Full Text Journal Articles by
Author Farhat Jabeen

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Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation - hospital-based study.

Towseef Amin Rafeeqi, Farhat Jabeen, M A Waheed, Gulam Mohammed Husain, Alokananda Chakraborthy,

Background Vitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a ... Read more >>

J Complement Integr Med (Journal of complementary & integrative medicine)
[2020, 17(3):]

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CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome.

Sairish Ashraf, Shayaq Ul Abeer Rasool, Mudasar Nabi, Mohd Ashraf Ganie, Farhat Jabeen, Fouzia Rashid, Shajrul Amin,

Objective: Polycystic ovarian syndrome is a complex reproductive as well as endocrinological disorder characterized by anovulatory dysfunction, androgen excess and polycystic ovarian morphology. Hyperandrogenism is regarded as a cardinal feature of the disease. It is believed that the excess androgens are produced due to abnormality in steroid biosynthesis pathway wherein ... Read more >>

Gynecol. Endocrinol. (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2020, :1-5]

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Insecticidal and Genotoxic effects of some indigenous plant extracts in Culex quinquefasciatus Say Mosquitoes.

Muhammad Zulhussnain, Muhammad Kashif Zahoor, Hina Rizvi, Muhammad Asif Zahoor, Azhar Rasul, Aftab Ahmad, Humara Naz Majeed, Amer Rasul, Kanwal Ranian, Farhat Jabeen,

Five different weed plants viz. Convulvulus arvensis, Chenopodium murale, Tribulus terrestris, Trianthema portulacastrum, and Achyranthes aspera were investigated for their entomocidal and genotoxic effects against Culex quinquefasciatus mosquitoes. High mortality was observed at 72 hours in a dose dependent manner. Among all the tested plants, A. aspera was found highly significant ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6826]

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The role of garlic oil in the amelioration of oxidative stress and tissue damage in rohu Labeo rohita treated with silver nanoparticles

Muhammad Saleem Khan, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Wajid, Sabeen Sabri, Muhammad Shakir,

Aquatic contamination with silver nanoparticles (Ag-NPs) can cause toxicity in target organisms that are directly exposed to them. Oxidative stress and tissue alterations are potential endpoints of Ag-NPs toxicity. We determined whether garlic oil can ameliorate the effects of toxicity induced by amine-coated and spherical Ag-NPs in 100 ± 5 g freshwater rohu ... Read more >>

(Fisheries science : FS)
[2020, 86(2):255-269]

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Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction.

Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultana,

Eriocalyxin B (EriB), a potent ent-kaurene extracted from Isodon eriocalyx, has turned up as novel anti-cancer agent during recent years against a range of cancer types. TNBC (Triple negative breast cancer) is highly aggressive breast cancer, which is resistant towards current therapeutics due to absence of drug targets. Here, we ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(6(Supplementary)):2843-2848]

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Naheed Akhter, Sadia Zafar, Farhat Jabeen, Mohammad Ali Shariati, Naheed Akhtar, Zarfishan Riaz, Syed Hassan Altaf, Muhammad Daniyal, Muhammad Daniyal, Rabia Zahid, Fahad Said Khan,

CONTEXT:Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. OBJECTIVE:The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(2):161-174]

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Reconnoitring the impact of different extraction techniques on ginger bioactive moieties extraction, antioxidant characterization and physicochemical properties for their therapeutic effect.

Tanzeelur Rehman, Muhammad Umair Arshad, Rabia Shabir Ahmad, Bilal Rasool, Ghulam Hussain, Farhan Saeed, Muhammad Shahbaz, Aftab Ahmed, Muhammad Imran, Muhammad Asif Khan, Furukh Faiz, Yasmin Bano, Rizwan Munir, Muhammad Nadeem, Farhat Jabeen, Ali Imran,

The core directive of current study was to compare the different extraction techniques for their extraction yield of ginger bioactive moieties. Purposely, ultrasonic assisted and supercritical fluid extraction techniques were adapted alongside conventional solvent extraction for comparison. The variables targeted for the extraction process in different modules were time (20, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2223-2236]

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Neurotoxic effects of titanium dioxide nanoparticles on the brain of male sprague dawley rats.

Muhammad Asif Latif, Farhat Jabeen, Muhammad Ali, Azhar Rasul, Shahbana Naz, Muhammad Akram,

Titanium dioxide nanoparticles have diverse applications in many fields and are used in cosmetics, sterilization, paints, tooth paste, food products, air cleaning, sunscreens and waste water treatment plants due to their unique properties. But on the other hand, the wide use of titanium dioxide nanoparticles raises concerns to the upcoming ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2311-2316]

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Tuberculosis Preventive Therapy for Individuals Exposed to Drug-resistant Tuberculosis: Feasibility and Safety of a Community-based Delivery of Fluoroquinolone-containing Preventive Regimen.

