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Predictive value of sub classification of focal segmental glomerular sclerosis in Oxford classification of IgA nephropathy.

Fang Yu, Xuejing Zhu, Shuguang Yuan, Xiaojun Chen, Zheng Li, Zhong Qu, Hong Liu, Lin Sun, Fuyou Liu,

<h4>Background</h4>The Oxford classification of IgA nephropathy (IgAN) was revised in 2016 which lacked sufficient evidence for prognostic value of subclassification of focal segmental glomerular sclerosis (S lesion), and the proper proportion of S lesion for subclassification remains undetermined.<h4>Aim</h4>This study aimed to explore the predictive value of the new subclassification of ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):587-595]

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Boosting Alkaline Hydrogen and Oxygen Evolution Kinetic Process of Tungsten Disulfide-Based Heterostructures by Multi-Site Engineering.

Jinsong Zeng, Long Zhang, Qian Zhou, Liling Liao, Ying Qi, Haiqing Zhou, Dongyang Li, Fengming Cai, Hui Wang, Dongsheng Tang, Fang Yu,

Alkaline water electrolysis is an advanced technology for scalable H<sub>2</sub> production using surplus electricity from intermittent energy sources, but it remains challenging for non-noble electrocatalysts to split water into hydrogen and oxygen efficiently, especially for tungsten disulfide (WS<sub>2</sub> )-based catalysts. Density functional theory calculations in combination with experimental study are ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, :e2104624]

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Circ_0070203 Promotes Epithelial Mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis

Qiong Tang, Huiting Wen, Xiaoli Chen, Xiushu Xu, Xiaoer Chen, Yu Fang, Yingshan Gao, Liu longyang, Jing Li,

<h4>Background: </h4> Ovarian serous cystadenocarcinoma (OC) is a common malignant gynecological tumor that is found in women. Metastasis of ovarian cancer cells are the main causes of poor prognosis. Cell-acquired invasiveness is accompanied by the loss of epithelial features and gain of a mesenchymal phenotype, through a process known as ... Read more >>

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Towards Biomanufacturing of Cell-Derived Matrices.

Weng Wan Chan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee, Deepak Choudhury,

Cell-derived matrices (CDM) are the decellularised extracellular matrices (ECM) of tissues obtained by the laboratory culture process. CDM is developed to mimic, to a certain extent, the properties of the needed natural tissue and thus to obviate the use of animals. The composition of CDM can be tailored for intended ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(21):]

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Film Nanoarchitectonics of Pillar[5]arene for High-Performance Fluorescent Sensing: a Proof-of-Concept Study.

Binbin Zhai, Rongrong Huang, Jiaqi Tang, Min Li, Jinglun Yang, Gang Wang, Kaiqiang Liu, Yu Fang,

Substrates play crucial roles for the sensing performances of fluorescent films owing to their effect on the formation of a fluorescent adlayer. However, no such film has been developed through synthesizing a substrate with a defined structure. We herein report a kind of self-standing, uniform, and thickness tunable pillar[5]arene-based nanofilms ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, :]

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The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

Olga Giannakopoulou, Kuang Lin, Xiangrui Meng, Mei-Hsin Su, Po-Hsiu Kuo, Roseann E Peterson, Swapnil Awasthi, Arden Moscati, Jonathan R I Coleman, Nick Bass, Iona Y Millwood, Yiping Chen, Zhengming Chen, Hsi-Chung Chen, Mong-Liang Lu, Ming-Chyi Huang, Chun-Hsin Chen, Eli A Stahl, Ruth J F Loos, Niamh Mullins, Robert J Ursano, Ronald C Kessler, Murray B Stein, Srijan Sen, Laura J Scott, Margit Burmeister, Yu Fang, Jess Tyrrell, Yunxuan Jiang, Chao Tian, Andrew M McIntosh, Stephan Ripke, Erin C Dunn, Kenneth S Kendler, Robin G Walters, Cathryn M Lewis, Karoline Kuchenbaecker, ,

<h4>Importance</h4>Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.<h4>Objective</h4>To investigate the genetics of depression among individuals of East Asian and European descent living ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2021, 78(11):1258-1269]

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Proteoglycan-depleted regions of annular injury promote nerve ingrowth in a rabbit disc degeneration model.

