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Author FengChao Wang

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SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.

Mengjia Hu, Yukai Lu, Yan Qi, Zihao Zhang, Song Wang, Yang Xu, Fang Chen, Yong Tang, Shilei Chen, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Youcai Deng, Junping Wang,

Natural killer (NK)-cell development and maturation is a well-organized process. The steroid receptor coactivator 3 (SRC-3) is a regulator of the hematopoietic and immune systems; however, its role in NK cells is poorly understood. Here, SRC-3 displayed increased nuclear translocation in NK cells during terminal differentiation and upon inflammatory cytokine ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, :]

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Dehydration impeding ionic conductance through two-dimensional angstrom-scale slits.

YanZi Yu, JingCun Fan, Jun Xia, YinBo Zhu, HengAn Wu, FengChao Wang,

There has been long-standing academic interest in the study of ion transport in nanochannel systems, owing to its vast implications in understanding the nature of numerous environmental, biological and chemical processes. Here, we investigate ion transport through two-dimensional slits using molecular dynamics simulations. These slits with angstrom-scale height dimensions can ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(17):8449-8457]

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In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model.

Xue Zhang, Fengchao Wang, Yi Hu, Runze Chen, Dawei Meng, Liang Guo, Hailong Lv, Jisong Guan, Yichang Jia,

Many RNA-binding proteins, including TDP-43, FUS, and TIA1, are stress granule components, dysfunction of which causes amyotrophic lateral sclerosis (ALS). However, whether a mutant RNA-binding protein disrupts stress granule processing in vivo in pathogenesis is unknown. Here we establish a FUS ALS mutation, p.R521C, knock-in mouse model that carries impaired ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(5):1350-1367]

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Mib2 Deficiency Inhibits Microglial Activation and Alleviates Ischemia-Induced Brain Injury.

Xiaoheng Li, Yajin Liao, Yuan Dong, Shuoshuo Li, Fengchao Wang, Rong Wu, Zengqiang Yuan, Jinbo Cheng,

Neuroinflammation plays a critical role in ischemia-induced brain injury. Mib2, an E3 ubiquitin ligase, has been reported to regulate Notch signaling and participate in the peripheral immune system. However, the roles of Mib2 in the nervous system are not well characterized. In this study, we show that Mib2 is involved ... Read more >>

Aging Dis (Aging and disease)
[2020, 11(3):523-535]

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Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides.

Shilei Chen, Yan Qi, Song Wang, Yang Xu, Mingqiang Shen, Mengjia Hu, Changhong Du, Fang Chen, Mo Chen, Yukai Lu, Zihao Zhang, Yong Quan, Cheng Wang, Fengchao Wang, Junping Wang,

Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis is still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in thrombopoiesis reveals that MT has the capacity to promote ... Read more >>

J. Pineal Res. (Journal of pineal research)
[2020, 68(3):e12637]

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Microscopic Origin of Capillary Force Balance at Contact Line.

JingCun Fan, Joël De Coninck, HengAn Wu, FengChao Wang,

We investigate the underlying mechanism of capillary force balance at the contact line. In particular, we offer a novel approach to describe and quantify the capillary force on the liquid in coexistence with its vapor phase, which is crucial in wetting and spreading dynamics. Its relation with the interface tension ... Read more >>

Phys. Rev. Lett. (Physical review letters)
[2020, 124(12):125502]

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Correlation Between von Hippel-Lindau Gene Expression and Tumor SUVmax and Survival Prognosis in Hepatocellular Carcinoma.

Gen Li, Yong Shen, Fengchao Wang, Sun Hong, Ming Cai,

BACKGROUND We investigated the relationship between the 18F-FDG PET/CT metabolic parameter SUVmax in primary hepatocellular carcinoma (HCC) and expression of von Hippel-Lindau (VHL), as well as its effect on HCC survival prognosis. MATERIAL AND METHODS We retrospectively analyzed data for 62 HCC patients who received 18F-FDG PET/CT before surgery at ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e920473]

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Male fertility in Mus musculus requires the activity of TRYX5 in sperm migration into the oviduct.

Haihang Zhang, Yushan Li, Kuiqing Cui, Xiu Chen, Cuiling Shang, Wanping Min, Peng Jin, Zhaodi Jiang, Deshun Shi, Qingyou Liu, Fengchao Wang,

Nowadays, abnormal loss of serine proteases appears very frequently in male patients with unexplained sterility. In fact, many testis-specific serine proteases, the largest family among the four protease families implicated in murine spermatogenesis, are indispensable for reproduction. In the present study, we demonstrate that the previously uncharacterized testis-specific serine protease ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(9):6058-6072]

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MicroRNA-21 maintains hematopoietic stem cell homeostasis through sustaining the NF-κB signaling pathway in mice.

Mengjia Hu, Yukai Lu, Hao Zeng, Zihao Zhang, Shilei Chen, Yan Qi, Yang Xu, Fang Chen, Yong Tang, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Song Wang, Junping Wang,

Long-term hematopoietic output is dependent on hematopoietic stem cell (HSC) homeostasis which is maintained by a complex molecular network. Among these, microRNAs play crucial roles, while the underlying molecular basis has not been fully elucidated. Here, we show that miR-21 is enriched in murine HSCs, and mice with conditional knockout ... Read more >>

Haematologica (Haematologica)
[2020, :]

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Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells.

