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Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry.

Fiona Tea, Deepti Pilli, Sudarshini Ramanathan, Joseph A Lopez, Vera Merheb, Fiona X Z Lee, Alicia Zou, Ganesha Liyanage, Chelsea B Bassett, Selina Thomsen, Stephen W Reddel, Michael H Barnett, David A Brown, Russell C Dale, Fabienne Brilot, ,

Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which serum binding to MOG-expressing cells and control ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:119]

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International multicenter examination of MOG antibody assays.

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, James P Fryer, John Mills, Bianca Teegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stöcker, Juliane Eggert, Eoin P Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Maria Isabel Leite, Jacqueline Palace, Sarosh R Irani, Russell C Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean J Pittock, Patrick Waters,

OBJECTIVE:To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers. METHODS:The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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PRES-like presentation in MOG antibody-related demyelination (MARD).

Joel Corbett, Sandeep Bhuta, Kerri Prain, Fabienne Brilot, Arman Sabet, Simon A Broadley,

A 33-year-old male presented with a progressive four-week history of frontal headache and left visual field impairment. MRI brain confirmed bilateral, asymmetric, occipital vasogenic oedema, suggestive of posterior reversible encephalopathy syndrome (PRES). Serum testing for MOG antibodies was positive, confirming a diagnosis of MOG antibody-related demyelination (MARD). A similar PRES-like ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 72:453-455]

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The clinical profile of NMOSD in Australia and New Zealand.

Wajih Bukhari, Laura Clarke, Cullen O'Gorman, Elham Khalilidehkordi, Simon Arnett, Kerri M Prain, Mark Woodhall, Roger Silvestrini, Christine S Bundell, Sudarshini Ramanathan, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Wallace Brownlee, Helmut Butzkueven, William M Carroll, Celia Chen, Alan Coulthard, Russell C Dale, Chandi Das, Keith Dear, Marzena J Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor J Kilpatrick, John King, Chris Kneebone, Andrew J Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A L Macdonnell, Deborah F Mason, Pamela A McCombe, Jennifer Pereira, John D Pollard, Stephen W Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie M Yiu, Michael H Barnett, Allan G Kermode, Mark P Marriott, John Parratt, Mark Slee, Bruce V Taylor, Ernest Willoughby, Robert J Wilson, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A Broadley,

Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. ... Read more >>

J. Neurol. (Journal of neurology)
[2020, 267(5):1431-1443]

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Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.

Ariel Dahan, Fabienne Brilot, Richard Leventer, Andrew J Kornberg, Russell C Dale, Eppie M Yiu,

Neuromyelitis optica spectrum disorder is uncommon in children, and often seronegative for aquaporin-4 immunoglobulin G (AQP4-IgG). We conducted a retrospective study of 67 children presenting to a single Australian center with acquired demyelinating syndromes over a 7-year period. All patients were tested for AQP4-IgG. Five children (7.5%) had neuromyelitis optica ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(4):291-296]

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An international multicenter examination of MOG antibody assays

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, Jim Fryer, John Mills, Bianca Tegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stocker, Juliane Eggert, Eoin Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Isabel Leite, Jacqueline Palace, Sarosh Irani, Russell Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean Pittock, Patrick Waters,

Objectives: To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods: The following samples were analyzed: MOG-IgG clearly positive sera (n=39), MOG-IgG low positive sera (n=39), borderline negative sera (n=13), clearly negative sera (n=40), and healthy ... Read more >>

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Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.

Fiona Tea, Joseph A Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X Z Lee, Alicia Zou, Deepti Pilli, Ellis Patrick, Anneke van der Walt, Mastura Monif, Esther M Tantsis, Eppie M Yiu, Steve Vucic, Andrew P D Henderson, Anthony Fok, Clare L Fraser, Jeanette Lechner-Scott, Stephen W Reddel, Simon Broadley, Michael H Barnett, David A Brown, Jan D Lunemann, Russell C Dale, Fabienne Brilot, ,

Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves, spinal cord, and brain. While the clinical relevance of MOG Ab detection is becoming increasingly clear as therapeutic and prognostic differences from multiple sclerosis ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2019, 7(1):145]

Cited: 1 time

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AQP4 Antibody Assay Sensitivity Comparison in the Era of the 2015 Diagnostic Criteria for NMOSD.

Kerri Prain, Mark Woodhall, Angela Vincent, Sudarshini Ramanathan, Michael H Barnett, Christine S Bundell, John D E Parratt, Roger A Silvestrini, Wajih Bukhari, , Fabienne Brilot, Patrick Waters, Simon A Broadley,

We have compared five different assays for antibodies to aquaporin-4 in 181 cases of suspected Neuromyelitis optica spectrum disorders (NMOSD) and 253 controls to assess their relative utility. As part of a clinically-based survey of NMOSD in Australia and New Zealand, cases of suspected NMOSD were referred from 23 centers. ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:1028]

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Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring.

