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Author Femke H Bouwman

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New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

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Lumbar puncture patient video increases knowledge and reduces uncertainty: An RCT.

Rosha Babapour Mofrad, Agnetha D Fruijtier, Leonie N C Visser, Nina Hoogland, Maisa van Dijk, Frederique van Rossum, Femke H Bouwman, Ellen M A Smets, Charlotte E Teunissen, Wiesje M van der Flier,

<h4>Background</h4>Patients often perceive a lumbar puncture (LP) as an invasive procedure. We aimed to evaluate the impact of a 3-minute educational animation-video explaining the LP procedure, on patients' knowledge, uncertainty, anxiety, and post-LP complications.<h4>Methods</h4>We included 203 newly referred memory clinic patients, who were randomly assigned to one of three conditions: ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2021, 7(1):e12127]

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What patients want to know, and what we actually tell them: The ABIDE project.

Agnetha D Fruijtier, Leonie N C Visser, Femke H Bouwman, Rogier Lutz, Niki Schoonenboom, Kees Kalisvaart, Liesbeth Hempenius, Gerwin Roks, Leo Boelaarts, Jules J Claus, Mariska Kleijer, Marlijn de Beer, Wiesje M van der Flier, Ellen M A Smets,

<h4>Background</h4>We studied to what degree and at whose initiative 25 informational topics, formerly identified as important, are discussed in diagnostic consultations.<h4>Methods</h4>Audio recordings of clinician-patient consultations of 71 patients and 32 clinicians, collected in eight Dutch memory clinics, were independently content-coded by two coders. The coding scheme encompassed 25 informational topics.<h4>Results</h4>Approximately half ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12113]

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Psychosocial Effects of Corona Measures on Patients With Dementia, Mild Cognitive Impairment and Subjective Cognitive Decline.

Ingrid S van Maurik, Els D Bakker, Susanne van den Buuse, Freek Gillissen, Marleen van de Beek, Evelien Lemstra, Arenda Mank, Karlijn A van den Bosch, Mardou van Leeuwenstijn, Femke H Bouwman, Philip Scheltens, Wiesje M van der Flier,

<b>Background:</b> The recent COVID-19 pandemic is not only a major healthcare problem in itself, but also poses enormous social challenges. Though nursing homes increasingly receive attention, the majority of people with cognitive decline and dementia live at home. We aimed to explore the psychosocial effects of corona measures in memory ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:585686]

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Label-free vibrational imaging of different Aβ plaque types in Alzheimer's disease reveals sequential events in plaque development.

Dominik Röhr, Baayla D C Boon, Martin Schuler, Kristin Kremer, Jeroen J M Hoozemans, Femke H Bouwman, Samir F El-Mashtoly, Andreas Nabers, Frederik Großerueschkamp, Annemieke J M Rozemuller, Klaus Gerwert,

The neuropathology of Alzheimer's disease (AD) is characterized by hyperphosphorylated tau neurofibrillary tangles (NFTs) and amyloid-beta (Aβ) plaques. Aβ plaques are hypothesized to follow a development sequence starting with diffuse plaques, which evolve into more compact plaques and finally mature into the classic cored plaque type. A better molecular understanding ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):222]

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Retinal imaging in Alzheimer's and neurodegenerative diseases.

Peter J Snyder, Jessica Alber, Clemens Alt, Lisa J Bain, Brett E Bouma, Femke H Bouwman, Delia Cabrera DeBuc, Melanie C W Campbell, Maria C Carrillo, Emily Y Chew, M Francesca Cordeiro, Michael R Dueñas, Brian M Fernández, Maya Koronyo-Hamaoui, Chiara La Morgia, Roxana O' Carare, Srinivas R Sadda, Peter van Wijngaarden, Heather M Snyder,

In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2021, 17(1):103-111]

Cited: 1 time

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The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease.

Baayla D C Boon, Marjolein Bulk, Allert J Jonker, Tjado H J Morrema, Emma van den Berg, Marko Popovic, Jochen Walter, Sathish Kumar, Sven J van der Lee, Henne Holstege, Xiaoyue Zhu, William E Van Nostrand, Remco Natté, Louise van der Weerd, Femke H Bouwman, Wilma D J van de Berg, Annemieke J M Rozemuller, Jeroen J M Hoozemans,

Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we observed an atypical Aβ deposit, referred to as the coarse-grained plaque. In this study, we evaluate the plaque's association with clinical disease and perform in-depth immunohistochemical and morphological characterization. The ... Read more >>

Acta Neuropathol (Acta neuropathologica)
[2020, 140(6):811-830]

Cited: 1 time

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Clinicians' communication with patients receiving a MCI diagnosis: The ABIDE project.

