Full Text Journal Articles by
Author Feng Ming Spring Kong

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Association of Twice-Daily Radiotherapy With Subsequent Brain Metastases in Adults With Small Cell Lung Cancer.

Haiyan Zeng, Rui Li, Chen Hu, Guoqin Qiu, Hong Ge, Huiming Yu, Kaixian Zhang, Miaomiao Hu, Peng Zeng, Dan Xiao, Chuanwang Miao, Chuqing Wei, Meng Ni, Jingyi Shen, Hui Li, Jinbo Yue, Heming Lu, Bingjie Fan, Hui Zhu, Xudong Hu, Feng-Ming Spring Kong, Jinming Yu, Shuanghu Yuan,

Importance:Although thoracic twice-daily radiotherapy (TDRT) is one of the standards of care for small cell lung cancer, its association with brain metastases remains unknown. Objective:To investigate the association of TDRT vs once-daily radiotherapy (ODRT) with brain metastases after prophylactic cranial irradiation in patients with small cell lung cancer. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(5):e190103]

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Machine Learning to Build and Validate a Model for Radiation Pneumonitis Prediction in Patients with Non-Small Cell Lung Cancer.

Hao Yu, Huanmei Wu, Weili Wang, Shruti Jolly, Jian-Yue Jin, Chen Hu, Feng-Ming Spring Kong,

PURPOSE:Radiation pneumonitis is an important adverse event in patients with non-small cell lung cancer (NSCLC) receiving thoracic radiotherapy. However, the risk of radiation pneumonitis grade ≥ 2 (RP2) has not been well predicted. This study hypothesized that inflammatory cytokines or the dynamic changes during radiotherapy can improve predictive accuracy for ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(14):4343-4350]

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Circulating microRNAs as biomarkers of radiation-induced cardiac toxicity in non-small-cell lung cancer.

Peter G Hawkins, Yilun Sun, Robert T Dess, William C Jackson, Grace Sun, Nan Bi, Muneesh Tewari, James A Hayman, Gregory P Kalemkerian, Shirish M Gadgeel, Theodore S Lawrence, Randall K Ten Haken, Martha M Matuszak, Feng-Ming Spring Kong, Matthew J Schipper, Shruti Jolly,

PURPOSE:Radiation-induced cardiac toxicity (RICT) is an increasingly well-appreciated source of morbidity and mortality in patients receiving thoracic radiotherapy (RT). Currently available methods to predict RICT are suboptimal. We investigated circulating microRNAs (c-miRNAs) as potential biomarkers of RICT in patients undergoing definitive RT for non-small-cell lung cancer (NSCLC). METHODS:Data from 63 ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2019, 145(6):1635-1643]

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Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities.

Ariel E Marciscano, Adriana Haimovitz-Friedman, Percy Lee, Phuoc T Tran, Wolfgang A Tomé, Chandan Guha, Feng-Ming Spring Kong, Arjun Sahgal, Issam El Naqa, Andreas Rimner, Lawrence B Marks, Silvia C Formenti, Theodore L DeWeese,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

Cited: 1 time

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Stereotactic body radiotherapy as salvage treatment for recurrence of non-small cell lung cancer after prior surgery or radiotherapy.

Michael T Milano, Feng-Ming Spring Kong, Benjamin Movsas,

Treatment options for thoracic recurrences of non-small cell lung cancer (NSCLC) are limited. Stereotactic body radiation therapy (SBRT) is an emerging, potentially effective technology to manage recurrent NSCLC, although with limited prospective studies. This work reviews the outcomes of patients undergoing salvage SBRT for pulmonary recurrences after prior resection or ... Read more >>

Transl Lung Cancer Res (Translational lung cancer research)
[2019, 8(1):78-87]

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An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting.

