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Amyloid-beta Uptake by Peripheral Blood Monocytes is Reduced by Ageing and Alzheimer’s Disease

Si-Han Chen, Ding-Yuan Tian, Ying-Ying Shen, Yuan Cheng, Dong-Yu Fan, Hao-Lun Sun, Chen-Yang He, Pu-Yang Sun, Xian-Le Bu, Fan Zeng, Juan Deng, Zhi-Qiang Xu, Yang Chen, Yanjiang Wang,

Abstract Background Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes, the counterpartsof microglia in the periphery, in the development of AD remain unclear. In this study, we sought to investigate the alterations in ... Read more >>

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Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid β accumulation after Porphyromonas gingivalis infection.

Fan Zeng, Yicong Liu, Wanyi Huang, Hong Qing, Tomoko Kadowaki, Haruhiko Kashiwazaki, Junjun Ni, Zhou Wu,

Cerebrovascular-related amyloidogenesis is found in over 80% of Alzheimer's disease (AD) cases, and amyloid β (Aβ) generation is increased in the peripheral macrophages during infection of Porphyromonas gingivalis (P. gingivalis), a causal bacterium for periodontitis. In this study, we focused on receptor for advanced glycation end products (RAGE), the key ... Read more >>

J. Neurochem. (Journal of neurochemistry)
[2020, :]

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Amyloid-beta uptake by peripheral blood monocytes is reduced by ageing and Alzheimer’s disease

Si-Han Chen, Ding-Yuan Tian, Ying-Ying Shen, Yuan Cheng Bachelor, Dong-Yu Fan, Hao-Lun Sun, Chen-Yang He, Pu-Yang Sun, Xian-Le Bu, Fan Zeng, Juan Deng, Zhi-Qiang Xu, Yang Chen, Yan-Jiang Wang,

Abstract Background: Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes, the counterparts of microglia in the periphery, in the development of AD remain unclear. In this study, we sought to investigate the ... Read more >>

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EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma.

Lijie Huang, Zheng Wang, Yuanhao Chang, Kuanyu Wang, Xun Kang, Ruoyu Huang, Ying Zhang, Jing Chen, Fan Zeng, Fan Wu, Zheng Zhao, Guanzhang Li, Hua Huang, Tao Jiang, Huimin Hu,

Immune response mediated by macrophages is critical in tumor progression and implicates new targets in potential efficient immunotherapies. Tumor associated macrophages (TAM) are divided into either polarized M1 or M2 phenotype depending on different regulators of polarization and pro- or anti-oncogenic roles they play. Glioma-infiltrated TAMs have been newly reported ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(9):8397-8412]

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Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling.

Muzhou Jiang, Jie Meng, Fan Zeng, Hong Qing, Gregory Hook, Vivian Hook, Zhou Wu, Junjun Ni,

Lysosomes are known to mediate neurite outgrowth in neurons. However, the principal lysosomal molecule controlling that outgrowth is unclear. We studied primary mouse neurons in vitro and found that they naturally develop neurite outgrowths over time and as they did so the lysosomal cysteine protease cathepsin B (CTSB) mRNA levels ... Read more >>

J. Neurochem. (Journal of neurochemistry)
[2020, :]

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RGS16 promotes glioma progression and serves as a prognostic factor.

Ruoyu Huang, Guanzhang Li, Zheng Zhao, Fan Zeng, Kenan Zhang, Yanwei Liu, Kuanyu Wang, Huimin Hu,

BACKGROUND:RGS protein family members have recently became new potentially promising therapeutic targets in many cancers. However, as a key member of RGS family, RGS16 has seldom been studied in glioma. The present study was designed to investigate the prognostic value and biological function of RGS16 based on large-scale databases and ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2020, :]

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Identification of an ATP metabolism-related signature associated with prognosis and immune microenvironment in gliomas.

Ruoyu Huang, Guanzhang Li, Zhiliang Wang, Huimin Hu, Fan Zeng, Kenan Zhang, Kuanyu Wang, Fan Wu,

As the core element of material and energy metabolism pathways, the biological functions and prognostic significance of ATP metabolism in diffuse gliomas have so far remained unclear. Based on comprehensive analysis of ATP metabolism-related gene expression profiles, we constructed an ATP metabolism-related risk signature to determine the role of ATP ... Read more >>

Cancer Sci. (Cancer science)
[2020, :]

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Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the Plateau area

Yu lei, xiaobo huang, silang bamu, yunping lan, jianli lu, fan zeng,

Abstract Background: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread throughout China, but the clinical characteristics of Tibetan patients living in the Qinghai-Tibetan plateau are unknown. We aimed to investigate the epidemiological, clinical, laboratory and radiological characteristics of these patients. Methods: We included 67 Tibetan patients with confirmed ... Read more >>

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Clinical features of imported cases of coronavirus disease 2019 in Tibetan patients in the Plateau area

Yu Lei, yunping lan, jianli lu, xiaobo huang, bamu silang, fan zeng,

Abstract Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread throughout China, but the clinical characteristics of Tibetan patients living in the Qinghai-Tibetan plateau are unknown. We aimed to investigate the epidemiological, clinical, laboratory and radiological characteristics of these patients. We included 67 Tibetan patients with confirmed SARS-CoV-2 infection. ... Read more >>

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Facile Fabrication of High-Performance Pen Ink-Decorated Textile Strain Sensors for Human Motion Detection.

