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Rapid Synthesis of Luotonin A Derivatives via Synergistic Visible-Light Photoredox and Acid Catalysis.

Feng Wu, Wuheng Dong, Sijie Fan, Yao Yuan, Caiyun Liang, Aiyu Chen, Zuodong Yin, Zhaoguo Zhang,

The merging of visible-light photoredox and acid catalysis allowed for an intramolecular Povarov cycloaddition reaction using eosin Y as the photocatalyst and TsOH·H<sub>2</sub>O as the co-catalyst. A visible-light-promoted dehydrogenative cyclization protocol enabled the construction of Luotonin A derivatives with up to 97% yield. ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2022, :]

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Comprehensive Characterization And Clinical Relevance of CLEC4G Expression Across Human Cancers

Yong Li, Huiqin Huang, Xiangli Ye, Xiaoping Li, Zhenghui Huang, Longlong Gong, Feng Wu,

Liver and lymph node sinusoidal endothelial cell C-type lectin (CLEC4G) interacts with the surface glycoproteins of enveloped viruses and mediates immune evasion for viruses. Recent studies have indicated that the expression of CLEC4G affects the development and microenvironment of tumors. In the present study, we revealed comprehensive characterization of CLEC4G ... Read more >>

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Context-Aware Visual Policy Network for Fine-Grained Image Captioning.

Zheng-Jun Zha, Daqing Liu, Hanwang Zhang, Yongdong Zhang, Feng Wu,

With the maturity of visual detection techniques, we are more ambitious in describing visual content with open-vocabulary, fine-grained and free-form language, i.e., the task of image captioning. In particular, we are interested in generating longer, richer and more fine-grained sentences and paragraphs as image descriptions. Image captioning can be translated ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2022, 44(2):710-722]

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Timing of splenectomy after acute spinal cord injury.

Feng Wu, Xiao-Hui Li, Min-Jie Gong, Jia-Qi An, Xiao-Yan Ding, Sheng-Li Huang,

Spinal cord injury (SCI) is a devastating condition. Splenectomy may play a protective role in the development of SCI. However, little is known about whether the timing of splenectomy affects the outcome after SCI. Investigation into splenectomy after SCI would provide insight into how the timing can be selected following ... Read more >>

eNeuro (eNeuro)
[2022, :]

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Polydopamine Nanoparticle‐Mediated Dopaminergic Immunoregulation in Colitis (Adv. Sci. 1/2022)

Juanjuan Li, Weiliang Hou, Sisi Lin, Lu Wang, Chao Pan, Feng Wu, Jinyao Liu,

Dopaminergic Immunoregulation In article number 2104006 by Jinyao Liu and co‐workers, the dopaminergic system is exploited to suppress hyperactive immune responses in local inflamed tissues by polydopamine nanoparticles, which stimulate regulatory T lymphocytes and dendritic cells, while inhibit T helper cells to assist the reversion of inflammatory responses. The application ... Read more >>

(Advanced Science)
[2022, 9(1):]

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Statin Therapy May Be Associated with Reduced Mortality Risk of Sepsis Patients: A Retrospective Study from the MIMIC-IV Database

Jian Shi, Shiyu Zhou, Kerong Chen, Xingui Dai, Lulan Li, Zhongqing Chen, Feng Wu, Shengli An, Zhenhua Zeng,

<h4>Background: </h4> It is controversial whether statin therapy is beneficial for sepsis patients. A large retrospective cohort study was conducted to evaluate the association between statin therapy and mortality in sepsis patients.MethodsAdult (≥18 years) sepsis patients were enrolled and divided into two groups: the statin group and the no-statin group. ... Read more >>

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Excess Folic Acid Supplementation before and during Pregnancy and Lactation Alters Behaviors and Brain Gene Expression in Female Mouse Offspring.

