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Author Fei You

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Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells.

Tongtong Wang, Jing Du, Dexia Kong, Guosheng Yang, Qihao Zhou, Fei You, Yan Lin, Ying Wang,

The main active compound of Garcinia hanburyi (referred to as gamboge) is gambogic acid (GA), which has long been a Chinese herbal medicine for treating several types of cancer. However, the potential therapeutic role and mechanisms of GA in T‑cell acute lymphoblastic leukemia (T‑ALL) remain unclear. In the present study, ... Read more >>

Oncol. Rep. (Oncology reports)
[2020, :]

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Oligomeric ricinoleic acid preparation promoted by an efficient and recoverable Brønsted acidic ionic liquid.

Fei You, Xing He, Song Gao, Hong-Ru Li, Liang-Nian He,

Raw material from biomass and green preparation processes are the two key features for the development of green products. As a bio-lubricant in metalworking fluids, estolides of ricinoleic acid are considered as the promising substitute to mineral oil with a favorable viscosity and viscosity index. Thus, an efficient and sustainable ... Read more >>

Beilstein J Org Chem (Beilstein journal of organic chemistry)
[2020, 16:351-361]

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Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3/NF-kB/IL-6 and VEGF Loop.

Cheng Chen, Fei You, FengHua Wu, YuShen Luo, GuoHua Zheng, HanLin Xu, Yi Liu,

Natural plants are considered as a huge treasure for anticancer. Amomum tsaoko, a plant of Zingiberaceae, is used widely as a food and traditional medicine in East Asia. In previous studies, Amomum tsaoko has antitumor effect on liver cancer cells, but the mechanism is not clear. Here, we demonstrated that ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:2390125]

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Luteolin attenuates sepsis‑induced myocardial injury by enhancing autophagy in mice.

Bin Wu, Haixu Song, Miaomiao Fan, Fei You, Liang Zhang, Jian Luo, Junzhi Li, Lingpeng Wang, Congye Li, Ming Yuan,

Sepsis‑induced cardiomyopathy (SIC) is a complication of severe sepsis and septic shock characterized by an invertible myocardial depression. This study sought to explore the potential effects and mechanism of luteolin, a flavonoid polyphenolic compound, in lipopolysaccharide (LPS)‑induced myocardial injury. Experimental mice were randomly allocated into 3 groups (25 mice in ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 45(5):1477-1487]

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Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate.

Iontcho R Vlahov, Longwu Qi, Hari Krishna R Santhapuram, Albert Felten, Garth L Parham, Ning Zou, Kevin Wang, Fei You, Jeremy F Vaughn, Spencer J Hahn, Hanna F Klein, Paul J Kleindl, Joe Reddy, Dan Reno, Jeff Nicoson, Christopher P Leamon,

Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone therapeutics or as warheads for small molecule drug conjugates (SMDCs), dose-limiting toxicities are often observed. As an ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2020, 30(7):126987]

Cited: 1 time

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Safety and Efficacy of 25G vitrectomy surgery for malignant glaucoma in pseudophakia

fei you,

Abstract Background: malignant glaucoma after cataract surgery is still one of the serious complications, if not handled properly,it may lead to serious consequences. It is notoriously difficult to treat. 25G vitrectomy was performed to evaluate the safety and efficacy for the treatment of malignant glaucoma in pseudophakia. Methods: This is ... Read more >>

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[Electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-HT, 5-HIAA, TNF-α and IL-1β contents in hypothalamus in insomnia rats].

Lei Tang, Fei You, Xing Hu, Yun-Fei Li,

OBJECTIVE:To observe the therapeutic effect of electroacupuncture (EA) at five Back-Shu points on sleep, hippocampal peripheral benzodiazepine receptor (PBR) expression and hypothalamic 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β contents in insomnia rats, so as to explore its mechanisms underlying improvement of insomnia. METHODS:Forty ... Read more >>

Zhen Ci Yan Jiu (Zhen ci yan jiu = Acupuncture research)
[2019, 44(8):560-565]

Cited: 1 time

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CO2 Capture and in situ Catalytic Transformation.

Hong-Chen Fu, Fei You, Hong-Ru Li, Liang-Nian He,

The escalating rate of fossil fuel combustion contributes to excessive CO2 emission and the resulting global climate change has drawn considerable attention. Therefore, tremendous efforts have been devoted to mitigate the CO2 accumulation in the atmosphere. Carbon capture and storage (CCS) strategy has been regarded as one of the promising ... Read more >>

Front Chem (Frontiers in chemistry)
[2019, 7:525]

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Topoisomerase Inhibitors and Targeted Delivery in Cancer Therapy.

Fei You, Changshou Gao,

DNA topoisomerases are enzymes that catalyze the alteration of DNA topology with transiently induced DNA strand breakage, essential for DNA replication. Topoisomerases are validated cancer chemotherapy targets. Anticancer agents targeting Topoisomerase I and II have been in clinical use and proven to be highly effective, though with significant side effects. ... Read more >>

Curr Top Med Chem (Current topics in medicinal chemistry)
[2019, 19(9):713-729]

Cited: 2 times

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DNA Damaging Agents in Cancer Therapy.

