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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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New evidence of direct oral anticoagulation therapy on cardiac valve calcifications, renal preservation and inflammatory modulation.

Luca Di Lullo, Carlo Lavalle, Michele Magnocavallo, Marco Valerio Mariani, Domenico Giovanni Della Rocca, Paolo Severino, Biagio Raffaele Di Iorio, Domenico Russo, Francesco Summaria, Giovanni Battista Forleo, Claudio Ronco, Massimo Mancone, Cristina Chimenti, Fabio Miraldi, Andrea Natale, Antonio Bellasi,

<h4>Background</h4>Rivaroxaban is a direct inhibitor of activated Factor X (FXa), an anti-inflammatory protein exerting a protective effect on the cardiac valve and vascular endothelium. We compare the effect of Warfarin and Rivaroxaban on inflammation biomarkers and their contribution to heart valve calcification progression and renal preservation in a population of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 345:90-97]

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Myocardial Aldosterone Receptor and Aquaporin 1 Up-Regulation Is Associated with Cardiomyocyte Remodeling in Human Heart Failure

Andrea Frustaci, Claudio Letizia, Cristina Chimenti, Romina Verardo, Maria Alfarano, Rossella Scialla, Giulia Bagnato, Fabio Miraldi, Luigi Sansone, Matteo Antonio Russo,

Background: Abnormal aldosterone signaling is a recognized source of cardiovascular damage. Its influence on cardiomyocyte structure, function, and hormonal receptors when associated with heart failure is still unreported. Methods: Twenty-six consecutive patients with heart failure (LVEF < 40%) and normal coronaries and valves underwent left ventricular endomyocardial biopsy (EMB) for ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Myocardial Aldosterone Receptor and Aquaporin 1 Up-Regulation Is Associated with Cardiomyocyte Remodeling in Human Heart Failure.

Andrea Frustaci, Claudio Letizia, Cristina Chimenti, Romina Verardo, Maria Alfarano, Rossella Scialla, Giulia Bagnato, Fabio Miraldi, Luigi Sansone, Matteo Antonio Russo,

<h4>Background</h4>Abnormal aldosterone signaling is a recognized source of cardiovascular damage. Its influence on cardiomyocyte structure, function, and hormonal receptors when associated with heart failure is still unreported.<h4>Methods</h4>Twenty-six consecutive patients with heart failure (LVEF < 40%) and normal coronaries and valves underwent left ventricular endomyocardial biopsy (EMB) for evaluation of myocardial ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Michele Magnocavallo, Marco Valerio Mariani, Lucrezia Netti, Lucia Ilaria Birtolo, Paolo De Orchi, Cristina Chimenti, Viviana Maestrini, Fabio Miraldi, Carlo Lavalle, Viviana Caputo, Raffaele Palmirotta, Massimo Mancone, Francesco Fedele,

<b>Background:</b> IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: a Systematic Review.

Omar Giacinto, Alessandro Minati, Mario Lusini, Francesco Cardetta, Sara Saltarocchi, Mizar D'Abramo, Fabio Miraldi, Massimo Chello,

<h4>Purpose</h4>Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This systematic review aimed to investigate the efficacy of colchicine, indomethacin, and dexamethasone in the treatment and prophylaxis of PPS.<h4>Methods</h4>Literature research was carried out using PubMed. Studies investigating ≥ 10 patients with clinically PPS treated with colchicine, dexamethasone, and indomethacin and compared ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache.

Armando Perrotta, Giuseppe Biondi-Zoccai, Wael Saade, Fabio Miraldi, Andrea Morelli, Antonino G Marullo, Elena Cavarretta, Roberto Carnevale, Elena DE Falco, Isotta Chimenti, Sebastiano Sciarretta, Paola Frati, Mamas A Mamas, Sara Ciardi, Luigi Frati, Giacomo Frati, Mariangela Peruzzi,

<h4>Background</h4>New messenger RNA (mRNA) and adenovirus-based vaccines (AdV) against Coronavirus disease 2019 (COVID-19) have entered large scale clinical trials. Since healthcare professionals (HCPs) and armed forces personnel (AFP) represent a high-risk category, they act as a suitable target population to investigate vaccine-related side effects, including headache, which has emerged as ... Read more >>