Long Xin, Weixin Xu, Jian Wang, Fang Yu, Shunwu Fan, Xinwei Xu, Yang Yang,

<h4>Background</h4>To assess the effects of proteoglycan-depleted regions of annular disruptions on nerve ingrowth in the injury site <i>in vivo</i>.<h4>Methods</h4>New Zealand white rabbits (<i>n</i> = 18) received annular injuries at L3/4, L4/5, and L5/6. The experimental discs were randomly assigned to four groups: (a) an annular defect was created; (b) an ... Read more >>

Open Med (Wars) (Open medicine (Warsaw, Poland))
[2021, 16(1):1616-1627]

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Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

Yu Xiao, Wan Jin, Kaiyu Qian, Kai Wu, Gang Wang, Wei Jiang, Rui Cao, Lingao Ju, Yan Zhao, Hang Zheng, Tongzu Liu, Luyuan Chang, Zilin Xu, Ting Wang, Jun Luo, Liuying Shan, Fang Yu, Xintong Chen, Dongmei Liu, Hong Cao, Zhonghua Yang, Sheng Li, Hongjie Shi, Zhongqiang Guo, Yan Gong, Nan Liu, Shenjuan Li, Yejinpeng Wang, Xinyue Cao, Wenjun Ding, Wei Zhou, Diansheng Cui, Ye Tian, Chundong Ji, Yongwen Luo, Xin Hong, Haoli Ma, Fangjin Chen, Minsheng Peng, Yi Zhang, Xinghuan Wang,

Intratumor heterogeneity (ITH) of bladder cancer (BLCA) facilitates therapy resistance and immune evasion to affect clinical prognosis directly. However, the molecular and cellular mechanism generating ITH in BLCA remains elusive. Here we show that a TM4SF1-positive cancer subpopulation (TPCS) drives ITH diversification in BLCA. By extensive profiling of the epigenome ... Read more >>

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Effect of Grain Refiner on Fracture Toughness of 7050 Ingot and Plate.

Fang Yu, Xiangjie Wang, Tongjian Huang, Daiyi Chao,

In this paper, two types of grain refining alloys, Al-3Ti-0.15C and Al-5Ti-0.2B, were used to cast two types of 7050 rolling ingots. The effect of Al-3Ti-0.15C and Al-5Ti-0.2B grain refiners on fracture toughness in different directions for 7050 ingots after heat treatment and 7050-T7651 plates was investigated using optical electron ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(21):]

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ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues.

Xuan Liu, Wenbo Chen, Yu Fang, Siqi Yang, Liuping Chang, Xingyu Chen, Haidong Ye, Xinyu Tang, Shan Zhong, Wen Zhang, Zhiqiang Dong, Leng Han, Chunjiang He,

Gene expression and immune status in human tissues are changed with aging. There is a need to develop a comprehensive platform to explore the dynamics of age-related gene expression and immune profiles across tissues in genome-wide studies. Here, we collected RNA-Seq datasets from GTEx project, containing 16 704 samples from 30 ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, 22(6):]

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Towards Biomanufacturing of Cell-Derived Matrices

Weng Wan Chan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee, Deepak Choudhury,

Cell-derived matrices (CDM) are the decellularised extracellular matrices (ECM) of tissues obtained by the laboratory culture process. CDM is developed to mimic, to a certain extent, the properties of the needed natural tissue and thus to obviate the use of animals. The composition of CDM can be tailored for intended ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(21):]

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Experiences of Work-Family Conflict and Mental Health Symptoms by Gender Among Physician Parents During the COVID-19 Pandemic.

