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Author Fatih Dede

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Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems

Didem Turgut, Serhan Vahit Pişkinpaşa, Ezgİ Çoşkun Yenigün, Nihal Aydemir, Fatih Dede,

Background/aim:Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, 50(6):1566-1572]

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Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group.

Aydin Turkmen, Abdullah Sumnu, Egemen Cebeci, Halil Yazici, Necmi Eren, Nurhan Seyahi, Kamil Dilek, Fatih Dede, Ulver Derici, Abdulkadir Unsal, Garip Sahin, Murat Sipahioglu, Mahmut Gok, Erhan Tatar, Belda Dursun, Savas Sipahi, Murvet Yilmaz, Gultekin Suleymanlar, Sena Ulu, Ozkan Gungor, Sim Kutlay, Zerrin Bicik Bahcebasi, Idris Sahin, Ilhan Kurultak, Kultigin Turkmen, Zulfikar Yilmaz, Rumeyza Turan Kazancioglu, Caner Cavdar, Ferhan Candan, Zeki Aydin, Duriye Deren Oygar, Cuma Bulent Gul, Mustafa Arici, Saime Paydas, Dilek Guven Taymez, Mehmet Kucuk, Sinan Trablus, Kenan Turgutalp, Leyla Koc, Siren Sezer, Murat Duranay, Simge Bardak, Lutfullah Altintepe, Izzet Hakki Arikan, Alper Azak, Ali Riza Odabas, Gulizar Manga Sahin, Savas Ozturk,

BACKGROUND:The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group. METHODS:Data of patients who underwent renal biopsy ... Read more >>

BMC Nephrol (BMC nephrology)
[2020, 21(1):481]

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Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group.

Zeki Aydin, Kultigin Turkmen, Fatih Dede, Emre Yasar, Savas Ozturk, Mehmet Aydin, Erhan Tatar, Garip Sahin, Gulizar Manga, Ozgur Oto, Abdullah Sumnu, Eray Eroglu, Tamer Dincer, Belda Dursun, Necmi Eren, Mustafa Sevinc, Fatma Betul Guzel, Serkan Yalin, Sim Kutlay, Suheyla Apaydin, Haci Bayram Berktas, Sinan Kazan, Hamad Dheir, Feyza Bora, Taner Basturk, Idris Sahin,

BACKGROUND:In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. METHODS:Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2020, :]

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Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group.

Abdullah Sumnu, Kultigin Turkmen, Egemen Cebeci, Aydin Turkmen, Necmi Eren, Nurhan Seyahi, Aysegul Oruc, Fatih Dede, Ülver Derici, Taner Basturk, Garip Şahin, Murat Sipahioglu, Gulizar Manga Sahin, Erhan Tatar, Belda Dursun, Savas Sipahi, Mürvet Yılmaz, Gultekin Suleymanlar, Sena Ulu, Ozkan Gungor, Sim Kutlay, Zerrin Bicik Bahçebaşı, İdris Sahin, Ilhan Kurultak, Can Sevinc, Zulfikar Yilmaz, Rumeyza Turan Kazancioglu, Caner Cavdar, Ferhan Candan, Zeki Aydin, Deren Oygar, Bulent Gul, Bulent Altun, Saime Paydas, Sami Uzun, Zulal Istemihan, Metin Ergul, Mevlut Tamer Dincer, Mustafa Gullulu, Serhan Piskinpasa, Omer Faruk Akcay, Abdulkadir Unsal, Sumeyra Koyuncu, Mahmut Gok, Savas Ozturk,

PURPOSE:Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. METHODS:Data were obtained from national multicenter (47 centers) data entered into the Turkish Society ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2020, :]

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Evaluation of BD Barricor™ Plasma Blood Collection Tube for Biochemical Tests.

Arzu Kösem, Canan Topçuoğlu, Sevilay Sezer, Şimal K Cevher, Ezgi C Yenigün, Fatih Dede, Turan Turhan,

BACKGROUND:Blood from patients who are receiving anticoagulant therapy may take longer to clot. Anticoagulation is an important component of the dialysis prescription. We compared BD Vacutainer® Barricor™ Plasma Blood Collection Tubes (BD BarrricorTM), BD Vacutainer® PST™ Lithium Heparin Tubes (BD PST™), and BD (Becton-Dickinson, Franklin Lakes, NJ, USA) Vacutainer Serum ... Read more >>

Clin Lab (Clinical laboratory)
[2019, 65(12):]

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Fabry Disease Prevalence in Renal Replacement Therapy in Turkey.

