Full Text Journal Articles by
Author F Edward Dudek


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Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus.

Bryan S Barker, Jay Spampanato, Hilary S McCarren, Melissa Smolik, Cecelia E Jackson, Eden N Hornung, David T Yeung, F Edward Dudek, John H McDonough,

Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an excess of peripheral ailments, OP intoxication induces status epilepticus (SE) which if left untreated may lead to permanent brain damage or death. Benzodiazepines are typically the primary therapies ... Read more >>

Neuroscience (Neuroscience)
[2020, 425:280-300]

Cited: 0 times

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Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning.

Timothy B C Johnstone, Hilary S McCarren, Jay Spampanato, F Edward Dudek, John H McDonough, Derk Hogenkamp, Kelvin W Gee,

Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE). Extrasynaptic GABAARs, such as those containing α4β3δ subunits, are a putative pharmacological target to comprehensively manage nerve agent-induced seizures since they ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:560]

Cited: 1 time

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Spontaneous Recurrent Absence Seizure-like Events in Wild-Caught Rats.

Jeremy A Taylor, Jon D Reuter, Rebecca A Kubiak, Toni T Mufford, Carmen J Booth, F Edward Dudek, Daniel S Barth,

Absence epilepsy is a heritable human neurological disorder characterized by brief nonconvulsive seizures with behavioral arrest, moderate-to-severe loss of consciousness (absence), and distinct spike-wave discharges (SWDs) in the EEG and electrocorticogram (ECoG). Genetic models of this disorder have been created by selectively inbreeding rats for absence seizure-like events with similar ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2019, 39(24):4829-4841]

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Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.

Heidi L Grabenstatter, F Edward Dudek,

OBJECTIVE:Animal models of chronic epilepsy with spontaneous recurrent seizures (SRSs) may be useful in the discovery and mechanistic analyses of antiseizure drugs (ASDs). Carbamazepine (CBZ), a widely used ASD with a well-defined mechanism, was analyzed in this proof-of-principle study to determine how a traditional ASD affects the properties of SRSs. ... Read more >>

Epilepsia (Epilepsia)
[2019, 60(4):636-647]

Cited: 0 times

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Methodologic recommendations and possible interpretations of video-EEG recordings in immature rodents used as experimental controls: A TASK1-WG2 report of the ILAE/AES Joint Translational Task Force.

Ozlem Akman, Yogendra H Raol, Stéphane Auvin, Miguel A Cortez, Hana Kubova, Marco de Curtis, Akio Ikeda, F Edward Dudek, Aristea S Galanopoulou,

The use of immature rodents to study physiologic aspects of cortical development requires high-quality recordings electroencephalography (EEG) with simultaneous video recording (vEEG) of behavior. Normative developmental vEEG data in control animals are fundamental for the study of abnormal background activity in animal models of seizures or other neurologic disorders. Electrical ... Read more >>

Epilepsia Open (Epilepsia open)
[2018, 3(4):437-459]

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Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats.

Erika A Scholl, Stephanie M Miller-Smith, Steven L Bealer, Mark J Lehmkuhle, Jeffrey J Ekstrand, F Edward Dudek, John H McDonough,

Exposure to nerve agents (NAs) and other organophosphates (OPs) can initiate seizures that rapidly progress to status epilepticus (SE). While the electrographic and neuropathological sequelae of SE evoked by NAs and OPs have been characterized in adult rodents, they have not been adequately investigated in immature animals. In this study ... Read more >>

Neurotoxicology (Neurotoxicology)
[2018, 66:10-21]

Cited: 5 times

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Progression of convulsive and nonconvulsive seizures during epileptogenesis after pilocarpine-induced status epilepticus.

Zachariah Z Smith, Alexander M Benison, Florencia M Bercum, F Edward Dudek, Daniel S Barth,

Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions. The definition of nonconvulsive seizures based on brain electrical activity alone has been controversial. Here ... Read more >>

J. Neurophysiol. (Journal of neurophysiology)
[2018, 119(5):1818-1835]

Cited: 1 time

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The antihelminthic moxidectin enhances tonic GABA currents in rodent hippocampal pyramidal neurons.

Jay Spampanato, Anne Gibson, F Edward Dudek,

Macrocyclic lactones (MLs) are commonly used treatments for parasitic worm and insect infections in humans, livestock, and companion animals. MLs target the invertebrate glutamate-activated chloride channel that is not present in vertebrates. MLs are not entirely inert in vertebrates, though; they have been reported to have activity in heterologous expression ... Read more >>

J. Neurophysiol. (Journal of neurophysiology)
[2018, 119(5):1693-1698]

Cited: 0 times

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Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats.