Leonie N C Visser, Ingrid S van Maurik, Femke H Bouwman, Salka Staekenborg, Ralph Vreeswijk, Liesbeth Hempenius, Marlijn H de Beer, Gerwin Roks, Leo Boelaarts, Mariska Kleijer, Wiesje M van der Flier, Ellen M A Smets,

BACKGROUND:We aimed to explore clinicians' communication, including the discussion of diagnosis, cause, prognosis and care planning, in routine post-diagnostic testing consultations with patients with Mild Cognitive Impairment (MCI). METHODS:Thematic content analysis was used to analyze audiotaped consultations in which 10 clinicians (eight neurologists and two geriatricians) from 7 memory clinics, ... Read more >>

PLoS One (PloS one)
[2020, 15(1):e0227282]

Cited: 2 times

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Can post-mortem MRI be used as a proxy for in vivo? A case study.

Baayla D C Boon, Petra J W Pouwels, Laura E Jonkman, Matthijs J Keijzer, Paolo Preziosa, Wilma D J van de Berg, Jeroen J G Geurts, Philip Scheltens, Frederik Barkhof, Annemieke J M Rozemuller, Femke H Bouwman, Martijn D Steenwijk,

<i>Post-mortem</i> <i>in situ</i> MRI has been used as an intermediate between brain histo(patho)logy and <i>in vivo</i> imaging. However, it is not known how comparable <i>post-mortem</i> <i>in situ</i> is to <i>ante-mortem</i> imaging. We report the unique situation of a patient with familial early-onset Alzheimer's disease due to a <i>PSEN1</i> mutation, who underwent <i>ante-mortem</i> ... Read more >>

Brain Commun (Brain communications)
[2019, 1(1):fcz030]

Cited: 0 times

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Communicating uncertainties when disclosing diagnostic test results for (Alzheimer's) dementia in the memory clinic: The ABIDE project.

Leonie N C Visser, Sophie A R Pelt, Marleen Kunneman, Femke H Bouwman, Jules J Claus, Kees J Kalisvaart, Liesbeth Hempenius, Marlijn H de Beer, Gerwin Roks, Leo Boelaarts, Mariska Kleijer, Wiesje M van der Flier, Ellen M A Smets, Marij A Hillen,

<h4>Background</h4>The development of novel diagnostics enables increasingly earlier diagnosis of Alzheimer's disease (AD). Timely diagnosis may benefit patients by reducing their uncertainty regarding the cause of symptoms, yet does not always provide patients with the desired certainty.<h4>Objective</h4>To examine, using both quantitative and qualitative methods, uncertainty communicated by memory clinic clinicians ... Read more >>

Health Expect (Health expectations : an international journal of public participation in health care and health policy)
[2020, 23(1):52-62]

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ABIDE Delphi study: topics to discuss in diagnostic consultations in memory clinics.

Agnetha D Fruijtier, Leonie N C Visser, Ingrid S van Maurik, Marissa D Zwan, Femke H Bouwman, Wiesje M van der Flier, Ellen M A Smets,

<h4>Background</h4>Information given to patients and caregivers during the clinician-patient encounter varies considerably between memory clinic professionals. Patients and caregivers express a clear desire for more information. It is unclear what information patients and caregivers value most during the diagnostic process and whether this is concordant with professionals' opinion. We aimed ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2019, 11(1):77]

Cited: 3 times

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Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study.

Ingrid S van Maurik, Stephanie J Vos, Isabelle Bos, Femke H Bouwman, Charlotte E Teunissen, Philip Scheltens, Frederik Barkhof, Lutz Frolich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckart Rüther, Flavio Nobili, Giovanni B Frisoni, Luiza Spiru, Yvonne Freund-Levi, Asa K Wallin, Harald Hampel, Hilkka Soininen, Magda Tsolaki, Frans Verhey, Iwona Kłoszewska, Patrizia Mecocci, Bruno Vellas, Simon Lovestone, Samantha Galluzzi, Sanna-Kaisa Herukka, Isabel Santana, Ines Baldeiras, Alexandre de Mendonça, Dina Silva, Gael Chetelat, Stephanie Egret, Sebastian Palmqvist, Oskar Hansson, Pieter Jelle Visser, Johannes Berkhof, Wiesje M van der Flier, ,

<h4>Background</h4>Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia.<h4>Methods</h4>In this modelling study, we included people ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(11):1034-1044]

Cited: 7 times

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Retinal thickness as a potential biomarker in patients with amyloid-proven early- and late-onset Alzheimer's disease.