Serkan Feyyaz Yalın, Necmi Eren, Ayse Sinangil, Vural Taner Yilmaz, Erhan Tatar, Ali Riza Ucar, Mustafa Sevinc, Özgür Can, Alp Gurkan, Nurol Arik, Sabahat Alisir Ecder, Murathan Uyar, Murat Yasar, Sibel Gulcicek, Meral Mese, Hamad Dheir, Ulkem Cakir, Şimal Köksal Cevher, Kultigin Turkmen, Bahtisen Guven, Dilek Guven Taymez, Banu Erkalma Senates, Tevfik Ecder, Huseyin Kocak, Adam Uslu, Erol Demir, Taner Basturk, Melike Betul Ogutmen, Can Kinalp, Belda Dursun, Zerrin Bicik Bahcebasi, Savas Sipahi, Fatih Dede, Meric Oruc, Yasar Caliskan, Ahmed Genc, Berna Yelken, Mehmet Rıza Altıparmak, Aydin Turkmen, Nurhan Seyahi,

BACKGROUND:Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from lack of alpha-galactosidase A (AGALA) activity in lysosomes. OBJECTIVE:In this multicenter study, we aimed to evaluate the prevalence of FD in renal transplant (Tx) recipients in Turkey. We also screened dialysis patients as a control group. METHODS:All Tx and ... Read more >>

Nephron (Nephron)
[2019, 142(1):26-33]

Cited: 2 times

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The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension.

Emel Aydin, Ihsan Ates, Mehmet Fettah Arikan, Nisbet Yilmaz, Fatih Dede,

This study aimed to examine the relationship between the ratio of monocyte frequency to high-density lipoprotein (HDL) cholesterol level (the monocyte/HDL ratio (MHR)) and asymptomatic organ damage (AOD) in primary hypertension (PHT). A total of 366 participants were enrolled in the study, including 275 cases currently being followed up after ... Read more >>

Hypertens. Res. (Hypertension research : official journal of the Japanese Society of Hypertension)
[2017, 40(8):758-764]

Cited: 6 times

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The relationship between dietary salt intake and ambulatory blood pressure variability in non-diabetic hypertensive patients.

Nihal Ozkayar, Fatih Dede, Ihsan Ates, Fatma Akyel, Tolga Yildirim, Bulent Altun,

High dietary salt intake was reported to increase blood pressure by numerous studies, but no study has investigated the effect of dietary salt intake on blood pressure variability (BPV). This study aimed to determine if daily salt intake is related to ambulatory BPV. The study included 136 primary hypertensive patients ... Read more >>

Nefrologia (Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
[2016, 36(6):694-700]

Cited: 4 times

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Effect of metabolic acidosis on QT intervals in patients with chronic kidney disease.

Ezgi Coskun Yenigun, Cenk Aypak, Didem Turgut, Mehmet Zafer Aydin, Fatih Dede,

There is a strong association between chronic kidney disease (CKD) and cardiovascular events. Increased arrhythmia risk in kidney disease is one of the main predominant factors in increased mortality and sudden cardiac death. To estimate this risk, noninvasive measurement of repolarization abnormalities including QT interval and its heart rate-corrected value ... Read more >>

Int J Artif Organs (The International journal of artificial organs)
[2016, 39(6):272-276]

Cited: 3 times

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Is thyroid function associated with masked hypertension?

İhsan Ateş, Mustafa Altay, Mustafa Kaplan, Mehmet Fettah Arıkan, Nihal Özkayar, Mehmet Erdem Alagüney, Fatih Dede, Adem Özkara,

Anatol J Cardiol (Anatolian journal of cardiology)
[2016, 16(8):644]

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Systemic Lupus Erythematosus as a Rare Cause of Anemia Resistant to Erythropoiesis-stimulating Agents.

Ezgi Coskun Yenigun, Nergiz Bayrakci, Simal Koksal Cevher, Nihal Ozkayar, Fatih Dede,

Erythropoiesis-stimulating agents (ESAs) play an important role in the management of anemia in patients with chronic kidney disease, but the goals cannot be reached in 5% to 10% of the patients despite high-dose ESA treatment. In case of ESA resistance, all causes of anemia encountered in the general population should ... Read more >>

Iran J Kidney Dis (Iranian journal of kidney diseases)
[2016, 10(2):97-99]

Cited: 0 times

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Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?