Amyn A Malik, Junaid Fuad, Sara Siddiqui, Farhana Amanullah, Maria Jaswal, Zainab Barry, Farhat Jabeen, Razia Fatima, Courtney M Yuen, Naseem Salahuddin, Aamir J Khan, Salmaan Keshavjee, Mercedes C Becerra, Hamidah Hussain,

BACKGROUND:Observational studies have demonstrated the effectiveness of a fluoroquinolone-based regimen to treat individuals presumed to be infected with drug-resistant tuberculosis (DR-TB). We sought to assess the feasibility of this approach in an urban setting in South Asia. METHODS:From February 2016 until March 2017, all household contacts of DR-TB patients enrolled ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(9):1958-1965]

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Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review.

Ghazala Shaheen, Muhammad Akram, Farhat Jabeen, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Daniyal, Muhammad Riaz, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Sabira Sultana, Rida Zainab, Muslim Khan,

Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2019, 46(7):613-624]

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Histopathological changes and antioxidant responses in common carp (Cyprinus carpio) exposed to copper nanoparticles.

Aasma Noureen, Farhat Jabeen, Tanveer A Tabish, Muhammad Ali, Rehana Iqbal, Sajid Yaqub, Abdul Shakoor Chaudhry,

Despite the rapid increase of nanotechnology in a wide array of industrial sectors, the biosafety profile of nanomaterials remains undefined. The accelerated use of nanomaterials has increased the potential discharge of nanomaterials into the environment in different ways. The aquatic environment is mainly susceptible as it is likely to act ... Read more >>

Drug Chem Toxicol (Drug and chemical toxicology)
[2019, :1-8]

Cited: 1 time

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Progress and prospects in the management of psoriasis and developments in phyto-therapeutic modalities.

Muhammad Daniyal, Muhammad Akram, Rida Zainab, Naveed Munir, Syed Muhammad Ali Shah, Bin Liu, Wei Wang, Muhammad Riaz, Farhat Jabeen,

The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2019, 32(3):e12866]

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Ameliorative effects of Moringa oleifera on copper nanoparticle induced toxicity in Cyprinus carpio assessed by histology and oxidative stress markers.

Aasma Noureen, Farhat Jabeen, Tanveer A Tabish, Muhammad Kashif Zahoor, Muhammad Ali, Rehana Iqbal, Sajid Yaqub, Abdul Shakoor Chaudhry,

Nanoparticles (NPs) enter the environment mainly through waste water effluents, accidental spillage, and industrial runoffs. This is worrying because NPs can enter the human body owing to their large aspect-to-size ratio and reactive surfaces that facilitate their penetration through biological barriers and thus can induce oxidative stress in host cells. ... Read more >>

Nanotechnology (Nanotechnology)
[2018, 29(46):464003]

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Malic enzyme 2 as a potential therapeutic drug target for cancer.

Iqra Sarfraz, Azhar Rasul, Ghulam Hussain, Syed Makhdoom Hussain, Matloob Ahmad, Bushra Nageen, Farhat Jabeen, Zeliha Selamoglu, Muhammad Ali,

Reprogrammed metabolic profile is a biochemical fingerprint of cancerous cells, which represents one of the "hallmarks of cancer." The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular growth, survival, and proliferation. The NADP(+)-dependent mitochondrial malic enzyme 2 (ME2) has been widely appreciated ... Read more >>

IUBMB Life (IUBMB life)
[2018, 70(11):1076-1083]

Cited: 2 times

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Comparative evaluation of antibacterial activity of foot muscle extracts from genus Physa and genus Ceciloides (Mollusca: Gastropoda).

Javaria Altaf, Muhammad Hidayat Rasool, Saira Akhtar, Maleeha Manzoor, Tahira Younas, Bakhtawer Ansari, Gulraiz Ahmad, Farhat Jabeen, Muhammad Ali, Rizwan Munir,

The aim of this study is to explore the presence of antimicrobial bioactive agents in the foot muscle extracts of snails belonging to genus Physa and Ceciloides. Antibacterial activity of foot extracts belonging to species named as P. fontinalis, P. gyrina, P. acuta, C. acicula, C. eulima, C. petitiana, was ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1555-1563]

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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities.

Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu,

Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted ... Read more >>

(Advances in pharmacological sciences)
[2018, 2018:9794625]

Cited: 10 times

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Investigating the bioavailability of graphene quantum dots in lung tissues via Fourier transform infrared spectroscopy.

Tanveer A Tabish, Liangxu Lin, Muhammad Ali, Farhat Jabeen, Muhammad Ali, Rehana Iqbal, David W Horsell, Paul G Winyard, Shaowei Zhang,

Biomolecular fractions affect the fate and behaviour of quantum dots (QDs) in living systems but how the interactions between biomolecules and QDs affect the bioavailability of QDs is a major knowledge gap in risk assessment analysis. The transport of QDs after release into a living organism is a complex process. ... Read more >>

(Interface focus)
[2018, 8(3):20170054]

Cited: 2 times

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Evaluating toxicity of copper(II) oxide nanoparticles (CuO-NPs) through waterborne exposure to tilapia (Oreochromis mossambicus) by tissue accumulation, oxidative stress, histopathology, and genotoxicity.