Jurre den Haan, Jacoba A van de Kreeke, Elles Konijnenberg, Mara ten Kate, Anouk den Braber, Frederik Barkhof, Bart N van Berckel, Charlotte E Teunissen, Philip Scheltens, Pieter Jelle Visser, Frank D Verbraak, Femke H Bouwman,

Introduction:Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well-characterized AD and control participants, considering ophthalmological confounders. Methods:We included 57 amyloid-proven AD cases and 85 cognitively normal, amyloid-negative controls. All subjects underwent retinal thickness measurements ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:463-471]

Cited: 4 times

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Development of memory clinics in the Netherlands over the last 20 years.

Angélique A A Gruters, Inez H G B Ramakers, Roy P C Kessels, Femke H Bouwman, Marcel G M Olde Rikkert, Marco M Blom, Marjolein E de Vugt, Frans R J Verhey,

<h4>Objectives</h4>Memory clinics (MCs) have been established to improve diagnosis and treatment of cognitive disorders, including dementia. The aim of this study was to determine the characteristics and working methods of MCs in the Netherlands in 2016. More insight into different working methods can be used to improve the quality of ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2019, 34(8):1267-1274]

Cited: 2 times

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Added value of amyloid PET in individualized risk predictions for MCI patients.

Ingrid S van Maurik, Laura M van der Kall, Arno de Wilde, Femke H Bouwman, Philip Scheltens, Bart N M van Berckel, Johannes Berkhof, Wiesje M van der Flier,

<h4>Introduction</h4>To construct a prognostic model based on amyloid positron emission tomography (PET) to predict clinical progression in individual patients with mild cognitive impairment (MCI).<h4>Methods</h4>We included 411 MCI patients from the Alzheimer's Disease Neuroimaging Initiative. Prognostic models were constructed with Cox regression with demographics, magnetic resonance imaging, and/or amyloid PET to ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:529-537]

Cited: 2 times

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Clinician-patient communication during the diagnostic workup: The ABIDE project.

Leonie N C Visser, Marleen Kunneman, Laxsini Murugesu, Ingrid van Maurik, Marissa Zwan, Femke H Bouwman, Jacqueline Schuur, Hilje A Wind, Marjolijn S J Blaauw, J Jolijn Kragt, Gerwin Roks, Leo Boelaarts, Annemieke C Schipper, Niki Schooneboom, Philip Scheltens, Wiesje M van der Flier, Ellen M A Smets,

<h4>Introduction</h4>We aimed to describe clinician-patient communication in the diagnostic process of memory clinics, specifically clinician behavior known to facilitate knowledgeable participation of patients during consultations.<h4>Methods</h4>In this multicenter, observational study, we audio-recorded routine diagnostic consultations of 41 clinicians and 136 patients/caregivers at eight memory clinics. Patients/caregivers completed surveys after each audiotaped ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:520-528]

Cited: 3 times

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Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer's disease.

Jurre den Haan, Lajos Csinscik, Tom Parker, Ross W Paterson, Catherine F Slattery, Alexander Foulkes, Femke H Bouwman, Frank D Verbraak, Philip Scheltens, Tunde Peto, Imre Lengyel, Jonathan M Schott, Sebastian J Crutch, Timothy J Shakespeare, Keir X X Yong,

<h4>Background</h4>Retinal thickness can be measured non-invasively with optical coherence tomography (OCT) and may offer compelling potential as a biomarker for Alzheimer's disease (AD). Retinal thinning is hypothesized to be a result of retrograde atrophy and/or parallel neurodegenerative processes. Changes in the visual pathway are of particular interest in posterior cortical ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2019, 11(1):62]

Cited: 6 times

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Development and Usability of ADappt: Web-Based Tool to Support Clinicians, Patients, and Caregivers in the Diagnosis of Mild Cognitive Impairment and Alzheimer Disease.

Ingrid S van Maurik, Leonie Nc Visser, Ruth E Pel-Littel, Marieke M van Buchem, Marissa D Zwan, Marleen Kunneman, Wiesje Pelkmans, Femke H Bouwman, Mirella Minkman, Niki Schoonenboom, Philip Scheltens, Ellen Ma Smets, Wiesje M van der Flier,

<h4>Background</h4>As a result of advances in diagnostic testing in the field of Alzheimer disease (AD), patients are diagnosed in earlier stages of the disease, for example, in the stage of mild cognitive impairment (MCI). This poses novel challenges for a clinician during the diagnostic workup with regard to diagnostic testing ... Read more >>

JMIR Form Res (JMIR formative research)
[2019, 3(3):e13417]

Cited: 3 times

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Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease?

