Full Text Journal Articles by
Author Fabian Trillsch

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The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer.

Fangfang Chen, Thomas Kolben, Sarah Meister, Bastian Czogalla, Theresa M Kolben, Anna Hester, Alexander Burges, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Artur Mayerhofer, Sven Mahner, Udo Jeschke, Susanne Beyer,

<h4>Objective</h4>Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. Furthermore, RSV targets Sirtuin1 (Sirt1), a histone deacetylase.<h4>Study design</h4>123 tissue samples of patients with serous or mucinous ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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COVID-19 vaccination in patients with breast cancer and gynecological malignancies: A German perspective.

Marie Forster, Rachel Wuerstlein, Alexander Koenig, Niklas Amann, Susanne Beyer, Till Kaltofen, Tom Degenhardt, Alexander Burges, Fabian Trillsch, Sven Mahner, Nadia Harbeck, Anca Chelariu-Raicu,

<h4>Introduction</h4>The side effects of systemic cancer therapy and the lack of clinical data on safety and efficacy of COVID-19 vaccination in cancer patients cause uncertainty among the patients about whether to get vaccinated or not. Here, we evaluated attitude towards and effects of COVID-19 vaccination in patients with breast and ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2021, 60:214-222]

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The Platelet-Activating Factor Receptor's Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine.

Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development. In this study, we aimed to evaluate the prognostic value of PAFR in epithelial ovarian cancer (EOC) and the potential use ... Read more >>

Cells (Cells)
[2021, 10(9):]

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Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer.

Nicole Elisabeth Topalov, Doris Mayr, Clemens Scherer, Anca Chelariu-Raicu, Susanne Beyer, Anna Hester, Fabian Kraus, Mingjun Zheng, Till Kaltofen, Thomas Kolben, Alexander Burges, Sven Mahner, Fabian Trillsch, Udo Jeschke, Bastian Czogalla,

The impact of Actin beta-like 2 (ACTBL2), a novel described actin isoform, on epithelial ovarian cancer (EOC) biology has not been investigated so far. In this study, we analyzed the prognostic and functional significance of ACTBL2 and its regulatory element Nuclear factor of activated T-cells 5 (NFAT5). The expression of ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:713026]

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Changes in gynecologic and breast cancer diagnoses during the first wave of the COVID-19 pandemic: analysis from a tertiary academic gyneco-oncological center in Germany.

Till Kaltofen, Friederike Hagemann, Nadia Harbeck, Rachel Wuerstlein, Bernd Peter Kost, Alexander Burges, Sven Mahner, Fabian Trillsch,

<h4>Purpose</h4>With the beginning of 2021, the world has been suffering from the COVID-19 pandemic for more than 1 year. More and more, we are able to evaluate side effects of the pandemic in the healthcare sector. A negative impact on cancer diagnoses is one of them. Careful observation of trends ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

Cited: 1 time

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Changes in Stem Cell Regulation and Epithelial Organisation during Carcinogenesis and Disease Progression in Gynaecological Malignancies.

Paula Cunnea, Christina Fotopoulou, Jennifer Ploski, Fabian Trillsch, Sven Mahner, Mirjana Kessler,

Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.

Tilman L R Vogelsang, Aurelia Vattai, Elisa Schmoeckel, Till Kaltofen, Anca Chelariu-Raicu, Mingjun Zheng, Sven Mahner, Doris Mayr, Udo Jeschke, Fabian Trillsch,

Trace amine-associated receptor 1 (TAAR1) is a G<sub>αs</sub>- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T<sub>1</sub>AM) reduces cell viability and induces cell death and DNA damage. Aim ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(16):]

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Diagnostic workup for endometrioid borderline ovarian tumors (eBOT) requires histopathological evaluation of the uterus.

Juliane Reichenbach, Elisa Schmoeckel, Sven Mahner, Fabian Trillsch,

<h4>Background</h4>For young borderline ovarian tumor (BOT) patients, preservation of the uterus was incorporated as an accepted option into treatment guidelines. For the endometrioid subtype (eBOT) however, adequate histological evaluation is challenging and might be associated with synchronous endometrial disorders or misinterpreted as spread from uterine primaries.<h4>Case presentation</h4>We report the cases ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2021, 14(1):89]

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Identification of a Novel Tumor Microenvironment Prognostic Signature for Advanced-Stage Serous Ovarian Cancer.