Xingyue Yang, Wenyan Sun, Qian Wu, Hongyan Lin, Zhixing Lu, Xin Shen, Yongqi Chen, Yan Zhou, Li Huang, Feng Wu, Fei Liu, Dandan Chu,

Use of folic acid (FA) during early pregnancy protects against birth defects. However, excess FA has shown gender-specific neurodevelopmental toxicity. Previously, we fed the mice with 2.5 times the recommended amount of FA one week prior to mating and during the pregnancy and lactation periods, and detected the activated expression ... Read more >>

Nutrients (Nutrients)
[2021, 14(1):]

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Advanced NIR ratiometric probes for intravital biomedical imaging.

Haoying Huang, Ruijuan Qiu, Hongchao Yang, Feng Ren, Feng Wu, Yejun Zhang, Hong Zhang, Chunyan Li,

Near-infrared (NIR) fluorescence imaging technology (NIR-I region, 650-950 nm and NIR-II region, 1000-1700 nm), with deeper tissue penetration and less disturbance from auto-fluorescence than that in visible region (400-650 nm), is playing a more and more extensive role in the field of biomedical imaging. With the development of precise medicine, ... Read more >>

Biomed Mater (Biomedical materials (Bristol, England))
[2021, 17(1):]

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Structure and chlorophyll fluorescence of heteroblastic foliage affect first-year growth in Pinus massoniana Lamb. seedlings.

Haoyun Wang, Feng Wu, Min Li, Xiaokun Zhu, Changshuang Shi, Changchang Shao, Guijie Ding,

Pine seedlings exhibit heteroblastic foliage (primary and secondary needles) during seedling development. However, few trials have studied how heteroblastic foliage influences pine seedling growth by seasonal variation. This study first investigated the anatomical differences between the primary and secondary needles of one-year-old Pinus massoniana seedlings. We measured chlorophyll fluorescence (ChlF) ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2022, 170:206-217]

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Interactions of Anti-Inflammatory and Antibiotic Drugs at Mineral Surfaces Can Control Environmental Fate and Transport.

Tao Luo, Jing Xu, Wei Cheng, Lian Zhou, Rémi Marsac, Feng Wu, Jean-François Boily, Khalil Hanna,

Various pharmaceutical compounds often coexist in contaminated soils, yet little is known about how their interactions impact their mobility. We here show that two typical antibiotic and anti-inflammatory agents (nalidixic acid (NA) and niflumic acid (NFA)) commonly form dimers at several representative soil- and sediment-building minerals of contrasting composition and ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, :]

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P-Doped Ni/NiO Heterostructured Yolk-Shell Nanospheres Encapsulated in Graphite for Enhanced Lithium Storage.

Liqianyun Xu, Xixue Zhang, Renjie Chen, Feng Wu, Li Li,

The development of high-efficiency lithium-ion battery electrodes composed of recycled materials is crucial for the commercialization of retired batteries, but it remains a significant barrier. The usage and recycling of spent graphite are encouraged by the huge number of batteries that are going to be dismantled. Here, an anode made ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, :e2105897]

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Polyethyleneimine-complexed charge-reversed yeast cell walls for the enhanced oral delivery of pseudovirus-based antigens.

Fengmin Yang, Lu Meng, Sisi Lin, Feng Wu, Jinyao Liu,

Oral vaccination has wide applicability in poor areas, particularly during the epidemic periods of infectious diseases. However, successful oral antigen delivery and immune activation remain highly challenging due to the instability of vaccines in gastric acid and the low capture of antigens in the intestine. Here, we present a facile ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(95):12768-12771]

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Alterations in Immune Response Profile of Tumor-Draining Lymph Nodes after High-Intensity Focused Ultrasound Ablation of Breast Cancer Patients.

Xue-Qiang Zhu, Pei Lu, Zhong-Lin Xu, Qiang Zhou, Jun Zhang, Zhi-Biao Wang, Feng Wu,

Previous studies have revealed that high-intensity focused ultrasound (HIFU) ablation can trigger an antitumor immune response. The aim of this study was to investigate immune response in tumor-draining lymph nodes (TDLNs) after HIFU treatment. Forty-eight female patients with biopsy-confirmed breast cancer were divided into a control group and an HIFU ... Read more >>

Cells (Cells)
[2021, 10(12):]

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AVLSM: Adaptive Variational Level Set Model for Image Segmentation in the Presence of Severe Intensity Inhomogeneity and High Noise.