Shuaitao Yang, Chengwei Li, Xiyu Chen, Yongpeng Zhao, Hao Zhang, Ningxuan Wen, Zeng Fan, Lujun Pan,

Recently, wearable strain sensors have increasingly attracted much attention due to their potential applications in human motion detection and personal health monitoring. To date, it is still a challenge to fabricate a flexible strain sensor with both comfort and high performance. In this study, we dip the commercially available spandex/polyamide ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(17):19874-19881]

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Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in a Chinese Cohort.

Wei-Wei Li, Zhen Wang, Dong-Yu Fan, Ying-Ying Shen, Dong-Wan Chen, Hui-Yun Li, Ling Li, Heng Yang, Yu-Hui Liu, Xian-Le Bu, Wang-Sheng Jin, Fan Zeng, Zhi-Qiang Xu, Jin-Tai Yu, Li-Yong Chen, Yan-Jiang Wang,

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer's disease (sAD) and pathological biomarkers in cerebrospinal fluid (CSF), 462 sAD patients and 463 age-matched cognitively normal (CN) controls were genotyped for 35 single-nucleotide polymorphisms (SNPs) that are significantly associated with sAD. Then, the alleles found to be ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2020, :]

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Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression.

Yiming Liu, Li Ding, Bowen Zhang, Ziliang Deng, Yi Han, Sihan Wang, Shu Yang, Zeng Fan, Jing Zhang, Hongmin Yan, Dongmei Han, Lijuan He, Wen Yue, Hengxiang Wang, Yanhua Li, Xuetao Pei,

We reported a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow (BM). Single doses of TPO treatment to the recipients immediately after BM transplantation showed significantly improved homing of HSPCs to the BM, which subsequently resulted in enhanced ... Read more >>

Stem Cells Transl Med (Stem cells translational medicine)
[2020, 9(6):661-673]

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Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients

Zheng Zhao, Ke’nan Zhang, Qiangwei Wang, Guanzhang Li, Fan Zeng, Ying Zhang, Fan Wu, Ruichao Chai, Zheng Wang, Chuanbao Zhang, Wei Zhang, Zhaoshi Bao, Tao Jiang,

Abstract Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids in the understanding of the pathophysiology and therapy of glioma. However, comprehensive genomic data and analysis platforms are relatively limited. In this study, we developed the Chinese Glioma Genome ... Read more >>

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Comprehensive profiling identifies a novel signature with robust predictive value and reveals the potential drug resistance mechanism in glioma.

Fan Zeng, Kuanyu Wang, Xiu Liu, Zheng Zhao,

BACKGROUND:Gliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance is the main obstacle in treatment and its mechanism is still unclear. METHODS:We firstly developed a multi-gene signature by integrated analysis of cancer ... Read more >>

Cell Commun. Signal (Cell communication and signaling : CCS)
[2020, 18(1):2]

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Adsorption of dissolved organic matter from landfill leachate using activated carbon prepared from sewage sludge and cabbage by ZnCl2.

Fan Zeng, Xiaofeng Liao, Danping Pan, Huangang Shi,

Sewage sludge and cabbage (Brassica oleracea) were used to prepare activated carbon by high-temperature inert carbonization with the activator ZnCl2. The physicochemical characteristics of the sludge-based activated carbon (SAC) were analyzed, and the effects on the removal of chemical oxygen demand (COD) from the landfill leachate by the adsorbent dosage, ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(5):4891-4904]

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Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor-NPY pathway.

Xiao-Qin Wan, Fan Zeng, Xu-Feng Huang, He-Qin Yang, Lan Wang, Yan-Chuan Shi, Zhi-Hui Zhang, Shu Lin,

AIMS:Many patients taking risperidone for the treatment of psychiatric disorders experience substantial body weight gain. Researchers have speculated that risperidone induces obesity by modulating central signals; however, the precise central mechanisms involved remain to be fully elucidated. METHODS:Twenty-four C57BL/6J mice were divided into four groups: a control group; a risperidone-treated ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2020, 26(5):558-566]

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Radiotherapy was associated with the lower incidence of metachronous second primary lung cancer.

Zhi Gang Hu, Yu Feng Tian, Wen Xin Li, Fan Jun Zeng,

Our study aims to estimate the incidence of metachronous second primary lung cancer(SPLC) in initial primary lung cancer(IPLC) survivors and to determine whether radiotherapy affects the risk of metachronous SPLC in the first five years after the diagnosis of lung cancer. Incidence data of IPLC individuals who survived ≥2 years ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19283]

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Siglecs, Novel Immunotherapy Targets, Potentially Enhance The Effectiveness of Existing Immune Checkpoint Inhibitors in Glioma Immunotherapy.

