Full Text Journal Articles by
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A high performance lithium metal anode enabled by CF4 plasma treated carbon paper.

Fei Shen, Fan Zhang, Yuting Yin, Sile Chen, Jie Gao, Jun Li, Xiaogang Han,

To substantially boost the energy density of secondary batteries, research studies on lithium metal anodes are booming to develop technologies on lithium metal batteries. However, suffering from lithium dendritic growth and volume expansion, the batteries are still far from practical applications. Herein, carbon paper (CP) is superficially fluorinated by CF4 ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(27):11800-11807]

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Gold nanoparticle integrated artificial nanochannels for label-free detection of peroxynitrite.

Jing Wu, Xing Wang, Lei Ge, Rui Lv, Fan Zhang, Zhihong Liu,

A label-free method for rapid and highly sensitive detection of peroxynitrite (ONOO<sup>-</sup>) was proposed by employing well-designed N-(4-aminobutyl)-N-ethylisoluminol (ABEI) capped AuNP integrated artificial nanochannels. This work paves a new pathway to develop a versatile platform for the detection of different biological small molecules and reactive species. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(29):3583-3586]

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A recent update on the multifaceted health benefits associated with ginger and its bioactive components.

Run-Hui Ma, Zhi-Jing Ni, Yun-Yang Zhu, Kiran Thakur, Fan Zhang, Yuan-Yuan Zhang, Fei Hu, Jian-Guo Zhang, Zhao-Jun Wei,

Due to recent lifestyle shifts and health discernments among consumers, synthetic drugs are facing the challenge of controlling disease development and progression. Various medicinal plants and their constituents are recognized for their imminent role in disease management via modulation of biological activities. At present, research scholars have diverted their attention ... Read more >>

Food Funct (Food & function)
[2021, 12(2):519-542]

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Multi-omics reveals the anticancer mechanism of asparagus saponin-asparanin A on endometrial cancer Ishikawa cells.

Fan Zhang, Yuan-Yuan Zhang, Run-Hui Ma, Kiran Thakur, Jinzhi Han, Fei Hu, Jian-Guo Zhang, Zhao-Jun Wei,

Endometrial cancer (EC) is a malignancy that severely threatens women's health and there is an urgent need to find novel natural compounds as effective treatment drugs. At the same time, multi-omics analysis of cells has been widely used in basic research to find new pathogenesis and mechanisms. Due to the ... Read more >>

Food Funct (Food & function)
[2021, 12(2):614-632]

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Selective transmembrane transport of Aβ protein regulated by tryptophan enantiomers.

Fei Zhu, Wenqian Wang, Fan Zhang, Manivannan Kalavathi Dhinakaran, Yingqian Wang, Rui Wang, Jing Cheng, Maria Eugenia Toimil-Molares, Christina Trautmann, Haibing Li,

Tryptophan enantiomers (d/l-Trp) were introduced into artificial nanochannels to regulate the chiral selective transport of Aβ proteins. The l-Trp channel performs effectively selectivity for the transport of Aβ protein, which would provide a new perspective for the pathological studies of Alzheimer's disease. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(2):215-218]

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Near-infrared-II light excitation thermosensitive liposomes for photoacoustic imaging-guided enhanced photothermal-chemo synergistic tumor therapy.

Yeneng Dai, Wenyu Du, Diya Gao, Haowei Zhu, Fan Zhang, Kai Chen, Haiyang Ni, Meixing Li, Quli Fan, Qingming Shen,

Despite the great success of photothermal therapy (PTT), it still suffers from many obstacles, such as the limited penetration depth of light, thermoresistance of tumors, and limitations of mono-therapeutic modalities. Herein, second near-infrared (NIR-II, 1064 nm) light excitation thermosensitive liposomes ([email protected]) were fabricated for photoacoustic imaging (PAI) guided enhanced PTT-chemotherapy. ... Read more >>

Biomater Sci (Biomaterials science)
[2022, 10(2):435-443]

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Molecular basis of CONSTANS oligomerization in FLOWERING LOCUS T activation.