Zhiwei Lu, Yuhua Xie, Huanwei Huang, Kaiju Jiang, Bin Zhou, Fengchao Wang, Ting Chen,

Metabolites are major biological parameters sensed by many cell types in vivo, whether they function as signaling mediators of SC and niche cross talk to regulate tissue regeneration is largely unknown. We show here that deletion of the Notch pathway co-factor RBP-J specifically in mouse HFSCs triggers adjacent McSCs to ... Read more >>

Elife (eLife)
[2020, 9:]

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Megakaryocytes promote bone formation through coupling osteogenesis with angiogenesis by secreting TGF-β1.

Yong Tang, Mengjia Hu, Yang Xu, Fang Chen, Shilei Chen, Mo Chen, Yan Qi, Mingqiang Shen, Cheng Wang, Yukai Lu, Zihao Zhang, Hao Zeng, Yong Quan, Fengchao Wang, Yongping Su, Dongfeng Zeng, Song Wang, Junping Wang,

Rationale: The hematopoietic system and skeletal system have a close relationship, and megakaryocytes (MKs) may be involved in maintaining bone homeostasis. However, the exact role and underlying mechanism of MKs in bone formation during steady-state and stress conditions are still unclear. Methods: We first evaluated the bone phenotype with MKs ... Read more >>

Theranostics (Theranostics)
[2020, 10(5):2229-2242]

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Click RNA for Rapid Capture and Identification of Intracellular MicroRNA Targets.

Pengjuan Zhang, Haohao Fu, Shuangli Du, Fengchao Wang, Jie Yang, Wensheng Cai, Dingbin Liu,

Rapid capture and identification of the intracellular target genes of microRNAs (miRNAs) are the key to understanding miRNA functions and development of RNA-based therapeutics. However, developing biochemical tools that can fish out the target genes of miRNAs in live cells is a significant technical challenge. Here, we report a remarkably ... Read more >>

Anal. Chem. (Analytical chemistry)
[2019, 91(24):15740-15747]

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WFDC2 gene deletion in mouse led to severe dyspnea and type-I alveolar cell apoptosis.

Taojun Zhang, Huayang Long, Jinping Li, Zhenwen Chen, Fengchao Wang, Shi-Wen Jiang,

HE4 (Human Epididymis Protein 4) encoded by the wfdc2 gene was first identified as a highly expressed factor in human epididymis. HE4 expression levels in malignant lesions are correlated with the clinical manifestations of gynecologic cancers. HE4 serum test has been widely used for the triage of patients suspected of ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 522(2):456-462]

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Encapsulating a Single Nanoprobe in a Multifunctional Nanogel for High-Fidelity Imaging of Caspase Activity in Vivo.

Qiang Li, Xinkai Qiao, Fengchao Wang, Xuejing Li, Jie Yang, Yang Liu, Linqi Shi, Dingbin Liu,

The formation of a protein corona on nanoprobes in the blood can not only reduce the delivery efficiency to their destination but also inhibit the functions of the nanoprobes. Herein, we report a multifunctional nanogel that can shield a single gold nanoparticle (AuNP) probe from interaction with the serum proteins, ... Read more >>

Anal. Chem. (Analytical chemistry)
[2019, 91(21):13633-13638]

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A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota.

Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang, Jianxiang Zhang,

The incidence and prevalence of inflammatory bowel disease (IBD) increases steadily worldwide. There is an urgent need for effective and safe IBD therapies. Accelerated resolution of inflammation is a new strategy for the management of inflammatory diseases. For effective and safe IBD treatment, herein a smart nanotherapy (i.e. oxidation-responsive nanoparticles ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2019, 6(18):1900610]

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Optogenetic gene editing in regional skin.

Fei Li, Zhiwei Lu, Wenbo Wu, Nannan Qian, Fengchao Wang, Ting Chen,

Cell Res. (Cell research)
[2019, 29(10):862-865]

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Cross-Linked Poly(ethylene glycol) Shells for Nanoparticles: Enhanced Stealth Effect and Colloidal Stability.

Dianqi Li, Fengchao Wang, Huixia Di, Xuehui Liu, Pengjuan Zhang, Wen Zhou, Dingbin Liu,

Preventing protein corona formation and macrophage uptake is the key to improving the delivery efficiency of nanocarriers. Herein, we present a kind of cross-linking poly(ethylene glycol) (CL-PEG) shell-wrapped gold nanoparticles (namely, [email protected] NPs), which show much enhanced stealth effect and colloidal stability in physiological environments. Compared to the AuNPs coated ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2019, 35(26):8799-8805]

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Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency.