Guan-Zhang Li, Ke-Nan Zhang, Zheng Wang, Hui-Min Hu, Zhi-Liang Wang, Ruo-Yu Huang, Hao-Yu Jiang, You Zhai, Yue-Mei Feng, Yuan-Hao Chang, Ren-Peng Li, Fan Wu, Fan Zeng, Tao Jiang, Wei Zhang,

Background:Inhibitors of immune checkpoints have shown little effect in clinical trials involving glioma patients. Here, we explored novel targets for use in future treatments. Previous studies showed the sialic acid-binding Ig-like lectin (Siglec) family to have a specific role in immunosuppression. We aimed to study the characteristics and immune function ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:10263-10273]

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Hypoxia induced LBH overexpression accelerates malignant progression in glioma.

Ke-Nan Zhang, Fan Zeng, Rui-Chao Chai, Jing Chen, Tao Jiang,

EBioMedicine (EBioMedicine)
[2019, 49:4-5]

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Identifying adhesive components in a model tunicate.

Fan Zeng, Julia Wunderer, Willi Salvenmoser, Thomas Ederth, Ute Rothbächer,

Tunicates populate a great variety of marine underwater substrates worldwide and represent a significant concern in marine shipping and aquaculture. Adhesives are secreted from the anterior papillae of their swimming larvae, which attach and metamorphose into permanently adhering, filter-feeding adults. We recently described the cellular composition of the sensory adhesive ... Read more >>

Philos. Trans. R. Soc. Lond., B, Biol. Sci. (Philosophical transactions of the Royal Society of London. Series B, Biological sciences)
[2019, 374(1784):20190197]

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Transcriptomic Profiling Identifies a DNA Repair-Related Signature as a Novel Prognostic Marker in Lower Grade Gliomas.

Fan Zeng, Xiu Liu, Kuanyu Wang, Zheng Zhao, Guanzhang Li,

BACKGROUND:Gliomas are the most common and malignant intracranial tumors. The standard therapy is surgical resection combined with radiotherapy and chemotherapy. However, the emergence of radioresistance and chemoresistance, which is largely due to DNA damage repair, limits the therapeutic efficacy. Therefore, we identified a high-efficiency DNA damage repair-related risk signature as ... Read more >>

Cancer Epidemiol. Biomarkers Prev. (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2019, 28(12):2079-2086]

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Neurotrophin receptor p75 mediates amyloid β-induced tau pathology.

Lin-Lin Shen, Wei-Wei Li, Ya-Li Xu, Shi-Hao Gao, Man-Yu Xu, Xian-Le Bu, Yu-Hui Liu, Jun Wang, Jie Zhu, Fan Zeng, Xiu-Qing Yao, Chang-Yue Gao, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wang,

Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation. However, the mechanism by which Aβ induces tau phosphorylation in neurons remains unclear. Neurotrophin receptor p75 (p75NTR) is a receptor for Aβ and ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2019, 132:104567]

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Molecular and clinical characterization of TMEM71 expression at the transcriptional level in glioma.

Kuan-Yu Wang, Ruo-Yu Huang, Xue-Zhi Tong, Ke-Nan Zhang, Yan-Wei Liu, Fan Zeng, Hui-Min Hu, Tao Jiang,

BACKGROUND:Glioma is the most common and aggressive type of primary brain tumor in adults. Although radiotherapy and chemotherapy are used in the treatment of glioma, survival remains unsatisfactory. Chemoresistance is one of the primary reasons for the poor prognosis of glioma. Several studies have demonstrated that glioma stem cells (GSC) ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2019, 25(9):965-975]

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Prognostic factors and nomogram for cancer-specific death in non small cell lung cancer with malignant pericardial effusion.

Zhi Gang Hu, Ke Hu, Wen Xin Li, Fan Jun Zeng,

BACKGROUND:The prognosis of lung cancer with malignant pericardial effusion is very terrible owing to the impact of cardiac tamponade. The aim of our study seeks to identify prognostic factors and establish a prognostic nomogram of non small cell lung cancer (NSCLC) with malignant pericardial effusion. METHODS:NSCLC patients with malignant pericardial ... Read more >>

PLoS ONE (PloS one)
[2019, 14(5):e0217007]

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Liver Sinusoidal Endothelial Cells Promote the Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells.

Huilin Li, Haiyun Pei, Xiaoyan Xie, Sihan Wang, Yali Jia, Bowen Zhang, Zeng Fan, Yiming Liu, Yun Bai, Yi Han, Lijuan He, Xue Nan, Wen Yue, Xuetao Pei,

Cord blood (CB) is an attractive source of hematopoietic stem cells (HSCs) for hematopoietic cell transplantation. However, its application remains limited due to the low number of HSCs/progenitors in a single CB unit and its notoriously difficulty in expanding ex vivo. Here, we demonstrated that the human fetal liver sinusoidal ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(8):]

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