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Author F Drago

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Updates on lymphogranuloma venereum.

G Ciccarese, F Drago, A Rebora, A Parodi,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, 35(8):1606-1607]

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The "Great Lockdown": Inactive workers and mortality by Covid-19.

Nicola Borri, Francesco Drago, Chiara Santantonio, Francesco Sobbrio,

In response to the Covid-19 outbreak, the Italian Government imposed an economic lockdown on March 22, 2020, and ordered the closing of all non-essential economic activities. This paper estimates the causal effects of this measure on mortality by Covid-19 and on mobility patterns. The identification of the causal effects exploits ... Read more >>

Health Econ (Health economics)
[2021, :]

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Cardiac Defects and Genetic Syndromes: Old Uncertainties and New Insights

Giulio Calcagni, Flaminia Pugnaloni, Maria Cristina Digilio, Marta Unolt, Carolina Putotto, Marcello Niceta, Anwar Baban, Francesca Piceci Sparascio, Fabrizio Drago, Alessandro De Luca, Marco Tartaglia, Bruno Marino, Paolo Versacci,

Recent advances in understanding the genetic causes and anatomic subtypes of cardiac defects have revealed new links between genetic etiology, pathogenetic mechanisms and cardiac phenotypes. Although the same genetic background can result in different cardiac phenotypes, and similar phenotypes can be caused by different genetic causes, researchers’ effort to identify ... Read more >>

Genes (Basel) (Genes)
[2021, 12(7):]

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The impact of SARS-Cov-2 on the Nervous system and Mental Health.

Mohamed Said Boulkrane, Victoria Ilina, Roman Melchakov, Mikhail Arisov, Julia Fedotova, Lucia Gozzo, Filippo Drago, Weihong Lu, Alexey Sarapultsev, Vadim Tceilikman, Denis Baranenko,

The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2021, :]

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Rituximab in Multiple Sclerosis: Are We Ready for Regulatory Approval?

Serena Brancati, Lucia Gozzo, Laura Longo, Daniela Cristina Vitale, Filippo Drago,

Despite the availability of a lot of effective disease-modifying drugs, multiple sclerosis (MS) (in particular the progressive forms) still represents an important unmet medical need, because of issues in terms of effectiveness, duration of response, safety, and patient compliance. An increasing body of evidence from randomized clinical trials and real-world ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:661882]

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Clinical characteristics and risk of arrhythmic events in patients younger than 12 years diagnosed with Brugada syndrome.

Daniela Righi, Luigina Porco, Camilla Calvieri, Pietro Paolo Tamborrino, Corrado Di Mambro, Simone Paglia, Anwar Baban, Massimo Stefano Silvetti, Maria Gnazzo, Antonio Novelli, Alberto Eugenio Tozzi, Fabrizio Drago,

<h4>Background</h4>Brugada syndrome (BrS) is an inheritable disease with an increased risk of sudden cardiac death. Although several score systems have been proposed, the management of children with BrS has been inconsistently described.<h4>Objective</h4>The purpose of this study was to identify the characteristics, outcome, and risk factors associated with cardiovascular and arrhythmic ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

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The arrhythmic risk in Kearns-Sayre syndrome: still many questions unanswered-Authors' reply.

Corrado Di Mambro, Pietro Paolo Tamborrino, Fabrizio Drago,

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(6):981-982]

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Involvement of the cardiac conduction system in Kearns-Sayre syndrome is progressive: Authors' reply.

Corrado Di Mambro, Diego Martinelli, Pietro Paolo Tamborrino, Fabrizio Drago,

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(6):980]

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Progressive involvement of cardiac conduction system in paediatric patients with Kearns-Sayre syndrome: how to predict occurrence of complete heart block and sudden cardiac death?

Corrado Di Mambro, Pietro Paolo Tamborrino, Massimo Stefano Silvetti, Marie Laure Yammine, Cecilia Marcolin, Daniela Righi, Anwar Baban, Diego Martinelli, Carlo Dionisi Vici, Fabrizio Drago,

<h4>Aims</h4>The aims of this study are to evaluate the progressive involvement of the cardiac conduction system in the Kearn-Sayre syndrome (KSS) and to establish criteria for the prevention of episodes of syncope or sudden cardiac death.<h4>Methods and results</h4>This is a prospective monocentric study including KSS patients, with diagnosis based on ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(6):948-957]

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A novel multidimensional questionnaire for the assessment of emotional dysregulation in adolescents: Reactivity, Intensity, Polarity and Stability questionnaire-youth version (RIPoSt-Y).