Panminerva Med (Panminerva medica)
[2021, 63(3):324-331]

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Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: A Meta-analysis of Main Trials

Omar Giacinto, Alessandro Minati, Mario Lusini, Francesco Cardetta, Sara Saltarocchi, Mizar D'Abramo, Fabio Miraldi, Massimo Chello,

<h4>Purpose: </h4> Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This study represents a meta-analysis of trials on treatment and prophylaxis of PPS with colchicine, indomethacin and dexamethasone. The primary endpoint was to investigate the efficacy of these drugs, while the secondary endpoints were the efficacy in reducing ... Read more >>

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3D morphometric analysis of ascending aorta as an adjunctive tool to predict type A acute aortic dissection.

Wael Saade, Mattia Vinciguerra, Silvia Romiti, Francesco Macrina, Giacomo Frati, Fabio Miraldi, Ernesto Greco,

<h4>Background</h4>Acute type A aortic dissection (AAAD) is a pathological process that implicates the ascending aorta and represents a surgical emergency burdened by high mortality if not promptly treated in the first hours of onset. Despite best efforts, the annual incidence rates of aortic dissection has remained stable over the past ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2021, 13(6):3443-3457]

Cited: 1 time

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Beating Versus Arrested Heart Isolated Tricuspid Valve Surgery: Long-term Outcomes.

Marco Russo, Michele Di Mauro, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B Leviner, Andrea Biondi, Ester Della Ratta, Ugolino Livi, Erez Sharoni, Paul Werner, Carlo De Vincentiis, Marco Di Eusanio, Alfred Kocher, Carlo Antona, Fabio Miraldi, Giovanni Troise, Marco Solinas, Francesco Maisano, Guenther Laufer, Francesco Musumeci, Martin Andreas,

<h4>Background</h4>Isolated tricuspid valve (TV) surgery is a rare procedure generally considered at high risk for perioperative mortality and poor long-term outcomes. Surgical treatment can be performed with either an arrested heart (AH) or beating heart (BH) technique. The aim of this study was to compare the outcomes of isolated tricuspid ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Cardiac surgery practice during the COVID-19 outbreak: a multicentre national survey.

Antonino Salvatore Rubino, Luca Salvatore De Santo, Antonio Pisano, Michele di Mauro, Stefano Benussi, Valentino Borghetti, Alessandro Castiglioni, Luigi Chiariello, Andrea Colli, Antonio De Bellis, Carlo Maria De Filippo, Ruggero De Paulis, Giuseppe Di Benedetto, Marco Di Eusanio, Giuseppe Faggian, Brenno Fiorani, Pasquale Antonio Fratto, Angelo Giuseppe Giuffrida, Mattia Glauber, Gabriele Iannelli, Severino Iesu, Ugolino Livi, Gianluca Martinelli, Massimo Massetti, Pasquale Mastroroberto, Lorenzo Menicanti, Giuseppe Minniti, Fabio Miraldi, Gianfranco Montesi, Francesco Musumeci, Francesco Nicolini, Carlo Pace Napoleone, Paolo Panisi, Aniello Pappalardo, Francesco Patanè, Temistocle Ragni, Mauro Rinaldi, Salvatore Tribastone, Michele Triggiani, Francesco Paolo Tritto, Carlo Zebele, Alessandro Parolari, Gino Gerosa, Marisa De Feo, ,

<h4>Objectives</h4>Healthcare systems worldwide have been overburdened by the coronavirus disease 2019 (COVID-19) outbreak. Accordingly, hospitals had to implement strategies to profoundly reshape both non-COVID-19 medical care and surgical activities. Knowledge about the impact of the COVID-19 pandemic on cardiac surgery practice is pivotal. The goal of the present study was ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2021, 59(4):901-907]

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Myocarditis-associated necrotizing coronary vasculitis: incidence, cause, and outcome.

