Full Text Journal Articles by
Author Fenglin Li

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Immune function of cytosolic manganese superoxide dismutase from Macrobrachium rosenbergii in response to bacterial infection

Yanan Li, Fanbin Zhan, Fenglin Li, Zhijie Lu, Fei Shi, Zizheng Xu, Youcheng Yang, Lijuan Zhao, Zhendong Qin, Li Lin,

An excess of reactive oxygen species (ROS) usually disrupts the balance of the antioxidant system and impairs the homeostasis of cells, resulting in serious oxidative damage. Therefore, a better understanding of how the immune system protects itself against such excessive oxidative stress is crucial. SODs play an indispensable role in ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 541:Not Available]

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Alginate oligosaccharide improves fat metabolism and antioxidant capacity in the liver of grass carp (Ctenopharyngodon idellus)

Minxuan Yang, Zhijie Lu, Fenglin Li, Fei Shi, Fanbin Zhan, Yulei Zhang, Lijuan Zhao, Yanan Li, Jun Li, Li Lin, Zhendong Qin,

The aim of the current study was to investigate the potentially beneficial effects of alginate oligosaccharide (AOS) on the modulation of growth, fatty acid metabolism, and antioxidant capacity in grass carp (Ctenopharyngodon idellus), and the fundamental mechanisms involved. AOS enhanced the growth performance of grass carp in a dose-dependent manner. ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 540:Not Available]

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Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development.

Yiyi Yao, Fenglin Li, Jiansong Huang, Jie Jin, Huafeng Wang,

Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persistence existence of leukemia stem cells (LSCs). Bone marrow microenvironment (BMM), the home of hematopoiesis, has ... Read more >>

Exp Hematol Oncol (Experimental hematology & oncology)
[2021, 10(1):39]

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Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution.

Nicholas A Swanson, Ravi K Lokareddy, Fenglin Li, Chun-Feng David Hou, Sebastian Leptihn, Mikhail Pavlenok, Michael Niederweis, Ruth A Pumroy, Vera Y Moiseenkova-Bell, Gino Cingolani,

Hershey and Chase used bacteriophage T2 genome delivery inside Escherichia coli to demonstrate that DNA, not protein, is the genetic material. Seventy years later, our understanding of viral genome delivery in prokaryotes remains limited, especially for short-tailed phages of the Podoviridae family. These viruses expel mysterious ejection proteins found inside ... Read more >>

Mol Cell (Molecular cell)
[2021, :]

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Global, regional, and national burdens of leukemia from 1990 to 2017: a systematic analysis of the global burden of disease 2017 study.

Xiangjie Lin, Jinghan Wang, Xin Huang, Huafeng Wang, Fenglin Li, Wenle Ye, Shujuan Huang, Jiajia Pan, Qing Ling, Wenwen Wei, Shihui Mao, Yu Qian, Jie Jin, Jiansong Huang,

We described the spatial and temporal trends of the annual leukemia incidence, prevalence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2017. Leukemia case numbers and age-standardized rates (ASRs) were extracted from the Global Burden of Disease (GBD) study 2017. The estimated annual percentage change (EAPC) in the ASR ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(7):10468-10489]

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Inhibition of CPT1a as a Prognostic Marker can Synergistically Enhance the Antileukemic Activity of ABT199

shihui mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang, Jie Jin,

<h4>Background: </h4> Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can facilitate cancer metabolic adaptation. Previous reports demonstrated that CPT1a acts as a potential molecular target in solid tumors ... Read more >>

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Development and validation of a novel circular RNA as an independent prognostic factor in acute myeloid leukemia.

Jinghan Wang, Jiajia Pan, Shujuan Huang, Fenglin Li, Jiansong Huang, Xia Li, Qing Ling, Wenle Ye, Yungui Wang, Wenjuan Yu, Jie Jin,

<h4>Background</h4>Although there are many clinical and molecular biomarkers in acute myeloid leukemia (AML), the novel and reliable biomarkers are still required to predict the overall survival at the time of disease diagnosis.<h4>Methods</h4>In order to identify independent predictors, we firstly selected 60 cytogenetically normal AML (CN-AML) patients using the propensity score ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):28]

Cited: 1 time

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Use of Network Pharmacology to Investigate the Mechanism by Which Allicin Ameliorates Lipid Metabolism Disorder in HepG2 Cells.

