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Author Fang Liu

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A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish.

Tao Deng, Xiaojuan Wang, Shengjun Wu, Shiyou Hu, Wei Liu, Tongkai Chen, Zhiqiang Yu, Qin Xu, Fang Liu,

A new FRET probe has been prepared for ratiometric fluorescence detection of hydroxyl radicals. It has been successfully used for detecting mitochondria-localized drug activation in living cells and imaging endogenous hydroxyl radicals in zebrafish gastrointestinal (GI) tracts under normal culturing conditions. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(32):4432-4435]

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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.

Huan Han, Qingfeng Ma, Cong Li, Rui Liu, Li Zhao, Wei Wang, Pingan Zhang, Xinghui Liu, Guosheng Gao, Fang Liu, Yingan Jiang, Xiaoming Cheng, Chengliang Zhu, Yuchen Xia,

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1123-1130]

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Design and synthesis of a vanadate-based ratiometric fluorescent probe for sequential recognition of Cu2+ ions and biothiols.

Hui-Hui Zeng, Zhi-Ying Zhou, Fang Liu, Jie Deng, Shu-Yun Huang, Guo-Ping Li, Pei-Qing Lai, Yue-Ping Xie, Wei Xiao,

A novel YVO4:[email protected] core-shell nanomaterial with two main emission peaks at 405 and 617 nm was synthesized through a simple mixing method, in which the carbon quantum dots (CDs) self-assembled with the YVO4:Eu3+ nanoparticle, due to the high affinity of oxygen-containing groups such as -COOH or -OH of CDs to ... Read more >>

Analyst (The Analyst)
[2019, 144(24):7368-7377]

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Semi-Supervised Machine Learning Enables the Robust Detection of Multireference Character at Low Cost

Chenru Duan, Fang Liu, Aditya Nandy, Heather Kulik,

Multireference (MR) diagnostics are common tools for identifying strongly correlated electronic structure that makes single reference (SR) methods (e.g., density functional theory or DFT) insufficient for accurate property prediction. However, MR diagnostics typically require computationally demanding correlated wavefunction theory (WFT) calculations, and diagnostics often disagree or fail to predict MR ... Read more >>

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Identification of novel genetic factors underlying the host-pathogen interaction between barley (Hordeum vulgare L.) and powdery mildew (Blumeria graminis f. sp. hordei).

Maria Pogoda, Fang Liu, Dimitar Douchkov, Armin Djamei, Jochen C Reif, Patrick Schweizer, Albert W Schulthess,

Powdery mildew is an important foliar disease of barley (Hordeum vulgare L.) caused by the biotrophic fungus Blumeria graminis f. sp. hordei (Bgh). The understanding of the resistance mechanism is essential for future resistance breeding. In particular, the identification of race-nonspecific resistance genes is important because of their regarded durability ... Read more >>

PLoS ONE (PloS one)
[2020, 15(7):e0235565]

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Data-Driven Approaches Can Overcome the Cost-Accuracy Trade-Off in Multireference Diagnostics.

Chenru Duan, Fang Liu, Aditya Nandy, Heather J Kulik,

High-throughput computational screening typically employs methods (i.e., density functional theory or DFT) that can fail to describe challenging molecules, such as those with strongly correlated electronic structure. In such cases, multireference (MR) correlated wavefunction theory (WFT) would be the appropriate choice but remains more challenging to carry out and automate ... Read more >>

J Chem Theory Comput (Journal of chemical theory and computation)
[2020, :]

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Immunotherapeutic effects of allogeneic mesenchymal stem cells on systemic lupus erythematosus.

Fang Liu, Hui Chen, Tao Chen, Chak-Sing Lau, Fu-Xun Yu, Kun Chen, Hou-Ping Chen, Run-Sang Pan, Godfrey Chi-Fung Chan, Xiang-Yan Zhang, Ying-Jie Nie,

Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex-histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this study. MRL/lpr mice which can develop acquired SLE-like ... Read more >>

Lupus (Lupus)
[2020, 29(8):872-883]

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Does hypoperfusion outperform blood pressure as a better predictor in the risk stratification of acute heart failure?

Ying Zhou, Fang Liu, Jungang Nie,

Eur. Heart J. (European heart journal)
[2020, 41(25):2411]

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Chiral organophosphorous pesticides fosthiazate: absolute configuration, stereoselective bioactivity, toxicity, and degradation in vegetables.

Lianshan Li, Jiang-Yan Xu, Bo Lv, Amir E Kaziem, Fang Liu, Hai-Yan Shi, MingHua Wang,

Fosthiazate is a widely used chiral organophosphorous nematicide with four stereoisomers. The present study systemically assessed the stereoselectivity of fosthiazate for the first time, including absolute configuration confirmation, stereoselective bioactivity toward nematode and aphid, toxicity to honeybees, and the stereoselective degradation in cucumber and pepper under field conditions. The absolute ... Read more >>

J. Agric. Food Chem. (Journal of agricultural and food chemistry)
[2020, :]

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Comparative life cycle assessment of two ceramsite production technologies for reusing municipal solid waste incinerator fly ash in China.