Xiaolin Zeng, Xinchen Lv, Rui Liu, Hang He, Shiqi Liang, Lixian Chen, Fan Zhang, Liu Chen, Yuehui He, Jiamu Du,

The transcription factor CONSTANS (CO) integrates day-length information to induce the expression of florigen FLOWERING LOCUS T (FT) in Arabidopsis. We recently reported that the C-terminal CCT domain of CO forms a complex with NUCLEAR FACTOR-YB/YC to recognize multiple cis-elements in the FT promoter, and the N-terminal tandem B-box domains ... Read more >>

J Integr Plant Biol (Journal of integrative plant biology)
[2022, :]

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Genomic features and tumor immune microenvironment alteration in NSCLC treated with neoadjuvant PD-1 blockade.

Shuhang Wang, Pei Yuan, Beibei Mao, Ning Li, Jianming Ying, Xiuli Tao, Wei Tang, Lei Zhang, Xiao Geng, Fan Zhang, Qi Xue, Lijia Wu, Henghui Zhang, Shugeng Gao, Jie He,

Several clinical trials have shown the safety and effectiveness of PD-1/PD-L1 inhibitors in neoadjuvant therapy in resectable non-small cell lung cancer (NSCLC). However, 18-83% patients can benefit from it. In this study, we aimed to assess the association of PD-L1 expression, tumor mutation burden, copy number alteration (CNA, including copy ... Read more >>

NPJ Precis Oncol (NPJ precision oncology)
[2022, 6(1):2]

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Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses.

Yanjun Yang, Fangman Chen, Ning Xu, Qichao Yao, Ran Wang, Xiaochun Xie, Fan Zhang, Yan He, Dan Shao, Wen-Fei Dong, Jiangli Fan, Wen Sun, Xiaojun Peng,

Although chemo-photodynamic therapy demonstrates promising synergetic therapeutic effects in malignant tumors, the light-controlled drug release, synergism and biocompatibility of current nanocarriers are limited. Herein, we report a red light-responsive, self-destructive carrier constructed using polyethylene glycol-modified, diselenide-bridged mesoporous silica nanoparticles. The carrier is co-encapsulated with the chemo-drug doxorubicin and the photosensitizer ... Read more >>

Biomaterials (Biomaterials)
[2022, 281:121368]

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Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice.

Yixuan Qiu, Jiaming Yu, Xueying Ji, Huiyuan Yu, Mengjuan Xue, Fan Zhang, Yi Li, Zhijun Bao,

Sarcopenia is the age-related decrease in skeletal muscle mass, and current therapies for this disease are ineffective. We previously showed that ileal farnesoid X receptor (FXR)-fibroblast growth factor 15/19 (FGF15/19) signaling acts as a regulator of gut microbiota to mediate host skeletal muscle. However, the therapeutic potential of this pathway ... Read more >>

Mech Ageing Dev (Mechanisms of ageing and development)
[2022, 202:111630]

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NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring.

Peng Pei, Hongxing Hu, Ying Chen, Shangfeng Wang, Jing Chen, Jiang Ming, Yiwei Yang, Caixia Sun, Shichang Zhao, Fan Zhang,

In situ monitoring of tissue regeneration progression is of primary importance to basic medical research and clinical transformation. Despite significant progress in the field of tissue engineering and regenerative medicine, few technologies have been established to in situ inspect the regenerative process. Here, we present an integrated second near-infrared (NIR-II, ... Read more >>

Nano Lett (Nano letters)
[2022, :]

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Genome assembly of alfalfa cultivar zhongmu-4 and identification of SNPs associated with agronomic traits.

Ruicai Long, Fan Zhang, Zhiwu Zhang, Mingna Li, Lin Chen, Xue Wang, Wenwen Liu, Tiejun Zhang, Long-Xi Yu, Fei He, Xueqian Jiang, Xijiang Yang, Changfu Yang, Zhen Wang, Junmei Kang, Qingchuan Yang,

Alfalfa (Medicago sativa L.) is the most important legume forage crop worldwide with high nutritional value and yield. For a long time, the breeding of alfalfa was hampered by lacking reliable information on the autotetraploid genome and molecular markers linked to important agronomic traits. We herein report the de novo ... Read more >>

Genomics Proteomics Bioinformatics (Genomics, proteomics & bioinformatics)
[2022, :]

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Histone H3K4 methyltransferase DcATX1 promotes ethylene induced petal senescence in carnation

