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Author Feng Ming Spring Kong

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Central Airway Toxicity After High Dose Radiation: A Combined Analysis of Prospective Clinical Trials for Non-Small Cell Lung Cancer.

Weili Wang, Martha M Matuszak, Chen Hu, Ke Colin Huang, Eileen Chen, Douglas Arenberg, Jeffrey L Curtis, Shruti Jolly, Jian-Yue Jin, Mitchell Machtay, Randall K Ten Haken, Feng-Ming Spring Kong,

PURPOSE:To study the dosimetric risk factors for radiation-induced proximal bronchial tree (PBT) toxicity in patients treated with radiotherapy for non-small cell lung cancer (NSCLC). METHODS AND MATERIALS:Patients with medically inoperable/unresectable NSCLC treated with conventionally fractionated 3D conformal radiotherapy (3DCRT) in prospective clinical trials were eligible for this study. PBT and ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2020, :]

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Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

Jian-Yue Jin, Anxin Gu, Weili Wang, Nancy L Oleinick, Mitchell Machtay, Feng-Ming Spring Kong,

PURPOSE:"FLASH" radiotherapy (RT) is a potential paradigm-changing RT technology with marked tumor killing and normal tissue sparing. However, the mechanism of the FLASH effect is not well understood. We hypothesize that the ultra-high dose rate FLASH-RT significantly reduces the killing of circulating immune cells which may partially contribute to the ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 149:55-62]

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Stereotactic body radiotherapy in patients with multiple lung tumors: a focus on lung dosimetric constraints.

Michael T Milano, Alina Mihai, John Kang, Deepinder P Singh, Vivek Verma, Haoming Qiu, Yuhchyau Chen, Feng-Ming Spring Kong,

Introduction: Lung dosimetric constraints with stereotactic body/ablative radiotherapy (SBRT/SABR) for multiple lung lesions are not well-characterized in published literature. Classically, the lung is considered a 'parallel' organ, for which injury to functional subunits could result in partially compromised function of that organ/tissue. Therefore, with SBRT/SABR for >1 thoracic target (especially ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2019, 19(11):959-969]

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A framework for modeling radiation induced lymphopenia in radiotherapy.

Jian-Yue Jin, Todd Mereniuk, Anirudh Yalamanchali, Weili Wang, Mitchell Machtay, Feng-Ming Spring Kong, Susannah Ellsworth,

INTRODUCTION:Associations between radiation-induced lymphopenia (RIL) and survival have been extensively reported. However, the immune system is not considered as an organ-at-risk (OAR) in radiotherapy. This study aimed to develop the framework of an immune OAR model that may be utilized to predict and minimize RIL. METHODS:A dynamic model was first ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 144:105-113]

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Radiation Therapy for Thoracic Malignancies.

Victor Ho-Fun Lee, Li Yang, Yong Jiang, Feng-Ming Spring Kong,

Radiotherapy is the most commonly used nonsurgical modality in treatment of lung cancers, non-small cell lung cancer (NSCLC) in particular. Radiation therapy has been increasingly used as definitive radical treatment, either alone or in combination with concurrent chemoradiation for locally advanced disease. More recently with the advent of novel radiation ... Read more >>

Hematol. Oncol. Clin. North Am. (Hematology/oncology clinics of North America)
[2020, 34(1):109-125]

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Combined Stereotactic Body Radiotherapy and Checkpoint Inhibition in Unresectable Hepatocellular Carcinoma: A Potential Synergistic Treatment Strategy.

Chi-Leung Chiang, Albert C Y Chan, Keith W H Chiu, Feng-Ming Spring Kong,

Background: Current treatments of unresectable hepatocellular carcinoma (HCC) are trans-arterial chemo-embolization (TACE), stereotactic body radiotherapy (SBRT), and targeted therapy. However, these treatments are limited in efficacy and safety for patients with large tumor sizes. Here, we report a case series of combined SBRT and anti-PD-1 therapy in patients with unresectable ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1157]

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A Validation Study on IDO Immune Biomarkers for Survival Prediction in Non-Small Cell Lung Cancer: Radiation Dose Fractionation Effect in Early-Stage Disease.

