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A novel signal amplified electrochemiluminescence biosensor based on MIL-53(Al)@CdS QDs and SiO2@AuNPs for trichlorfon detection.

Defen Feng, Fucun Wei, Yeyu Wu, Xuecai Tan, Fang Li, Yongkuai Lu, Gaochao Fan, Heyou Han,

An ultrasensitive electrochemiluminescence (ECL) biosensor was developed based on MIL-53(Al)@CdS QDs and SiO<sub>2</sub>@AuNPs for trichlorfon detection. Metal-organic frameworks (MOFs) were used as a loading platform that provided a large surface area to load targets and modified materials onto the electrode. At the same time, SiO<sub>2</sub>@AuNPs loaded plenty of AuNPs which ... Read more >>

Analyst (The Analyst)
[2021, 146(4):1295-1302]

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Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19.

Yu-Jie Dai, Shi-Yao Wan, Shuai-Shuai Gong, Jin-Cheng Liu, Fang Li, Jun-Ping Kou,

Coronavirus disease-2019 (COVID-19) is a new highly infectious disease caused by a novel coronavirus. Recently, the number of new cases infected pneumonia in the world continues to increase, which has aroused great concern from the international community. At present, there are no small-molecule specific anti-viral drugs for the treatment. The ... Read more >>

Chin J Nat Med (Chinese journal of natural medicines)
[2020, 18(12):881-889]

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Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT.

Peipei Wang, Guozhu Hou, Fang Li, Xin Cheng,

<h4>Abstract</h4>A 62-year-old man presented with a huge lesion of left kidney on ultrasound in a health examination 1 month ago. The mass showed hypervascularity on enhanced CT and intense FDG uptake on FDG PET/CT in the lower pole of kidney, which suggested renal malignancy. The histopathological result after surgical resection ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):510-511]

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Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Abhishek Jauhari, Sergei V. Baranov, Yalikun Suofu, Jinho Kim, Tanisha Singh, Svitlana Yablonska, Fang Li, Xiaomin Wang, Patrick Oberly, M. Beth Minnigh, Samuel M. Poloyac, Diane L. Carlisle, Robert M. Friedlander,

J Clin Invest (The Journal of clinical investigation)
[2021, 131(9):]

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Total excision of lumps and reconstructed the scrotum wall in situ for multiple epidermal cysts of scrotum: a case report

ShangChao Wu, GuanYi Li, Hui Xu, Wenbin Niu, Xin Zhong, Fang Li,

<h4>Background: </h4> Epidermoid cysts are the common benign epithelial cysts that may occur in the dermis or subcutaneous tissue. It have been observed in several organs,especially in the skin of the scalp, ear, face, and back.However, the multiple epidermal cysts over the scrotum is a rare condition. We report a ... Read more >>

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Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

Abhishek Jauhari, Sergei V Baranov, Yalikun Suofu, Jinho Kim, Tanisha Singh, Svitlana Yablonska, Fang Li, Xiaomin Wang, Patrick Oberly, M Beth Minnigh, Samuel M Poloyac, Diane L Carlisle, Robert M Friedlander,

J Clin Invest (The Journal of clinical investigation)
[2021, 131(9):]

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Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.

Jiabi Qin, Jinqi Li, Fang Li, Mengting Sun, Tingting Wang, Jingyi Diao, Senmao Zhang, Liu Luo, Yihuan Li, Letao Chen, Peng Huang, Ping Zhu,

Although it is generally recognized that genetic and environmental factors are associated with the risk of congenital heart disease (CHD), the mechanism remains largely uncertain. This study aimed to investigate the association of maternal folate use, the time when folate use was started, and polymorphisms of the reduced folate carrier ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, :]

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Effects of Health Qigong Exercises on Physical Function on Patients with Parkinson's Disease.

Zhirong Wan, Xiaolei Liu, Hui Yang, Fang Li, Lingling Yu, Lei Li, Yulin Wang, Hao Jiang, Junjie Zou, Jichen Du,

<h4>Purpose</h4>To measure motor function improvements in patients with Parkinson's disease (PD) using Health Qigong exercises.<h4>Patients and methods</h4>Fifty-two PD patients (Hoehn and Yahr stages I to IV) were randomly divided into experimental and control groups. Twenty-six PD patients in the experimental group were intervened with routine medicine and fitness Qigong exercise. ... Read more >>

J Multidiscip Healthc (Journal of multidisciplinary healthcare)
[2021, 14:941-950]

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Learning-Based Stock Market Trending Analysis by Incorporating Social Media Sentiment Analysis

Zhaoxia Wang, Zhenda HU, Fang LI, Seng-Beng HO,

Stock market trending analysis is one of the key research topics in financial analysis. Various theories once highlighted the non-viability of stock market prediction. With the advent of machine learning and Artificial Intelligence (AI), more and more efforts have been devoted to this research area, and predicting the stock market ... Read more >>

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Effects of an on-table Reconstruction Technique Combined With Miniplate Internal Fixation and Prosthesis for the Treatment of Isolated Mason III Radial Head Fractures

Lei HAN, feng Can Wang, geng Yun Hu, li Wei Fang, Song Zhou-feng,

<h4>Background: </h4> In this retrospective study we analyzed a consecutive series of patients affected by isolated radial head Mason III fractures and treated with an on-table reconstruction technique combined with miniplate internal fixation or prosthesis. <h4>Methods: </h4> This study included 42 patients affected by isolated radial head Mason III fractures ... Read more >>

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18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix.