Shan Feng, Ruiming Wang, Hualiang Tan, Linlin Zhong, Yunjiang Cheng, Manzhu Bao, Hong Qiao, Fan Zhang,

Petal senescence is controlled by a complex regulatory network. Epigenetic regulation like histone modification influences chromatin state and gene expression. However, involvement of histone methylation in regulating petal senescence is still largely unknown. Here, we found that the trimethylation of histone H3 at Lysine 4 (H3K4me3) is increased during the ... Read more >>

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Investigation of the Relationship between MBP Gene Polymorphisms and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

Fan Zhang, Jiao Zeng, Xiaoli Zhang, Jiapeng Gu, Yongkai Han, Ping Zhang, Wenqiang Li, Renjun Gu,

<h4>Background: </h4> Increasing evidence reveals that delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) results from the combined effects of environmental and genetic factors. The main pathological feature of DEACMP was generalized demyelination of cerebral white matter. Myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) and serum samples from ... Read more >>

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Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.

Manoj V Maddali, Matthew Churpek, Tai Pham, Emanuele Rezoagli, Hanjing Zhuo, Wendi Zhao, June He, Kevin L Delucchi, Chunxue Wang, Nancy Wickersham, J Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M Hendrickson, Kirsten N Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D Liu, Michael A Matthay, Lorraine B Ware, John G Laffey, Giacomo Bellani, Carolyn S Calfee, Pratik Sinha, ,

<h4>Background</h4>Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2022, :]

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Rheumatoid Arthritis Synovial Inflammation Quantification Using Computer Vision.

Steven Guan, Bella Mehta, David Slater, James R Thompson, Edward DiCarlo, Tania Pannellini, Diyu Pearce-Fisher, Fan Zhang, Soumya Raychaudhuri, Caryn Hale, Caroline S Jiang, Susan Goodman, Dana E Orange,

<h4>Objective</h4>We quantified inflammatory burden in rheumatoid arthritis (RA) synovial tissue by using computer vision to automate the process of counting individual nuclei in hematoxylin and eosin images.<h4>Methods</h4>We adapted and applied computer vision algorithms to quantify nuclei density (count of nuclei per unit area of tissue) on synovial tissue from arthroplasty ... Read more >>

ACR Open Rheumatol (ACR open rheumatology)
[2022, :]

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An integrated model to optimize irrigation amount and time in shallow groundwater area under drought conditions.

Xiaoxing Zhang, Ping Guo, Shanshan Guo, Fan Zhang, Chenglong Zhang,

Drought is one of the main factors negatively affecting crop growth. Optimizing irrigation time and irrigation amount are two effective ways to improve crop yield and water use efficiency. In order to achieve process-based optimization in shallow groundwater area, a comprehensive model is established by combining EPIC crop growth module, ... Read more >>

J Contam Hydrol (Journal of contaminant hydrology)
[2022, 246:103956]

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MicroRNA profile as potential molecular signature for attention deficit hyperactivity disorder in children.

Ping Zhu, Jing Pan, Qian Qian Cai, Fan Zhang, Min Peng, Xing Li Fan, Hua Ji, Yi Wei Dong, Xing Zhong Wu, Li Hui Wu,

<h4>Aims</h4>Attention deficit/hyperactivity disorder (ADHD) is a prevalent disorder of neurodevelopment in children. The diagnosis of ADHD mainly relies on the symptoms and some may be misdiagnosed due to age-based variation in behaviours. This study aimed to explore biomarkers that are greatly needed for the accurate diagnosis of ADHD.<h4>Methods</h4>742 samples were ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2022, :1-27]

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Effects of chiral herbicide dichlorprop on Arabidopsis thaliana metabolic profile and its implications for microbial communities in the phyllosphere.

Danyan Qiu, Yizhi Ye, Mingjing Ke, Nuohan Xu, Zhenyan Zhang, Fan Zhang, Jian Kang, Yitian Yu, Tao Lu, Haifeng Qian,

Dichlorprop (2-(2,4-dichlorophenoxy) propionic acid, DCPP), a commonly used herbicide for weed control, can be residually detected in soil. It is still unclear whether chiral DCPP exerts an enantioselective adverse effect on plant metabolism and the microbial community of the phyllosphere. In this study, we selected Arabidopsis thaliana as a model ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2022, :]

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Efficacy of acupuncture and its influence on the emotional network in adult insomnia patients: protocol for a randomized controlled clinical trial.