Andrea Frustaci, Maria Alfarano, Romina Verardo, Chiara Agrati, Rita Casetti, Fabio Miraldi, Nicola Galea, Claudio Letizia, Cristina Chimenti,

<h4>Aims</h4>Necrotizing coronary vasculitis (NCV) is a rare entity usually associated to myocarditis which incidence, cause, and response to therapy is unreported.<h4>Methods and results</h4>Among 1916 patients with biopsy-proven myocarditis, 30 had NCV. Endomyocardial samples were retrospectively investigated with immunohistochemistry for toll-like receptor 4 (TLR4) and real-time polymerase chain reaction (PCR) for ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(16):1609-1617]

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Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study.

Lorenzo Loffredo, Roberto Carnevale, Simona Battaglia, Roberta Marti, Stefano Pizzolo, Simona Bartimoccia, Cristina Nocella, Vittoria Cammisotto, Sebastiano Sciarretta, Isotta Chimenti, Elena De Falco, Elena Cavarretta, Mariangela Peruzzi, Antonino Marullo, Fabio Miraldi, Francesco Violi, Andrea Morelli, Giuseppe Biondi-Zoccai, Giacomo Frati,

Tobacco habit still represents the leading preventable cause of morbidity and mortality worldwide. Heat-not-burn cigarettes (HNBCs) are considered as an alternative to traditional combustion cigarettes (TCCs) due to the lack of combustion and the absence of combustion-related specific toxicants. The aim of this observational study was to assess the effect ... Read more >>

Thorax (Thorax)
[2021, 76(6):618-620]

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Von Willebrand factor with increased binding capacity is associated with reduced platelet aggregation but enhanced agglutination in COVID-19 patients: another COVID-19 paradox?

Franco Ruberto, Antonio Chistolini, Mariaignazia Curreli, Giacomo Frati, Antonino G M Marullo, Giuseppe Biondi-Zoccai, Massimo Mancone, Sebastiano Sciarretta, Fabio Miraldi, Francesco Alessandri, Giancarlo Ceccarelli, Francesco Barone, Cristina Santoro, Domenico Alvaro, Francesco Pugliese, Fabio M Pulcinelli, ,

Patients with Coronavirus-associated disease-2019 (COVID-19) display alterations of the hemostatic system and the presence of a prothrombotic status frequently leading to vascular complications. However, the impact of COVID-19 on platelet activity, aggregation and agglutination still needs to be clarified. We measured total levels of von Willebrand factor (vWF) and vWF ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 52(1):105-110]

Cited: 3 times

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Clinical Conundrum: Three Management Strategies for Three-Vessel Coronary Artery Disease?

Giuseppe Biondi-Zoccai, Giacomo Frati, Fabio Miraldi, Giovanni A Chiariello, Francesco Versaci,

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2020, 76(5):489-491]

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Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study.

Giusy Tiseo, Elena Cavarretta, Arianna Forniti, Cristina Nocella, Sebastiano Sciarretta, Ornella Spagnolello, Enrico Baldini, Mariangela Peruzzi, Giuliano Bertazzoni, Francesco Menichetti, Antonino G M Marullo, Fabio Miraldi, Andrea Morelli, Giacomo Frati, Roberto Carnevale, Falcone Marco,

<h4>Background</h4>Although preclinical studies highlighted the potential role of NADPH oxidase (NOX) in sepsis, only few studies evaluated the oxidative stress in patients with sepsis and septic shock. The objective of the study is to appraise the oxidative stress status and platelet function in patients with sepsis and septic shock compared ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:4165358]

Cited: 1 time

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Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review.

Fabio Infusino, Massimiliano Marazzato, Massimo Mancone, Francesco Fedele, Claudio Maria Mastroianni, Paolo Severino, Giancarlo Ceccarelli, Letizia Santinelli, Elena Cavarretta, Antonino G M Marullo, Fabio Miraldi, Roberto Carnevale, Cristina Nocella, Giuseppe Biondi-Zoccai, Cristiano Pagnini, Sonia Schiavon, Francesco Pugliese, Giacomo Frati, Gabriella d'Ettorre,

The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 44 times

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Extracorporeal membrane oxygenation for critically ill patients with coronavirus-associated disease 2019: an updated perspective of the European experience.