Fengfeng Mao, Teng Liu, Xinfeng Hou, Hanqing Zhao, Wenhui He, Cong Li, Zhiyi Jing, Jianhua Sui, Fengchao Wang, Xiaohui Liu, Jun Han, Christoph H Borchers, Jian-She Wang, Wenhui Li,

Sodium taurocholate cotransporting polypeptide (NTCP, encoded by Slc10a1/SLC10A1) deficiency can result in hypercholanemia but no obvious symptoms in both mice and humans. However, the consequence of and response to long-term hypercholanemia caused by NTCP deficiency remain largely unexplored. Here, we analyzed lifelong dynamics of serum total bile acid (TBA) levels ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2019, 294(31):11853-11862]

Cited: 1 time

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Superstrong Noncovalent Interface between Melamine and Graphene Oxide.

Jun Xia, YinBo Zhu, ZeZhou He, FengChao Wang, HengAn Wu,

There have been growing academic interests in the study of strong organic molecule-graphene [or graphene oxide (GO)] systems, owing to their essential noncovalent nature and the consequent chemomechanical behavior within the interface. A more recent experimental measurement [ Chem 2018, 4, 896-910] reported that the melamine-GO interface exhibits a remarkable ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(18):17068-17078]

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Mup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysis.

Haixia Yang, Wei Zhang, Shan Lu, Guangqing Lu, Hongjuan Zhang, Yinghua Zhuang, Yue Wang, Mengqiu Dong, Yu Zhang, Xingang Zhou, Peng Wang, Lei Yu, Fengchao Wang, Liang Chen,

Acta Biochim. Biophys. Sin. (Shanghai) (Acta biochimica et biophysica Sinica)
[2019, 51(6):660]

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Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.

Shiming Peng, Wen Xiao, Dapeng Ju, Baofa Sun, Nannan Hou, Qianlan Liu, Yanli Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, Ran Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, Tao Cai, Yong-Liang Zhao, Fengchao Wang, Yongzhan Nie, Gang Zhi, Yun-Gui Yang, Eric Erquan Zhang, Niu Huang,

Recent studies have established the involvement of the fat mass and obesity-associated gene (FTO) in metabolic disorders such as obesity and diabetes. However, the precise molecular mechanism by which FTO regulates metabolism remains unknown. Here, we used a structure-based virtual screening of U.S. Food and Drug Administration-approved drugs to identify ... Read more >>

Sci Transl Med (Science translational medicine)
[2019, 11(488):]

Cited: 5 times

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Assembly of DNA Probes into Superstructures for Dramatically Enhancing Enzymatic Stability and Signal-to-Background Ratio.

Fengchao Wang, Qiang Li, Pengjuan Zhang, Xuehui Liu, Ang Li, Jie Yang, Dingbin Liu,

DNA fluorescent probes are versatile tools that are widely used for biological detection in tubes. Using DNA probes in living systems, however, represents a significant challenge because of the endogenous nuclease-induced DNA degradation and strong background fluorescence in complex biological environments. Here, we show that assembling DNA probes into core-satellite ... Read more >>

ACS Sens (ACS sensors)
[2018, 3(12):2702-2708]

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Macrophages activate mesenchymal stem cells to acquire cancer-associated fibroblast-like features resulting in gastric epithelial cell lesions and malignant transformation in vitro.

Qiang Zhang, Shuo Chai, Wei Wang, Chengcheng Wan, Feng Zhang, Yuyun Li, Fengchao Wang,

The majority of premalignant gastric lesions develop in the mucosa that has been modified by chronic inflammation. As components of the gastritis microenvironment, mesenchymal stem cells (MSCs) and macrophages are critically involved in the initiation and development of the chronic gastritis-associated gastric epithelial lesions/malignancy process. However, in this process, the ... Read more >>

Oncol Lett (Oncology letters)
[2019, 17(1):747-756]

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Publisher Correction: Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing.

Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong, Xin Zhou, Yuan Wei, Xinglong Wu, Xiaoye Wang, Xiaoying Fan, Jie Yan, Xu Zhi, Yun Gao, Hongshan Guo, Xiao Jin, Wendong Wang, Yunuo Mao, Fengchao Wang, Lu Wen, Wei Fu, Hao Ge, Jie Qiao, Fuchou Tang,

In the PDF version of this Resource originally published, on the author list the superscript number 9 to indicate Rui Wang was an equally contributing author was missing owing to a technical error. This has now been amended. In addition, the authors wish to replace Supplementary Table 2, as in ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2018, 20(10):1227]

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Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury.

Zhengxin Ying, Chenjie Pan, Tianyu Shao, Liqing Liu, Lin Li, Dejia Guo, Sitao Zhang, Tianyi Yuan, Ran Cao, Zhaodi Jiang, She Chen, Fengchao Wang, Xiaodong Wang,

Successful regeneration of severed peripheral nerves requires the breakdown and subsequent clearance of myelin, tightly packed membrane sheaths of Schwann cells that protect nerve fibers and harbor nerve growth-inhibitory proteins. How Schwann cells initiate myelin breakdown in response to injury is still largely unknown. Here we report that, following sciatic nerve ... Read more >>

Mol. Cell (Molecular cell)
[2018, 72(3):457-468.e5]

Cited: 2 times

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