Elena Frank, Zhuo Zhao, Yu Fang, Lisa S Rotenstein, Srijan Sen, Constance Guille,

The COVID-19 pandemic has placed increased strain on health care workers and disrupted childcare and schooling arrangements in unprecedented ways. As substantial gender inequalities existed in medicine before the pandemic, physician mothers may be at particular risk for adverse professional and psychological consequences. To assess gender differences in work-family factors ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(11):e2134315]

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Monomorphic Epitheliotropic Intestinal T Cell Lymphoma With Lower Gastrointestinal Hemorrhage: A Case Report and Literature Review

Cheng Zhou, Lin Yang, Hai-Juan Xiao, Xiao-Yan Ma, Rui-Ni Li, Yu Fang,

Enteropathy-associated T cell lymphoma(EATL) is a kind of malignant lymphoma with strong invasiveness. Due to poor effect of conventional symptomatic treatment, the prognosis is not as good as other T-cell lymphomas. A 63-year-old man was admitted to our hospital due to hematochezia. No definite cause was found by electronic gastroscopy ... Read more >>

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High-Quality Genome Sequence Resource of a Rice False Smut Fungus Ustilaginoidea virens Isolate, UV-FJ-1.

Jiandong Bao, Rong Wang, Shilei Gao, Zhe Wang, Yu Fang, Lv Wu, Mo Wang,

<i>Ustilaginoidea virens</i> is the fungal pathogen causing rice false smut, resulting in not only yield lost but also grain pollution with toxic mycotoxins. Here we deployed PacBio Sequel II HIFI-read sequencing technology to generate a near-complete genome assembly for the <i>U. virens</i> isolate UV-FJ-1 (38.48 Mb), which was isolated from ... Read more >>

Phytopathology (Phytopathology)
[2021, :PHYTO01210007A]

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Understanding parental self-medication with antibiotics among parents of different nationalities: a cross-sectional study.

Zhongliang Zhou, Dantong Zhao, Huarui Zhang, Chi Shen, Dan Cao, Guanping Liu, Liang Zhu, Yu Fang,

<h4>Background</h4>There is an increasing trend on the practices of parental self-medication with antibiotics (PSMA) around world, accelerating the antibiotic abuse. This study aims to examine the nationality differences in the practices of PSMA and knowledge, attitudes and practices (KAP) toward antibiotic use, and understand the practices of PSMA among parents ... Read more >>

Glob Health Res Policy (Global health research and policy)
[2021, 6(1):42]

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Investigation of Anxiety, Depression, Sleep, and Family Function in Caregivers of Children With Epilepsy.

Meiyan Zhang, Huiting Zhang, Shuxian Hu, Man Zhang, Yu Fang, Junjie Hu, Jianxiang Liao,

Objective: Epilepsy is a chronic disease that places a heavy burden on caregivers. Previous studies have shown that caregivers of epilepsy patients often experience anxiety and depression; however, few comprehensive studies have assessed their sleep quality and family function. Based on the current understanding of the anxiety and depression state ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:744017]

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Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis.

Ayat S Hammad, Fang Yu, Welathanthrige S Botheju, Asha Elmi, Ethel Alcantara-Adap, Khaled Machaca,

Store-operated Ca<sup>2+</sup> entry (SOCE) is a ubiquitous Ca<sup>2+</sup> influx pathway required for multiple physiological functions including cell motility. SOCE is triggered in response to depletion of intracellular Ca<sup>2+</sup> stores following the activation of the endoplasmic reticulum (ER) Ca<sup>2+</sup> sensor STIM1, which recruits the plasma membrane (PM) Ca<sup>2+</sup> channel Orai1 at ... Read more >>

Cell Calcium (Cell calcium)
[2021, 100:102496]

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H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.

Rui Liang, Xiaopeng Shen, Fan Wang, Xin Wang, Alex DesJarlais, Anam Syed, Raymond Saba, Zhi Tan, Fang Yu, Xuan Ji, Shreesti Shrestha, Yinghong Ren, Jin Yang, Yoonjung Park, Robert J Schwartz, Benjamin Soibam, Bradley K McConnell, M David Stewart, Ashok Kumar, Yu Liu,

<h4>Background</h4>Skeletal muscle atrophy is a debilitating complication of many chronic diseases, disuse conditions, and ageing. Genome-wide gene expression analyses have identified that elevated levels of microRNAs encoded by the H19X locus are among the most significant changes in skeletal muscles in a wide scope of human cachectic conditions. We have ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2021, :]

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A Qualitative Study Exploring the Management of Medicine Shortages in the Community Pharmacy of Pakistan.

