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Age-dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

<h4>Background</h4>Age-dependent differences in clinical presentation and viral loads in infants and young children with respiratory syncytial virus (RSV) infection, and their correlation with disease severity are poorly defined.<h4>Methods</h4>Previously healthy children <2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and viral loads measured by polymerase chain ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):116-122]

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Generation of two induced pluripotent stem cell lines SPPHi001-A and SPPHi002-A from a Huntington's disease family of Southwestern China.

Bin Li, Fang Ye, Li Chen, Xiangyu Yang, Ji Zhang, Yun Luo, Jie Xu, Yongjie Luo, Su Wang,

The Huntington's disease (HD) is still a devastating neurological disease without a specific cure. In this report, the peripheral blood mononuclear cells (PBMCs) from two members of a HD family from Southwestern China were reprogrammed into hiPSC lines by an episomal and non-integrating Sendai virus delivery method. The induced HD-hiPSC ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 50:102149]

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Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43.

Xiaoyang Zheng, Xiaoying Cai, Fang Ye, Ying Li, Qin Wang, Zhiyi Zuo, Wenqi Huang, Zhongxing Wang,

<h4>Background</h4>Astrocyte Connexin 43 (Cx43) is essential for the trophic and protective support of neurons during brain ischemia reperfusion (I/R) injury. It is believed that dexmedetomidine participates in Cx43-mediated effects. However, its mechanisms remained unclear. This study aims to address the relationship and regulation among them.<h4>Methods</h4>Adult male Sprague-Dawley rats were allocated ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2020, 20(1):299]

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Downregulation of GSK-3β Expression via Ultrasound-Targeted Microbubble Destruction Enhances Atherosclerotic Plaque Stability in New Zealand Rabbits.

Lifei Yang, Lingzi Chen, Ye Fang, Suya Ma,

Accumulating evidence suggests that atherosclerosis (AS) is the underlying cause of vascular diseases, including heart disease and stroke. Ultrasound-targeted microbubble destruction (UTMD) technology provides a tolerable, efficient and effective system for drug delivery and gene transfection, which has broad application prospects in the treatment of AS. In addition, glycogen synthase ... Read more >>

Ultrasound Med Biol (Ultrasound in medicine & biology)
[2020, :]

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Competing endogenous RNA network in newly diagnosed multiple myeloma by genetic microarray.

Yu-Qin He, Zhi-Yao Zhang, Hui-Xing Zhou, Fang Ye, Wen-Ming Chen,

Chin Med J (Engl) (Chinese medical journal)
[2020, 133(21):2619-2621]

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[Comparison of different minimally invasive internal fixation in the treatment of pelvic anterior ring fracture].

Hai-Lin Xing, Shu-Hua Lan, Shu-Ming Huang, Chong Wang, Xu-Feng Chu, Ji-Fei Ye, Fang Ye, Quan-Zhou Wu,

<h4>Objective</h4>To compare the clinical efficacy of three minimally invasive methods of anterior column screw, plate and screw rod system in the treatment of anterior pelvic ring fracture.<h4>Methods</h4>From December 2015 to September 2018, 77 patients with pelvic anterior ring fracture were treated and followed up, including 45 males and 32 females, ... Read more >>

Zhongguo Gu Shang (Zhongguo gu shang = China journal of orthopaedics and traumatology)
[2020, 33(11):1042-1047]

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Effects of processed Aconiti tuber on the extinction and reinstatement of morphine-induced conditioned place preference in rats.

Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Shu,

<h4>Aim of the study</h4>To investigate the effect of processed Aconiti tuber (PAT) administered during or after the time of conditioned place preference (CPP) training on the extinction and reinstatement of morphine-priming CPP in rats. The dynorphin level in rats' nucleus accumbens (NAc) is detected as a target of the Dynorphin/Kappa ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, 267:113524]

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Temporal changes of CT findings between non-severe and severe cases of COVID-19 pneumonia: a multi-center, retrospective, longitudinal Study.