Qing Cai, Yiming Qian, Sanping Zhou, Jinxing Li, Yee-Hong Yang, Feng Wu, David Zhang,

Intensity inhomogeneity and noise are two common issues in images but inevitably lead to significant challenges for image segmentation and is particularly pronounced when the two issues simultaneously appear in one image. As a result, most existing level set models yield poor performance when applied to this images. To this ... Read more >>

IEEE Trans Image Process (IEEE transactions on image processing : a publication of the IEEE Signal Processing Society)
[2022, 31:43-57]

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Tunning Intermolecular Interaction of Peptide-Conjugated AIEgen in Nano-Confined Space for Quantitative Detection of Tumor Marker Secreted from Cells.

Feng Wu, Yu Huang, Xian Yang, Jing-Jing Hu, Xiaoding Lou, Fan Xia, Yanlin Song, Lei Jiang,

Determining the expression level of biomarkers is crucial for disease diagnosis. However, the low abundance of biomarkers in the early stage makes the detection extremely difficult by traditional aggregation-induced emission (AIE)-based fluorescent probes. Here, by tuning the intermolecular interaction, a two steps-based MP/NPs-SLIPS sensing system is designed for ultrasensitive detection ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(48):16257-16263]

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Closed-loop selective recycling process of spent LiNixCoyMn1-x-yO2 batteries by thermal-driven conversion.

Jiao Lin, Cheng Cui, Xiaodong Zhang, Ersha Fan, Renjie Chen, Feng Wu, Li Li,

The consumption of lithium-ion batteries raises raw material demand for and the pressure on ecological sustainability. Metals can be recovered in shorter paths while considerably boosting material use, hence selective recycling of specific elements is becoming a hotspot. This paper proposes a thermally-driven closed-loop recycling process for scrap LiNi<sub>1/3</sub>Co<sub>1/3</sub>Mn<sub>1/3</sub>O<sub>2</sub> cathodes, ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2022, 424(Pt D):127757]

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Preclinical studies for plant-based oral enzyme replacement therapy (Oral-ERT) in Pompe disease knockout mice with transgenic tobacco seeds expressing human GAA (tobrhGAA)

Frank Martiniuk, Adra Mack, Justin Martiniuk, Shoreh Miller, Gregory Voronin, David Reimer, Nancy Rossi, Leslie Sheppard Bird, Sussan Saleh, Ruby Gupta, Mariel Nigro, Peter Meinke, Benedikt Schoser, Feng Wu, Angelo Kambitsis, John Arvanitopoulos, Elena Arvanitopoulos, Kam-Meng Tchou-Wong,

<h4>ABSTRACT</h4> Genetic deficiency of acid α -glucosidase (GAA) results in glycogen storage disease type II (GSDII) or Pompe disease (PD) encompassing at least four clinical subtypes of varying severity (infantile; childhood, juvenile and late onset). Our objective is to develop an innovative and affordable approach for enzyme replacement therapy (ERT) ... Read more >>

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Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5/GPX4 axis.

Huixin Li, Wei Liu, Xiaoyu Zhang, Feng Wu, Dan Sun, Zunyi Wang,

Breast cancer (BC) serves as a prevalent and mortal malignancy among female globally. Ferroptosis, as an oxidative cell death that characterized by abnormal iron accumulation, plays critical role in cancer development. Ketamine is a rapid-acting anesthetic agent and has presented potential anti-tumor properties. However, the effect of Ketamine on breast ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 585:111-116]

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Air-Evacuation-Relevant Hypobaria Following Traumatic Brain Injury Plus Hemorrhagic Shock in Rats Increases Mortality and Injury to the Gut, Lungs, and Kidneys.

Julie L Proctor, Juliana Medina, Parisa Rangghran, Pratistha Tamrakar, Catriona Miller, Adam Puche, Wei Quan, Turhan Coksaygan, Cinthia B Drachenberg, Robert E Rosenthal, Deborah M Stein, Rosemary Kozar, Feng Wu, Gary Fiskum,

<h4>Abstract</h4>Rats exposed to hypobaria equivalent to what occurs during aeromedical evacuation within a few days after isolated traumatic brain injury exhibit greater neurologic injury than those remaining at sea level. Moreover, administration of excessive supplemental O2 during hypobaria further exacerbates brain injury. This study tested the hypothesis that exposure of ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(5):793-802]

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Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice.