Weili Wang, Lei Huang, Jian-Yue Jin, Wenhu Pi, Susannah G Ellsworth, Shruti Jolly, Andrew L Mellor, Mitchell Machtay, Feng-Ming Spring Kong,

PURPOSE:We recently reported that indoleamine 2, 3-dioxygenase (IDO) activity is significantly correlated with more distant metastasis and worse survival. The present study examined whether radiotherapy (RT) dose fractionation correlates with IDO-mediated immune activity in patients with early-stage NSCLC.Methods: Patients with newly diagnosed stage I-II NSCLC treated with either conventionally fractionated ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(1):282-289]

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Machine Learning to Build and Validate a Model for Radiation Pneumonitis Prediction in Patients with Non-Small Cell Lung Cancer.

Hao Yu, Huanmei Wu, Weili Wang, Shruti Jolly, Jian-Yue Jin, Chen Hu, Feng-Ming Spring Kong,

PURPOSE:Radiation pneumonitis is an important adverse event in patients with non-small cell lung cancer (NSCLC) receiving thoracic radiotherapy. However, the risk of radiation pneumonitis grade ≥ 2 (RP2) has not been well predicted. This study hypothesized that inflammatory cytokines or the dynamic changes during radiotherapy can improve predictive accuracy for ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(14):4343-4350]

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Association of Twice-Daily Radiotherapy With Subsequent Brain Metastases in Adults With Small Cell Lung Cancer.

Haiyan Zeng, Rui Li, Chen Hu, Guoqin Qiu, Hong Ge, Huiming Yu, Kaixian Zhang, Miaomiao Hu, Peng Zeng, Dan Xiao, Chuanwang Miao, Chuqing Wei, Meng Ni, Jingyi Shen, Hui Li, Jinbo Yue, Heming Lu, Bingjie Fan, Hui Zhu, Xudong Hu, Feng-Ming Spring Kong, Jinming Yu, Shuanghu Yuan,

Importance:Although thoracic twice-daily radiotherapy (TDRT) is one of the standards of care for small cell lung cancer, its association with brain metastases remains unknown. Objective:To investigate the association of TDRT vs once-daily radiotherapy (ODRT) with brain metastases after prophylactic cranial irradiation in patients with small cell lung cancer. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(5):e190103]

Cited: 1 time

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Circulating microRNAs as biomarkers of radiation-induced cardiac toxicity in non-small-cell lung cancer.

Peter G Hawkins, Yilun Sun, Robert T Dess, William C Jackson, Grace Sun, Nan Bi, Muneesh Tewari, James A Hayman, Gregory P Kalemkerian, Shirish M Gadgeel, Theodore S Lawrence, Randall K Ten Haken, Martha M Matuszak, Feng-Ming Spring Kong, Matthew J Schipper, Shruti Jolly,

PURPOSE:Radiation-induced cardiac toxicity (RICT) is an increasingly well-appreciated source of morbidity and mortality in patients receiving thoracic radiotherapy (RT). Currently available methods to predict RICT are suboptimal. We investigated circulating microRNAs (c-miRNAs) as potential biomarkers of RICT in patients undergoing definitive RT for non-small-cell lung cancer (NSCLC). METHODS:Data from 63 ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2019, 145(6):1635-1643]

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Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities.

Ariel E Marciscano, Adriana Haimovitz-Friedman, Percy Lee, Phuoc T Tran, Wolfgang A Tomé, Chandan Guha, Feng-Ming Spring Kong, Arjun Sahgal, Issam El Naqa, Andreas Rimner, Lawrence B Marks, Silvia C Formenti, Theodore L DeWeese,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, :]

Cited: 1 time

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Stereotactic body radiotherapy as salvage treatment for recurrence of non-small cell lung cancer after prior surgery or radiotherapy.

Michael T Milano, Feng-Ming Spring Kong, Benjamin Movsas,

Treatment options for thoracic recurrences of non-small cell lung cancer (NSCLC) are limited. Stereotactic body radiation therapy (SBRT) is an emerging, potentially effective technology to manage recurrent NSCLC, although with limited prospective studies. This work reviews the outcomes of patients undergoing salvage SBRT for pulmonary recurrences after prior resection or ... Read more >>

Transl Lung Cancer Res (Translational lung cancer research)
[2019, 8(1):78-87]

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Modern Radiation Further Improves Survival in Non-Small Cell Lung Cancer: An Analysis of 288,670 Patients.

