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Author Fabian Trillsch

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs).

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background</h4>An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2021, 23(1):45]

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G Protein-Coupled Estrogen Receptor Correlates With Dkk2 Expression and Has Prognostic Impact in Ovarian Cancer Patients.

Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Alexander Burges, Sven Mahner, Philipp Rathert, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Wnt pathway modulator Dickkopf 2 (Dkk2) and signaling of the G protein-coupled estrogen receptor (GPER) seem to have essential functions in numerous cancer types. For epithelial ovarian cancer (EOC), it has not been proven if either Dkk2 or the GPER on its own have an independent impact on overall survival ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:564002]

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The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.

Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic regulators of transcriptional activity representing, an epigenetic modification of Histone H3. Previous reports have suggested that the broad H3K4me3 domain can be considered as an epigenetic signature for tumor-suppressor genes in human cells. G-protein-coupled estrogen receptor (GPER), ... Read more >>

Cells (Cells)
[2021, 10(3):]

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Diagnostic Workup for Endometrioid Borderline Ovarian Tumors (eBOT) Requires Histopathological Evaluation of the Uterus

Juliane Reichenbach, Elisa Schmoeckel, Sven Mahner, Fabian Trillsch,

<h4>Background: </h4> For young borderline ovarian tumor (BOT) patients, preservation of the uterus was incorporated as an accepted option into treatment guidelines. For the endometrioid subtype (eBOT) however, adequate histological evaluation is challenging and might be associated with synchronous endometrial disorders or misinterpreted as spread from uterine primaries. Case presentationWe ... Read more >>

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NGS-guided precision oncology in metastatic breast and gynecological cancer: first experiences at the CCC Munich LMU.

Elena Sultova, C Benedikt Westphalen, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Doris Mayr, Martina Rudelius, Steffen Ormanns, Volker Heinemann, Klaus H Metzeler, Philipp A Greif, Alexander Burges, Fabian Trillsch, Sven Mahner, Nadia Harbeck, Rachel Wuerstlein,

<h4>Purpose</h4>Comprehensive genomic profiling identifying actionable molecular alterations aims to enable personalized treatment for cancer patients. The purpose of this analysis was to retrospectively assess the impact of personalized recommendations made by a multidisciplinary tumor board (MTB) on the outcome of patients with breast or gynecological cancers, who had progressed under ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2020, :]

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Development and Validation of a Novel 11-Gene Prognostic Model for Serous Ovarian Carcinomas Based on Lipid Metabolism Expression Profile.

Mingjun Zheng, Heather Mullikin, Anna Hester, Bastian Czogalla, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Anca Chelariu-Raicu, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen,

(1) Background: Biomarkers might play a significant role in predicting the clinical outcomes of patients with ovarian cancer. By analyzing lipid metabolism genes, future perspectives may be uncovered; (2) Methods: RNA-seq data for serous ovarian cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The non-negative ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

Cited: 1 time

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Breast Adipose Tissue Macrophages (BATMs) have a Stronger Correlation with Breast Cancer Survival than Breast Tumor Stroma Macrophages (BTSMs)

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background: </h4> An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This ... Read more >>

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Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.

Bastian Czogalla, Alexandra Partenheimer, Susann Badmann, Elisa Schmoeckel, Doris Mayr, Thomas Kolben, Susanne Beyer, Anna Hester, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Background</h4>Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in epithelial ovarian cancer ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(1):100910]

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β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation.

Bastian Czogalla, Alexandra Partenheimer, Udo Jeschke, Viktoria von Schönfeldt, Doris Mayr, Sven Mahner, Alexander Burges, Manuela Simoni, Beatrice Melli, Riccardo Benevelli, Sara Bertini, Livio Casarini, Fabian Trillsch,

Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional scaffold protein regulating signal transduction and internalization of activated G protein-coupled receptors (GPCRs), has been considered ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:554733]

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Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

Till Kaltofen, Valentina Preinfalk, Stephanie Schwertler, Patricia Fraungruber, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Bastian Czogalla, Doris Mayr, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Canonical Wnt/ β-catenin pathway is one mechanism being activated in platinum-resistant epithelial ovarian cancer (EOC). Detecting potential targets for Wnt pathway modulation as a putative future therapeutic approach was the aim of this study.<h4>Methods</h4>Biological effects of different Wnt modulators (SB216763, XAV939 and triptolide) on the EOC cell lines A2780 and ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(10):2559-2574]

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Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients.