Meng Dai, Xiaoming Liu, Xiqi Zhu, Tiejun Liu, Cihao Xu, Fang Ye, Lian Yang, Yu Zhang,

<b>Background and aim:</b> To perform a longitudinal analysis of serial CT findings over time in patients with COVID-19 pneumonia. <b>Methods:</b> From February 5 to March 8, 2020, 73 patients (male to female, ratio of 43:30; mean age, 51 years) with COVID-19 pneumonia were retrospectively enrolled and followed up until discharge ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(17):2653-2662]

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1465. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children with Respiratory Syncytial Virus Infection (RSV) Infection

Helena Brenes-Chacon, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Differences in clinical presentation and viral loads according to age in young children with RSV, and their correlation with disease severity are poorly defined. The aim of this study was to define age-dependent the differences in demographic, clinical factors and viral loads between children < 2 years of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S734-S735]

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A single-cell survey of cellular hierarchy in acute myeloid leukemia.

Junqing Wu, Yanyu Xiao, Jie Sun, Huiyu Sun, Haide Chen, Yuanyuan Zhu, Huarui Fu, Chengxuan Yu, Weigao E, Shujing Lai, Lifeng Ma, Jiaqi Li, Lijiang Fei, Mengmeng Jiang, Jingjing Wang, Fang Ye, Renying Wang, Ziming Zhou, Guodong Zhang, Tingyue Zhang, Qiong Ding, Zou Wang, Sheng Hao, Lizhen Liu, Weiyan Zheng, Jingsong He, Weijia Huang, Yungui Wang, Jin Xie, Tiefeng Li, Tao Cheng, Xiaoping Han, He Huang, Guoji Guo,

<h4>Background</h4>Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of different AML subtypes.<h4>Methods</h4>Using Microwell-seq, a high-throughput single-cell mRNA sequencing platform, we analyzed the cellular hierarchy of bone marrow samples from 40 patients ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2020, 13(1):128]

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Early diagnosis of WT1 nephropathy and follow up in a Chinese multicenter cohort.

Shuzhen Sun, Linan Xu, Yunli Bi, Jing Wang, Zhiqing Zhang, Xiaoshan Tang, Qi Cao, Yihui Zhai, Jing Chen, Xiaoyan Fang, Jialu Liu, Ye Fang, Tianchao Xiang, Yanyan Qian, Bingbing Wu, Huijun Wang, Wenhao Zhou, Jian Shen, Kuiran Dong, Xiaorong Liu, Bixia Zheng, Aihua Zhang, Xiaowen Wang, Yubing Wu, Duan Ma, Qian Shen, Jia Rao, Hong Xu,

<h4>Background</h4>WT1 mutations cause a wide spectrum of renal and extrarenal manifestations concerning urogenital development and the development of tumors.<h4>Methods</h4>We retrospectively collected the information on the genotype and phenotype of WT1 nephropathy from the multicenter registry since 2014 to 2019. All patients were stratified by renal function decline status or by ... Read more >>

Eur J Med Genet (European journal of medical genetics)
[2020, 63(11):104047]

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The Pharmacokinetics and Tissue Distributions of Nine Steroidal Saponins from Paris polyphylla in Rats.

Wei Lu, Meng Pan, Penghua Zhang, Tao Zheng, Liangyong Huang, Fang Ye, Pan Lei,

<h4>Background and objectives</h4>Paris polyphylla (P. polyphylla) is a herb widely used in traditional Chinese medicine to treat various diseases. This study used ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to study the pharmacokinetics and tissue distributions of nine steroidal saponins from P. polyphylla.<h4>Methods</h4>P. polyphylla extract was administered to rats intravenously (i.v.) ... Read more >>

Eur J Drug Metab Pharmacokinet (European journal of drug metabolism and pharmacokinetics)
[2020, 45(5):665-673]

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Mapping a mammalian adult adrenal gland hierarchy across species by microwell-seq.

