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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China.

Yan Ma, Dong Shan Zhu, Ren Bo Chen, Nan Nan Shi, Si Hong Liu, Yi Pin Fan, Gui Hui Wu, Pu Ye Yang, Jiang Feng Bai, Hong Chen, Li Ying Chen, Qiao Feng, Tuan Mao Guo, Yong Hou, Gui Fen Hu, Xiao Mei Hu, Yun Hong Hu, Jin Huang, Qiu Hua Huang, Shao Zhen Huang, Liang Ji, Hai Hao Jin, Xiao Lei, Chun Yan Li, Min Qing Li, Qun Tang Li, Xian Yong Li, Hong De Liu, Jin Ping Liu, Zhang Liu, Yu Ting Ma, Ya Mao, Liu Fen Mo, Hui Na, Jing Wei Wang, Fang Li Song, Sheng Sun, Dong Ting Wang, Ming Xuan Wang, Xiao Yan Wang, Yin Zhen Wang, Yu Dong Wang, Wei Wu, Lan Ping Wu, Yan Hua Xiao, Hai Jun Xie, Hong Ming Xu, Shou Fang Xu, Rui Xia Xue, Chun Yang, Kai Jun Yang, Sheng Li Yuan, Gong Qi Zhang, Jin Bo Zhang, Lin Song Zhang, Shu Sen Zhao, Wan Ying Zhao, Kai Zheng, Ying Chun Zhou, Jun Teng Zhu, Tian Qing Zhu, Hua Min Zhang, Yan Ping Wang, Yong Yan Wang, ,

<h4>Objective</h4>Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.<h4>Methods</h4>A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. ... Read more >>

Biomed Environ Sci (Biomedical and environmental sciences : BES)
[2020, 33(12):893-905]

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CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

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Systemic Inflammasome Activation and Pyroptosis Associate with the Progression of Alzheimer’s Disease

wenjuan rui, Hong Xiao, Yi Fan, Zhongxuan Ma, Ming Xiao, Sheng Li, Jingping Shi,

<h4>Background: </h4> Growing evidence indicates that inflammasome-mediated inflammation plays an important role in the pathophysiology of Alzheimer’s disease (AD). Likewise, gasdermin D (GSDMD) as executive molecule in inflammasome-induced pyroptosis is also involved in many neurological disorders. However, it is not clear whether inflammasome and pyroptosis is activated in the periphery ... Read more >>

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Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.

Fan Yang, Zhenqiang He, Hao Duan, Duo Zhang, Juehui Li, Huijuan Yang, Jay F Dorsey, Wei Zou, S Ali Nabavizadeh, Stephen J Bagley, Kalil Abdullah, Steven Brem, Lin Zhang, Xiaowei Xu, Katelyn T Byrne, Robert H Vonderheide, Yanqing Gong, Yi Fan,

Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages (Mϕs). Consistent with a pro-tumor role of IL-6 in alternative Mϕs polarization, we here show that targeting IL-6 by genetic ablation or pharmacological inhibition moderately improves T-cell infiltration into GBM and ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3424]

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TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1.

Jian Zhao, Baoshan Cai, Zhugui Shao, Lei Zhang, Yi Zheng, Chunhong Ma, Fan Yi, Bingyu Liu, Chengjiang Gao,

Protein ubiquitination plays an important role in the regulation of TGF-β-activated kinase 1 (TAK1)-mediated NF-κB activation. It is well established that TAK1 activation is tightly regulated with its binding partners, TAK1-binding proteins (TAB1-3). However, the tight regulation of TAK1 activation remains elusive. Here, using Trim26-knockout mice and Trim26-transgenic mice, we ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2021, :]

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Dichotomous and stable gamma delta T-cell number and function in healthy individuals.

Lingling Ou, Huaishan Wang, Qin Liu, Jie Zhang, Hezhe Lu, Liangping Luo, Changzheng Shi, Shaoqiang Lin, Liyun Dong, Yeye Guo, Lili Huang, Jinjin Zhu, Xiangfan Yin, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Cathy Zheng, Yi Fan, Wei Guo, Xiaowei Xu,

<h4>Background</h4>Gamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, adoptive immunotherapy with γδT cells has exhibited mixed treatment responses. Better understanding of γδT cell biology and stratifying healthy donors for allogeneic adoptive therapy is clinically needed to ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(5):]

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Fibrocartilage Stem Cells in the Temporomandibular Joint: Insights From Animal and Human Studies.

Yi Fan, Chen Cui, Peiran Li, Ruiye Bi, Ping Lyu, Yanxi Li, Songsong Zhu,

Temporomandibular disorders (TMD) are diseases involving the temporomandibular joint (TMJ), masticatory muscles, and osseous components. TMD has a high prevalence, with an estimated 4.8% of the U.S. population experiencing signs and symptoms, and represents a financial burden to both individuals and society. During TMD progression, the most frequently affected site ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:665995]

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Universal and Programmable Rolling Circle Amplification-CRISPR/Cas12a-Mediated Immobilization-Free Electrochemical Biosensor.

