Full Text Journal Articles by
Author Federico E Turkheimer

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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.

Michele Frison, Danilo Faccenda, Rosella Abeti, Manuel Rigon, Daniela Strobbe, Britannie S England-Rendon, Diana Cash, Katy Barnes, Mona Sadeghian, Marija Sajic, Lisa A Wells, Dong Xia, Paola Giunti, Kenneth Smith, Heather Mortiboys, Federico E Turkheimer, Michelangelo Campanella,

Dysfunctional mitochondria characterise Parkinson's Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to pathological cues, is therefore pivotal to inform early diagnosis and therapy in the condition, especially in its idiopathic forms. This study proposes the 18 kDa Translocator Protein (TSPO) to be one of those. ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, :]

Cited: 0 times

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

Cited: 1 time

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Integration of human whole-brain transcriptome and neuroimaging data: Practical considerations of current available methods.

Pierluigi Selvaggi, Gaia Rizzo, Mitul A Mehta, Federico E Turkheimer, Mattia Veronese,

The Allen Human Brain Atlas (AHBA) is the first example of human brain transcriptomic mappings and detailed anatomical annotations which, for the first time, has allowed the integration of human brain transcriptomics with neuroimaging. This has been made possible because the AHBA offered an original dataset that contains mRNA expression ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2021, 355:109128]

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Neural diffusivity and pre-emptive epileptic seizure intervention.

Erik D Fagerholm, Chayanin Tangwiriyasakul, Karl J Friston, Inês R Violante, Steven Williams, David W Carmichael, Suejen Perani, Federico E Turkheimer, Rosalyn J Moran, Robert Leech, Mark P Richardson,

The propagation of epileptic seizure activity in the brain is a widespread pathophysiology that, in principle, should yield to intervention techniques guided by mathematical models of neuronal ensemble dynamics. During a seizure, neural activity will deviate from its current dynamical regime to one in which there are significant signal fluctuations. ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2020, 16(12):e1008448]

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Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed patients: implications for inflammation and depression.

Federico E Turkheimer, Noha Althubaity, Julia Schubert, Maria A Nettis, Oliver Cousins, Danai Dima, Valeria Mondelli, Edward T Bullmore, Carmine Pariante, Mattia Veronese,

The relationship between peripheral and central immunity and how these ultimately may cause depressed behaviour has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of depression that proposes a direct effect of peripheral cytokines and ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2021, 91:487-497]

Cited: 8 times

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Evaluation of [13N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain.

Alice Egerton, Joel T Dunn, Nisha Singh, Zilin Yu, Jim O'Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E Turkheimer, Paul K Marsden, Alexander Hammers, Antony Gee,

<h4>Purpose</h4>The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glutamate to glutamine requires ammonia, we evaluated whether [<sup>13</sup>N]ammonia positron emission tomography (PET) could reliability quantify ... Read more >>

EJNMMI Res (EJNMMI research)
[2020, 10(1):146]

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A GABA Interneuron Deficit Model of the Art of Vincent van Gogh.

Federico E Turkheimer, Erik D Fagerholm, Miriam Vignando, Jessica Dafflon, Pedro F Da Costa, Paola Dazzan, Robert Leech,

Vincent van Gogh was one of the most influential artists of the Western world, having shaped the post-impressionist art movement by shifting its boundaries forward into abstract expressionism. His distinctive style, which was not valued by the art-buying public during his lifetime, is nowadays one of the most sought after. ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:685]

Cited: 0 times

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GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513.

Tiago Reis Marques, Abhishekh H Ashok, Ilinca Angelescu, Faith Borgan, Jim Myers, Anne Lingford-Hughes, David J Nutt, Mattia Veronese, Federico E Turkheimer, Oliver D Howes,

A loss of GABA signaling is a prevailing hypothesis for the pathogenesis of schizophrenia. Preclinical studies indicate that blockade of the α5 subtype of the GABA receptor (α5-GABA<sub>A</sub>Rs) leads to behavioral phenotypes associated with schizophrenia, and postmortem evidence indicates lower hippocampal α5-GABA<sub>A</sub>Rs protein and mRNA levels in schizophrenia. However, it ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, 26(6):2616-2625]

Cited: 5 times

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The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study.