Shujing Lai, Lifeng Ma, Weigao E, Fang Ye, Haide Chen, Xiaoping Han, Guoji Guo,

Recently, single-cell RNA-seq technologies have been rapidly updated, leading to a revolution in biology. We previously developed Microwell-seq, a cost-effective and high-throughput single cell RNA sequencing(scRNA-seq) method with a very simple device. Most cDNA libraries are sequenced using an expensive Illumina platform. Here, we present the first report showing combined ... Read more >>

Cell Regen (Cell regeneration (London, England))
[2020, 9(1):11]

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Genetic and pathological findings in a boy with psoriasis and C3 glomerulonephritis: A case report and literature review.

Lei Wei, Ye Fang, Guanghai Cao, Shufeng Zhang, Ming Tian, Qian Shen, Hong Xu, Cuihua Liu, Jia Rao,

<h4>Background</h4>Psoriasis is a chronic inflammatory dermatosis with complex genetic basis supported by family investigation. Renal involvement in psoriasis is sparsely studied and its pathogenesis is still unclear.<h4>Methods and results</h4>We describe the case of a 7-year-old boy presented new onset of nephropathy two weeks after a flare-up of psoriasis. His mother ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2020, 8(10):e1430]

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Temporal Changes of CT Findings between Non-emergency and Emergency Patients with COVID-19 Pneumonia: A Multi-centered, Retrospective, Longitudinal Study

Meng Dai, Xiaoming Liu, Xiqi Zhu, Tiejun Liu, Cihao Xu, Fang Ye, Lian Yang, Yu Zhang,

<h4>Objective: </h4> To analyze the differences between clinical evaluation and the detailed imaging features in the time course of lung changes in diverse clinical types. <h4>Methods: </h4> 73 patients with COVID-19 pneumonia were retrospectively collected from three institutions in China. Radiographic features, CT score were analyzed and compared between non-emergency ... Read more >>

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Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells.

Luoyao Yang, Xiaoyi Li, Anli Jiang, Xintong Li, Wei Chang, Jun Chen, Fang Ye,

As a widely acknowledged environmental pollutant, lead (Pb) exhibits neurological toxicity primarily due to the vulnerability of neural system. It is suggested that Pb could perturb mitochondrial function, triggering the following disturbance of cellular homeostasis. Here, we focused on the role of mitochondrial dynamics in Pb-induced cell damage. Pb exposure ... Read more >>

Redox Biol (Redox biology)
[2020, 36:101626]

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Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China.

Li Liu, Wei Liu, Lulin Nie, Zhiwei Guo, Yi Luo, Weihong Chen, Weimin Liu, Feiqi Zhu, Lu Wang, Jiafei Zhang, Xian Wang, Tian Li, Erwei Gao, Li Zhou, Kaiwu He, Yidan Huang, Chunjie Yuan, Qingqing Zhu, Fang Ye, Xingchen Yu, Jing Yuan, Jianjun Liu,

<h4>Purpose</h4>The Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.<h4>Participants</h4>The cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e034317]

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Adjusting the Morphology and Properties of SiC Nanowires by the Catalyst Control

Chuchu Guo, Laifei Cheng, Fang Ye,

Herein, we report the growth of SiC nanowires on a single crystal Si substrate by pyrolysis of polycarbosilane and using two catalyst (Al 2 O 3 and Ni) films with different thickness (2, 4, and 6 nm). The catalyst films were deposited on the Si substrate, and the SiC nanowires ... Read more >>

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Diagnosis of fatal central nervous system malformations based on prenatal colour doppler ultrasound.