Hai-Long Zhao, Fang Liu, Han-Qiao Liu, Lei Wang, Rui Zhang, Ying Hao,

Harmless treatment and reuse of municipal solid waste incinerator fly ash are challenging. Two reuse technologies of converting incinerator fly ash to ceramsites via rotary kiln sintering and non-sintering have been demonstrated in China. Field monitoring results reveal that the destruction efficiency of PCDD/Fs are both higher than 99% in ... Read more >>

Waste Manag (Waste management (New York, N.Y.))
[2020, 113:447-455]

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Positive SARS-CoV-2 RNA recurs repeatedly in a case recovered from COVID-19: dynamic results from 108 days of follow-up.

Fang Liu, Zhao-Bin Cai, Jin-Song Huang, Wen-Yan Yu, Hai-Ying Niu, Yan Zhang, Dong-Ming Sui, Fei Wang, Li-Zhi Xue, Ai-Fang Xu,

The evidence of long-term clinical dynamic on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA re-positive case are less. We performed a 108 days follow-up on dynamic clinical presentations in a case, who hospitalized three times due to the positive recurrence of SARS-CoV-2 RNA after discharge, to understand the prognosis ... Read more >>

Pathog Dis (Pathogens and disease)
[2020, :]

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Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis.

Rui Liu, Xinghui Liu, Li Yuan, Huan Han, Muhammad Adnan Shereen, Jiesheng Zhen, Zhili Niu, Dong Li, Fang Liu, Kailang Wu, Zhen Luo, Chengliang Zhu,

BackgroundThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused coronavirus disease 2019 (COVID-19) epidemic in China, December 2019. The clinical features and treatment of COVID-19 patients remain largely elusive. However, accurate detection is required for SARS-CoV-2 infection diagnosis. We aimed to evaluate the antibodies-based test and nucleic acid-based test for ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2020, 86:106746-106746]

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Roles of gonad-inhibiting hormone in the protandric simultaneous hermaphrodite peppermint shrimp†.

Wenyuan Shi, Fang Liu, An Liu, Huiyang Huang, Qi Lin, Chaoshu Zeng, Haihui Ye,

To date, the molecular mechanisms of the unique gonadal development mode known as protandric simultaneous hermaphroditism (PSH) are unclear in crustaceans. In this study, cDNA of a gonad-inhibiting hormone (Lv-GIH1) was isolated from the PSH peppermint shrimp Lysmata vittata, and its expression was exclusively found in the eyestalk ganglion. qRT-PCR ... Read more >>

Biol. Reprod. (Biology of reproduction)
[2020, :]

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Efficacy of delayed 18F-FDG hybrid PET/MRI for epileptic focus identification: a prospective cohort study.

Fang Liu, Weiwei Ruan, Xuejun Deng, Yangmeihui Song, Wenyu Song, Fan Hu, Jinxia Guo, Xiaoli Lan,

OBJECTIVE:We sought to investigate the contribution of delayed 18F-FDG imaging data to epileptogenic zone (EZ) identification using a hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) system. METHODS:Forty-one patients with epilepsy underwent a brain dual time point 18F-FDG PET/MRI examination. All early imaging was acquired at approximately 40 min. Late imaging was ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2020, :]

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Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p.

Muyu Yu, Jinghuan Huang, Tonghe Zhu, Junxi Lu, Junli Liu, Xiaolin Li, Xiaoyu Yan, Fang Liu,

Diabetic wounds remain a serious clinical challenge whereas current therapies have limited effects on reducing the high disability and morbidity. Impaired vascularization is closely associated with delayed healing of diabetic wounds and liraglutide (Lira), a GLP-1R receptor agonist, has been reported to promote the angiogenic ability of endothelial cells. However, ... Read more >>

Biomater Sci (Biomaterials science)
[2020, :]

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Accuracy and Reliability of Computer-aided Anatomical Measurements for Vertebral Body and Disc Based on Computed Tomography Scans.

Jie Yao, Bo Dong, Ju Sun, Jian-Tao Liu, Fang Liu, Xiao-Wei Li, Pu-Wei Yuan, Jian-Bao Zhang,

OBJECTIVE:To assess whether the computed tomography (CT)-based method of three-dimensional (3D) analysis (Mimics) was accurate and reliable for spine surgical anatomical measurements. METHODS:A total of 40 lumbar segments and 32 inter-vertebral discs from eigth adult male cadavers without fractures or deformities fixed with the classical formaldehyde method were included in ... Read more >>

Orthop Surg (Orthopaedic surgery)
[2020, :]

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Nrn1 Overexpression Attenuates Retinal Ganglion Cell Apoptosis, Promotes Axonal Regeneration, and Improves Visual Function Following Optic Nerve Crush in Rats.