Jeremy A Taylor, Krista M Rodgers, Florencia M Bercum, Carmen J Booth, F Edward Dudek, Daniel S Barth,

Genetically inherited absence epilepsy in humans is typically characterized by brief (seconds) spontaneous seizures, which involve spike-wave discharges (SWDs) in the EEG and interruption of consciousness and ongoing behavior. Genetic (inbred) models of this disorder in rats have been used to examine mechanisms, comorbidities, and antiabsence drugs. SWDs have also ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2017, 37(24):5861-5869]

Cited: 6 times

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Staged anticonvulsant screening for chronic epilepsy.

Yevgeny Berdichevsky, Yero Saponjian, Kyung-Il Park, Bonnie Roach, Wendy Pouliot, Kimberly Lu, Waldemar Swiercz, F Edward Dudek, Kevin J Staley,

Current anticonvulsant screening programs are based on seizures evoked in normal animals. One-third of epileptic patients do not respond to the anticonvulsants discovered with these models. We evaluated a tiered program based on chronic epilepsy and spontaneous seizures, with compounds advancing from high-throughput in vitro models to low-throughput in vivo ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2016, 3(12):908-923]

Cited: 6 times

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Maternal Stress Combined with Terbutaline Leads to Comorbid Autistic-Like Behavior and Epilepsy in a Rat Model.

Florencia M Bercum, Krista M Rodgers, Alex M Benison, Zachariah Z Smith, Jeremy Taylor, Elise Kornreich, Heidi L Grabenstatter, F Edward Dudek, Daniel S Barth,

Human autism is comorbid with epilepsy, yet, little is known about the causes or risk factors leading to this combined neurological syndrome. Although genetic predisposition can play a substantial role, our objective was to investigate whether maternal environmental factors alone could be sufficient. We examined the independent and combined effects ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(48):15894-15902]

Cited: 9 times

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Asla Pitkänen, Katarzyna Lukasiuk, F Edward Dudek, Kevin J Staley,

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, ... Read more >>

Cold Spring Harb Perspect Med (Cold Spring Harbor perspectives in medicine)
[2015, 5(10):]

Cited: 37 times

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Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy.

Krista M Rodgers, F Edward Dudek, Daniel S Barth,

Variable-duration oscillations and repetitive, high-voltage spikes have been recorded in the electrocorticogram (ECoG) of rats weeks and months after fluid percussion injury (FPI), a model of traumatic brain injury. These ECoG events, which have many similarities to spike-wave-discharges (SWDs) and absence seizures, have been proposed to represent nonconvulsive seizures characteristic ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(24):9194-9204]

Cited: 19 times

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Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System.

Andrew Zayachkivsky, Mark J Lehmkuhle, F Edward Dudek,

Many progressive neurologic diseases in humans, such as epilepsy, require pre-clinical animal models that slowly develop the disease in order to test interventions at various stages of the disease process. These animal models are particularly difficult to implement in immature rodents, a classic model organism for laboratory study of these ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2015, (101):e52554]

Cited: 6 times

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Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus.

Jay Spampanato, F Edward Dudek,

Valnoctamide (VCD), a derivative of valproate, suppresses electrographic seizures in animal models of status epilepticus (SE), even when the seizures are resistant to benzodiazepines (BZDs). We therefore tested the effect of VCD on miniature inhibitory postsynaptic currents (mIPSCs) in CA1 pyramidal cells to determine if VCD acts directly on γ-aminobutyric ... Read more >>

Epilepsia (Epilepsia)
[2014, 55(9):e94-8]

Cited: 6 times

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When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?

Ray Dingledine, Nicholas H Varvel, F Edward Dudek,

The effect of seizures on neuronal death and the role of seizure-induced neuronal death in acquired epileptogenesis have been debated for decades. Isolated brief seizures probably do not kill neurons; however, severe and repetitive seizures (i.e., status epilepticus) certainly do. Because status epilepticus both kills neurons and also leads to ... Read more >>

Adv. Exp. Med. Biol. (Advances in experimental medicine and biology)
[2014, 813:109-122]

Cited: 33 times

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Epilepsy biomarkers.

Jerome Engel, Asla Pitkänen, Jeffrey A Loeb, F Edward Dudek, Edward H Bertram, Andrew J Cole, Solomon L Moshé, Samuel Wiebe, Frances E Jensen, Istvan Mody, Astrid Nehlig, Annamaria Vezzani,

A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of ... Read more >>

Epilepsia (Epilepsia)
[2013, 54 Suppl 4:61-69]

Cited: 67 times

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Issues related to development of antiepileptogenic therapies.

