforts, the pathogenesis of MS still remains unclear. Toll-like receptors (TLRs) are a family of type I transmembrane receptors that play a crucial ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2019, 12:314]

Cited: 4 times

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The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis.

Fengna Chu, Mingchao Shi, Chao Zheng, Donghui Shen, Jie Zhu, Xiangyu Zheng, Li Cui,

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by chronic inflammation, demyelination, as well as axonal and neuronal loss in the central nervous system (CNS). Macrophages and microglia are important components of the innate immune system. They participate in the primary response to microorganisms and play a role ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2018, 318:1-7]

Cited: 59 times

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Roles of macrophage migration inhibitory factor in Guillain-Barré syndrome and experimental autoimmune neuritis: beneficial or harmful?

Donghui Shen, Yue Lang, Fengna Chu, Xiujuan Wu, Ying Wang, Xiangyu Zheng, Hong-Liang Zhang, Jie Zhu, Kangding Liu,

<h4>Introduction</h4>Macrophage migration inhibitory factor (MIF) plays an important role in the pathogenesis of Guillain-Barré syndrome (GBS) and its animal model experimental autoimmune neuritis (EAN), which may offer an opportunity for the development of the novel therapeutic strategies for GBS. Areas covered: 'macrophage migration inhibitory factor' and 'Guillain-Barré syndrome' were used ... Read more >>

Expert Opin Ther Targets (Expert opinion on therapeutic targets)
[2018, 22(7):567-577]

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Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review.

Yue Lang, Fengna Chu, Donghui Shen, Weiguanliu Zhang, Chao Zheng, Jie Zhu, Li Cui,

Inflammasomes are multiprotein complexes that can sense pathogen-associated molecular patterns and damage-associated molecular signals. They are involved in the initiation and development of inflammation via activation of IL-1<i>β</i> and IL-18. Many recent studies suggest a strong correlation between inflammasomes and neurological diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2018, 2018:1549549]

Cited: 19 times

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Beneficial or Harmful Role of Macrophages in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis.

Donghui Shen, Fengna Chu, Yue Lang, Yunlong Geng, Xiangyu Zheng, Jie Zhu, Kangding Liu,

Guillain-Barré syndrome (GBS), an immune-mediated demyelinating peripheral neuropathy, is characterized by acute weakness of the extremities and areflexia or hyporeflexia. Experimental autoimmune neuritis (EAN) is a common animal model for GBS, which represents a CD4<sup>+</sup> T cell-mediated inflammatory autoimmune demyelination of the peripheral nervous system (PNS), and is used to ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2018, 2018:4286364]

Cited: 9 times

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Mass spectrometry-based metabolomics for tuberculosis meningitis.

Peixu Zhang, Weiguanliu Zhang, Yue Lang, Yan Qu, Fengna Chu, Jiafeng Chen, Li Cui,

Tuberculosis meningitis (TBM) is a prevalent form of extra-pulmonary tuberculosis that causes substantial morbidity and mortality. Diagnosis of TBM is difficult because of the limited sensitivity of existing laboratory techniques. A metabolomics approach can be used to investigate the sets of metabolites of both bacteria and host, and has been ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2018, 483:57-63]

Cited: 3 times

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Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives.

Fengna Chu, Mingchao Shi, Yue Lang, Donghui Shen, Tao Jin, Jie Zhu, Li Cui,

The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of MS is not clear, and it should involve ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2018, 2018:8168717]

Cited: 37 times

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Epilepsia partialis continua present with shoulder joint-trunk-hip joint rhythmic clonic seizure: a case report.

Yudan Lv, Zan Wang, Fengna Chu, Chang Liu, Hongmei Meng,

Epilepsia partialis continua (EPC) is a particular type of epilepsy which is distinguished from "common epilepsy" by its characteristic semiological features. However, unusual manifestations should be described in order to give awareness at clinical diagnosis. In this case report we describe a rare EPC case not previously reported, in which ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2016, 12:2363-2366]

Cited: 2 times

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A patient with progressive cognitive decline and periodic abnormal waves in EEG: PLEDs of neurosyphilis or PSDs of Creutzfeldt-Jakob disease?

Yudan Lv, Fengna Chu, Hongmei Meng, Zan Wang, Li Cui,

We report one Chinese patient with neurosyphilis exhibiting periodic lateralized epileptiform discharges (PLEDs) in the electroencephalogram (EEG). The patient (male, 59 years old) manifested with progressive cognitive decline and abnormal behavior. After several days, he gradually lost contact with others, and fell into a coma. EEG revealed periodic abnormal waves, ... Read more >>

Clin EEG Neurosci (Clinical EEG and neuroscience)
[2014, 45(3):218-221]

Cited: 3 times

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