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High Plasma Llevels of Aβ1-42 Affect Monocytes and Macrophages via Biphasic Effects on Myeloid-Derived Suppressor Cells and Granulocyte-Monocyte Progenitors in Mouse Models of Alzheimer’s Disease

Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu,

Backgroud : Microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Plasma Aβ 1-42 levels significantly increase 15 years before the onset of dominantly inherited AD. The effects of high plasma levels of Aβ 1-42 on monocytes and macrophages, the hematogenous counterparts of microglia, remain unclear. <h4>Methods: ... Read more >>

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Impact of Increased Hemoglobin on Spontaneous Intracerebral Hemorrhage.

Yuxuan Lu, Haiqiang Jin, Yuhua Zhao, Yuxian Li, Jun Xu, Jiayu Tian, Xiaoting Luan, Siwei Chen, Wei Sun, Shouzi Zhang, Shunliang Xu, Feiqi Zhu, Luzeng Chen, Dunzhu Mima, Yongan Sun, Cidan Zhuoga,

<h4>Background</h4>Studies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH.<h4>Methods</h4>A retrospective single-center study using medical records from a database processed by univariate and multivariate analyses was performed in the People's Hospital of Tibet ... Read more >>

Neurocrit Care (Neurocritical care)
[2021, :]

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The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer's Disease and Other Neurological Disorders.

Yacoubou Abdoul Razak Mahaman, Fang Huang, Kidane Siele Embaye, Xiaochuan Wang, Feiqi Zhu,

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has been implicated in Alzheimer's disease (AD), the most common form of dementia, and many other neurological diseases. The protein level and activity of STEP have been found to be elevated in most of these disorders, and specifically in AD ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:680118]

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Factors associated with caregiving status and caregiver burden for patients with Alzheimer's disease in China

Yuxian Li, Haiqiang Jin, Jiong Zhou, Jun Xu, Jiayu Tian, Siwei Chen, Xiaoting Luan, Ailian Du, Feiqi Zhu, Xiaowen Kou, Wei Sun, Luzeng Chen, Jianxing Qiu, Huali Wang, Hengge Xie, Yongan Sun,

<h4>Background: </h4> The prevalence of Alzheimer's disease (AD) is rapidly in China, which puts a great deal of pressure on the patient’s family and society. The way of patient care deserves social attention. This study focused on the caregiving status and the relationship between caregivers’ burden and patient factors based ... Read more >>

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Severe periodontitis is associated with the serum levels of hypersensitive C reactive protein and lipoprotein-associated phospholipase A2 in the patients of acute ischemic stroke.

Chunchun Chen, Jinhua Zhu, Xuhui Deng, Zhi Yang, Weifeng Lin, Ying Ma, Shuxuan Huang, Lue Chen, Yuan Liu, Feiqi Zhu,

<h4>Background</h4>Periodontitis is associated with the pathogenesis of atherosclerotic plaque, and hypersensitive C reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are the serum biomarkers of the stability of atherosclerotic plaque. Whether periodontitis is associated with the serum level of hs-CRP and Lp-PLA2 of acute ischemic stroke remains unclear.<h4>Material and methods</h4>We ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2021, 88:232-236]

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Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

Mingchao Shi, Fengna Chu, Xiaoping Tian, Qiaolifan Aerqin, Feiqi Zhu, Jie Zhu,

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the pathogenic factors unsuccessful over past decades. It has been evidenced that the innate immune is strongly implicated in the pathogenesis of AD. However, the role of adaptive ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420987224]

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AD Resemblance Atrophy Index as a Diagnostic Biomarker for Alzheimer's Disease: A Retrospective Clinical and Biological Validation.

Yingren Mai, Qun Yu, Feiqi Zhu, Yishan Luo, Wang Liao, Lei Zhao, Chunyan Xu, Wenli Fang, Yuting Ruan, Zhiyu Cao, Ming Lei, Lisa Au, Vincent C T Mok, Lin Shi, Jun Liu,

<h4>Background</h4>Magnetic resonance imaging (MRI) provides objective information about brain structural atrophy in patients with Alzheimer's disease (AD). This multi-structural atrophic information, when integrated as a single differential index, has the potential to further elevate the accuracy of AD identification from normal control (NC) compared to the conventional structure volumetric index.<h4>Objective</h4>We ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, 79(3):1023-1032]

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miR-218 contributes to drug resistance in multiple myeloma via targeting LRRC28.

Haifei Chen, Weiling Cao, Jiao Chen, Danbo Liu, Lingyun Zhou, Fang Du, Feiqi Zhu,

Multiple myeloma (MM) is a malignant neoplasm featured by obvious drug resistance and poor prognosis. MicroRNAs (miRNAs) are a class of small noncoding RNAs with crucial roles in many biological processes including cancer initiation and progression. The current study aims to investigate the pathogenic role and molecular mechanism of miRNAs ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2021, 122(3-4):305-314]

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Characteristics of acute ischemic stroke in hospitalized patients in Tibet: a retrospective comparative study.