Bijun Cheng, Tianjiao Li, Fenglin Li,

Allicin has been well documented to exhibit a wide spectrum of biological activities, especially lipid-lowering activity, as a promising candidate for the management of nonalcoholic fatty liver disease (NALFD). However, the mechanisms underlying the therapeutic effects of allicin require further investigation. It is tempting to think of combining network pharmacology ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2021, 2021:3956504]

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Aeromonas hydrophila infection activates death receptor apoptosis pathway in the red blood cells of grass carp (Ctenopharyngodon idellus)

Zhijie Lu, Minxuan Yang, Kai Zhang, Fanbin Zhan, Fenglin Li, Fei Shi, Yanan Li, Lijuan Zhao, Jun Li, Li Lin, Zhendong Qin,

Fish blood contains RBCs (Red blood cells) as the major cells. Unlike the absence of nucleus in mammalian RBC, fish RBC contains a nucleus. Previous researches have indicated that fish RBCs have a significant function in immune responses. However, the mechanism underlying the immune responses against bacterial infection of teleost ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2021, 532:Not Available]

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CPT1B, a Metabolic Molecule, Is Also an Independent Risk Factor in CN-AML

Qing Ling, Shihui Mao, Jiajia Pan, Wenwen Wei, Yu Qian, Fenglin Li, Shujuan Huang, Wenle Ye, Xiangjie Lin, Jiansong Huang, Jinghan Wang, Jie Jin,

<h4>Background: </h4> In recent years, fatty acid oxidation has been considered as an important energy source for tumorigenesis and development. There are extensive studies on CPT1A, a kind of fatty acid oxidation rate-limiting enzyme. However, prognostic value and regulatory network of another subtype CPT1B in AML remains elusive. This submission ... Read more >>

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Expression and clinical significance of phospholipase D1 in de novo acute myeloid leukemia.

Ying Lu, Jiasi Zhou, Renzhi Pei, Fenglin Li, Jie Jin, Lei Jiang,

<b>Objective:</b> Phospholipase D (PLD) is known to participate in several aspects of cellular processes including cell mitosis, migration, phagocytosis, and membrane vesicle trafficking. The role of PLD has been investigated in multiple cancers except hematologic malignances. <b>Methods:</b> We enrolled 291 patients with <i>de novo</i> acute myeloid leukemia (AML) and detected ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):270-275]

Cited: 1 time

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The immune function of heme oxygenase-1 from grass carp (Ctenopharyngodon idellus) in response to bacterial infection.

Zhijie Lu, Fanbin Zhan, Minxuan Yang, Fenglin Li, Fei Shi, Yanan Li, Menglan Zhang, Lijuan Zhao, Kai Zhang, Jun Li, Li Lin, Zhendong Qin,

Heme oxygenase (HO)-1, a rate-limiting enzyme in heme catabolism, results in the formation of equivalent amounts of biliverdin (BV), carbon monoxide (CO) and ferrous iron (Fe<sup>2+</sup>). Previous studies have revealed that HO-1 plays an important role in immune responses. However, the mechanism underlying the immune responses against bacterial infection of ... Read more >>

Fish Shellfish Immunol (Fish & shellfish immunology)
[2021, 112:168-178]

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Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella).

Minxuan Yang, Zhijie Lu, Fenglin Li, Fei Shi, Fanbin Zhan, Lijuan Zhao, Yanan Li, Jun Li, Li Lin, Zhendong Qin,

The red blood cells (RBCs) of fish make up around 95% of the total peripheral blood cells, and the long-held paradigm is that RBCs are mainly responsible for transporting oxygen. Previous studies have showed that the RBCs can be involved in the immune response against bacterial infection; however, this mechanism ... Read more >>

Fish Shellfish Immunol (Fish & shellfish immunology)
[2021, 112:159-167]

Cited: 1 time

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Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation.