Tingting Huang, He Li, Shoumei Zhang, Fang Liu, Dong Wang, Jiajun Xu,

Neuritin (Nrn1) is a small highly conserved extracellular membrane protein involved in the process of neural cell survival and differentiation, axonal and dendritic growth, and synapse formation and maturation. Previous studies have demonstrated that intravitreal injection of recombinant Nrn1 as a gene therapy could alleviate retinal ganglion cell (RGC) apoptosis ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2020, :]

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Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing of enteric coated tablets, pellets and microparticles.

Nathan Scott, Kavil Patel, Tariro Sithole, Konstantina Xenofontos, Valentyn Mohylyuk, Fang Liu,

Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the disturbance of the hydrodynamics ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 585:119562]

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Noninvasive investigation of the cardiodynamic response to 6MWT in people after stroke using impedance cardiography.

Fang Liu, Alice Y M Jones, Raymond C C Tsang, Yao Wang, Jing Zhou, Mingchao Zhou, Yulong Wang,

This is a cross-section observational study that investigated the cardiodynamic response to a 6-minute walk test (6MWT) in patients after stroke using impedance cardiography (ICG). Patients diagnosed with stroke were invited to participate in a 6MWT on consecutive days. Heart rate (HR), cardiac output (CO), stroke volume (SV) and cardiac ... Read more >>

PLoS ONE (PLoS ONE)
[2020, 15(6):e0233000]

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The impact of lower extremity neuropathy and artery disease on gait characteristics in type 2 diabetic individuals

Lei Xu, Hui Zeng, Wenqi Shen, Jungong Zhao, Mingzhe Shao, Jun Zhao, Hua Chen, Hai Hu, Patrick Esser, Helen Dawes, Fang Liu,

Abstract Background It is generally believed that gait characteristics of diabetic neuropathic patients differ from non-diabetic ones. However, it is still unclear whether these changes during walking could also be extended for different conditions of type 2 diabetes mellitus (T2DM), especially diabetic individuals with lower extremity complications. Methods ... Read more >>

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Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations.

Junwen Wang, Fang Liu, Xiusheng Song, Tuo Li,

BACKGROUND:The polymorphisms rs6885224 and rs634990 have been reported to be associated with high myopia in many populations. As there is still no report on whether these two SNPs are associated with myopia in the Tujia and Miao minority areas of China, we conducted a replication study to evaluate the association ... Read more >>

BMC Ophthalmol (BMC Ophthalmology)
[2020, 20(1):255]

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A 1p/19q Codeletion Associated Immune Signature for Predicting Lower Grade Glioma Prognosis

Jie Xu, Fang Liu, Yuntao Li, Liang Shen,

Abstract Background : Lower grade gliomas (LGGs) with codeletion of chromosomal arms 1p and 19q (1p/19 codeletion) has a favorable outcome. However, its overall survival (OS) varies. Here, we established an immune signature associated with 1p/19q codeletion for accurate prediction of prognosis of LGGs. Methods : We extracted RNA sequencing ... Read more >>

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Association of 5p15.2 and 15q14 with High Myopia in Tujia and Miao Chinese Populations

Junwen Wang, Fang Liu, Xiusheng Song, Tuo Li,

Abstract Background : The polymorphisms rs6885224 and rs634990 have been reported to be associated with high myopia in many populations. As there is still no report on whether these two SNPs are associated with myopia in the Tujia and Miao minority areas of China, we conducted a replication study to ... Read more >>

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The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.

Yan Ting Liu, Fang Liu, Lei Cao, Li Xue, Wei Ting Gu, Yong Zhi Zheng, Hao Tang, Yu Wang, Hong Yao, Yong Zhang, Wan Qun Xie, Bo Han Ren, Zhuo Hui Xiao, Ying Jie Nie, Ronggui Hu, Zhe Bao Wu,

Pituitary adenoma (PA) is one of the most common intracranial tumors, and approximately 40% of all PAs are prolactinomas. Dopamine agonists (DAs), such as cabergoline (CAB), have been successfully used in the treatment of prolactinomas. The expression of dopamine type 2 receptor (DRD2) determines the therapeutic effect of DAs, but ... Read more >>

Acta Neuropathol. (Acta neuropathologica)
[2020, :]

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Pathophysiologic Role of Molecules Determining Arteriovenous Differentiation in Adult Life.

Fang Liu, Zhong Yao, Ping Lü, Qi-Bin Jiao, Qin Liu, Hong-Xiao Wu, Yun You, Susumu Minamisawa,

The structural differences between arteries and veins are genetically predetermined. Vascular identity markers, the molecular markers specific to veins and arteries, determine the differential development of vessels during embryogenesis and their expression persists in adult vessels. It is revealed that they can be reactivated under various pathophysiologic conditions even after ... Read more >>

J. Vasc. Res. (Journal of vascular research)
[2020, :1-9]

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