Full Text Journal Articles by
Author Fathi Hassan


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Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae.

Sabine Stoetzel, Deeksha Malhan, Ute Wild, Christian Helbing, Fathi Hassan, Sameh Attia, Klaus D Jandt, Christian Heiss, Thaqif El Khassawna,

Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these properties by adding bioactive coatings. In this preclinical study, extracellular matrix properties and cellular balance at the implant/bone interface ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 23(1):]

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DXA reference values of the humanoid sheep model in preclinical studies.

Christoph Biehl, Jakob Schmitt, Sabine Stoetzel, Deeksha Malhan, Fathi Hassan, Gero Knapp, Christian Heiss, Thaqif El Khassawna,

<h4>Background</h4>Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not established. This study aims to determine the reference parameters of the skeletal system (peak bone mass = PBM, ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11183]

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

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Lack of efficacy of transgenic pea (Pisum sativum L.) stably expressing antifungal genes against Fusarium spp. in three years of confined field trials.

Jagroop Gill Kahlon, Hans-Jörg Jacobsen, Syama Chatterton, Fathi Hassan, Robyne Bowness, Linda M Hall,

Fusarium root rot is a major pea disease in Canada and only partial tolerance exists in germplasm. Transgenic technologies may hold promise but the economic benefits of genetically modified (GM) pea will need to surpass the regulatory costs, time and labor involved in bringing a GM crop to market. European ... Read more >>

GM Crops Food (GM crops & food)
[2018, 9(2):90-108]

Cited: 0 times

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Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste.

Qusai Al Khasawnah, Fathi Hassan, Deeksha Malhan, Markus Engelhardt, Diaa Eldin S Daghma, Dima Obidat, Katrin S Lips, Thaqif El Khassawna, Christian Heiss,

<h4>Background</h4>The study aim is to avoid tooth extraction by nonsurgical treatment of periapical lesion. It assesses healing progress in response to calcium hydroxide-iodoform-silicon oil paste (CHISP). Numeric Pain Rating Scale was used to validate the approach. Furthermore, CHISP was used to treat cystic lesions secondary to posttraumatic avulsion of permanent ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:8198795]

Cited: 1 time

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Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.

Diaa Eldin S Daghma, Deeksha Malhan, Paul Simon, Sabine Stötzel, Stefanie Kern, Fathi Hassan, Katrin Susanne Lips, Christian Heiss, Thaqif El Khassawna,

Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlooked. The current study ... Read more >>

J Bone Miner Metab (Journal of bone and mineral metabolism)
[2018, 36(3):297-306]

Cited: 7 times

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Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

Thaqif El Khassawna, Felix Merboth, Deeksha Malhan, Wolfgang Böcker, Diaa E S Daghma, Sabine Stoetzel, Stefanie Kern, Fathi Hassan, Dirk Rosenbaum, Judith Langenstein, Natali Bauer, Anja Schlagenhauf, Angela Rösen-Wolff, Felix Schulze, Markus Rupp, Dirk Hose, Anja Secklinger, Anita Ignatius, Hans-Joachim Wilke, Katrin S Lips, Christian Heiss,

Osteoporosis induction in a sheep model by steroid administration combined with ovariectomy recapitulates decreased bone formation and substandard matrix mineralization in patients. Recently, the role of osteocytes has been frequently addressed, with focus on their role in osteoclastogenesis. However, the quantification of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin ... Read more >>

Am J Pathol (The American journal of pathology)
[2017, 187(8):1686-1699]

Cited: 6 times

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Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals.

Thaqif El Khassawna, Diaa Eldin S Daghma, Sabine Stoetzel, Seemun Ray, Stefanie Kern, Deeksha Malhan, Volker Alt, Ulrich Thormann, Anja Henß, Marcus Rohnke, Annette Stengel, Fathi Hassan, Stefan Maenz, Klaus D Jandt, Michael Diefenbeck, Matthias Schumacher, Michael Gelinsky, Katrin Susanne Lips, Christian Heiss,

Bone histology of decalcified or undecalcified samples depends on the investigation. However, in research each method provides different information to answer the scientific question. Decalcification is the first step after sample fixation and governs what analysis is later feasible on the sections. Besides, decalcification is favored for immunostaining and in ... Read more >>

Biomed Res Int (BioMed research international)
[2017, 2017:2023853]

Cited: 1 time

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Molecular and functional characterization of cry1Ac transgenic pea lines.

Alemayehu Teressa Negawo, Linda Baranek, Hans-Jörg Jacobsen, Fathi Hassan,

Transgenic pea lines transformed with the cry1Ac gene were characterized at molecular (PCR, RT-PCR, qRT-PCR and immunostrip assay) and functional levels (leaf paint and insect feeding bioassays). The results showed the presence, expression, inheritance and functionality of the introduced transgene at different progeny levels. Variation in the expression of the ... Read more >>

GM Crops Food (GM crops & food)
[2016, 7(3-4):159-174]

Cited: 1 time

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Enhanced tolerance to drought and salt stresses in transgenic faba bean (Vicia faba L.) plants by heterologous expression of the PR10a gene from potato.

Moemen S Hanafy, Antar El-Banna, Heinz Martin Schumacher, Hans-Jörg Jacobsen, Fathi S Hassan,

<h4>Key message</h4>We report for the first time that expression of potato PR10a gene in faba bean causes enhanced tolerance to drought and salinity. Grain legumes such as soybean (Glycine max L. Merrill), pea (Pisum sativum L.) and faba bean (Vicia faba L.) are staple sources of protein for human and ... Read more >>

Plant Cell Rep (Plant cell reports)
[2013, 32(5):663-674]

Cited: 14 times

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Effect of antifungal genes expressed in transgenic pea (Pisum sativum L.) on root colonization with Glomus intraradices.

Fathi Hassan, Mojgan Sharifi Noorian, Hans-Jörg Jacobsen,

Pathogenic fungi have always been a major problem in agriculture. One of the effective methods for controlling pathogen fungi to date is the introduction of resistance genes into the genome of crops. It is interesting to find out whether the induced resistance in crops will have a negative effect on ... Read more >>

GM Crops Food (GM crops & food)
[2012, 3(4):301-309]

Cited: 2 times

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Enhancing transgenic pea (Pisum sativum L.) resistance against fungal diseases through stacking of two antifungal genes (chitinase and glucanase).

Awah Anna Amian, Jutta Papenbrock, Hans-Jörg Jacobsen, Fathi Hassan,

One way of enhancing and broadening resistance of plants to different biotic and abiotic stresses is to combine transgenes expressing several genes into a single line. This can be done using different strategies such as crossing, single vector with multiple genes, co-transformation, sequential transformation and IRES elements. In the present ... Read more >>

GM Crops (GM crops)
[2011, 2(2):104-109]

Cited: 19 times

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A family 19 chitinase (Chit30) from Streptomyces olivaceoviridis ATCC 11238 expressed in transgenic pea affects the development of T. harzianum in vitro.

Fathi Hassan, Jochen Meens, Hans-Jörg Jacobsen, Heiko Kiesecker,

Embryo axes excised from mature seeds of pea (Pisum sativum L.) cv. 'Sponsor' were used as explants for Agrobacterium-mediated transformation using pGreenII 0229 binary vectors. The vectors harbored a chimeric chitinase gene (chit30), driven by the constitutive 35S promoter or the elicitor inducible stilbene synthase (vst) promoter from grape (Vitis ... Read more >>

J Biotechnol (Journal of biotechnology)
[2009, 143(4):302-308]

Cited: 11 times

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