Bayram Inan, Ihsan Ates, Nihal Ozkayar, Harun Kundi, Canan Topcuoglu, Fatih Dede, Engin Sennaroglu,

In this study, our aim was to determine total oxidative stress and asymmetric dimethylarginine (ADMA) levels in patients with masked hypertension (MHT) and to examine their association with blood pressure.Fifty patients diagnosed with MHT and 48 healthy volunteers without any known chronic diseases have been included in this study.When compared ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2016, 38(3):294-298]

Cited: 5 times

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The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients.

Nihal Özkayar, Fatma Akyel, Ayşe Nurdan Barça, Serhan Vahit Pişkinpaşa, Turan Turhan, İhsan Ateş, Fatih Dede,

BACKGROUND/AIM:We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. MATERIALS AND METHODS:This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2016, 46(1):13-17]

Cited: 0 times

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Factors associated with mortality in patients presenting to the emergency department with severe hypernatremia.

Ihsan Ates, Nihal Özkayar, Güvenç Toprak, Nisbet Yılmaz, Fatih Dede,

Hypernatremia is a common electrolyte disorder associated with prolonged hospitalization and death. Severe hypernatremia is defined as a serum sodium (Na(+)) concentration >160 mmol/L. To the best of our knowledge, there is little information on patients with severe hypernatremia, Na(+) >160 mmol/L. Therefore, in this study, we aimed to determine ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2016, 11(3):451-459]

Cited: 4 times

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Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension.

Ihsan Ates, Nihal Ozkayar, Bayram Inan, Fatma Meric Yilmaz, Canan Topcuoglu, Salim Neselioglu, Ozcan Erel, Fatih Dede, Nisbet Yilmaz,

We aimed to investigate the thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension with a novel and automated method. Blood thiol/disulphide homeostasis, which consists of native thiol/disulphide exchanges, was investigated in 45 patients with primary hypertension and 45 healthy controls. The levels of native thiol, total thiol, and native ... Read more >>

J Am Soc Hypertens (Journal of the American Society of Hypertension : JASH)
[2016, 10(2):159-166]

Cited: 21 times

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Coexistence of immunoglobulin M nephropathy and autoimmune hemolytic anemia: 2 rare entities.

Nergiz Bayrakci, Nihal Ozkayar, Muge Erek Ersozen, Aysel Colak, Ebru Gok Oguz, Fatih Dede,

Immunoglobulin M (IgM) nephropathy is described as mesengial proliferative glomerulonephritis with diffuse mesengial IgM deposition. We report a patient diagnosed with IgM nephropathy and concomitant autoimmune hemolytic anemia syndrome associated with cold-reacting autoantibodies. Complete remission was achieved with systemic corticosteroid and plasmapheresesis. ... Read more >>

Iran J Kidney Dis (Iranian journal of kidney diseases)
[2015, 9(6):472-474]

Cited: 0 times

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Association between high platelet indices and proteinuria in patients with hypertension.

Ihsan Ates, Mesudiye Bulut, Nihal Ozkayar, Fatih Dede,

We aimed to determine the association between platelet indices including plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and proteinuria associated with hypertension (HT) as well as the relative power of each to predict proteinuria.The study included 223 patients (68 men and 155 women) with primary HT. PCT, ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2015, 35(6):630-634]

Cited: 14 times

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Is disulphide/thiol ratio related to blood pressure in masked hypertension?

İhsan Ateş, Nihal Ozkayar, Mustafa Altay, Fatma Meriç Yilmaz, Canan Topçuoğlu, Murat Alışık, Özcan Erel, Fatih Dede,

Dynamic thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defence and detoxification. In this study, we sought to investigate dynamic thiol/disulphide homeostasis in patients with masked hypertension (MHT) and its relationship with blood pressure. Forty patients (23 men, 17 women) with newly diagnosed MHT and ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2016, 38(2):150-154]

Cited: 8 times

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Unknown aspect of the old disease: does dyslipidemia in systemic AA amyloidosis differ from the dyslipidemia in primary glomerulonephritis?