Jiansong Huang, Shujuan Huang, Zhixin Ma, Xiangjie Lin, Xia Li, Xin Huang, Jinghan Wang, Wenle Ye, Yang Li, Daqiang He, Min Yang, Jiajia Pan, Qing Ling, Fenglin Li, Shihui Mao, Huafeng Wang, Yungui Wang, Jie Jin,

Ibrutinib, an irreversible inhibitor of Bruton's tyrosine kinase, has a favorable safety profile in patients with B cell-related malignancies. A primary adverse effect of ibrutinib is thrombocytopenia in the early stages of treatment, but platelet counts increase or recover as treatment continues. Currently, the effects of ibrutinib on megakaryopoiesis remain ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2021, 121(2):192-205]

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Aeromonas Hydrophila Infection Activates Death Receptor Apoptosis Pathway in the RBCs of Grass Carp (Ctenopharyngodon idellus)

Zhijie Lu, Minxuan Yang, Kai Zhang, Fanbin Zhan, Fenglin Li, Fei Shi, Yanan Li, Lijuan Zhao, Jun Li, Li Lin, Zhendong Qin,

<h4>Background: </h4> Fish blood contains RBCs (Red blood cells) as the major cells. Unlike the absence of nucleus in mammalian RBC, fish RBC contains a nucleus. Previous researches have indicated that fish RBCs have a significant function in immune responses. However, the mechanism underlying the immune responses against bacterial infection ... Read more >>

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Bacillus subtilis H2 modulates immune response, fat metabolism and bacterial flora in the gut of grass carp (Ctenopharyngodon idellus).

Fei Shi, Yingjuan Zi, Zhijie Lu, Fenglin Li, Minxuan Yang, Fanbin Zhan, Yanan Li, Jun Li, Lijuan Zhao, Li Lin, Zhendong Qin,

Functional ingredients such as Bacillus subtilis are used in aquaculture to improve fish condition, modulate microbiota and promote a healthy intestinal system. However, the underlying mechanisms of grass carp treated with B. subtilis are not fully characterized. This study investigated the gut microbes of grass carp after treated with B. ... Read more >>

Fish Shellfish Immunol (Fish & shellfish immunology)
[2020, 106:8-20]

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Abivertinib synergistically strengthens the anti-leukemia activity of venetoclax in acute myeloid leukemia in a BTK-dependent manner.

Shujuan Huang, Chenying Li, Xiang Zhang, Jiajia Pan, Fenglin Li, Yunfei Lv, Jingwen Huang, Qing Ling, Wenle Ye, Shihui Mao, Xin Huang, Jie Jin,

B-cell lymphoma 2 (BCL-2), a crucial member of the anti-apoptotic BCL-2 family, is frequently dysregulated in cancer and plays an important role in acute myeloid leukemia (AML). Venetoclax is a highly selective BCL-2 inhibitor that has been approved by the FDA for treating elderly AML patients. However, the emergence of ... Read more >>

Mol Oncol (Molecular oncology)
[2020, 14(10):2560-2573]

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Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.

Jingrui Jin, Xia Li, Wenjian Guo, Fenglin Li, Jiansong Huang, Xin Huang, Jiajia Pan, Shujuan Huang, Wenle Ye, Qing Ling, Jie Jin,

Acute myeloid leukemia (AML) is a highly aggressive disease with high mortality and recurrence rates, for which novel therapeutic approaches are required. Hybrid anticancer agents with dual effects have been reported to possess therapeutic potential to treat AML. However, the efficacy and underlying toxicity of these hybrids in combination with ... Read more >>

Oncol Rep (Oncology reports)
[2020, 44(1):273-282]

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Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China.

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin,

This study aimed to investigate the prevalence, clinical characteristics, and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM). A retrospective analysis was conducted on 411 patients with newly diagnosed MM; among which, 270 received bortezomib-based therapies, and 141 received thalidomide-based therapies. Fluorescence in situ hybridization ... Read more >>

Front Med (Frontiers of medicine)
[2020, 14(3):327-334]

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A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.