Nina Ditsch, Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Jutta Engel, Doris Mayr, Elisa Schmoeckel,

<h4>Purpose</h4>Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact on patients survival in ovarian cancer (OvCa).<h4>Methods</h4>The presence of the thyroid hormone receptors ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(8):1923-1932]

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M2 Macrophages Infiltrating Epithelial Ovarian Cancer Express MDR1: A Feature That May Account for the Poor Prognosis.

Susann Badmann, Sabine Heublein, Doris Mayr, Anna Reischer, Yue Liao, Thomas Kolben, Susanne Beyer, Anna Hester, Christine Zeder-Goess, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

Multi drug resistance protein 1 (MDR1) expression on tumor cells has been widely investigated in context of drug resistance. However, the role of MDR1 on the immune cell infiltrate of solid tumors remains unknown. The aim of this study was to analyze the prognostic significance of a MDR1+ immune cell ... Read more >>

Cells (Cells)
[2020, 9(5):]

Cited: 5 times

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Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.

Susanne Beyer, Fangfang Chen, Sarah Meister, Bastian Czogalla, Theresa M Kolben, Anna Hester, Alexander Burges, Fabian Trillsch, Elisa Schmöckel, Doris Mayr, Artur Mayerhofer, Sven Mahner, Udo Jeschke, Thomas Kolben,

Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2020, 154(2):189-195]

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Cytoplasmic VDR expression as an independent risk factor for ovarian cancer.

Bastian Czogalla, Eileen Deuster, Yue Liao, Doris Mayr, Elisa Schmoeckel, Cornelia Sattler, Thomas Kolben, Anna Hester, Sophie Fürst, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

The vitamin D receptor (VDR), primarily known as a crucial mediator of calcium homeostasis and metabolism, has been shown to play a significant role in various cancer entities. Previous studies have focused on vitamin D and its receptor in gynecological cancers, noting that the receptor is upregulated in epithelial ovarian ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2020, 154(4):421-429]

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H3K4me3 Is a Potential Mediator for Antiproliferative Effects of Calcitriol (1α,25(OH)2D3) in Ovarian Cancer Biology.

Nan Han, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Posttranslational histone modification plays an important role in tumorigenesis. Histone modification is a dynamic response of chromatin to various signals, such as the exposure to calcitriol (1α,25(OH)<sub>2</sub>D<sub>3</sub>). Recent studies suggested that histone modification levels could be used to predict patient outcomes in various cancers. Our study evaluated the expression level ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

Cited: 1 time

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PD-L1 expression and survival in p16-negative and -positive squamous cell carcinomas of the vulva.

Bastian Czogalla, Deborah Pham, Fabian Trillsch, Miriam Rottmann, Julia Gallwas, Alexander Burges, Sven Mahner, Thomas Kirchner, Udo Jeschke, Doris Mayr, Elisa Schmoeckel,

AIM:Programmed death-ligand 1 (PD-L1) has become a widely used predictive biomarker for therapy with checkpoint inhibitors in a variety of cancers. Here, we studied the expression of PD-L1 in squamous cell carcinomas of the vulva (SCCV) with regard to HPV status via its surrogate marker p16. Additionally, the status of PD-L1 ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(3):569-577]

Cited: 4 times

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THR alpha and its subtypes alpha1 and alpha2 are prognostic markers for survival of ovarian cancer patients

Nina Ditsch, Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Jutta Engel, Doris Mayr, Elisa Schmoeckel,

<h4>Background: </h4> Ovarian cancer is most lethal in comparison to all other gynecological cancer cases. Within this study, we aimed to investigate the expression of the thyroid hormone receptor alpha and its influence on patient survival in ovarian cancer (OvCa). Methods The presence of the thyroid hormone receptors ... Read more >>

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EP3 receptor is a prognostic factor in TA-MUC1-negative ovarian cancer.

Bastian Czogalla, Christina Kuhn, Sabine Heublein, Elisa Schmöckel, Doris Mayr, Thomas Kolben, Fabian Trillsch, Alexander Burges, Sven Mahner, Udo Jeschke, Anna Hester,

PURPOSE:Prostaglandin-mediated inflammatory reactions play a major role in different cancers. Recently, it has been observed that prostaglandin E2-receptor 3 (EP3) might be an independent prognostic factor for overall survival in cervical and endometrial cancer. The role of EP3 expression in ovarian cancer is currently unknown. METHODS:EP3 expression was analyzed by ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2019, 145(10):2519-2527]

Cited: 4 times

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Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology.