Robert A McCutcheon, Sameer Jauhar, Fiona Pepper, Matthew M Nour, Maria Rogdaki, Mattia Veronese, Federico E Turkheimer, Alice Egerton, Philip McGuire, Mitul M Mehta, Oliver D Howes,

<h4>Background</h4>Striatal dopamine dysfunction is thought to underlie symptoms in psychosis, yet it remains unclear how a single neurotransmitter could cause the diverse presentations that are observed clinically. One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, 5(11):1040-1051]

Cited: 2 times

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Normalizing the Abnormal: Do Antipsychotic Drugs Push the Cortex Into an Unsustainable Metabolic Envelope?

Federico E Turkheimer, Pierluigi Selvaggi, Mitul A Mehta, Mattia Veronese, Fernando Zelaya, Paola Dazzan, Anthony C Vernon,

The use of antipsychotic medication to manage psychosis, principally in those with a diagnosis of schizophrenia or bipolar disorder, is well established. Antipsychotics are effective in normalizing positive symptoms of psychosis in the short term (delusions, hallucinations and disordered thought). Their long-term use is, however, associated with side effects, including ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(3):484-495]

Cited: 2 times

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Corrigendum to: Normalizing the Abnormal: Do Antipsychotic Drugs Push the Cortex Into an Unsustainable Metabolic Envelope?

Federico E Turkheimer, Pierluigi Selvaggi, Mitul A Mehta, Mattia Veronese, Fernando Zelaya, Paola Dazzan, Anthony C Vernon,

Schizophr Bull (Schizophrenia bulletin)
[2020, :]

Cited: 0 times

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Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter.

Paolo Zanotti-Fregonara, Mattia Veronese, Gaia Rizzo, Belen Pascual, Joseph C Masdeu, Federico E Turkheimer,

Mol Imaging Biol (Molecular imaging and biology)
[2020, 22(1):10-12]

Cited: 2 times

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[18F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis.

Antonio Carotenuto, Beniamino Giordano, George Dervenoulas, Heather Wilson, Mattia Veronese, Zachary Chappell, Sotirios Polychronis, Gennaro Pagano, Jane Mackewn, Federico E Turkheimer, Steven C R Williams, Alexander Hammers, Eli Silber, Peter Brex, Marios Politis,

<h4>Purpose</h4>We evaluated myelin changes throughout the central nervous system in Multiple Sclerosis (MS) patients by using hybrid [<sup>18</sup>F]florbetapir PET-MR imaging.<h4>Methods</h4>We included 18 relapsing-remitting MS patients and 12 healthy controls. Each subject performed a hybrid [<sup>18</sup>F]florbetapir PET-MR and both a clinical and cognitive assessment. [<sup>18</sup>F]florbetapir binding was measured as distribution volume ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, 47(2):366-378]

Cited: 2 times

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A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies.

Daniela Perani, Leonardo Iaccarino, Adriaan A Lammertsma, Albert D Windhorst, Paul Edison, Ronald Boellaard, Oskar Hansson, Agneta Nordberg, Andreas H Jacobs, ,

Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2019, 15(8):1081-1103]

Cited: 1 time

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Widespread microglial activation in multiple system atrophy.

Dorothee Kübler, Tobias Wächter, Nicole Cabanel, Zhangjie Su, Federico E Turkheimer, Richard Dodel, David J Brooks, Wolfgang H Oertel, Alexander Gerhard,

<h4>Background</h4>The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [<sup>11</sup> C](R)-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.<h4>Methods</h4>Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2019, 34(4):564-568]

Cited: 7 times

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Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies.

Daniela Perani, Leonardo Iaccarino, Andreas H Jacobs, ,

<h4>Introduction</h4>A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2019, 11:327-332]

Cited: 0 times

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Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis.

Julia J Schubert, Mattia Veronese, Livia Marchitelli, Benedetta Bodini, Matteo Tonietto, Bruno Stankoff, David J Brooks, Alessandra Bertoldo, Paul Edison, Federico E Turkheimer,

Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of brain homeostasis. <sup>11</sup>C-Pittsburgh compound B (PiB) PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer disease. The current study investigates the magnitude of <sup>11</sup>C-PiB PET signal in the lateral ventricles of ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2019, 60(10):1452-1460]

Cited: 8 times

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Covariance statistics and network analysis of brain PET imaging studies.