Jiamei Yan, Chaoyu Zhou, Fang Ye, Chunyan Gu,

<h4>Objective</h4>Fatal central nervous system (CNS) malformation is one of the most common congenital malformations, and is an important cause of infant mortality. Ultrasound diagnostic technology has the advantages of fast, safe, economic, convenient and real-time dynamic imaging, and it is the first choice for imaging diagnosis of the foetus. This ... Read more >>

Neurosci Lett (Neuroscience letters)
[2020, 733:135140]

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The First Study of Successful Pregnancies in Chinese patients with Phenylketonuria

Lin Wang, Fang Ye, Hui Zou, Kundi Wang, Zhihua Chen, Qin Hui, Bingjuan Han, Chun He, Xiaowen Li, Ming Shen,

<h4>Background: </h4> Since the inception of newborn screening programs in China in the 1990s, pregnancy among patients with inherited, metabolic disorders has become more common. This study explores the management and outcomes of planned, full-term pregnancies in patients with phenylketonuria (PKU). Method Married patients with PKU from 2012 to 2017 ... Read more >>

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Integrating population variation and protein structural analysis to improve the clinical genetic diagnosis and treatment in children with congenital nephrogenic diabetes insipidus

Panli LIAO, Tianchao XIANG, Hongxia LI, Ye FANG, Xiaoyan FANG, Zhiqing ZHANG, Qi CAO, Yihui ZHAI, Jing CHEN, Linan XU, Xiaoshan TANG, Xiaowen WANG, Xiaorong LIU, Qian SHEN, Lizhi CHEN, Xiaoyun JIANG, Duan MA, hong XU, jia RAO,

<h4>Background: </h4> and Objectives: Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder characterized by renal inability to concentrate urine. Establishing the genetic diagnosis appears particularly important to NDI for early detection and differential diagnosis. Method: We utilized a Chinese multicenter registry to investigate genotype and phenotype in children ... Read more >>

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A Highly Aligned Nanowire-Based Strain Sensor for Ultrasensitive Monitoring of Subtle Human Motion.

Ning Tang, Cheng Zhou, Danyao Qu, Ye Fang, Youbin Zheng, Wenwen Hu, Ke Jin, Weiwei Wu, Xuexin Duan, Hossam Haick,

Achieving highly accurate responses to external stimuli during human motion is a considerable challenge for wearable devices. The present study leverages the intrinsically high surface-to-volume ratio as well as the mechanical robustness of nanostructures for obtaining highly-sensitive detection of motion. To do so, highly-aligned nanowires covering a large area were ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(24):e2001363]

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Inflammation as a risk factor for stroke in atrial fibrillation: data from a microarray data analysis.

Yingyuan Li, Wulin Tan, Fang Ye, Shihong Wen, Rong Hu, Xiaoying Cai, Kebing Wang, Zhongxing Wang,

OBJECTIVE:Stroke is a severe complication of atrial fibrillation (AF). We aimed to discover key genes and microRNAs related to stroke risk in patients with AF using bioinformatics analysis. METHODS:GSE66724 microarray data, including peripheral blood samples from eight patients with AF and stroke and eight patients with AF without stroke, were ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(5):300060520921671]

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Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors.

Nai-Yuan Chen, Yu-Lan Xie, Guo-Dong Lu, Fang Ye, Xin-Yu Li, Yu-Wen Huang, Ming-Li Huang, Tie-Yu Chen, Cui-Ping Li,

In an attempt to search for new natural product-based antitumor agents, a series of novel (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole were designed and synthesized. The primary bioassay showed that compounds 5r and 5s presented certain inhibitory activity against cancer cells, weak cytotoxic activity against normal cells, and inhibitory ... Read more >>

Mol Divers (Molecular diversity)
[2020, :]

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The first study of successful pregnancies in Chinese patients with Phenylketonuria.

Lin Wang, Fang Ye, Hui Zou, Kundi Wang, Zhihua Chen, Qin Hui, Bingjuan Han, Chun He, Xiaowen Li, Ming Shen,

<h4>Background</h4>Since the inception of newborn screening programs in China in the 1990s, pregnancy among patients with inherited, metabolic disorders has become more common. This study explores the management and outcomes of planned, full-term pregnancies in patients with phenylketonuria (PKU).<h4>Method</h4>Married patients with PKU from 2012 to 2017 were enrolled to receive ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):253]

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