Mingjun Zheng, Junyu Long, Anca Chelariu-Raicu, Heather Mullikin, Theresa Vilsmaier, Aurelia Vattai, Helene Hildegard Heidegger, Falk Batz, Simon Keckstein, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen,

(1) Background: The tumor microenvironment is involved in the growth and proliferation of malignant tumors and in the process of resistance towards systemic and targeted therapies. A correlation between the gene expression profile of the tumor microenvironment and the prognosis of ovarian cancer patients is already known. (2) Methods: Based ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

Cited: 1 time

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Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.

Tabea L Bauer, Katrin Collmar, Till Kaltofen, Ann-Katrin Loeffler, Lorena Decker, Jan Mueller, Sabine Pinter, Stephan A Eisler, Sven Mahner, Patricia Fraungruber, Stefan Kommoss, Annette Staebler, Lewis Francis, R Steven Conlan, Johannes Zuber, Udo Jeschke, Fabian Trillsch, Philipp Rathert,

Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(15):]

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The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group.

Annette Hasenburg, Hellmut Plett, Bernhard Krämer, Elena Braicu, Bastian Czogalla, Michaela Bossart, Susanne Singer, Doris Mayr, Annette Staebler, Andreas du Bois, Stefan Kommoss, Theresa Link, Alexander Burges, Florian Heitz, Jacqueline Keul, Fabian Trillsch, Philipp Harter, Pauline Wimberger, Paul Buderath, Maximilian Klar,

<h4>Purpose</h4>Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient's sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 304(6):1541-1549]

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Endometrial Cancer Lymphadenectomy Trial (ECLAT) (pelvic and para-aortic lymphadenectomy in patients with stage I or II endometrial cancer with high risk of recurrence; AGO-OP.6).

Günter Emons, Jae-Weon Kim, Karin Weide, Nikolaus de Gregorio, Pauline Wimberger, Fabian Trillsch, Boris Gabriel, Dominik Denschlag, Stefan Kommoss, Mustafa Aydogdu, Thomas Papathemelis, Martina Gropp-Meier, Mustafa-Zelal Muallem, Cristin Kühn, Andreas Müller, Matthias Frank, Michael Weigel, Holger Bronger, Björn Lampe, Jörn Rau, Carmen Schade-Brittinger, Philipp Harter,

<h4>Background</h4>The impact of comprehensive pelvic and para-aortic lymphadenectomy on survival in patients with stage I or II endometrial cancer with a high risk of recurrence is not reliably documented. The side effects of this procedure, including lymphedema and lymph cysts, are evident.<h4>Primary objective</h4>Evaluation of the effect of comprehensive pelvic and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(7):1075-1079]

Cited: 1 time

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Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway.

Yue Liao, Susann Badmann, Till Kaltofen, Doris Mayr, Elisa Schmoeckel, Eileen Deuster, Mareike Mannewitz, Sarah Landgrebe, Thomas Kolben, Anna Hester, Susanne Beyer, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

Aberrantly activated Wnt/β-catenin signaling pathway, as well as platelet-activating factor (PAF), contribute to cancer progression and metastasis of many cancer entities. Nonetheless, the role of the degradation enzyme named platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in ovarian cancer etiology is still unclear. This study investigated the functional impact of platelet-activating factor acetylhydrolase ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(7):]

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The Platelet-activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and its Experimental Inhibition by Rupatadine

Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development. In this study, we aimed to evaluate the prognostic value of PAFR in epithelial ovarian cancer (EOC) and the potential use ... Read more >>

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The role of Resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer

Fangfang Chen, Thomas Kolben, Sarah Meister, Bastian Czogalla, Theresa Kolben, Anna Hester, Alexander Burges, Fabian Trillsch, Eisa Schmoeckel, Doris Mayr, Artur Mayerhofer, Sven Mahner, Udo Jeschke, Susanne Beyer,

<h4>Objective: </h4> Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynecologic cancers. Furthermore, RSV targets Sirtuin1 (Sirt1), a histone deacetylase. Study design: 123 tissue samples of patients ... Read more >>

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

Cited: 1 time

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G Protein-Coupled Estrogen Receptor Correlates With Dkk2 Expression and Has Prognostic Impact in Ovarian Cancer Patients.

Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Alexander Burges, Sven Mahner, Philipp Rathert, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Wnt pathway modulator Dickkopf 2 (Dkk2) and signaling of the G protein-coupled estrogen receptor (GPER) seem to have essential functions in numerous cancer types. For epithelial ovarian cancer (EOC), it has not been proven if either Dkk2 or the GPER on its own have an independent impact on overall survival ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:564002]

Cited: 3 times

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The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.

Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic regulators of transcriptional activity representing, an epigenetic modification of Histone H3. Previous reports have suggested that the broad H3K4me3 domain can be considered as an epigenetic signature for tumor-suppressor genes in human cells. G-protein-coupled estrogen receptor (GPER), ... Read more >>

Cells (Cells)
[2021, 10(3):]

Cited: 3 times

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Diagnostic Workup for Endometrioid Borderline Ovarian Tumors (eBOT) Requires Histopathological Evaluation of the Uterus

Juliane Reichenbach, Elisa Schmoeckel, Sven Mahner, Fabian Trillsch,

<h4>Background: </h4> For young borderline ovarian tumor (BOT) patients, preservation of the uterus was incorporated as an accepted option into treatment guidelines. For the endometrioid subtype (eBOT) however, adequate histological evaluation is challenging and might be associated with synchronous endometrial disorders or misinterpreted as spread from uterine primaries. Case presentationWe ... Read more >>

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NGS-guided precision oncology in metastatic breast and gynecological cancer: first experiences at the CCC Munich LMU.

Elena Sultova, C Benedikt Westphalen, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Doris Mayr, Martina Rudelius, Steffen Ormanns, Volker Heinemann, Klaus H Metzeler, Philipp A Greif, Alexander Burges, Fabian Trillsch, Sven Mahner, Nadia Harbeck, Rachel Wuerstlein,

<h4>Purpose</h4>Comprehensive genomic profiling identifying actionable molecular alterations aims to enable personalized treatment for cancer patients. The purpose of this analysis was to retrospectively assess the impact of personalized recommendations made by a multidisciplinary tumor board (MTB) on the outcome of patients with breast or gynecological cancers, who had progressed under ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 303(5):1331-1345]

Cited: 3 times

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Development and Validation of a Novel 11-Gene Prognostic Model for Serous Ovarian Carcinomas Based on Lipid Metabolism Expression Profile.

Mingjun Zheng, Heather Mullikin, Anna Hester, Bastian Czogalla, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Anca Chelariu-Raicu, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen,

(1) Background: Biomarkers might play a significant role in predicting the clinical outcomes of patients with ovarian cancer. By analyzing lipid metabolism genes, future perspectives may be uncovered; (2) Methods: RNA-seq data for serous ovarian cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The non-negative ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

Cited: 4 times

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Breast Adipose Tissue Macrophages (BATMs) have a Stronger Correlation with Breast Cancer Survival than Breast Tumor Stroma Macrophages (BTSMs)

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background: </h4> An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This ... Read more >>

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Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.

Bastian Czogalla, Alexandra Partenheimer, Susann Badmann, Elisa Schmoeckel, Doris Mayr, Thomas Kolben, Susanne Beyer, Anna Hester, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Background</h4>Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in epithelial ovarian cancer ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(1):100910]

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β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation.

Bastian Czogalla, Alexandra Partenheimer, Udo Jeschke, Viktoria von Schönfeldt, Doris Mayr, Sven Mahner, Alexander Burges, Manuela Simoni, Beatrice Melli, Riccardo Benevelli, Sara Bertini, Livio Casarini, Fabian Trillsch,

Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional scaffold protein regulating signal transduction and internalization of activated G protein-coupled receptors (GPCRs), has been considered ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:554733]

Cited: 2 times

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Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

Till Kaltofen, Valentina Preinfalk, Stephanie Schwertler, Patricia Fraungruber, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Bastian Czogalla, Doris Mayr, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Canonical Wnt/ β-catenin pathway is one mechanism being activated in platinum-resistant epithelial ovarian cancer (EOC). Detecting potential targets for Wnt pathway modulation as a putative future therapeutic approach was the aim of this study.<h4>Methods</h4>Biological effects of different Wnt modulators (SB216763, XAV939 and triptolide) on the EOC cell lines A2780 and ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(10):2559-2574]

Cited: 2 times

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