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A novel signal amplified electrochemiluminescence biosensor based on MIL-53(Al)@CdS QDs and SiO2@AuNPs for trichlorfon detection.

Defen Feng, Fucun Wei, Yeyu Wu, Xuecai Tan, Fang Li, Yongkuai Lu, Gaochao Fan, Heyou Han,

An ultrasensitive electrochemiluminescence (ECL) biosensor was developed based on MIL-53(Al)@CdS QDs and SiO<sub>2</sub>@AuNPs for trichlorfon detection. Metal-organic frameworks (MOFs) were used as a loading platform that provided a large surface area to load targets and modified materials onto the electrode. At the same time, SiO<sub>2</sub>@AuNPs loaded plenty of AuNPs which ... Read more >>

Analyst (The Analyst)
[2021, 146(4):1295-1302]

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Use of Recombinant Human Bone Morphogenetic Protein-2 With Iliac Crest Bone Graft Instead of Iliac Crest Bone Graft Alone in Lumbar Spondylolysis.

Hao Meng, Yuan Gao, Guangmin Zhao, Tiansheng Sun, Fang Li,

<h4>Study design</h4>A retrospective study.<h4>Objective</h4>The aim of this study was to evaluate the clinical and radiographic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in pars repair of lumbar spondylolysis.<h4>Summary of background data</h4>BMP-2 is a growth factor that plays a role in the formation of bone and promotes bone healing. However, ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, :]

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Association Between Time to Endovascular Therapy and Outcomes in Patients With Acute Basilar Artery Occlusion.

Hong Fei Sang, Jun Jie Yuan, Zhongming Qiu, Min Zhang, Xiao Gang Hu, Wen Hua Liu, Ning Wang, Hong Xing Han, Tie Yu Tang, Guo Yong Zeng, Hui Dong, Xing Min Long, Ling Fei Li, Feng Li Li, Shuai Liu, Wei Dong Luo, Jia Cheng Huang, Jia Xing Song, Lin Yu Li, Lu Ming Chen, Dong Jing Xie, De Ping Wu, Fang Fei Li, Wen Jie Zi, Qingwu Yang,

<h4>Objective</h4>To characterize the association of onset to puncture time (OPT) with clinical outcomes among patients with acute basilar artery occlusion receiving endovascular therapy (EVT) in clinical practice.<h4>Methods</h4>Using the EVT for Acute Basilar Artery Occlusion (BASILAR) study, we identified consecutive patients with acute basilar artery occlusion receiving EVT in 47 comprehensive ... Read more >>

Neurology (Neurology)
[2021, :]

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Clinical significance of SIRT3 and inflammatory factors in multiple myeloma patients with bortezomib-induced peripheral neuropathy: a cohort study.

Huiqi Yang, Can Liu, Fen Yuan, Fang Li,

The present study aimed to investigate the role of SIRT3 and inflammatory factors in bortezomib-induced peripheral neuropathy (PN). This prospective observational cohort study included a total of 159 patients of multiple myeloma patients during June 2016 to June 2019. All patients received the strategy of bortezomib and dexamethasone and were ... Read more >>

Scand J Clin Lab Invest (Scandinavian journal of clinical and laboratory investigation)
[2021, :1-7]

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Population Structure Analysis Revealed Water or Ancient Hub-induced Genetic Diversity of Cultivated-type Tea Plants in Guizhou Plateau

Zhifei Zhao, Qinfei Song, Dingchen Bai, Suzhen Niu, Yingqin He, Dahe Qiao, Zhengwu Chen, Caiyun Li, Jing Luo, Fang Li,

<h4>Background: </h4> Tea plants originated from the southwest of China. Guizhou is one of the origin center of tea plants, which is rich in tea plant germplasm resources. However, the distribution characteristics and transmission model of tea plant were still unclear. Results We collected 253 cultivated-type tea plant accessions ... Read more >>

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Diagnostic and prognostic value of FDG PET-CT in patients with suspected recurrent thymic epithelial tumors.