Hesham Elhalawani, Baher Elgohari, Timothy A Lin, Abdallah S R Mohamed, Thomas J Fitzgerald, Fran Laurie, Kenneth Ulin, Jayashree Kalpathy-Cramer, Thomas Guerrero, Emma B Holliday, Gregory Russo, Abhilasha Patel, William Jones, Gary V Walker, Musaddiq Awan, Mehee Choi, Roi Dagan, Omar Mahmoud, Anna Shapiro, Feng-Ming Spring Kong, Daniel Gomez, Jing Zeng, Roy Decker, Femke O B Spoelstra, Laurie E Gaspar, Lisa A Kachnic, Charles R Thomas, Paul Okunieff, Clifton D Fuller,

Introduction:Target delineation variability is a significant technical impediment in multi-institutional trials which employ intensity modulated radiotherapy (IMRT), as there is a real potential for clinically meaningful variances that can impact the outcomes in clinical trials. The goal of this study is to determine the variability of target delineation among participants ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2019, 15:83-92]

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Modern Radiation Further Improves Survival in Non-Small Cell Lung Cancer: An Analysis of 288,670 Patients.

Monica Cheng, Shruti Jolly, William O Quarshie, Nirav Kapadia, Fawn D Vigneau, Feng-Ming Spring Kong,

Background: Radiation therapy plays an increasingly important role in the treatment of patients with non-small-cell lung cancer (NSCLC). The purpose of the present study is to assess the survival outcomes of radiotherapy treatment compared to other treatment modalities and to determine the potential role of advanced technologies in radiotherapy on ... Read more >>

J Cancer (Journal of Cancer)
[2019, 10(1):168-177]

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Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma?

Feng-Ming Spring Kong, Vitali Moiseenko, Jing Zhao, Michael T Milano, Ling Li, Andreas Rimner, Shiva Das, X Allen Li, Moyed Miften, ZhongXing Liao, Mary Martel, Soren M Bentzen, Andrew Jackson, Jimm Grimm, Lawrence B Marks, Ellen Yorke,

PURPOSE:Stereotactic body radiation therapy (SBRT) has become the standard of care for inoperable early-stage non-small cell lung cancer and is often used for recurrent lung cancer and pulmonary metastases. Radiation-induced lung toxicity (RILT), including radiation pneumonitis and pulmonary fibrosis, is a major concern for which it is important to understand ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, :]

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Chest Wall Toxicity After Stereotactic Body Radiation Therapy: A Pooled Analysis of 57 Studies.

Jie-Tao Ma, Yang Liu, Li Sun, Michael T Milano, Shu-Ling Zhang, Le-Tian Huang, Wei Jing, Jian-Zhu Zhao, Cheng-Bo Han, Feng-Ming Spring Kong,

PURPOSE:The significance of clinical and dosimetric risk factors in relation to chest wall (CW) injury after stereotactic body radiation therapy (SBRT) for lung tumors were analyzed through a meta-analysis of 57 published studies. METHODS AND MATERIALS:Studies related to CW injury after lung SBRT were obtained through searching PubMed, Embase, and ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 103(4):843-850]

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Doses of radiation to the pericardium, instead of heart, are significant for survival in patients with non-small cell lung cancer.

Jianxin Xue, Chengbo Han, Andrew Jackson, Chen Hu, Huan Yao, Weili Wang, James Hayman, Weijun Chen, Jianyue Jin, Gregory P Kalemkerian, Martha Matuzsak, Struti Jolly, Feng-Ming Spring Kong,

BACKGROUND AND PURPOSE:Higher cardiac dose was associated with worse overall survival in the RTOG0617 study. Pericardial effusion (PCE) is a common cardiac complication of thoracic radiation therapy (RT). We investigated whether doses of radiation to the heart and pericardium are associated with PCE and overall survival in patients treated with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 133:213-219]

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Greater reduction in mid-treatment FDG-PET volume may be associated with worse survival in non-small cell lung cancer.

Feng-Ming Spring Kong, Ling Li, Weili Wang, Jeff Campbell, Jennifer L Waller, Morand Piert, Milton Gross, Monica Cheng, Dawn Owen, Matthew Stenmark, Ke Colin Huang, Kirk A Frey, Randall K Ten Haken, Theodore S Lawrence,

BACKGROUND AND PURPOSE:This study tested the hypotheses that 1) changes in mid-treatment fluorodeoxyglucose (FDG)-positron emission tomography (PET) parameters are predictive of overall survival (OS) and 2) mid-treatment FDG-PET-adapted treatment has the potential to improve survival in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS:Patients with stage I-III NSCLC ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 132:241-249]

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Comparison of predictive powers of functional and anatomic dosimetric parameters for radiation-induced lung toxicity in locally advanced non-small cell lung cancer.