Monica Cheng, Shruti Jolly, William O Quarshie, Nirav Kapadia, Fawn D Vigneau, Feng-Ming Spring Kong,

Background: Radiation therapy plays an increasingly important role in the treatment of patients with non-small-cell lung cancer (NSCLC). The purpose of the present study is to assess the survival outcomes of radiotherapy treatment compared to other treatment modalities and to determine the potential role of advanced technologies in radiotherapy on ... Read more >>

J Cancer (Journal of Cancer)
[2019, 10(1):168-177]

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An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting.

Hesham Elhalawani, Baher Elgohari, Timothy A Lin, Abdallah S R Mohamed, Thomas J Fitzgerald, Fran Laurie, Kenneth Ulin, Jayashree Kalpathy-Cramer, Thomas Guerrero, Emma B Holliday, Gregory Russo, Abhilasha Patel, William Jones, Gary V Walker, Musaddiq Awan, Mehee Choi, Roi Dagan, Omar Mahmoud, Anna Shapiro, Feng-Ming Spring Kong, Daniel Gomez, Jing Zeng, Roy Decker, Femke O B Spoelstra, Laurie E Gaspar, Lisa A Kachnic, Charles R Thomas, Paul Okunieff, Clifton D Fuller,

Introduction:Target delineation variability is a significant technical impediment in multi-institutional trials which employ intensity modulated radiotherapy (IMRT), as there is a real potential for clinically meaningful variances that can impact the outcomes in clinical trials. The goal of this study is to determine the variability of target delineation among participants ... Read more >>

Clin Transl Radiat Oncol (Clinical and Translational Radiation Oncology)
[2019, 15:83-92]

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Organs at Risk Considerations for Thoracic Stereotactic Body Radiation Therapy: What Is Safe for Lung Parenchyma?

Feng-Ming Spring Kong, Vitali Moiseenko, Jing Zhao, Michael T Milano, Ling Li, Andreas Rimner, Shiva Das, X Allen Li, Moyed Miften, ZhongXing Liao, Mary Martel, Soren M Bentzen, Andrew Jackson, Jimm Grimm, Lawrence B Marks, Ellen Yorke,

PURPOSE:Stereotactic body radiation therapy (SBRT) has become the standard of care for inoperable early-stage non-small cell lung cancer and is often used for recurrent lung cancer and pulmonary metastases. Radiation-induced lung toxicity (RILT), including radiation pneumonitis and pulmonary fibrosis, is a major concern for which it is important to understand ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, :]

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Chest Wall Toxicity After Stereotactic Body Radiation Therapy: A Pooled Analysis of 57 Studies.

Jie-Tao Ma, Yang Liu, Li Sun, Michael T Milano, Shu-Ling Zhang, Le-Tian Huang, Wei Jing, Jian-Zhu Zhao, Cheng-Bo Han, Feng-Ming Spring Kong,

PURPOSE:The significance of clinical and dosimetric risk factors in relation to chest wall (CW) injury after stereotactic body radiation therapy (SBRT) for lung tumors were analyzed through a meta-analysis of 57 published studies. METHODS AND MATERIALS:Studies related to CW injury after lung SBRT were obtained through searching PubMed, Embase, and ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 103(4):843-850]

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Doses of radiation to the pericardium, instead of heart, are significant for survival in patients with non-small cell lung cancer.

Jianxin Xue, Chengbo Han, Andrew Jackson, Chen Hu, Huan Yao, Weili Wang, James Hayman, Weijun Chen, Jianyue Jin, Gregory P Kalemkerian, Martha Matuzsak, Struti Jolly, Feng-Ming Spring Kong,

BACKGROUND AND PURPOSE:Higher cardiac dose was associated with worse overall survival in the RTOG0617 study. Pericardial effusion (PCE) is a common cardiac complication of thoracic radiation therapy (RT). We investigated whether doses of radiation to the heart and pericardium are associated with PCE and overall survival in patients treated with ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 133:213-219]

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Comparison of predictive powers of functional and anatomic dosimetric parameters for radiation-induced lung toxicity in locally advanced non-small cell lung cancer.