Guozhu Hou, Yuanyuan Jiang, Fang Li, Wuying Cheng,

This study aimed to evaluate the diagnostic and prognostic value of FDG PET/CT in patients with suspected recurrent thymic epithelial tumors (TETs). We retrospectively reviewed 83 patients with histopathologically proven TETs (50 thymomas; 33 thymic carcinomas) who underwent FDG PET/CT after surgery. The sensitivity and specificity of FDG PET/CT in ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):20521]

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Incidence, aetiology, and enviromental risk factors of community-acquired pneumonia requiring hospitalization in China: a 3-year, prospective, age-stratified, multi-centre case-control study

Tian Qin, Haijian Zhou, Hongyu Ren, Jiantong Meng, Yinju Du, Mahemut Mahemut, Peng Wang, Nana Luo, Fei Tian, Ming Li, Pu Zhou, Fang Li, Pengyuan Duan, Yinan Li, Na Zhao, Qiwu Yuan, Jinzhong Zhang, Lihong Cheng, Longze Luo, Ming Fang, Xin Huang, Changguo Gu, Huifang Zhou, Min Yang, Shan Lu, Xiangkun Jiang, Hualiang Lin, Huaiyu Tian, Biao Kan, Jianguo Xu,

Abstract <h4>Background</h4> Community-acquired pneumonia (CAP) is a leading infectious cause of hospitalisation and death worldwide. The knowledge about the incidence and aetiology of CAP in China was fragmented. <h4>Methods</h4> A multicenter study performed at four hospitals in four regions in China and clinical samples from CAP patients were collected and ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, :]

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Correction: Mapping and role of T cell response in SARS-CoV-2-infected mice.

Zhen Zhuang, Xiaomin Lai, Jing Sun, Zhao Chen, Zhaoyong Zhang, Jun Dai, Donglan Liu, Yuming Li, Fang Li, Yanqun Wang, Airu Zhu, Junxiang Wang, Wenhui Yang, Jicheng Huang, Xiaobo Li, Lingfei Hu, Liyan Wen, Jianfen Zhuo, Yanjun Zhang, Dingbin Chen, Suxiang Li, Shuxiang Huang, Yongxia Shi, Kui Zheng, Nanshan Zhong, Jingxian Zhao, Dongsheng Zhou, Jincun Zhao,

J Exp Med (The Journal of experimental medicine)
[2021, 218(11):]

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Lamiophlomis herba: A comprehensive overview of its chemical constituents, pharmacology, clinical applications, and quality control.

Yu Li, Fang Li, Ting-Ting Zheng, Lei Shi, Zhi-Gang Zhang, Tian-Mei Niu, Qiu-Yue Wang, Dong-Sheng Zhao, Wei Li, Pan Zhao,

Lamiophlomis rotata (Benth.) Kudo (LR) is an extensively used Chinese herbal medicine. It contains a variety of chemical constituents with significant biological activities that were first recorded in the classical masterpiece of Tibetan Medicine, Somaratsa. In this review, we summarize the information regarding the traditional uses, chemical constituents, pharmacological effects, ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 144:112299]

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Type 2 diabetes mellitus potentiates acute acrylonitrile toxicity: Potentiation reduction by phenethyl isothiocyanate.

Jie Zhou, Xueyu Zhu, Ying Dong, Bobo Yang, Rongzhu Lu, Guangwei Xing, Suhua Wang, Fang Li,

Acrylonitrile (AN) is a known animal carcinogen and suspected human carcinogen. Recently, occupational exposure to AN has considerably increased. Previously, we demonstrated that streptozotocin-induced diabetes potentiates AN-induced acute toxicity in rats and that the induced cytochrome P450 2E1 (CYP2E1) is responsible for this effect. In the present study, we examined ... Read more >>

Toxicol Ind Health (Toxicology and industrial health)
[2021, :7482337211048583]

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CsAlaDC and CsTSI work coordinately to determine theanine biosynthesis in tea plants (Camellia sinensis L.) and confer high levels of L-theanine accumulation in a non-tea plant.

Biying Zhu, Jiayi Guo, Chunxia Dong, Fang Li, Siming Qiao, Shijia Lin, Tianyuan Yang, Yingling Wu, Shilai Bao, William J Lucas, Zhaoliang Zhang,

Theanine, one of the most important components of teas, confers the umami taste and relaxation effect of tea infusion. As a non-proteinogenic amino acid, theanine solely accumulates to high levels in tea plants (Camellia sinensis L.); however, the underlying mechanism remains largely unknown. Theanine is biosynthesized from ethylamine and glutamate ... Read more >>

Plant Biotechnol J (Plant biotechnology journal)
[2021, :]

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The chloroplast genomes of four Bupleurum (Apiaceae) species endemic to Southwestern China, a diversity center of the genus, as well as their evolutionary implications and phylogenetic inferences.