Min Qing, Sheng Liang Chen, Zhe Sun, Yi Fan, Hong Qun Luo, Nian Bing Li,

The development of a sensing platform with high sensitivity and specificity, especially programmability and universal applicability, for the detection of clinically relevant molecules is highly valuable for disease monitoring and confirmation but remains a challenge. Here, for the first time, we introduce the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(20):7499-7507]

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Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.

Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun Hu,

Osteoarthritis (OA) is the most common chronic joint disease in the elderly population. Growing evidence indicates that a balance between autophagy and apoptosis in chondrocytes plays a key role in OA's cartilage degradation. Thus, drugs targeting the balance between apoptosis and autophagy are potential therapeutic approaches for OA treatment. In ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(5):448]

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Prostate stromal tumor with prostatic cysts after transurethral resection of the prostate: A case report.

Li-Wei Zhao, Ji Sun, Yu-Yong Wang, Run-Miao Hua, Sheng-Cheng Tai, Kai Wang, Yi Fan,

<h4>Background</h4>A prostatic stromal tumor is deemed to be a rare oncology condition. Based on the retrospective analysis of clinical data and scientific literature review, a case of prostatic stromal tumor was reported in this article to explore the diagnosis, treatment and prognosis of this rare disease.<h4>Case summary</h4>The present case involved ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2021, 9(12):2830-2837]

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Hepatitis B immunoglobulin (HBIG) combined with long-term entecavir prophylaxis for hepatitis B virus infection in allogeneic hematopoietic stem cell transplantation with hepatitis B surface antigen-positive donors.

Yaoyao Shen, Jiaqian Qi, Yi Wang, Jia Chen, Yi Fan, Ying Wang, Depei Wu, Yang Xu,

Leuk Lymphoma (Leukemia & lymphoma)
[2021, :1-4]

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Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils.

Jifeng Zhao, Yun Li, Yan Li, Shi Xu, Tingting Tao, Ye Hua, Ji Zhang, Yi Fan,

Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in prion-like αSyn spreading is the cholinergic innervated vagus nervous system ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:637319]

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Pure rotational Raman lidar for full-day troposphere temperature measurement at Zhongshan Station (69.37°S, 76.37°E), Antarctica.

Fuchao Liu, Rui Wang, Fan Yi, Wentao Huang, Chao Ban, Weilin Pan, Zhangjun Wang, Hongqiao Hu,

A pure rotational Raman lidar (PRRL) for full-day troposphere temperature measurement was deployed in February 2020 at Zhongshan Station (69.37°S, 76.37°E), Antarctica, by the 36<sup>th</sup> Chinese National Antarctic Research Expedition. The PRRL emits a 532.23-nm laser light and employs a 203.2-mm telescope to collect atmospheric backscatter. Cubic nonpolarizing beam splitters ... Read more >>

Opt Express (Optics express)
[2021, 29(7):10059-10076]

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Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.

Christopher J Collins, Fan Yi, Remwilyn Dayuha, Phi Duong, Simon Horslen, Michelle Camarata, Ayse K Coskun, Roderick H J Houwen, Tudor L Pop, Heinz Zoller, Han-Wook Yoo, Sung Won Jung, Karl H Weiss, Michael L Schilsky, Peter Ferenci, Si Houn Hahn,

<h4>Background & aims</h4>Both existing clinical criteria and genetic testing have significant limitations for the diagnosis of Wilson disease (WD), often creating ambiguities in patient identification and leading to delayed diagnosis and ineffective management. ATP7B protein concentration, indicated by direct measurement of surrogate peptides from patient dried blood spot samples, could ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 160(7):2367-2382.e1]

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Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1/STAT6 pathways.

Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan,

<h4>Background</h4>Increasing evidence suggests that microglia experience two distinct phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a neuroprotective M2 phenotype. Promoting the phenotype shift of M1 microglia to M2 microglia is thought to improve functional recovery after AIS. Minocycline, a tetracycline antibiotic, can improve functional recovery after ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 186:114464]

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Efficiency and Toxicity of Ruxolitinib as the Salvage Treatment in Steroid-Refractory Acute Graft-Versus-Host Disease after Haplo-Identical Stem Cell Transplantation.

Yin Liu, Yi Fan, Wenli Zhang, Jia Chen, Qiao Cheng, Xiao Ma, Zhihong Lin, Depei Wu, Yang Xu,

Haplo-identical stem cell transplantation (haplo-SCT) for hematological malignancies has ushered in a new era in which everyone has a potential donor. However, the occurrence of steroid-refractory acute graft-versus-host disease (SR-aGVHD), with no priority among second-line therapies, leads to late mortality after haplo-SCT. Ruxolitinib is the first drug recommended for SR-aGVHD. ... Read more >>

Transplant Cell Ther (Transplantation and cellular therapy)
[2021, 27(4):332.e1-332.e8]

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Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.

Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-Jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H Eric Xu, Yan Zhang, Jin-Peng Sun,

Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available<sup>1-3</sup>. Here we report that glucocorticoid stress hormones activate adhesion G-protein-coupled receptor G3 (ADGRG3; also known as GPR97)<sup>4-6</sup>, a prototypical adhesion GPCR. The cryo-electron microscopy structures of GPR97-G<sub>o</sub> complexes bound ... Read more >>

Nature (Nature)
[2021, 589(7843):620-626]

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Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor.

Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Jennifer Koenitzer, Yali Chen, Stephanie Briceno, Rajarshi Bhadra, Elizabeth Duperret, Johnni Gullo-Brown, Chan Gao, Dandan Zhao, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John Morrison, Michael Quigley, John T Hunt, Luisa Salter-Cid, Emma Lees, Miguel A Sanjuan, Jinqi Liu,

<h4>Background</h4>Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice. Pharmacological inhibition of HPK1 is desirable to investigate the role of HPK1 in human immune cells with therapeutic implications. However, a ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2021, 9(1):]

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Characterization of Novel Rhabdoviruses in Chinese Bats.

Dong-Sheng Luo, Bei Li, Xu-Rui Shen, Ren-Di Jiang, Yan Zhu, Jia Wu, Yi Fan, Hervé Bourhy, Ben Hu, Xing-Yi Ge, Zheng-Li Shi, Laurent Dacheux,

Bats, the second largest order of mammals worldwide, harbor specific characteristics such as sustaining flight, a special immune system, unique habits, and ecological niches. In addition, they are the natural reservoirs of a variety of emerging or re-emerging zoonotic pathogens. <i>Rhabdoviridae</i> is one of the most diverse families of RNA ... Read more >>

Viruses (Viruses)
[2021, 13(1):]

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Minocycline Promotes Functional Recovery in Ischemic Stroke by Modulating Microglia Polarization Through STAT1/STAT6 Pathways

Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan,

<h4>Background: </h4> Increasing evidence suggests that microglia experience two distinct phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a neuroprotective M2 phenotype. Promoting the phenotype shift of M1 microglia to M2 microglia is thought to improve functional recovery after AIS. Minocycline, a tetracycline antibiotic, can improve functional ... Read more >>

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Statistical analysis of age-related skin parameters.

Hong Meng, Weixuan Lin, Yinmao Dong, Li Li, Fan Yi, Qingyang Meng, Yue Li, Yifan He,

<h4>Background</h4>Due to the increasing interest in human anti-aging, demand for a higher quality of life, and technological advancement, the development of anti-aging skincare has great market prospects. Most cosmetic companies develop products driven by the market or focus on the mechanism of action of substances and the behavior of skin; ... Read more >>

Technol Health Care (Technology and health care : official journal of the European Society for Engineering and Medicine)
[2021, 29(S1):65-76]

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Fluctuation in red cell distribution width predicts disseminated intravascular coagulation morbidity and mortality in sepsis: a retrospective single-center study.

Yi W Fan, Dan Liu, Jia M Chen, Wen J Li, Cheng J Gao,

<h4>Background</h4>Red cell distribution width (RDW) values increase in many diseases and conditions, including sepsis. However, the relationship between RDW fluctuation and prognosis in patients with sepsis or the likely morbidity associated with sepsis-induced disseminated intravascular coagulation (DIC) has not been previously investigated. This study examined the association between dynamic changes ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(1):52-64]

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Raman spectroscopic analysis of skin penetration and moisturizing effects of Bionics vernix caseosa cream compared with Vaseline.

Hong Meng, Yating Yin, Wenhai Wu, Yuhong Liu, Li Li, Yinmao Dong, Yi Fan, Yue Li, Yifan He,

<h4>Background</h4>The stratum corneum (SC) is the outermost layer of human skin and deemed as barrier against chemical exposure and water loss. Moisturizers have beneficial effects in treating dry skin, especially the SC. Confocal Raman spectroscopy (CRS) was used to evaluate the efficacy of moisturizers on skin hydration and penetration, with ... Read more >>

Technol Health Care (Technology and health care : official journal of the European Society for Engineering and Medicine)
[2021, 29(S1):327-334]

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The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors.

Ranjay Chakraborty, Michael J Collins, Henry Kricancic, Daniel Moderiano, Brett Davis, David Alonso-Caneiro, Fan Yi, Karthikeyan Baskaran,

<h4>Purpose</h4>The intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults ... Read more >>

J Optom (Journal of optometry)
[2021, :]

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Controlling Nutritional Status Score Evaluates Prognosis in Patients With Non-Muscle Invasive Bladder Cancer.

Jiaguo Huang, Liwei Zhao, Kai Wang, Ji Sun, Shengcheng Tai, Runmiao Hua, Yufu Yu, Yi Fan,

<h4>Objective</h4>We investigated the clinical value of the Controlling Nutritional Status score in evaluating the prognosis of patients with non-muscle invasive bladder cancer.<h4>Methods</h4>We conducted a retrospective analysis of the clinical data of 88 patients with non-muscle invasive bladder cancer who underwent transurethral resection of bladder tumor or partial cystectomy between January ... Read more >>

Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2021, 28:10732748211021078]

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