Hannah F Jones, Alvin C C Ho, Suvasini Sharma, Shekeeb S Mohammad, Kavitha Kothur, Shrujna Patel, Fabienne Brilot, Adam J Guastella, Russell C Dale, ,

Epidemiological studies, animal models, and case-control studies indicate maternal immune activation may be an important factor involved in disease expression of autism spectrum disorder (ASD), Tourette syndrome, and obsessive-compulsive disorder (OCD). We report eight children (mean age 6y 6mo [range 4-15y]; six males and two females) referred over a 2-year ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(8):984-988]

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Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children.

Esther M Tantsis, Kristina Prelog, Gulay Alper, Leslie Benson, Mark Gorman, Ming Lim, Shekeeb S Mohammad, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dale, ,

AIM:We used magnetic resonance imaging (MRI) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (EV71-TM), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (MOG-TM), aquaporin-4 antibody positive transverse myelitis (AQP4-TM), transverse myelitis in multiple sclerosis (MS-TM), and unclassified transverse myelitis (UNC-TM). METHOD:We performed ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(9):1108-1116]

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Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children.

Sudarshini Ramanathan, Gina L O'grady, Stephen Malone, Claire G Spooner, David A Brown, Deepak Gill, Fabienne Brilot, Russell C Dale,

Myelin oligodendrocyte glycoprotein (MOG) antibodies have a strong association with acute disseminated encephalomyelitis (ADEM) in children, and bilateral and recurrent optic neuritis in children and adults. Recent reports suggest that seizures and encephalopathy may occur in children and adults with MOG antibody-associated disease. We describe the clinical, laboratory, and radiological ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(5):610-614]

Cited: 2 times

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Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.

Sudarshini Ramanathan, Shekeeb Mohammad, Esther Tantsis, Tina Kim Nguyen, Vera Merheb, Victor S C Fung, Owen Bruce White, Simon Broadley, Jeannette Lechner-Scott, Steve Vucic, Andrew P D Henderson, Michael Harry Barnett, Stephen W Reddel, Fabienne Brilot, Russell C Dale, ,

OBJECTIVE:We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS:We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS:The most ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(2):127-137]

Cited: 34 times

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Editorial: Induction of Central Nervous System Disease by the Adaptive Immune Response.

Robert Weissert, Fabienne Brilot,

Front Immunol (Frontiers in immunology)
[2017, 8:1218]

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Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description.

Kerrie-Anne Chen, Fabienne Brilot, Russell C Dale, Antony R Lafferty, Peter Ian Andrews,

To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE).A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2017, 21(6):898-901]

Cited: 1 time

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Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System.

Deepti Pilli, Alicia Zou, Fiona Tea, Russell C Dale, Fabienne Brilot,

It is being increasingly recognized that a dysregulation of the immune system plays a vital role in neurological disorders and shapes the treatment of the disease. Aberrant T cell responses, in particular, are key in driving autoimmunity and have been traditionally associated with multiple sclerosis. Yet, it is evident that ... Read more >>

Front Immunol (Frontiers in immunology)
[2017, 8:652]

Cited: 8 times

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Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders.

Nese Sinmaz, Fiona Tea, Deepti Pilli, Alicia Zou, Mazen Amatoury, Tina Nguyen, Vera Merheb, Sudarshini Ramanathan, Sandra T Cooper, Russell C Dale, Fabienne Brilot,

Anti-Dopamine-2 receptor (D2R) antibodies have been recently identified in a subgroup of children with autoimmune movement and psychiatric disorders, however the epitope(s) and mechanism of pathogenicity remain unknown. Here we report a major biological role for D2R extracellular N-terminus as a regulator of receptor surface availability, and as a major ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2016, 4(1):126]

Cited: 5 times

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Utility of CSF Cytokine/Chemokines as Markers of Active Intrathecal Inflammation: Comparison of Demyelinating, Anti-NMDAR and Enteroviral Encephalitis.

Kavitha Kothur, Louise Wienholt, Shekeeb S Mohammad, Esther M Tantsis, Sekhar Pillai, Philip N Britton, Cheryl A Jones, Rajeshwar R Angiti, Elizabeth H Barnes, Timothy Schlub, Sushil Bandodkar, Fabienne Brilot, Russell C Dale,

BACKGROUND:Despite the discovery of CSF and serum diagnostic autoantibodies in autoimmune encephalitis, there are still very limited CSF biomarkers for diagnostic and monitoring purposes in children with inflammatory or autoimmune brain disease. The cause of encephalitis is unknown in up to a third of encephalitis cohorts, and it is important ... Read more >>

PLoS ONE (PloS one)
[2016, 11(8):e0161656]

Cited: 25 times

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B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination.

