Full Text Journal Articles by
Author Fangtian Bu


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The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.

Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li,

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis; however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was used to predict the potential upstream targets of HDAC2, and the role of miR-455-3p was explored. The dual luciferase reporter assay showed that miR-455-3p binds to the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21700]

Cited: 0 times

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The Long Non-coding RNA MEG3/miR-let-7c-5p Axis Regulates Ethanol-Induced Hepatic Steatosis and Apoptosis by Targeting NLRC5.

Qin Wang, Mingfang Li, Zhiming Shen, Fangtian Bu, Haixia Yu, Xueyin Pan, Yang Yang, Xiaoming Meng, Cheng Huang, Jun Li,

Ethanol (EtOH)-induced hepatic injury, characterized by hepatic steatosis with apoptosis, causes heavy health burden personally and socially. Long non-coding RNAs (lncRNAs) have been implicated in liver diseases. However, the role of lncRNA maternally expressed gene 3 (MEG3) in EtOH-induced hepatic injury remains unknown. The aim of present study was to ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:302]

Cited: 5 times

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Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis.

Yuting Wu, Fangtian Bu, Haixia Yu, Wanxia Li, Cheng Huang, Xiaoming Meng, Lei Zhang, Taotao Ma, Jun Li,

Liver fibrosis, resulting from chronic and persistent injury to the liver, is a worldwide health problem. Advanced liver fibrosis results in cirrhosis, liver failure and even hepatocellular cancer (HCC), often eventually requiring liver transplantation, poses a huge health burden on the global community. However, the specific pathogenesis of liver fibrosis ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2017, 315:35-49]

Cited: 15 times

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