Jingrui Jin, Shihui Mao, Fenglin Li, Xia Li, Xin Huang, Mengxia Yu, Wenjian Guo, Jie Jin,

Acute myeloid leukemia (AML) is a devastating disease. Hybrid agents with dual activity, which have been shown to possess anti-cancer effect, are expected to potentially improve the prognosis of AML patients. EDO-S101 is a novel alkylating deacetylase inhibitor molecule synthesized by the addition of the hydroxamic acid of histone deacetylases ... Read more >>

Med Oncol (Medical oncology (Northwood, London, England))
[2019, 36(9):77]

Cited: 2 times

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RARγ-rearrangements resemble acute promyelocytic leukemia and benefit from 3 + 7 regimen.

Xiang Zhang, Fenglin Li, Jinghan Wang, Shanshan Suo, Qing Ling, Wenjuan Yu, Jie Jin,

Leuk Lymphoma (Leukemia & lymphoma)
[2019, 60(7):1831-1834]

Cited: 5 times

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High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.

Xia Li, Chenying Li, Jingrui Jin, Jinghan Wang, Jiansong Huang, Zhixin Ma, Xin Huang, Xiao He, Yile Zhou, Yu Xu, Mengxia Yu, Shujuan Huang, Xiao Yan, Fenglin Li, Jiajia Pan, Yungui Wang, Yongping Yu, Jie Jin,

<h4>Background</h4>PARP-1 plays a critical role in DNA damage repair and contributes to progression of cancer. To explore the role of PARP-1 in acute myeloid leukemia (AML), we analyzed the expression of PARP-1 in AML and its relation to the clinical prognosis. Then, we investigated the efficacy and mechanism of PARP ... Read more >>

EBioMedicine (EBioMedicine)
[2018, 38:47-56]

Cited: 9 times

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Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma.

Xiao Yan, Yile Zhou, Shujuan Huang, Xia Li, Mengxia Yu, Jiansong Huang, Jinghan Wang, Zhixin Ma, Jingrui Jin, Jiajia Pan, Chenying Li, Fenglin Li, Jie Jin,

<h4>Purpose</h4>We researched into the effect and mechanism of AC0010, a novel BTK inhibitor, in MCL, and compared its efficacy and safety with Ibrutinib to develop a preclinical study for the future therapy of MCL.<h4>Methods</h4>MTS assay was used to detect the growth inhibition caused by AC0010 and Ibrutinib, respectively, in MCL ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2018, 144(4):697-706]

Cited: 2 times

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The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells.

Zhaodi Zheng, Wenzhen Zhu, Bingwu Yang, Rongfei Chai, Tingting Liu, Fenglin Li, Guanghui Ren, Shuhua Ji, Shan Liu, Guorong Li,

Metformin, a widely used antidiabetic drug, exhibits anticancer effects which are mediated by the phosphatidylinositol 3-kinase (PI3K)/serine/threonine kinase (AKT) signaling pathway. However, its use in anticancer therapy combined with other natural products remains unclear. Flavone as the core structure of flavonoids has been demonstrated to induce cell apoptosis without causing ... Read more >>

Oncol Lett (Oncology letters)
[2018, 15(4):5952-5958]

Cited: 7 times

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High Expression of TET1 Predicts Poor Survival in Cytogenetically Normal Acute Myeloid Leukemia From Two Cohorts.

Jinghan Wang, Fenglin Li, Zhixin Ma, Mengxia Yu, Qi Guo, Jiansong Huang, Wenjuan Yu, Yungui Wang, Jie Jin,

Ten-Eleven-Translocation 1 (TET1) plays a role in the DNA methylation process and gene activation. Recent reports suggest TET1 acts as an oncogene in leukemia development. However, the clinical relevance and biological insight of TET1 expression in cytogenetically normal acute myeloid leukemia (CN-AML) is unknown. In this study, quantification of TET1 ... Read more >>

EBioMedicine (EBioMedicine)
[2018, 28:90-96]

Cited: 10 times

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