Rong Huang, Xuena Xie, Aimin Chen, Fang Li, Enwei Tian, Zhi Chao,

<h4>Background</h4>As one of the largest genera in Apiaceae, Bupleurum L. is well known for its high medicinal value. The genus has frequently attracted the attention of evolutionary biologist and taxonomist for its distinctive characteristics in the Apiaceae family. Although some chloroplast genomes data have been now available, the changes in ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):714]

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Blockade of T helper 17 cell function ameliorates recurrent Clostridioides difficile infection in mice.

Siqi Wang, Wenlin Deng, Fang Li, Y E Chen, P U Wang,

Clostridioides difficile infection (CDI) is a common infection of the gastrointestinal tract. Typically, 20%-30% of CDI patients experience recurrent C.difficile infection (RCDI). Although the role of Th17 in infectious and inflammatory diseases including CDI has gained attention, reports on the correlation between Th17 and RCDI are scarce. In this study, ... Read more >>

Acta Biochim Biophys Sin (Shanghai) (Acta biochimica et biophysica Sinica)
[2021, 53(10):1290-1299]

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18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix.

Yuanyuan Jiang, Guozhu Hou, Li Huo, Fang Li, Zhaohui Zhu, Wuying Cheng,

<h4>Objectives</h4>The aim of this study was to investigate the value of [18F]fluoro-2-deoxy-D-glucose (18F-FDG) PET/computed tomography (CT) to detect recurrent cervical neuroendocrine carcinoma and its subsequent impact on patient management.<h4>Methods</h4>A total of 25 patients who had undergone 30 18F-FDG PET/CT studies for suspected recurrent cervical neuroendocrine carcinoma (18 small cells, 2 ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2021, 42(10):1151-1156]

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Comparison of three ionic liquids pretreatment of Arundo donax L. for enhanced photo-fermentative hydrogen production.

Zhou Chen, Danping Jiang, Tian Zhang, Tingzhou Lei, Huan Zhang, Jiabin Yang, Xuenan Shui, Fang Li, Yang Zhang, Quanguo Zhang,

Ionic liquids (ILs) pretreatment has been regarded as a promising green way to treat lignocellulosic biomass. 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF<sub>4</sub>), 1-allyl-3-methylimidazolium chloride ([Amim]Cl), and 1-Butyl-3-methylimidazolium Hydrogen Sulfate ([Bmim]HSO<sub>4</sub>) with different loadings (2, 4, 8, and 16 g/L) were adopted to pretreat the Arundo donax L.. 16 g/L [Bmim]HSO<sub>4</sub> pretreated Arundo donax ... Read more >>

Bioresour Technol (Bioresource technology)
[2021, :126088]

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Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis.

Ji Zhang, Juan Ding, Ming Yu, Fang Li, Xue Zhou, Hongxia Shuai,

<h4>Background</h4>Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play crucial roles in DN pathogenesis.<h4>Objective</h4>The purpose of the present study was to explore the role and mechanism of lncRNA tetratricopeptide repeat domain 2B antisense RNA 1 (TTC28-AS1) in ... Read more >>

Genes Genomics (Genes & genomics)
[2021, :]

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Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib-Induced QT Interval Prolongation.

Juan Zhang, Dan Luo, Fang Li, Zhiyi Li, Xiaoli Gao, Jie Qiao, Lin Wu, Miaoling Li,

Inhibition of human ether-a-go-go-related gene (hERG) potassium channel is responsible for acquired long QT syndromes, which leads to life-threatening cardiac arrhythmia. A multikinase inhibitor, vandetanib, prolongs the progression-free survival time in advanced medullary thyroid cancer. However, vandetanib has been reported to induce significant QT interval prolongation, which limits its clinical ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:3520034]

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Molecular switches regulating the potency and immune evasiveness of SARS-CoV-2 spike protein

Yushun Wan, Linfen Huang, Xiujuan Zhang, Jian Shang, Stanley Perlman, Lanying Du, Fang Li,

What enabled SARS-CoV-2, but not other coronaviruses, to cause a global pandemic? Here we investigated key structural determinants of the pandemic. Using SARS-CoV-1 and bat RaTG13-CoV as comparisons, we identified two molecular switches that regulate the conformations of SARS-CoV-2 spike protein: (i) a furin motif loop turns SARS-CoV-2 spike from ... Read more >>

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Prognostic Value of FDG PET/CT in Patients With Neuroendocrine Carcinoma of the Uterine Cervix.