Yuanyuan Jiang, Guozhu Hou, Li Huo, Fang Li, Zhaohui Zhu, Wuying Cheng,

<h4>Objectives</h4>The aim of this study was to investigate the value of [18F]fluoro-2-deoxy-D-glucose (18F-FDG) PET/computed tomography (CT) to detect recurrent cervical neuroendocrine carcinoma and its subsequent impact on patient management.<h4>Methods</h4>A total of 25 patients who had undergone 30 18F-FDG PET/CT studies for suspected recurrent cervical neuroendocrine carcinoma (18 small cells, 2 ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2021, :]

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The Design and Research of a New Hybrid Surface Plasmonic Waveguide Nanolaser.

Yahui Liu, Fang Li, Cheng Xu, Zhichong He, Jie Gao, Yunpeng Zhou, Litu Xu,

Using the hybrid plasmonic waveguide (HPW) principle as a basis, a new planar symmetric Ag-dielectric-SiO<sub>2</sub> hybrid waveguide structure is designed and applied to nanolasers. First, the effects on the electric field distribution and the characteristic parameters of the waveguide structure of changes in the material, the nanometer radius, and the ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(9):]

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A438079 affects colorectal cancer cell proliferation, migration, apoptosis, and pyroptosis by inhibiting the P2X7 receptor.

Ying Zhang, Fang Li, Lili Wang, Yi Lou,

<h4>Background</h4>Our previous study identified elevated expression of the P2X7 receptor (P2X7R) in colorectal cancer (CRC) patients, suggesting the receptor is a target for predicting poor disease prognosis. A438079 is a highly selective P2X7R antagonist, however, no studies have identified A438079 effects and mechanisms toward the biological behavior of CRC cells, ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 558:147-153]

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HPLC-QTOF/MS-based metabolomics to explore the molecular mechanisms of Yiqi Fumai Lyophilized Injection in heart failure mice.

Guang-Ying Yuan, Ze-Liang Liu, Qiong Lai, Fei Fu, Lu Zhang, Jun-Ping Kou, Bo-Yang Yu, Fang Li,

Chronic heart failure is a common and fatal disease triggered by loss of normal cardiac function. Yiqi Fumai Lyophilized Injection is widely used in the treatment of cardiovascular diseases, especially chronic heart failure. In this study, a model of chronic heart failure in mice was established with permanent coronary artery ... Read more >>

J Sep Sci (Journal of separation science)
[2021, :]

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Inflammatory Arthritis Induced by Anti-Programmed Death-1 Shown in 68Ga-FAPI PET/CT in a Patient With Esophageal Carcinoma.

Yaping Luo, Qingqing Pan, Huaxia Yang, Fang Li, Fengchun Zhang,

<h4>Abstract</h4>A 30-year-old woman with esophageal squamous cell carcinoma experienced joint pain and swelling in bilateral knees, wrists, and hand joints during the course of neoadjuvant immunochemotherapy. She underwent 18F-FDG and 68Ga-FAPI PET/CT for response assessment of the tumor and evaluating her arthritis. 68Ga-FAPI PET/CT detected intense uptake in multiple joints, ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(5):431-432]

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Identifying influential neighbors in social networks and venue affiliations among young MSM: a data science approach to predict HIV infection.

Yang Xiang, Kayo Fujimoto, Fang Li, Qing Wang, Natascha Del Vecchio, John Schneider, Degui Zhi, Cui Tao,

<h4>Objective</h4>Young MSM (YMSM) bear a disproportionate burden of HIV infection in the United States and their risks of acquiring HIV may be shaped by complex multilayer social networks. These networks are formed through not only direct contact with social/sex partners but also indirect anonymous contacts encountered when attending social venues. ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(Suppl 1):S65-S73]

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The effects of cages implantation on surgical and adjacent segmental intervertebral foramina.

Changyan Wu, Xiaojuan Yang, Xu Gao, Liwei Shao, Fang Li, Yunxin Sun, Xiaoyu Liu, Shuaihao Yao, Yifu Sun,

<h4>Objection</h4>The overarching goal of our research was to compare the clinical and radiological outcomes with different sizes of cages implantation in anterior cervical discectomy and fusion (ACDF), and to evaluate the effects on surgical and adjacent segmental intervertebral foramina.<h4>Methods</h4>The clinical data of 61 patients were analyzed retrospectively. The radiological data ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):280]

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Design of an Interactive Two-Way Telemedicine Service System for Smart Home Care for the Elderly.