Bastian Czogalla, Maja Kahaly, Doris Mayr, Elisa Schmoeckel, Beate Niesler, Anna Hester, Christine Zeder-Göß, Thomas Kolben, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

Purpose:This study aimed to investigate the potential prognostic impact of nuclear factor erythroid 2-related factor 2 (NRF2) and progesterone receptor A (PRA)/progesterone receptor B (PRB) in ovarian cancer patients which might be the rationale for putative new treatment strategies. Patients and methods:The presence of NRF2 and PRA/PRB was investigated in ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:7673-7684]

Cited: 2 times

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Correlation of the Aryl Hydrocarbon Receptor with FSHR in Ovarian Cancer Patients.

Eileen Deuster, Doris Mayr, Anna Hester, Thomas Kolben, Christine Zeder-Göß, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

Expression of the aryl hydrocarbon receptor (AhR) has been described in various tumor entities from different organs. However, its role in ovarian cancer has not been thoroughly investigated. We aimed to elucidate the prognostic impact of AhR, its correlation with the follicle-stimulating hormone receptor (FSHR), and their functional role in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(12):]

Cited: 5 times

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Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer.

Sabine Heublein, Sabina Page, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch, Frederik Marmé, Sven Mahner, Udo Jeschke, Aurelia Vattai,

Anti-tumor efficacy of Gatipotuzumab, a therapeutic antibody targeting Tumor-Associated Mucin-1 (TA-MUC1), in relapsed ovarian cancer (OC) appeared to be rather heterogeneous. Whether adding a second anti-neoplastic drug may augment response towards Gatipotuzumab, has not been elucidated so far. Since it is known that anti-MUC1 antibodies may alter estrogen receptor activity ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(2):]

Cited: 1 time

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Uterine and Tubal Lavage for Earlier Cancer Detection Using an Innovative Catheter: A Feasibility and Safety Study.

Elisabeth Maritschnegg, Florian Heitz, Nina Pecha, Jirí Bouda, Fabian Trillsch, Christoph Grimm, Adriaan Vanderstichele, Christiane Agreiter, Philipp Harter, Eva Obermayr, Ignace Vergote, Robert Zeillinger, Paul Speiser,

<h4>Objectives</h4>Poor survival of high-grade serous pelvic cancer is caused by a lack of effective screening measures. The detection of exfoliated cells from high-grade serous pelvic cancer, or precursor lesions, is a promising concept for earlier diagnosis. However, collecting those cells in the most efficient way while fulfilling all requirements for ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(9):1692-1698]

Cited: 2 times

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Interaction of ERα and NRF2 Impacts Survival in Ovarian Cancer Patients.

Bastian Czogalla, Maja Kahaly, Doris Mayr, Elisa Schmoeckel, Beate Niesler, Thomas Kolben, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

Nuclear factor erythroid 2-related factor 2 (NRF2) regulates cytoprotective antioxidant processes. In this study, the prognostic potential of NRF2 and its interactions with the estrogen receptor α (ERα) in ovarian cancer cells was investigated. NRF2 and ERα protein expression in ovarian cancer tissue was analyzed as well as mRNA expression ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 20(1):]

Cited: 7 times

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Morphology and tumour-infiltrating lymphocytes in high-stage, high-grade serous ovarian carcinoma correlated with long-term survival.

Silvia Darb-Esfahani, Ivonne Kolaschinski, Fabian Trillsch, Sven Mahner, Nicole Concin, Ignace Vergote, Els Van Nieuwenhuysen, Patriciu Achimas-Cadariu, Joanna Glajzer, Hannah Woopen, Stefan Wienert, Eliane T Taube, Mandy Stanske, Hagen Kulbe, Carsten Denkert, Jalid Sehouli, Elena I Braicu,

<h4>Aims</h4>Advanced-stage ovarian high-grade serous carcinoma (HGSC) is a poor-prognosis cancer; however, a small and poorly characterised subset of patients shows long-term survival. We aimed to establish a cohort of HGSC long-term survivors for histopathological and molecular analysis.<h4>Methods and results</h4>Paraffin blocks from 151 patients with primary FIGO III/IV HGSC and progression-free ... Read more >>

Histopathology (Histopathology)
[2018, 73(6):1002-1012]

Cited: 3 times

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