Yuanyuan Jiang, Guozhu Hou, Fang Li, Zhaohui Zhu, Wuying Cheng,

<h4>Purpose</h4>We evaluated the prognostic value of metabolic parameters measured on pretreatment FDG PET/CT in patients with cervical neuroendocrine carcinomas (NECs).<h4>Methods</h4>A total of 22 patients with cervical NECs who underwent pretreatment FDG PET/CT were retrospectively reviewed. The SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary lesion ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, :]

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Site-based performance of 131I-MIBG imaging and 99mTc-HYNIC-TOC scintigraphy in the detection of nonmetastatic extra-adrenal paraganglioma.

Guozhu Hou, Yuanyuan Jiang, Fang Li, Zhaohui Zhu, Hongli Jing,

<h4>Objectives</h4>This study aimed to evaluate the performance of 131I-metaiodobenzylguanidine (MIBG) imaging to detect nonmetastatic extra-adrenal paragangliomas at their respective sites (abdominal vs. thoracic vs. head and neck vs. urinary bladder), and compare it with that of 99mTc-hydrazinonicotinyl-tyr3-octreotide (HYNIC-TOC) scintigraphy.<h4>Methods</h4>We retrospectively analyzed 235 patients with nonmetastatic extra-adrenal paragangliomas who underwent preoperative ... Read more >>

Nucl Med Commun (Nuclear medicine communications)
[2021, :]

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Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated.

Tanisha Singh, Yuanyuan Jiao, Lisa M Ferrando, Svitlana Yablonska, Fang Li, Emily C Horoszko, David Lacomis, Robert M Friedlander, Diane L Carlisle,

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal survival but the developmental timing and mechanistic importance of mitochondrial dysfunction in sporadic ALS (sALS) neurons is not fully understood. We used human induced pluripotent stem cells and generated a developmental ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):18916]

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miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis.

Fang Li, Shan-Shan Li, Hui Chen, Jian-Zhi Zhao, Jie Hao, Jin-Ming Liu, Xiu-Guang Zu, Wei Cui,

Cardiac fibrosis could induce abnormal cardiac function and become a novel target for cardiac hypertrophy and chronic heart failure. MiRNA-320 is a crucial miRNA in cardiovascular disease, but it is poorly understood whether it plays a role in cardiac fibrosis pathogenesis. We aimed to identify the specific underlying mechanism of ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(18):22516-22527]

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Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest Drosophila suzukii.

Nikolay P Kandul, Esther J Belikoff, Junru Liu, Anna Buchman, Fang Li, Akihiko Yamamoto, Ting Yang, Isaiah Shriner, Maxwell J Scott, Omar S Akbari,

Originally from Asia, Drosophila suzukii Matsumura is a global pest of economically important soft-skinned fruits. Also commonly known as spotted wing drosophila, it is largely controlled through repeated applications of broad-spectrum insecticides by which resistance has been observed in the field. There is a pressing need for a better understanding ... Read more >>

CRISPR J (The CRISPR journal)
[2021, 4(5):739-751]

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Letter: hepatocellular carcinoma risk in patients with non-selective beta blockers-authors' reply.

Karn Wijarnpreecha, Fang Li, Yifang Dang, C Burcin Taner, Liu Yang, Cui Tao,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1095-1096]

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Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis.

Haoran Ke, Fang Li, Wenlin Deng, Zitong Li, Siqi Wang, Pinjing Lv, Ye Chen,

The present study aimed to determine if metformin exerts anti-inflammatory and mucus-protective effects via the gut microbiota. Metformin has extensive benefits including anti-inflammatory effects. Previous studies showed that metformin changed the gut microbiota composition and increases the number of goblet cells. Intestinal dysbiosis and goblet cell depletion are important features ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:726707]

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