Yuxuan Lu, Cidan Zhuoga, Haiqiang Jin, Feiqi Zhu, Yuhua Zhao, Zhijie Ding, Shihua He, Ailian Du, Jun Xu, Jingjing Luo, Yongan Sun,

<h4>Background</h4>Numerous studies on acute ischemic stroke (AIS) have been conducted at low-altitude regions, and the related findings have been used to guide clinical management. However, corresponding studies at high altitude are few. This study aimed to analyse the clinical characteristics of AIS patients at high-altitude regions through a hospital-based comparative ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):380]

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Early-onset Alzheimer's disease may be associated with sortilin-related receptor 1 gene mutation: A family report and review.

Liming Cao, Feiqi Zhu, Guozhen Qiu,

<i>Background</i>: Early-onset Alzheimer's disease is a rare condition that differs from the usual memory-disordered presentation of typical Alzheimer's disease. Early-onset Alzheimer's disease is believed to have a genetic basis, and sporadic Alzheimer's disease has been associated with sortilin-related receptor 1 polymorphism. <i>Case presentation</i>: This report describes and discusses the family ... Read more >>

Radiol Case Rep (Radiology case reports)
[2021, 16(1):30-34]

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Characteristics of acute ischemic stroke in hospitalized patients in Tibet: A retrospective comparative study

Yuxuan Lu, Cidan Zhuoga, Haiqiang Jin, Feiqi Zhu, Yuhua Zhao, Zhijie Ding, Shihua He, Ailian Du, Jun Xu, Jingjing Luo, Yongan Sun,

<h4>Background: </h4> Numerous studies on acute ischemic stroke (AIS) have been conducted at low-altitude regions, and the related findings have been used to guide clinical management. However, corresponding studies at high altitude are few. This study aimed to analyse the clinical characteristics of AIS patients at high-altitude regions through a ... Read more >>

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Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer's Disease.

Feiqi Zhu, Chunrong Li, Fengna Chu, Xiaoping Tian, Jie Zhu,

Alzheimer's disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:544235]

Cited: 6 times

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Diabetes mellitus is associated with elevated urinary pyrrole markers of γ-diketones known to cause axonal neuropathy.

Xiao Chen, Wei Liu, Lu Wang, Dafeng Lin, Lulin Nie, Kaiwu He, Zhiwei Guo, Feiqi Zhu, Wenting Feng, Weimin Liu, Jing Yuan, Xifei Yang, Peter Spencer, Jianjun Liu,

<h4>Introduction</h4>Progressive distal symmetrical axonal neuropathy, a complication of diabetes mellitus (DM), has an unknown cause. Normal physiological metabolism and diabetic dysmetabolism are associated with the generation of γ-diketones. γ-Diketones form pyrroles with protein amines, notably with axonal proteins required for the maintenance of nerve fiber integrity, especially elongate, large-diameter peripheral ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

Cited: 1 time

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Serum level of lipoprotein-associated phospholipase A2 is a potential biomarker of vertebrobasilar dolichoectasia and its progression to cerebral infarction.

Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang, Chunchun Chen, Shuxuan Huang, Lue Chen, Ying Ma, Weifeng Lin, Feiqi Zhu,

<h4>Background</h4>There are no effective therapies to prevent the occurrence and progression of vertebrobasilar dolichoectasia (VBD). In this study, we investigated the relationship between serum levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the occurrence and progression of VBD.<h4>Methods</h4>Sixty (60) cases without VBD and ischemia stroke were considered as Group A, 100 ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, 42(2):599-605]

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Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China.

Li Liu, Wei Liu, Lulin Nie, Zhiwei Guo, Yi Luo, Weihong Chen, Weimin Liu, Feiqi Zhu, Lu Wang, Jiafei Zhang, Xian Wang, Tian Li, Erwei Gao, Li Zhou, Kaiwu He, Yidan Huang, Chunjie Yuan, Qingqing Zhu, Fang Ye, Xingchen Yu, Jing Yuan, Jianjun Liu,

<h4>Purpose</h4>The Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.<h4>Participants</h4>The cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e034317]

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Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease.

Chongyang Chen, Pan Liu, Jing Wang, Haitao Yu, Zaijun Zhang, Jianjun Liu, Xiao Chen, Feiqi Zhu, Xifei Yang,

Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of β-amyloid (Aβ) and intracellular neurofibrillary tangles containing hyperphosphorylated tau protein. No effective therapy is available for this disease. In this study, we investigated the potential therapeutic effects of dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid, on AD, and found that ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:624339]

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Severe Periodontitis Is Associated with Early-Onset Poststroke Depression Status.

Weifeng Lin, Li Xiong, Zhi Yang, Xuhui Deng, Jinhua Zhu, Chunchun Chen, Shuxuan Huang, Ying Ma, Feiqi Zhu,

<h4>Background</h4>Poststroke depression (PSD) is one of the most common complications after ischemic stroke, and periodontitis is associated with depression. However, whether severe periodontitis is associated with early-onset PSD status remains unknown. In this study, we aimed to investigate whether there is an association between severe periodontitis and PSD status in ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, 28(12):104413]

Cited: 1 time

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GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats.

Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wang,

Post-traumatic stress disorder (PTSD) manifests in neurocognitive deficits in association with increased tau deposition, which mainly consist of phosphorylated tau in Alzheimer disease (AD) brain. However, the exact mechanism of PTSD inducing tau hyperphosphorylation remains unclear and therefore no effective treatment options are currently available. We here show that employing ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(18):7978-7995]

Cited: 1 time

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Prevention of cognitive decline in old age-varying effects of interventions in different populations.

Chengxuan Qiu, Gunilla Johansson, Feiqi Zhu, Miia Kivipelto, Bengt Winblad,

Ann Transl Med (Annals of translational medicine)
[2019, 7(Suppl 3):S142]

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Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.

Chongyang Chen, Xin Jiang, Yingchao Li, Haitao Yu, Shupeng Li, Zaijun Zhang, Hua Xu, Ying Yang, Gongping Liu, Feiqi Zhu, Xiaohu Ren, Liangyu Zou, Benhong Xu, Jianjun Liu, Peter S Spencer, Xifei Yang,

Excessive copper can cause neurotoxicity and contribute to the development of some neurological diseases; however, copper neurotoxicity and the potential mechanisms remain poorly understood. We used proteomics and phosphoproteomics to quantify protein changes in the hippocampus of wild-type and 3xTg-AD mice, both of which were treated at 6 months of ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2019, 135:144-156]

Cited: 9 times

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Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats.

Maibouge Tanko Mahamane Salissou, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Fang Huang, Yuman Wang, Zhendong Xu, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiaochuan Wang,

Although few drugs are available today for the management of Alzheimer's disease (AD) and many plants and their extracts are extensively employed in animals' studies and AD patients, yet no drug or plant extract is able to reverse AD symptoms adequately. In the present study, <i>Tamarix gallica</i> (TG), a naturally ... Read more >>

Aging (Albany NY) (Aging)
[2018, 10(11):3229-3248]

Cited: 1 time

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The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro.

Pan Liu, Xiao Chen, Haizhe Zhou, Liqun Wang, Zaijun Zhang, Xiaohu Ren, Feiqi Zhu, Yi Guo, Xinfeng Huang, Jianjun Liu, Peter S Spencer, Xifei Yang,

Alzheimer's disease (AD), the most common neurodegenerative disease, has no effective treatment. Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of <i>Menispermum dauricum</i> DC, reportedly has neuroprotective effects in cerebral ischemia. Here, we investigated the effects of DAU on N2a cells stably transfected with Swedish mutant amyloid precursor ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2018, 2018:2025914]

Cited: 3 times

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The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD.

Xianfeng Huang, Jing Wang, Xiao Chen, Pan Liu, Shujin Wang, Fangchen Song, Zaijun Zhang, Feiqi Zhu, Xinfeng Huang, Jianjun Liu, Guoqiang Song, Peter S Spencer, Xifei Yang,

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has proved refractory to drug treatment. Given evidence of neuroprotection in animal models of ischemic stroke, we assessed the prenylflavonoid xanthohumol from the Common Hop (Humulus lupulus L.) for therapeutic potential in murine neuroblastoma N2a cells stably expressing human Swedish mutant ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:199]

Cited: 6 times

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Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer's disease.

Haitao Yu, Dian Wang, Liangyu Zou, Zaijun Zhang, Hua Xu, Feiqi Zhu, Xiaohu Ren, Benhong Xu, Jianhui Yuan, Jianjun Liu, Peter S Spencer, Xifei Yang,

Excessive copper intake can lead to neurotoxicity, but there is a lack of comprehensive understanding on the potential impact of copper exposure especially at a low-dose on brain. We used 3xTg-AD mice to explore the potential neurotoxicity of chronic, low-dose copper treatment (0.13 ppm copper chloride in drinking water) on behavior ... Read more >>

Arch Toxicol (Archives of toxicology)
[2018, 92(4):1363-1382]

Cited: 4 times

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[Clinical analysis of subpopulation of peripheral T and B lymphocytes in Chinese Parkinson's disease patients].

Siyun Zhang, Congcong Sun, Limin Zhang, Luan Cen, Mingshu Mo, Zhuolin Liu, Wei Huang, Feiqi Zhu, Ping Kang, Zhaojun Chen, Li Yi, Pingyi Xu,

<h4>Objective</h4>To explore the variations of subpopulation of peripheral lymphocytes in Parkinson's disease (PD) and locate its potential biomarkers for clinical evaluations.<h4>Methods</h4>The methods of direct immunostaining and flow cytometry were employed to test the percentages of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD19(+) lymphocytes in blood samples of 77 PD patients and 82 healthy ... Read more >>

Zhonghua Yi Xue Za Zhi (Zhonghua yi xue za zhi)
[2014, 94(47):3726-3730]

Cited: 2 times

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