Antonino G Marullo, Elena Cavarretta, Giuseppe Biondi Zoccai, Massimo Mancone, Mariangela Peruzzi, Fernando Piscioneri, Patrizio Sartini, Francesco Versaci, Andrea Morelli, Fabio Miraldi, Giacomo Frati,

<h4>Background</h4>Infection due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), i.e. coronavirus-associated disease 2019 (COVID-2019), may occasionally lead to acute respiratory distress syndrome (ARDS), requiring in the most severe cases extracorporeal membrane oxygenation (ECMO). Yet, limited data, if any, are currently available on the role of ECMO in critically ill patients with ... Read more >>

Minerva Cardioangiol (Minerva cardioangiologica)
[2020, 68(5):368-372]

Cited: 16 times

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Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

<h4>Aims</h4>Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :]

Cited: 4 times

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Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

AIMS:Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487320926780]

Cited: 6 times

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Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease.

Valeria Raparelli, Giulio Francesco Romiti, Valeria Spugnardi, Marco Borgi, Roberto Cangemi, Stefania Basili, Marco Proietti, ,

<h4>Background</h4>The reasons behind low adherence to the Mediterranean diet (Med-diet) are still not entirely known. We aimed to evaluate the effect of biological (i.e., sex-related) and psycho-socio-cultural (i.e., gender-related) factors on Med-diet adherence.<h4>Methods</h4>Baseline Med-diet adherence was measured using a self-administered questionnaire among adults with ischemic heart disease (IHD) from the ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

Cited: 1 time

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Hypothermia during Surgical Treatment of Type A Aortic Dissection: A 16 Years' Experience.

Francesco Macrina, Maria Cristina Acconcia, Luigi Tritapepe, Mizar D'abramo, Wael Saade, Alessandra Capelli, Fabio Miraldi,

Acute aortic dissection (AAD) is among the most challenging cases for surgical treatment and requires procedural expertise for its safe conduct. Aortic surgery has undergone several changes over the last years, especially concerning cerebral protection. The brilliant results obtained with the aid of selective anterograde cerebral perfusion led to a ... Read more >>

Int J Vasc Med (International journal of vascular medicine)
[2020, 2020:3893261]

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Echocardiography and Correction of Mitral Regurgitation: An Unbreakable Link.

Sara Cimino, Fabio Guarracino, Valentina Valenti, Giacomo Frati, Sebastiano Sciarretta, Fabio Miraldi, Luciano Agati, Ernesto Greco,

<h4>Background</h4>Degenerative mitral valve (MV) disease causing mitral regurgitation (MR) is the most common organic valve pathology and is classified based on leaflet motion. MV repair is indicated as the preferred technique (Class I indication) when the results are expected to be durable. Therefore, a detailed and systematic evaluation of MV ... Read more >>

Cardiology (Cardiology)
[2020, 145(2):110-120]

Cited: 4 times

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On the Road to Regeneration: "Tools" and "Routes" Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy.

Francesca Pagano, Vittorio Picchio, Isotta Chimenti, Alessia Sordano, Elena De Falco, Mariangela Peruzzi, Fabio Miraldi, Elena Cavarretta, Giuseppe Biondi Zoccai, Sebastiano Sciarretta, Giacomo Frati, Antonino G M Marullo,

PURPOSE OF REVIEW:Cardiac regenerative medicine is a field bridging together biotechnology and surgical science. In this review, we present the explored surgical roads to cell delivery and the known effects of each delivery method on cell therapy efficiency. We also list the more recent clinical trials, exploring the safety and ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2019, 21(11):133]

Cited: 2 times

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Get out of trouble during redo surgery for false aneurysm of the ascending aorta.

Ernesto Greco, Valeria Santamaria, Mizar D'Abramo, Marco Totaro, Giacomo Frati, Fabio Miraldi,

Asian Cardiovasc Thorac Ann (Asian cardiovascular & thoracic annals)
[2020, 28(2):104-107]

Cited: 0 times

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