Fei You, Changshou Gao,

Curr Top Med Chem (Current topics in medicinal chemistry)
[2019, 19(9):690]

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CSF miR-16 expression and its association with miR-16 and serotonin transporter in the raphe of a rat model of depression.

Qiong-Yan Shao, Fei You, Yong-Hua Zhang, Lin-Lin Hu, Wen-Juan Liu, Yi Liu, Jing Li, Sheng-Dong Wang, Ming-Fen Song,

BACKGROUND:Depression is a common mental disorder with unknown mechanism. Emerging evidence shows that miRNAs play a critical role in the process of depression. Here we reported the cerebrospinal fluid (CSF) miR-16 expression and its association with miR-16 and serotonin transporter (SERT) in the raphe of a rat model of depression. ... Read more >>

J Affect Disord (Journal of Affective Disorders)
[2018, 238:609-614]

Cited: 3 times

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Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.

Iontcho R Vlahov, Longwu Qi, Paul J Kleindl, Hari K Santhapuram, Albert Felten, Garth L Parham, Kevin Wang, Fei You, Jeremy F Vaughn, Spencer J Hahn, Hanna F Klein, Marilynn Vetzel, Joseph A Reddy, Melissa Nelson, Jeff Nicoson, Christopher P Leamon,

Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone therapeutics or as warheads for small molecule drug conjugates (SMDCs), dose-limiting toxicities are often observed. As an ... Read more >>

Bioconjug. Chem. (Bioconjugate chemistry)
[2017, 28(12):2921-2931]

Cited: 2 times

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MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40.

Ming Yuan, Liwei Zhang, Fei You, Jingyu Zhou, Yongjiang Ma, Feifei Yang, Ling Tao,

An increasing body of evidence indicates that inflammation and apoptosis are involved in the development of acute myocardial infarction (AMI). In this study, we sought to investigate the specific role and the underlying regulatory mechanism of miR-145-5p in myocardial ischemic injury. H9c2 cardiac cells were exposed to hypoxia to establish ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2017, 431(1-2):123-131]

Cited: 26 times

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Biopanning and characterization of peptides with Fe3O4 nanoparticles-binding capability via phage display random peptide library technique.

Fei You, Guangfu Yin, Ximing Pu, Yucan Li, Yang Hu, Zhongbin Huang, Xiaoming Liao, Yadong Yao, Xianchun Chen,

Functionalization of inorganic nanoparticles (NPs) play an important role in biomedical applications. A proper functionalization of NPs can improve biocompatibility, avoid a loss of bioactivity, and further endow NPs with unique performances. Modification with vairous specific binding biomolecules from random biological libraries has been explored. In this work, two 7-mer ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2016, 141:537-545]

Cited: 3 times

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[Impacts of the low-frequency electric stimulation at the acupoints on the content of plasma 5-HT and NE in the patients with post-stroke insomnia].

Lei Tang, Chaoyan Ma, Fei You, Lin Ding,

To compare the clinical efficacy on post-stroke insomnia between the low-frequency electric stimulation at the acupoints and the conventional western medication in the patients so as to explore the effect mechanism.One hundred and twenty patients of post-stroke insomnia were randomized into a low-frequency electric stimulation group, a medication group and ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2015, 35(8):763-767]

Cited: 4 times

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[Clinical research of post-stroke insomnia treated with low-frequency electric stimulation at acupoints in the patients].

Lei Tang, Fei You, Chao-Yang Ma,

OBJECTIVE: To compare the difference in the clinical efficacy on post-stroke insomnia between the low-frequency electric stimulation at the acupoints and the conventional western medication. METHODS: One hundred and twenty patients of post-stroke insomnia were randomized into a low-frequency electric stimulation group, a medication group and a placebo group, 40 ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2014, 34(8):747-750]

Cited: 1 time

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Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

Christopher P Leamon, Iontcho R Vlahov, Joseph A Reddy, Marilynn Vetzel, Hari Krishna R Santhapuram, Fei You, Alicia Bloomfield, Ryan Dorton, Melissa Nelson, Paul Kleindl, Jeremy F Vaughn, Elaine Westrick,

Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology studies. Structurally, vintafolide consists of 4 essential modules: (1) folic acid, (2) a hydrophilic peptide spacer, (3) a disulfide-containing, self-immolative linker, and (4) the cytotoxic drug, desacetylvinblastine hydrazide (DAVLBH). ... Read more >>

Bioconjug. Chem. (Bioconjugate chemistry)
[2014, 25(3):560-568]

Cited: 9 times

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A new diphenyl ether from the endophytic fungus Verticillium sp. isolated from Rehmannia glutinosa.