Sumaira Omer, Salamat Ali, Sundus Shukar, Ali Hassan Gillani, Yu Fang, Caijun Yang,

Managing medicine shortages consumes ample time of pharmacists worldwide. This study aimed to explore the strategies and resources being utilized by community pharmacists to tackle a typical shortage problem. Qualitative face-to-face interviews were conducted. A total of 31 community pharmacists from three cities (Lahore, Multan, and Dera Ghazi Khan) in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(20):]

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Chlorogenic Acid Exerts Neuroprotective Effect Against Hypoxia-Ischemia Brain Injury in Neonatal Rats by activating Sirt1 to Regulate the Nrf2-NF-κB Signaling Pathway

Yihui Zheng, Zhenlang Lin, Luyao Li, Binwen Chen, Yu Fang, Wei Lin, Tianlei Zhang, Xiaoli Feng, Xiaoyue Tao, Yiqing Wu, Xiaoqin Fu,

<h4>Background: </h4> Neonatal hypoxic-ischemic brain injury (HIE) is caused by perinatal asphyxia, which is associated with various confounding factors. Although studies on the pathogenesis and treatment of HIE have matured, sub-hypothermia is the only clinical treatment available for HIE. Previous evidence indicates that chlorogenic acid (CGA) exerts a potential neuroprotective ... Read more >>

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Resonance-Enhanced Two-Photon Absorption and Optical Power Limiting Properties of Three-Dimensional Perylene Bisimide Derivatives.

Wan Feng, Ke Liu, Jianyang Zang, Jiale Xu, Haonan Peng, Liping Ding, Taihong Liu, Yu Fang,

Push-pull organic structures characterized by an intramolecular charge transfer (ICT) process and π-electron delocalization are potentially interesting luminescent materials. A series of three-dimensional <i>o</i>-carborane-containing perylene bisimide derivatives (PBIs) were synthesized, and their optical properties were systematically investigated to illustrate the stereo effect, especially on the two-photon absorption (2PA) and optical ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2021, :]

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Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer.

Jing Wang, Liangbo Hu, Hongyue Zhang, Yu Fang, Tingliang Wang, Huaimin Wang,

Biomolecular condensates have been demonstrated as a ubiquitous phenomenon in biological systems and play a crucial role in controlling cellular functions. However, the spatiotemporal construction of artificial biomolecular condensates with functions remains challenging and has been less explored. Herein, a general approach is reported to construct biomolecular condensates (e.g., hydrogel) ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, :e2104704]

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Fundamentals of Radiation Oncology for Treatment of Vertebral Metastases.

Sujana Gottumukkala, Udayan Srivastava, Samantha Brocklehurst, J Travis Mendel, Kiran Kumar, Fang F Yu, Amit Agarwal, Bhavya R Shah, Shaleen Vira, Karuna M Raj,

The fields of both radiology and radiation oncology have evolved considerably in the past few decades, resulting in an increased ability to delineate between tumor and normal tissue to precisely target and treat vertebral metastases with radiation therapy. These scientific advances have also led to improvements in assessing treatment response ... Read more >>

Radiographics (Radiographics : a review publication of the Radiological Society of North America, Inc)
[2021, 41(7):2136-2156]

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Mechanistic Effects of Aerobic Exercise in Alzheimer's Disease: Imaging Findings From the Pilot FIT-AD Trial.

Fang Yu, Michelle A Mathiason, SeungYong Han, Jeffrey L Gunter, David Jones, Hugo Botha, Clifford Jack,

Despite strong evidence from animal models of Alzheimer's disease (AD) supporting aerobic exercise as a disease-modifying treatment for AD, human mechanistic studies are limited with mixed findings. The objective of this pilot randomized controlled trial was to examine the effects of 6-month aerobic exercise on hippocampal volume, temporal meta-regions of ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:703691]

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Modeling the Percutaneous Absorption of Solvent-deposited Solids Over a Wide Dose Range.

Fang Yu, Kevin Tonnis, Lijing Xu, Joanna Jaworska, Gerald B Kasting,

The transient absorption of two skin care agents, niacinamide (nicotinamide, NA) and methyl nicotinate (MN), solvent-deposited on ex vivo human skin mounted in Franz diffusion cells has been analyzed according to a new variation on a recently published mechanistic skin permeability model (Yu et al. 2020. J Pharm Sci 110:2149-56). ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2021, :]

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