Linlin Xiao, Guoren Yang, Jinhu Chen, Yuchen Yang, Xue Meng, Xiaohui Wang, Qingwei Wu, Zongwei Huo, Qingxi Yu, Jinming Yu, Feng-Ming Spring Kong, Shuanghu Yuan,

PURPOSE:To investigate the predictive value of the perfusion (Q) single-photon emission computed tomography (SPECT)-weighted dose-function histogram (DFH) obtained mid-treatment (mid-Tx) with radiotherapy (RT) for radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS:The study population consisted of NSCLC patients who were undergoing RT treatment ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2018, 129(2):242-248]

Cited: 1 time

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Pretreatment PET/CT imaging of angiogenesis based on 18F-RGD tracer uptake may predict antiangiogenic response.

Li Li, Li Ma, Dongping Shang, Zhiguo Liu, Qingxi Yu, Suzhen Wang, Xuepeng Teng, Qiang Zhang, Xudong Hu, Wei Zhao, Wenhong Hou, Jianyue Jin, Feng-Ming Spring Kong, Jinming Yu, Shuanghu Yuan,

PURPOSE:To explore the relationship between metabolic uptake of the 18F-ALF-NOTA-PRGD2 (18F-RGD) tracer on positron emission tomography/computerized tomography (PET/CT) and the antiangiogenic effect of apatinib in patients with solid malignancies. MATERIALS AND PATIENTS:Patients with measurable lesions scheduled for second- or third-line single-agent therapy with apatinib were eligible for this prospective clinical ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2019, 46(4):940-947]

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Review of thoracic reirradiation with stereotactic body radiation therapy: A focus on toxicity risks.

Michael T Milano, Alina Mihai, Feng-Ming Spring Kong,

Reirradiation of thoracic malignancies is clinically challenging in balancing the risks and efficacy. Stereotactic body radiation therapy (SBRT) can facilitate ablative dosing of discrete targets while minimizing normal tissue exposure; thus, SBRT is an attractive, minimally invasive option to consider for patients with recurrent or new malignancies within a previously ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(4):251-265]

Cited: 1 time

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Modeling Patient-Specific Dose-Function Response for Enhanced Characterization of Personalized Functional Damage.

Daniel Rocky Owen, Phillip S Boonstra, Benjamin L Viglianti, James M Balter, Matthew J Schipper, William C Jackson, Issam El Naqa, Shruti Jolly, Randall K Ten Haken, Feng-Ming Spring Kong, Martha M Matuszak,

PURPOSE:Functional-guided radiation therapy (RT) plans have the potential to limit damage to normal tissue and reduce toxicity. Although functional imaging modalities have continued to improve, a limited understanding of the functional response to radiation and its application to personalized therapy has hindered clinical implementation. The purpose of this study was ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, 102(4):1265-1275]

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Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary iminodiacetic acid (HIDA) scans.

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth,

PURPOSE:Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(6):429-436]

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Utilization of a hybrid finite-element based registration method to quantify heterogeneous tumor response for adaptive treatment for lung cancer patients.

Hoda Sharifi, Hong Zhang, Hassan Bagher-Ebadian, Wei Lu, Munther I Ajlouni, Jian-Yue Jin, Feng-Ming Spring Kong, Indrin J Chetty, Hualiang Zhong,

Tumor response to radiation treatment (RT) can be evaluated from changes in metabolic activity between two positron emission tomography (PET) images. Activity changes at individual voxels in pre-treatment PET images (PET1), however, cannot be derived until their associated PET-CT (CT1) images are appropriately registered to during-treatment PET-CT (CT2) images. This ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2018, 63(6):065017]

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Physician Bias in Prophylactic Cranial Irradiation Decision Making-An Opportunity for a Patient Decision Aid.