Wei Peng, Fei You, Xiao-Li Li, Min Jia, Cheng-Jian Zheng, Ting Han, Lu-Ping Qin,

AIM: To investigate the chemical constituents of the endophytic fungus Verticillium sp. isolated from Rehmannia glutinosa. METHODS: The compounds were isolated and purified by repeated column chromatography, and their structures were determined on the basis of physicochemical properties and spectral analysis. Their cytotoxic and antifungal activities were evaluated. RESULTS: Ten ... Read more >>

Chin J Nat Med (Chinese journal of natural medicines)
[2013, 11(6):673-675]

Cited: 1 time

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A specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2.

Chuying Ma, Guangfu Yin, Fei You, Yan Wei, Zhongbing Huang, Xianchun Chen, Danhong Yan,

Peptides are emerging as pharmaceutical agents in cancer therapy. The peptide, TLSGAFELSRDK (TLS) is a targeting ligand that can specifically triggers cellular uptake by binding to SKOV3 cells. Cell surface proteins and the C-terminal basic residues of the TLS are required for effective cell penetration, and the uptake process is ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2013, 35(11):1791-1797]

Cited: 6 times

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A specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2

Chuying Ma, Guangfu Yin, Fei You, Yan Wei, Zhongbing Huang, Xianchun Chen, Danhong Yan,

Peptides are emerging as pharmaceutical agents in cancer therapy. The peptide, TLSGAFELSRDK (TLS) is a targeting ligand that can specifically triggers cellular uptake by binding to SKOV3 cells. Cell surface proteins and the C-terminal basic residues of the TLS are required for effective cell penetration, and the uptake process is ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2013, 35(11):1791-1797]

Cited: 1 time

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Cell adhesion and invasion inhibitory effect of an ovarian cancer targeting peptide selected via phage display in vivo.

Ximing Pu, Chuying Ma, Guangfu Yin, Fei You, Yan Wei,

Organ-specific metastasis is of great importance since most of the cancer deaths are caused by spread of the primary cancer to distant sites. Therefore, targeted anti-metastases therapies are needed to prevent cancer cells from metastasizing to different organs. The phage clone pc3-1 displaying peptide WSGPGVWGASVK selected by phage display had ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 443(3):858-863]

Cited: 0 times

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Bifunctional inhibition of HIV-1 reverse transcriptase: a first step in designing a bifunctional triphosphate.

Dongyuan Piao, Aravind Basavapathruni, Pinar Iyidogan, Guangxiu Dai, Wolfgang Hinz, Adrian S Ray, Eisuke Murakami, Joy Y Feng, Fei You, Ginger E Dutschman, David J Austin, Kathlyn A Parker, Karen S Anderson,

The onset of resistance to approved anti-AIDS drugs by HIV necessitates the search for novel inhibitors of HIV-1 reverse transcriptase (RT). Developing single molecular agents concurrently occupying the nucleoside and nonnucleoside binding sites in RT is an intriguing idea but the proof of concept has so far been elusive. As ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2013, 23(5):1511-1518]

Cited: 3 times

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Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

Iontcho R Vlahov, Fei You, Hari Krishna R Santhapuram, Yu Wang, Jeremy F Vaughn, Spencer J Hahn, Paul J Kleindl, Mingjin Fan, Christopher P Leamon,

Efficient syntheses of folate receptor (FR) targeting conjugates of the anti-inflammatory, aminopterin hydrazide, are described. 2-{4-Benzoylamino}-5-oxo-5-{N'-[2-(pyridin-2-yldisulfanyl)-ethoxycarbonyl]-hydrazino}-pentanoic acid is synthesized from commercially available 4-[(2-amino-4-imino-3,4-dihydro-pteridin-6-yl-methyl)-amino]-benzoic acid. Conjugation of this novel, activated aminopterin hydrazide to folic acid through cysteine-terminating (C-terminus), peptide/carbohydrate spacers results in highly water soluble conjugates which allow for the release ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2011, 21(4):1202-1205]

Cited: 5 times

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Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.

Iontcho R Vlahov, Gregory D Vite, Paul J Kleindl, Yu Wang, Hari Krishna R Santhapuram, Fei You, Stephen J Howard, Soong-Hoon Kim, Francis F Y Lee, Christopher P Leamon,

Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug. ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2010, 20(15):4578-4581]

Cited: 15 times

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Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.

Iontcho R Vlahov, Hari Krishna R Santhapuram, Fei You, Yu Wang, Paul J Kleindl, Spencer J Hahn, Jeremy F Vaughn, Daniel S Reno, Christopher P Leamon,

To better regulate the biodistribution of the vinblastine-folate conjugate, EC145, a new folate-spacer that incorporates 1-amino-1-deoxy-D-glucitol-gamma-glutamate subunits into a peptidic backbone, was synthesized. Synthesis of Fmoc-3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-D-glucitol-gamma-glutamate 20, suitable for Fmoc-strategy solid-phase peptide synthesis (SPPS), was achieved in four steps from delta-gluconolactone. Addition of alternating glutamic acid and 20 moieties onto ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2010, 75(11):3685-3691]

Cited: 15 times

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