Mattia Veronese, Lucia Moro, Marco Arcolin, Ottavia Dipasquale, Gaia Rizzo, Paul Expert, Wasim Khan, Patrick M Fisher, Claus Svarer, Alessandra Bertoldo, Oliver Howes, Federico E Turkheimer,

The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-based covariance matrices, with the aim to explore ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2496]

Cited: 8 times

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Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies.

Tiago Reis Marques, Abhishekh H Ashok, Toby Pillinger, Mattia Veronese, Federico E Turkheimer, Paola Dazzan, Iris E C Sommer, Oliver D Howes,

<h4>Background</h4>Converging lines of evidence implicate an important role for the immune system in schizophrenia. Microglia are the resident immune cells of the central nervous system and have many functions including neuroinflammation, axonal guidance and neurotrophic support. We aimed to provide a quantitative review of in vivo PET imaging studies of ... Read more >>

Psychol Med (Psychological medicine)
[2019, 49(13):2186-2196]

Cited: 27 times

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Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study.

Seoyoung Kim, Wi Hoon Jung, Oliver D Howes, Mattia Veronese, Federico E Turkheimer, Yun-Sang Lee, Jae Sung Lee, Euitae Kim, Jun Soo Kwon,

<h4>Background</h4>Given that only a subgroup of patients with schizophrenia responds to first-line antipsychotic drugs, a key clinical question is what underlies treatment response. Observations that prefrontal activity correlates with striatal dopaminergic function, have led to the hypothesis that disrupted frontostriatal functional connectivity (FC) could be associated with altered dopaminergic function. ... Read more >>

Psychol Med (Psychological medicine)
[2019, 49(15):2533-2542]

Cited: 3 times

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Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging.

Nisha Singh, Mattia Veronese, Jim O'Doherty, Teresa Sementa, Salvatore Bongarzone, Diana Cash, Camilla Simmons, Marco Arcolin, Paul K Marsden, Antony Gee, Federico E Turkheimer,

<h4>Introduction</h4>The development of clinically useful tracers for PET imaging is enormously challenging and expensive. The intranasal (IN) route of administration is purported to be a viable route for delivering drugs to the brain but has, as yet, not been investigated for the delivery of PET tracers. If the intranasal (IN) ... Read more >>

Nucl Med Biol (Nuclear medicine and biology)
[2018, 66:32-39]

Cited: 2 times

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Determinants of treatment response in first-episode psychosis: an 18F-DOPA PET study.

Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Federico E Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes,

Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2019, 24(10):1502-1512]

Cited: 20 times

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Serotonergic dysregulation is linked to sleep problems in Parkinson's disease.

Heather Wilson, Beniamino Giordano, Federico E Turkheimer, Kallol Ray Chaudhuri, Marios Politis,

<h4>Introduction</h4>Sleep disturbances are common non-motor symptoms in Parkinson's disease (PD). Experimental studies suggest involvement of the serotonergic system in the regulation of sleep and arousal. Using [<sup>11</sup>C]DASB positron emission tomography, a marker of serotonin transporter availability, we investigated whether sleep dysfunction is associated with serotonergic dysfunction in PD.<h4>Methods</h4>We studied 14 ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2018, 18:630-637]

Cited: 11 times

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Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities.

Gaia Rizzo, Mattia Veronese, Matteo Tonietto, Benedetta Bodini, Bruno Stankoff, Catriona Wimberley, Sonia Lavisse, Michel Bottlaender, Peter S Bloomfield, Oliver Howes, Paolo Zanotti-Fregonara, Federico E Turkheimer, Alessandra Bertoldo,

The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main target of positron emission tomography (PET) ligands for neuroinflammation. Previous works showed that accounting for TSPO endothelial binding improves PET quantification for [<sup>11</sup>C]PBR28, [<sup>18</sup>F]DPA714 and [<sup>11</sup>C]-R-PK11195. It is still unclear, however, whether the vascular signal is ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2019, 39(5):874-885]

Cited: 15 times

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Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors.

Sagnik Bhattacharyya, Alice Egerton, Euitae Kim, Lula Rosso, Daniela Riano Barros, Alexander Hammers, Michael Brammer, Federico E Turkheimer, Oliver D Howes, Philip McGuire,

Use of Cannabis, the most widely used illicit drug worldwide, is associated with acute anxiety, and anxiety disorders following regular use. The precise neural and receptor basis of these effects have not been tested in man. Employing a combination of functional MRI (fMRI) and positron emission tomography (PET), we investigated ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):15025]

Cited: 14 times

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