Asla Pitkänen, Astrid Nehlig, Amy R Brooks-Kayal, F Edward Dudek, Daniel Friedman, Aristea S Galanopoulou, Frances E Jensen, Rafal M Kaminski, Jaideep Kapur, Henrik Klitgaard, Wolfgang Löscher, Istvan Mody, Dieter Schmidt,

Several preclinical proof-of-concept studies have provided evidence for positive treatment effects on epileptogenesis. However, none of these hypothetical treatments has advanced to the clinic. The experience in other fields of neurology such as stroke, Alzheimer's disease, or amyotrophic lateral sclerosis has indicated several problems in the design of preclinical studies, ... Read more >>

Epilepsia (Epilepsia)
[2013, 54 Suppl 4:35-43]

Cited: 39 times

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Epilepsy therapy development: technical and methodologic issues in studies with animal models.

Aristea S Galanopoulou, Merab Kokaia, Jeffrey A Loeb, Astrid Nehlig, Asla Pitkänen, Michael A Rogawski, Kevin J Staley, Vicky H Whittemore, F Edward Dudek,

The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new ... Read more >>

Epilepsia (Epilepsia)
[2013, 54 Suppl 4:13-23]

Cited: 17 times

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Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.

Jianxiong Jiang, Yi Quan, Thota Ganesh, Wendy A Pouliot, F Edward Dudek, Raymond Dingledine,

Prostaglandin E2 is now widely recognized to play critical roles in brain inflammation and injury, although the responsible prostaglandin receptors have not been fully identified. We developed a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, TG6-10-1, with a sufficient pharmacokinetic profile to be used in vivo. ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2013, 110(9):3591-3596]

Cited: 65 times

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Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory, Shaun R Stauffer, F Edward Dudek, Zixiu Xiang, Colleen M Niswender, J Scott Daniels, Carrie K Jones, Craig W Lindsley, P Jeffrey Conn,

BACKGROUND:Metabotropic glutamate receptor subtype 5 (mGlu5) activators have emerged as a novel approach to the treatment of schizophrenia. Positive allosteric modulators (PAMs) of mGlu5 have generated tremendous excitement and fueled major drug discovery efforts. Although mGlu5 PAMs have robust efficacy in preclinical models of schizophrenia, preliminary reports suggest that these ... Read more >>

Biol. Psychiatry (Biological psychiatry)
[2013, 73(6):501-509]

Cited: 51 times

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Mechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2.

F Edward Dudek,

Epilepsy Curr (Epilepsy currents)
[2012, 12(3):115-117]

Cited: 1 time

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Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.

Michele Simonato, Wolfgang Löscher, Andrew J Cole, F Edward Dudek, Jerome Engel, Rafal M Kaminski, Jeffrey A Loeb, Helen Scharfman, Kevin J Staley, Libor Velíšek, Henrik Klitgaard,

The antiepileptic drugs (AEDs) introduced during the past two decades have provided several benefits: they offered new treatment options for symptomatic treatment of seizures, improved ease of use and tolerability, and lowered risk for hypersensitivity reactions and detrimental drug-drug interactions. These drugs, however, neither attenuated the problem of drug-refractory epilepsy ... Read more >>

Epilepsia (Epilepsia)
[2012, 53(11):1860-1867]

Cited: 35 times

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Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state.

F Edward Dudek, Kevin J Staley,

The concept of a preictal state is based on the belief that it may be possible to predict seizures before they occur. The preictal state is viewed as a time period when a seizure is practically inevitable, or at least a period of greatly increased seizure probability. Changes in seizure ... Read more >>

Epilepsy Res. (Epilepsy research)
[2011, 97(3):324-331]

Cited: 12 times

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A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.

Atif Ali, Yashomati Dua, Jonathan E Constance, Michael R Franklin, F Edward Dudek,

PURPOSE: Convenient and effective methods for administering potential antiepileptic drugs (AEDs) chronically should facilitate many experiments in animal models of chronic epilepsy with spontaneous recurrent seizures. This proof-of-principle study aimed to optimize a once-per-day, drug-in-food protocol by testing the effect of carbamazepine (CBZ) on the frequency of convulsive seizures in ... Read more >>

Epilepsia (Epilepsia)
[2012, 53(1):199-206]

Cited: 8 times

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