Tyler P Robin, Timothy S Sannes, Feng-Ming Spring Kong, Francoise Mornex, Fred R Hirsch, Chad G Rusthoven, Laurie E Gaspar,

INTRODUCTION:Guidelines have recommended prophylactic cranial irradiation (PCI) for patients with limited-stage small-cell lung cancer with at least a partial response after thoracic chemoradiation. However, the survival advantage has been small and was observed in an era before magnetic resonance imaging and surveillance. Neurotoxicity also remains a concern, especially in older ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2018, 19(6):476-483]

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What Happens When Proton Meets Randomization: Is There a Future for Proton Therapy?

Feng-Ming Spring Kong,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2018, 36(18):1777-1779]

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Prediction of Radiation Esophagitis in Non-Small Cell Lung Cancer Using Clinical Factors, Dosimetric Parameters, and Pretreatment Cytokine Levels.

Peter G Hawkins, Philip S Boonstra, Stephen T Hobson, James A Hayman, Randall K Ten Haken, Martha M Matuszak, Paul Stanton, Gregory P Kalemkerian, Theodore S Lawrence, Matthew J Schipper, Feng-Ming Spring Kong, Shruti Jolly,

Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non-small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE has been less well studied. We analyzed data from 126 patients treated on 4 prospective clinical ... Read more >>

Transl Oncol (Translational oncology)
[2018, 11(1):102-108]

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Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization.

Michael MacManus, Sarah Everitt, Tanja Schimek-Jasch, X Allen Li, Ursula Nestle, Feng-Ming Spring Kong,

This article reviews key imaging modalities for lung cancer patients treated with radiation therapy (RT) and considers their actual or potential contributions to critical decision-making. An international group of researchers with expertise in imaging in lung cancer patients treated with RT considered the relevant literature on modalities, including computed tomography ... Read more >>

Transl Lung Cancer Res (Translational lung cancer research)
[2017, 6(6):670-688]

Cited: 3 times

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Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy.

Dirk De Ruysscher, Jianyue Jin, Tim Lautenschlaeger, Jin-Xiong She, Zhongxing Liao, Feng-Ming Spring Kong,

Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are ... Read more >>

Transl Lung Cancer Res (Translational lung cancer research)
[2017, 6(6):661-669]

Cited: 1 time

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Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation.

Brittany Z Dashevsky, Chenpeng Zhang, Li Yan, Cindy Yuan, Lingyun Xiong, Yongmei Liu, Haiyan Liu, Feng-Ming Spring Kong, Yonglin Pu,

TNM Stage 3B encompasses a wide range of primary tumor and nodal metastatic tumor burden. This study aimed to evaluate the prognostic value of quantitative FDG PET/CT parameters in patients with newly diagnosed Stage 3B Non-Small Cell Lung Cancer (NSCLC).Institutional review board approved retrospective study identified patients diagnosed with Stage ... Read more >>

Eur J Hybrid Imaging (European journal of hybrid imaging)
[2017, 1(1):8]

Cited: 2 times

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Potential future consideration for imaging and blood-based biomarkers for precision medicine in lung cancer.

Feng-Ming Spring Kong, Fred R Hirsch, Mitchell Machtay,

Transl Lung Cancer Res (Translational lung cancer research)
[2017, 6(6):713-715]

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Concurrent brain radiotherapy and EGFR-TKI may improve intracranial metastases control in non-small cell lung cancer and have survival benefit in patients with low DS-GPA score.

Yongmei Liu, Lei Deng, Xiaojuan Zhou, Youling Gong, Yong Xu, Lin Zhou, Jin Wan, Bingwen Zou, Yongsheng Wang, Jiang Zhu, Zhenyu Ding, Feng Peng, Meijuan Huang, Li Ren, Tim Lautenschlaeger, Feng-Ming Spring Kong, You Lu,

Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) has intracranial activity in EGFR-mutant Non-Small Cell Lung Cancer (NSCLC). The optimal timing of brain radiotherapy (RT) and appropriate patients who need early brain RT remains undetermined. This is a retrospective study of EGFR-mutant NSCLC patients with newly diagnosed brain metastases (BMs) before ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(67):111309-111317]

Cited: 3 times

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