Khurram Shahzad, Muhammad Naeem Khan, Farhat Jabeen, Nasreen Kosour, Abdul Shakoor Chaudhry, Muhammad Sohail,

Metal oxide nanoparticles are widely used in industries, and peak level can be confirmed in their surroundings. In the present study, the sub-lethal effects of CuO-NPs from low to high concentration as 0.5 to 1.5 mg/L were observed in tilapia (Oreochromis mossambicus). Accumulation of copper from CuO-NPs was increased with the ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2018, 25(16):15943-15953]

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Toxicity, Phytochemical Composition, and Enzyme Inhibitory Activities of Some Indigenous Weed Plant Extracts in Fruit Fly, Drosophila melanogaster.

Bushra Riaz, Muhammad Kashif Zahoor, Muhammad Asif Zahoor, Humara Naz Majeed, Irum Javed, Aftab Ahmad, Farhat Jabeen, Muhammad Zulhussnain, Kishwar Sultana,

Drosophila melanogaster being used as model organism is considered as pest of homes, restaurants, and fruit markets. The damaged fruits are also reported to serve as a carrier for various diseases. The current study was designed to evaluate the toxicity of petroleum extract of some weed plants, namely, Euphorbia prostrata, ... Read more >>

(Evidence-based complementary and alternative medicine : eCAM)
[2018, 2018:2325659]

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Assessment of copper nanoparticles (Cu-NPs) and copper (II) oxide (CuO) induced hemato- and hepatotoxicity in Cyprinus carpio.

Aasma Noureen, Farhat Jabeen, Tanveer A Tabish, Sajid Yaqub, Muhammad Ali, Abdul Shakoor Chaudhry,

Recently, Cu-based nanoparticles have drawn considerable attention for their various fascinating roles in multiple biological systems. It is recognized that their frequent use can create compatibility challenges for the recipient systems. Nevertheless, it is unclear how various biological interactions affect the compatibility of Cu oxide II (CuO) and Cu oxide ... Read more >>

Nanotechnology (Nanotechnology)
[2018, 29(14):144003]

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Ameliorative Effects of Selenium in ZnO NP-Induced Oxidative Stress and Hematological Alterations in Catla catla.

Muhammad Saleem Asghar, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Saleem Khan, Muhammad Shakeel, Abdul Shakoor Chaudhry,

Various applications of zinc oxide nanoparticles (ZnO NPs) can increase pollution in aquatic environments. Consequently, pollution can cause toxicity in fish as indicated by oxidative stress, hematotoxicity, and changes in gill and liver histology. Selenium is known for its antioxidant potential in scavenging the free radicals generated during ZnO NP-induced ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2018, 186(1):279-287]

Cited: 1 time

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Fraxinus: A Plant with Versatile Pharmacological and Biological Activities.

Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali,

Fraxinus, a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a ... Read more >>

(Evidence-based complementary and alternative medicine : eCAM)
[2017, 2017:4269868]

Cited: 11 times

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Assessment of Waterborne Amine-Coated Silver Nanoparticle (Ag-NP)-Induced Toxicity in Labeo rohita by Histological and Hematological Profiles.

Muhammad Saleem Khan, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Shakeel, Muhammad Saleem Asghar,

Silver nanoparticles (Ag-NPs) have wide applications in the medical field; however, the toxicological effects are still poorly studied. The study was aimed to determine the effects of 15.78 nm spherical and amine-coated Ag-NPs on hematology and histology of gills and liver tissues in 28 days treated Labeo rohita (L. rohita). It was ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2018, 182(1):130-139]

Cited: 1 time

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Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats.

Muhammad Shakeel, Farhat Jabeen, Rehana Iqbal, Abdul Shakoor Chaudhry, Sadia Zafar, Muhammad Ali, Muhammad Saleem Khan, Adeel Khalid, Samina Shabbir, Muhammad Saleem Asghar,

This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2018, 182(1):57-69]

Cited: 5 times

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Effect of Climatic Conditions and Water Bodies on Population Dynamics of the Dengue Vector, Aedes aegypti (Diptera: Culicidae).

Shabab Nasir, Farhat Jabeen, Sadia Abbas, Iram Nasir, Mustapha Debboun,

BACKGROUND:The population of mosquitoes is mainly influenced by the biotic and abiotic factors. Although Aedes aegypti was reported until 1960's in the Punjab, Pakistan, the population has increased dramatically since 2009 and caused severe epidemics in 2011 due to heavy floods and rains. Thus, this study was carried out to ... Read more >>

(Journal of arthropod-borne diseases)
[2017, 11(1):50-59]

Cited: 1 time

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