Linlin Xiao, Guoren Yang, Jinhu Chen, Yuchen Yang, Xue Meng, Xiaohui Wang, Qingwei Wu, Zongwei Huo, Qingxi Yu, Jinming Yu, Feng-Ming Spring Kong, Shuanghu Yuan,

PURPOSE:To investigate the predictive value of the perfusion (Q) single-photon emission computed tomography (SPECT)-weighted dose-function histogram (DFH) obtained mid-treatment (mid-Tx) with radiotherapy (RT) for radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS:The study population consisted of NSCLC patients who were undergoing RT treatment ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2018, 129(2):242-248]

Cited: 2 times

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Greater reduction in mid-treatment FDG-PET volume may be associated with worse survival in non-small cell lung cancer.

Feng-Ming Spring Kong, Ling Li, Weili Wang, Jeff Campbell, Jennifer L Waller, Morand Piert, Milton Gross, Monica Cheng, Dawn Owen, Matthew Stenmark, Ke Colin Huang, Kirk A Frey, Randall K Ten Haken, Theodore S Lawrence,

BACKGROUND AND PURPOSE:This study tested the hypotheses that 1) changes in mid-treatment fluorodeoxyglucose (FDG)-positron emission tomography (PET) parameters are predictive of overall survival (OS) and 2) mid-treatment FDG-PET-adapted treatment has the potential to improve survival in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS:Patients with stage I-III NSCLC ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 132:241-249]

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Pretreatment PET/CT imaging of angiogenesis based on 18F-RGD tracer uptake may predict antiangiogenic response.

Li Li, Li Ma, Dongping Shang, Zhiguo Liu, Qingxi Yu, Suzhen Wang, Xuepeng Teng, Qiang Zhang, Xudong Hu, Wei Zhao, Wenhong Hou, Jianyue Jin, Feng-Ming Spring Kong, Jinming Yu, Shuanghu Yuan,

PURPOSE:To explore the relationship between metabolic uptake of the 18F-ALF-NOTA-PRGD2 (18F-RGD) tracer on positron emission tomography/computerized tomography (PET/CT) and the antiangiogenic effect of apatinib in patients with solid malignancies. MATERIALS AND PATIENTS:Patients with measurable lesions scheduled for second- or third-line single-agent therapy with apatinib were eligible for this prospective clinical ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2019, 46(4):940-947]

Cited: 2 times

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Review of thoracic reirradiation with stereotactic body radiation therapy: A focus on toxicity risks.

Michael T Milano, Alina Mihai, Feng-Ming Spring Kong,

Reirradiation of thoracic malignancies is clinically challenging in balancing the risks and efficacy. Stereotactic body radiation therapy (SBRT) can facilitate ablative dosing of discrete targets while minimizing normal tissue exposure; thus, SBRT is an attractive, minimally invasive option to consider for patients with recurrent or new malignancies within a previously ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(4):251-265]

Cited: 2 times

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Utilization of a hybrid finite-element based registration method to quantify heterogeneous tumor response for adaptive treatment for lung cancer patients.

Hoda Sharifi, Hong Zhang, Hassan Bagher-Ebadian, Wei Lu, Munther I Ajlouni, Jian-Yue Jin, Feng-Ming Spring Kong, Indrin J Chetty, Hualiang Zhong,

Tumor response to radiation treatment (RT) can be evaluated from changes in metabolic activity between two positron emission tomography (PET) images. Activity changes at individual voxels in pre-treatment PET images (PET1), however, cannot be derived until their associated PET-CT (CT1) images are appropriately registered to during-treatment PET-CT (CT2) images. This ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2018, 63(6):065017]

Cited: 1 time

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Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary iminodiacetic acid (HIDA) scans.

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth,

PURPOSE:Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(6):429-436]

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Physician Bias in Prophylactic Cranial Irradiation Decision Making-An Opportunity for a Patient Decision Aid.

Tyler P Robin, Timothy S Sannes, Feng-Ming Spring Kong, Francoise Mornex, Fred R Hirsch, Chad G Rusthoven, Laurie E Gaspar,

INTRODUCTION:Guidelines have recommended prophylactic cranial irradiation (PCI) for patients with limited-stage small-cell lung cancer with at least a partial response after thoracic chemoradiation. However, the survival advantage has been small and was observed in an era before magnetic resonance imaging and surveillance. Neurotoxicity also remains a concern, especially in older ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2018, 19(6):476-483]

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What Happens When Proton Meets Randomization: Is There a Future for Proton Therapy?

Feng-Ming Spring Kong,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2018, 36(18):1777-1779]

Cited: 1 time

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