Jurre den Haan, Jacoba A van de Kreeke, Bart N van Berckel, Frederik Barkhof, Charlotte E Teunissen, Philip Scheltens, Frank D Verbraak, Femke H Bouwman,

<h4>Introduction</h4>The retina is a potential source of noninvasive vascular biomarkers for Alzheimer's disease (AD). We assessed retinal microvasculature in well-characterized AD cases, taking ophthalmological confounders into account.<h4>Methods</h4>We included 48 amyloid-positive AD patients and 38 amyloid-negative cognitively normal control subjects. All participants underwent ophthalmological screening to exclude interfering ocular disease. Using ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:383-391]

Cited: 8 times

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Personalized risk for clinical progression in cognitively normal subjects-the ABIDE project.

Ingrid S van Maurik, Rosalinde E R Slot, Sander C J Verfaillie, Marissa D Zwan, Femke H Bouwman, Niels D Prins, Charlotte E Teunissen, Philip Scheltens, Frederik Barkhof, Mike P Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof, Wiesje M van der Flier, ,

<h4>Background</h4>Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage takes far longer, and the interpretation of biomarker findings is particular relevant for individuals who present at a memory clinic, but are ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2019, 11(1):33]

Cited: 3 times

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7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease.

Boyd Kenkhuis, Laura E Jonkman, Marjolein Bulk, Mathijs Buijs, Baayla D C Boon, Femke H Bouwman, Jeroen J G Geurts, Wilma D J van de Berg, Louise van der Weerd,

Using 7T T2<sup>⁎</sup>-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 21:101665]

Cited: 6 times

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ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aβ42, levels in non-demented elderly.

Rosalinde E R Slot, Maartje I Kester, Argonde C Van Harten, Wesley Jongbloed, Femke H Bouwman, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Robert Veerhuis,

Apolipoprotein E (APOE) ε4 genotype is associated with increased cerebral amyloid beta (Aβ) deposition in nondemented elderly and suggested to influence ApoE as well as ApoJ (clusterin [Clu]) and ApoA1 expression. We aimed to assess whether APOE affects early Alzheimer's disease pathophysiology via these apolipoproteins. Cerebrospinal fluid (CSF) ApoE, Clu, ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2019, 79:101-109]

Cited: 4 times

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Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.

Steffen Wolfsgruber, José Luis Molinuevo, Michael Wagner, Charlotte E Teunissen, Lorena Rami, Nina Coll-Padrós, Femke H Bouwman, Rosalinde E R Slot, Linda M P Wesselman, Oliver Peters, Katja Luther, Katharina Buerger, Josef Priller, Christoph Laske, Stefan Teipel, Annika Spottke, Michael T Heneka, Emrah Düzel, Alexander Drzezga, Jens Wiltfang, Sietske A M Sikkes, Wiesje M van der Flier, Frank Jessen, ,

<h4>Introduction</h4>Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future dementia prevention trials. Currently, however, SCD is heterogeneously defined across studies, potentially leading to variations in the prevalence of AD ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2019, 11(1):8]

Cited: 6 times

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Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas.

Jurre den Haan, Tjado H J Morrema, Frank D Verbraak, Johannes F de Boer, Philip Scheltens, Annemieke J Rozemuller, Arthur A B Bergen, Femke H Bouwman, Jeroen J Hoozemans,

In-vivo labeling of retinal amyloid-beta(Aβ) and tau has potential as non-invasive biomarker for Alzheimer's disease (AD). However, literature on the presence of Aβ and phosphorylated tau (pTau) in AD retinas is inconclusive. We therefore assessed the presence of Aβ and pTau in post-mortem retinas in 6 AD and 6 control cases ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2018, 6(1):147]

Cited: 20 times

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Diagnostic performance of Elecsys immunoassays for cerebrospinal fluid Alzheimer's disease biomarkers in a nonacademic, multicenter memory clinic cohort: The ABIDE project.

Eline A J Willemse, Ingrid S van Maurik, Betty M Tijms, Femke H Bouwman, Andreas Franke, Isabelle Hubeek, Leo Boelaarts, Jules J Claus, Esther S C Korf, Rob J van Marum, Gerwin Roks, Niki Schoonenboom, Nicolaas Verwey, Marissa D Zwan, Simone Wahl, Wiesje M van der Flier, Charlotte E Teunissen,

<h4>Introduction</h4>We compared the automated Elecsys and manual Innotest immunoassays for cerebrospinal fluid (CSF) Alzheimer's disease biomarkers in a multicenter diagnostic setting.<h4>Methods</h4>We collected CSF samples from 137 participants in eight local memory clinics. Amyloid β(1-42) (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) were centrally analyzed with Innotest and Elecsys assays. ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2018, 10:563-572]

Cited: 7 times

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