Kavitha Kothur, Louise Wienholt, Esther M Tantsis, John Earl, Sushil Bandodkar, Kristina Prelog, Fiona Tea, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dale,

BACKGROUND:Myelin oligodendrocyte glycoprotein antibody (MOG Ab) associated demyelination represents a subgroup of autoimmune demyelination that is separate from multiple sclerosis and aquaporin 4 IgG-positive NMO, and can have a relapsing course. Unlike NMO and MS, there is a paucity of literature on immunopathology and CSF cytokine/chemokines in MOG Ab associated ... Read more >>

PLoS ONE (PloS one)
[2016, 11(2):e0149411]

Cited: 12 times

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Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein.

Kristina Kakalacheva, Stephan Regenass, Silke Wiesmayr, Tarik Azzi, Christoph Berger, Russell C Dale, Fabienne Brilot, Christian Münz, Kevin Rostasy, David Nadal, Jan D Lünemann,

A history of infectious mononucleosis (IM), symptomatic primary infection with the Epstein Barr virus, is associated with the development of autoimmune diseases and increases the risk to develop multiple sclerosis. Here, we hypothesized that immune activation during IM triggers autoreactive immune responses. Antibody responses towards cellular antigens using a HEp-2 ... Read more >>

Viruses (Viruses)
[2016, 8(2):]

Cited: 6 times

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Postencephalitic epilepsy and drug-resistant epilepsy after infectious and antibody-associated encephalitis in childhood: Clinical and etiologic risk factors.

Sekhar C Pillai, Shekeeb S Mohammad, Yael Hacohen, Esther Tantsis, Kristina Prelog, Elizabeth H Barnes, Deepak Gill, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale,

To define the risk factors for postencephalitic epilepsy (PE) and drug-resistant epilepsy (DRE) in childhood following infectious and autoimmune encephalitis, we included 147 acute encephalitis patients with a median follow-up of 7.3 years (range 2-15.8 years). PE was defined as the use of antiepileptic drugs (AEDs) for ≥24 months, and ... Read more >>

Epilepsia (Epilepsia)
[2016, 57(1):e7-e11]

Cited: 6 times

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Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.

Margherita Nosadini, Gulay Alper, Catherine J Riney, Leslie A Benson, Shekeeb S Mohammad, Sudarshini Ramanathan, Melinda Nolan, Richard Appleton, Richard J Leventer, Kumaran Deiva, Fabienne Brilot, Mark P Gorman, Amy T Waldman, Brenda Banwell, Russell C Dale,

To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categorized as ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2016, 3(1):e188]

Cited: 15 times

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The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.

Jean Francois Fonteneau, Fabienne Brilot, Christian Münz, Monique Gannagé,

NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2016, 196(1):64-71]

Cited: 14 times

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Immune therapy in autoimmune encephalitis: a systematic review.

Margherita Nosadini, Shekeeb S Mohammad, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dale,

We have reviewed the literature of immune therapy in autoimmune encephalitis associated with antibodies to cell surface antigens including N-methyl-D-aspartate receptor (NMDAR), leucine-rich, glioma-inactivated protein-1 (LGI1), contactin-associated protein-2 (Caspr2), the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), γ-aminobutyric acid-A receptor (GABAAR), γ-aminobutyric acid-B receptor (GABABR), Glycine R and other rarer antigens. Most studies ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2015, 15(12):1391-1419]

Cited: 40 times

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Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.

Sudarshini Ramanathan, Russell C Dale, Fabienne Brilot,

Myelin oligodendrocyte glycoprotein (MOG) is a protein exclusively expressed on the surface of oligodendrocytes and myelin in the central nervous system. MOG has been identified as a putative candidate autoantigen and autoantibody target in demyelination for almost three decades, with extensive literature validating its role in murine models of experimental ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2016, 15(4):307-324]

Cited: 65 times

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CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review.

Kavitha Kothur, Louise Wienholt, Fabienne Brilot, Russell C Dale,

Despite improved understanding of the pathogenesis of neuroinflammatory disorders of the brain and development of new diagnostic markers, our biomarker repertoire to demonstrate and monitor inflammation remains limited. Using PubMed database, we reviewed 83 studies on CSF cytokines and chemokines and describe the pattern of elevation and possible role of ... Read more >>

Cytokine (Cytokine)
[2016, 77:227-237]

Cited: 63 times

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