Serhan Piskinpasa, Kemal Agbaht, Hadim Akoglu, Fatma Akyel, Nihal Ozkayar, Ezgi Yenigun Coskun, Didem Turgut, Eyup Koc, Ali Riza Odabas, Fatih Dede,

AIM:To investigate the nature of dyslipidemia and its diversity in patients with systemic AA amyloidosis. METHODS:The reports of the kidney biopsies performed due to nephrotic proteinuria (>3.5 g/day/1.73 m(2)) with preserved renal function [glomerular filtration rate (GFR) >60 mL/min/1.73 m(2)] were reviewed. Clinical and laboratory data of the patients with systemic AA amyloidosis and ... Read more >>

Ren Fail (Renal failure)
[2015, 37(8):1273-1279]

Cited: 1 time

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Relationship between oxidative stress parameters and asymptomatic organ damage in hypertensive patients without diabetes mellitus.

Ihsan Ates, Nihal Ozkayar, Canan Topcuoglu, Fatih Dede,

We aimed to evaluate the levels of oxidative stress (OS) parameters such as total antioxidant status or TAS, total oxidant status (TOS), OS index (OSI), paraoxonase 1 (PON1), arylesterase, and total thiol in hypertensive patients with and without asymptomatic organ damage (AOD), and to determine the relationship between these parameters ... Read more >>

Scand Cardiovasc J (Scandinavian cardiovascular journal : SCJ)
[2015, 49(5):249-256]

Cited: 7 times

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Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.

Nihal Ozkayar, Serhan Piskinpasa, Fatma Akyel, Didem Turgut, Mesudiye Bulut, Turan Turhan, Fatih Dede,

We aimed to investigate the role of cathepsin D, an inflammatory and atherosclerotic mediator, in endothelial dysfunction in chronic kidney disease. The study included 65 patients with stage 2–4 chronic kidney disease (35 females, 30 males; mean age, 55.8±15.6 years). Serum creatinine and cathepsin D levels and glomerular filtration rates ... Read more >>

Nefrologia (Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
[2015, 35(1):72-79]

Cited: 7 times

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Prognostic factors in crescentic glomerulonephritis: a single-center experience.

Ramazan Ozturk, Ezgi Coskun Yenigun, Fatih Dede, Eyup Koc, Didem Turgut, Serhan Vahit Piskinpasa, Nihal Ozkayar, Ali Riza Odabas,

INTRODUCTION: Crescentic glomerulonephritis (CGN) is a fatal disease, rapidly leading to end-stage renal disease. Diagnosis should be accurate and treatment should be started immediately. We investigated the factors associated with the renal prognosis in CGN patients. MATERIALS AND METHODS: Forty-one patients with CGN who were followed up at the Nephrology ... Read more >>

Iran J Kidney Dis (Iranian journal of kidney diseases)
[2015, 9(1):31-38]

Cited: 0 times

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The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients.

Ihsan Ates, Nihal Ozkayar, Fatma Akyel, Canan Topcuoglu, Serdar Akyel, A Nurdan Barça, Fatih Dede,

BACKGROUND: This study aimed to measure the serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in hypertensive patients with/without asymptomatic organ damage (AOD), as well as to determine the relationship between the serum sTWEAK and IL17-A levels, and carotid intima media thickness (CIMT), proteinuria, ... Read more >>

BMC Nephrol (BMC nephrology)
[2014, 15:159]

Cited: 5 times

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A case report on allergic rash caused by icodextrin.

Şimal Köksal Cevher, Nihal Ozkayar, Fatih Dede,

Icodextrin may be used as an alternative to glucose as the osmotic agent in peritoneal dialysis with ultrafiltration failure. In general, icodextrin is known to be safe and well tolerated, but it can also cause hypersensitivity reactions such as skin rashes. Allergic rashes are generally defined as erythematous, itchy and ... Read more >>

Case Rep Nephrol Dial (Case reports in nephrology and dialysis)
[2015, 5(1):26-29]

Cited: 1 time

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Coexistence of autosomal dominant polycystic kidney disease and amyloidosis in a patient with nephrotic-range proteinuria.

Ezgi Coskun Yenigun, Fatih Dede, Nihal Ozkayar, Didem Turgut, Serhan Vahit Piskinpasa, Ramazan Ozturk, Eyup Koc, Ali Riza Odabas,

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by the development and growth of cysts in the kidneys. Non-nephritic-range proteinuria is a common presentation in ADPKD patients; however, nephrotic syndrome is a rare coincidence. A 52-year-old man is described who was diagnosed with secondary amyloidosis with ADPKD. ... Read more >>

Iran J Kidney Dis (Iranian journal of kidney diseases)
[2014, 8(3):243-245]

Cited: 3 times

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