Tongfei Jiang, Qi Zhang, Fang Yuan, Fan Zhang, Jing Guo,

<h4>Introduction</h4>Insomnia disorder (ID) is characterized by dissatisfaction with the quantity or quality of sleep and is often accompanied by negative emotions such as anxiety and depression. Patients with insomnia become trapped in a vicious circle of bad moods and poor sleep. Resting-state functional magnetic resonance imaging (r-fMRI) studies have shown ... Read more >>

Trials (Trials)
[2022, 23(1):11]

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LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b.

Fan Zhang, Bai-Hua Luo, Qi-Hui Wu, Qing-Ling Li, Ke-Da Yang,

<h4>Background</h4>Although long noncoding RNA HLA complex group 18 (lncRNA HCG18) has been suggested to regulate cell growth in several tumours, the function of HCG18 in epithelial ovarian cancer (EOC) and its mechanism are still unclear.<h4>Methods</h4>shRNAs were applied to reduce HCG18 and related genes. For overexpression of miRNA, a miRNA mimic ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2022, 28(1):2]

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Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial.

Baixue Jia, Xuelei Zhang, Ning Ma, Dapeng Mo, Feng Gao, Xuan Sun, Ligang Song, Lian Liu, Yiming Deng, Xiaotong Xu, Yong Zhang, Zengpin Liu, Sheng Guan, Fan Zhang, Bing Li, Hongbo Zheng, Xinfeng Liu, Yajie Liu, Kangning Chen, Jie Shuai, Jieqing Wan, Jun Wang, Xiangqun Shi, Tianxiao Li, Binge Chang, David S Liebeskind, Wengui Yu, Zhongrong Miao, ,

<h4>Importance</h4>In-stent restenosis (ISR) is the primary reason for stroke recurrence after intracranial stenting in patients who were treated with a standard bare-metal stent (BMS). Whether a drug-eluting stent (DES) could reduce the risk of ISR in intracranial atherosclerotic stenosis (ICAS) remains unclear.<h4>Objective</h4>To investigate whether a DES can reduce the risk ... Read more >>

JAMA Neurol (JAMA neurology)
[2022, :]

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Shell water-soluble matrix protein from oyster shells promoted proliferation, differentiation and mineralization of osteoblasts in vitro and vivo.

Xue Feng, Suisui Jiang, Fan Zhang, Runfang Wang, Yuanhui Zhao, Mingyong Zeng,

Matrix protein is secreted by the membrane of bivalve shellfish to and used to regulate shell biomineralization. In this study, we extracted water-soluble matrix protein (WSMP) from oyster shells to investigate its effects on osteogenic differentiation and mineralization of MC3T3-E1 cells and osteoporosis rats. Our results suggested that WSMP was ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2022, 201:288-297]

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Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus.

Zhiyong Xie, Huating Gu, Meizhu Huang, Xinyu Cheng, Congping Shang, Ting Tao, Dapeng Li, Yuan Xie, Jidong Zhao, Wei Lu, Zhibin Zhang, Cheng Zhan, Zongxiang Tang, Fan Zhang, Peng Cao,

Innate defensive behaviors triggered by environmental threats are important for animal survival. Among these behaviors, defensive attack toward threatening stimuli (for example, predators) is often the last line of defense. How the brain regulates defensive attack remains poorly understood. Here we show that noxious mechanical force in an inescapable context ... Read more >>

Nat Neurosci (Nature neuroscience)
[2022, 25(1):72-85]

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Bisphenol S exposure induces cytotoxicity in mouse Leydig cells.

Wenjuan Zhang, Tao Huang, Zhangbei Sun, Haibin Kuang, Yangyang Yuan, Weiying Zou, Fangming Liu, Fan Zhang, Bei Yang, Lei Wu, Dalei Zhang,

Bisphenol S (BPS), an increasingly used alternative to bisphenol A, has been linked to testosterone deficiency and male reproductive dysfunction in laboratory animals. This study aimed to examine the cytotoxicity of BPS exposure to Leydig cells and to investigate its possible mechanisms. After treatment with BPS (100, 200 and 400 μM) ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2022, 160:112805]

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