Kai-Ge Ma, Hai-Bo Hu, Jin-Song Zhou, Chao Ji, Qi-Sheng Yan, Si-Ming Peng, Lan-Dong Ren, Bing-Nan Yang, Xin-Li Xiao, Yan-Bing Ma, Feng Wu, Kai-Wei Si, Xiao-Lin Wu, Jian-Xin Liu,

In temporal lobe epilepsy (TLE), abnormal axon guidance and synapse formation lead to sprouting of mossy fibers in the hippocampus, which is one of the most consistent pathological findings in patients and animal models with TLE. Glypican 4 (Gpc4) belongs to the heparan sulfate proteoglycan family, which play an important ... Read more >>

Exp Neurol (Experimental neurology)
[2022, 347:113918]

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A Designed Lithiophilic Carbon Channel on Separator to Regulate Lithium Deposition Behavior.

Sainan Xu, Teng Zhao, Yusheng Ye, Tianyu Yang, Rui Luo, Li Li, Feng Wu, Renjie Chen,

Issues with unstable SEI formation and uncontrollable lithium dendrite growth impede the practical use of lithium anode in high-energy batteries. Herein, a lithiophilic carbon channel on separator is designed to regulate lithium deposition behavior. The designed channel is formed by carbon nanosheet with cubic cavity (CNCC) prepared by hard template ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2022, 18(2):e2104390]

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Research on the Characteristics of Food Impaction with Tight Proximal Contacts Based on Deep Learning.

Yitong Cheng, Zhijiang Wang, Yue Shi, Qiaoling Guo, Qian Li, Rui Chai, Feng Wu,

<h4>Objective</h4>Based on deep learning, the characteristics of food impaction with tight proximal contacts were studied to guide the subsequent clinical treatment of occlusal adjustment. At the same time, digital model building, software measurement, and statistical correlation analysis were used to explore the cause of tooth impaction and to provide evidence ... Read more >>

Comput Math Methods Med (Computational and mathematical methods in medicine)
[2021, 2021:1000820]

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Tailoring double-layer aromatic polymers with multi-active sites towards high performance aqueous Zn-organic batteries.

Yi Zhao, Yongxin Huang, Renjie Chen, Feng Wu, Li Li,

Unlike most reported organic-inorganic cathodes, the organic-organic zinc hosts can fully exploit the flexible structures and various redox chemistries of the organics. Herein, nanoporous carbon electrodeposited with a wrapped poly(<i>meta</i>-aminophenol, 3-AP) sandwich layer and a good conductive poly(<i>para</i>-aminophenol, 4-AP) skin, designated as a [email protected](3-AP)/poly(4-AP) cathode, has been synthesized for the ... Read more >>

Mater Horiz (Materials horizons)
[2021, 8(11):3124-3132]

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Weakly Supervised Neuron Reconstruction From Optical Microscopy Images With Morphological Priors.

Xuejin Chen, Chi Zhang, Jie Zhao, Zhiwei Xiong, Zheng-Jun Zha, Feng Wu,

Manually labeling neurons from high-resolution but noisy and low-contrast optical microscopy (OM) images is tedious. As a result, the lack of annotated data poses a key challenge when applying deep learning techniques for reconstructing neurons from noisy and low-contrast OM images. While traditional tracing methods provide a possible way to ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2021, 40(11):3205-3216]

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Effect of fluorouracil and plastic breast-conserving surgery in young patients with early breast cancer.

Feng Wu, Xiaoyu Zhang,

To explore the effect of fluorouracil and plastic breast-conserving surgery on the immune level, psychological status and quality of life of young patients with early breast cancer. Seventy-six young patients with early breast cancer admitted to Cangzhou Central Hospital from January 2016 to January 2017 were selected and divided into ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2021, 34(6(Supplementary)):2365-2370]

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