Fang Li,

In this paper, we deeply analyse and study the interactive telemedicine service system for elderly care in smart homes and design a data summarization method for large concurrent scenarios. The method first parses and reconstructs the data received by the system initially and then stores the reconstructed valid data into ... Read more >>

J Healthc Eng (Journal of healthcare engineering)
[2021, 2021:6632865]

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In vitro assessment of anti-fibrotic activity does not predict their in vivo efficacy in murine models of Duchenne muscular dystrophy.

Marine Theret, Marcela Low, Lucas Rempel, Fang Fang Li, Lin Wei Tung, Osvaldo Contreras, Chih-Kai Chang, Andrew Wu, Hesham Soliman, Fabio M V Rossi,

<h4>Aim</h4>Fibrosis is the most common complication from chronic diseases, and yet no therapy capable of mitigating its effects is available. Our goal is to unveil specific signaling regulating the fibrogenic process and to identify potential small molecule candidates that block fibrogenic differentiation of fibro/adipogenic progenitors.<h4>Method</h4>We performed a large-scale drug screen ... Read more >>

Life Sci (Life sciences)
[2021, :119482]

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Use of 18F-FDG PET/CT to differentiate ectopic adrenocorticotropic hormone-secreting lung tumors from tumor-like pulmonary infections in patients with ectopic Cushing syndrome

Guozhu Hou, Yuanyuan Jiang, Fang Li, Xin Cheng,

<h4>Background: </h4> Ectopic adrenocorticotropic hormone (ACTH)-secreting lung tumors represent the most common cause of ectopic Cushing syndrome (ECS). Pulmonary opportunistic infections are associated with ECS and occasionally difficult to differentiate from tumors by using computed tomography (CT) alone. The present study aimed to evaluate the usefulness of 18 F-fluorodeoxyglucose (FDG) ... Read more >>

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Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients.

Huanzi Zhong, Yanqun Wang, Zhun Shi, Lu Zhang, Huahui Ren, Weiqun He, Zhaoyong Zhang, Airu Zhu, Jingxian Zhao, Fei Xiao, Fangming Yang, Tianzhu Liang, Feng Ye, Bei Zhong, Shicong Ruan, Mian Gan, Jiahui Zhu, Fang Li, Fuqiang Li, Daxi Wang, Jiandong Li, Peidi Ren, Shida Zhu, Huanming Yang, Jian Wang, Karsten Kristiansen, Hein Min Tun, Weijun Chen, Nanshan Zhong, Xun Xu, Yi-Min Li, Junhua Li, Jincun Zhao,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus disease 2019 (COVID-19). However, the microbial composition of the respiratory tract and other infected tissues as well as their possible pathogenic contributions to varying degrees of disease severity in COVID-19 patients remain unclear. Between 27 January ... Read more >>

Cell Discov (Cell discovery)
[2021, 7(1):23]

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Stem-loop-primer assisted isothermal amplification enabling high-specific and ultrasensitive nucleic acid detection.

Guangcheng Luo, Tingting Yi, Qiang Wang, Bin Guo, Li Fang, Guoyuan Zhang, Xiaolan Guo,

It is highly desired to perform accurate and rapid nucleic acid detections for disease diagnosis at resource-limited setting, such as small clinics, remote areas and home. However, the challenges in sample handling, expensive equipment and complicated operation make canonical polymerase chain reaction (PCR) impossible to run the point-of-care testing (POCT). ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2021, 184:113239]

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Handgrip Strength Could Be an Early Predictor of Cognitive Impairment in the Chinese Population

Hang Su, Xiaokang Sun, Fang Li, Qihao Guo,

<h4>Background: </h4> This study aimed to explore the level and changes of handgrip strength in pre-clinical Alzheimer’s disease (AD) and AD participates, and to evaluate the association between handgrip strength and cognitive function.Methods1431 participants from the memory clinic of Shanghai JiaoTong University Affiliated Sixth People’s Hospital and community were enrolled ... Read more >>

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Nanosheet-assembled hierarchical flower-like g-C3N4 for enhanced photocatalytic CO2 reduction activity.

Fang Li, Dainan Zhang, Quanjun Xiang,

Here, nanosheet-assembled hierarchical flower-like g-C3N4 (CMN) was prepared through a molecular self-assembly and ethanol molecular insertion strategy. CMN possesses enhanced CO2 photoreduction capability due to the enhanced adsorption capacity for CO2, increased specific surface area, and improved carrier diffusion. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(16):2443-2446]

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Targeting IL-17alpha to promote anti-PD-1 therapy effect by screening the tumor immune microenvironment in a mouse oral carcinogenesis model.

Shan Wang, Xiaorong Yu, Fang Li, Haixia Fan, Eryang Zhao, Zheng Hu,

<h4>Background</h4>Resistance to PD-1 blocking agents is not uncommon, limiting their wide clinical success. Certain tumor-infiltrating immune cells (e.g., TILs/CTLs) have emerged as biomarkers of response, and absence of such immune cells contributes to resistance.<h4>Objective</h4>We deconvoluted the dynamic immune microenvironment in a mouse model of oral carcinogenesis for augmenting the resistance ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2021, :]

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