Gianluca Sesso, Annarita Milone, Flavia Drago, Valentina Viglione, Stefano Berloffa, Silvia Boldrini, Nina Loriaux, Elena Valente, Agnese Molesti, Francesca Placini, Anna Rita Montesanto, Simone Pisano, Gabriele Masi,

<h4>Background</h4>The failure to regulate emotions, namely emotional dysregulation (ED), is a relevant construct in adolescent psychiatry, in terms of prognostic and developmental implications. We developed and validated a novel self-report questionnaire for the assessment of ED, the RIPoSt-Y, both in clinical and non-clinical samples.<h4>Methods</h4>Items selection and subscales construction were conducted ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 291:359-367]

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Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice.

Oriana Maria Maurel, Sebastiano Alfio Torrisi, Cristina Barbagallo, Michele Purrello, Salvatore Salomone, Filippo Drago, Marco Ragusa, Gian Marco Leggio,

Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder occurring in susceptible individuals following a traumatic event. Understanding the mechanisms subserving trauma susceptibility/resilience is essential to develop new effective treatments. Increasing evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), may play a prominent role in mediating trauma susceptibility/resilience. In this ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(10):]

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Astrocytic Regulation of Basal Ganglia Dopamine/D2-Dependent Behaviors

Rosa Mastrogiacomo, Gabriella Trigilio, Daniel Dautan, Céline Devroye, Valentina Ferretti, Enrica Vitali, Genny Orso, Roberto Marotta, Federica Maltese, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Debora Rothmond, John Waddington, Filippo Drago, Maria Antonietta De Luca, Gian Marco Leggio, Cynthia Weickert, Francesca Managò, Francesco Papaleo,

Astrocytic involvement in dopamine dynamics related to motivational and sensorimotor gating abilities is unknown. We found that dysbindin-1 (Dys1) hypofunction increases the activity of astrocytes, which express only the isoform Dys1A that is reduced in the caudate of patients with schizophrenia. Astrocytic Dys1A disruption resulted in avolition and sensorimotor gating ... Read more >>

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Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition.

Grazia Maugeri, Claudio Bucolo, Filippo Drago, Settimio Rossi, Michelino Di Rosa, Rosa Imbesi, Velia D'Agata, Salvatore Giunta,

This study aimed to investigate the high glucose damage on human retinal pigment epithelial (RPE) cells, the role of p38 MAPK signaling pathway and how dimethyl fumarate can regulate that. We carried out <i>in vitro</i> studies on ARPE-19 cells exposed to physiological and high glucose (HG) conditions, to evaluate the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:684680]

Cited: 1 time

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Correction to: Regulatory, scientific, and ethical issues arising from institutional activity in one of the 90 Italian Research Ethics Committees.

G Benfatto, , , F Drago,

BMC Med Ethics (BMC medical ethics)
[2021, 22(1):52]

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Ulcer of the penis due to mycoplasma hominis infection: an example of pseudo-chancre.

Francesco Drago, Giulia Ciccarese, Mattia F Molle, Aurora Parodi,

Ital J Dermatol Venerol (Italian journal of dermatology and venereology)
[2021, :]

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Influence of Trace Elements on Neurodegenerative Diseases of The Eye-The Glaucoma Model.

Agnieszka Kamińska, Giovanni Luca Romano, Robert Rejdak, Sandrine Zweifel, Michal Fiedorowicz, Magdalena Rejdak, Anahita Bajka, Rosario Amato, Claudio Bucolo, Teresio Avitabile, Filippo Drago, Mario Damiano Toro,

Glaucoma is a heterogeneous group of chronic neurodegenerative disorders characterized by a relatively selective, progressive damage to the retinal ganglion cells (RGCs) and their axons, which leads to axon loss and visual field alterations. To date, many studies have shown the role of various elements, mainly metals, in maintaining the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(9):]

Cited: 3 times

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The Burden of Agoraphobia in Worsening Quality of Life in a Community Survey in Italy.

Antonio Preti, Martina Piras, Giulia Cossu, Elisa Pintus, Mirra Pintus, Goce Kalcev, Federico Cabras, Maria Francesca Moro, Ferdinando Romano, Matteo Balestrieri, Filippo Caraci, Liliana Dell'Osso, Guido Di Sciascio, Filippo Drago, Maria Carolina Hardoy, Rita Roncone, Carlo Faravelli, Mario Musu, Gabriele Finco, Antonio Egidio Nardi, Mauro Giovanni Carta,

<h4>Objective</h4>Current nosology redefined agoraphobia as an autonomous diagnosis distinct from panic disorder. We investigated the lifetime prevalence of agoraphobia, its association with other mental disorders, and its impact on the health-related quality of life (HR-QoL).<h4>Methods</h4>Community survey in 2,338 randomly selected adult subjects. Participants were interviewed with the Advanced Neuropsychiatric Tools ... Read more >>

Psychiatry Investig (Psychiatry investigation)
[2021, 18(4):277-283]

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Deciphering Genetic Variants of Warfarin Metabolism in Children With Ventricular Assist Devices.

Anwar Baban, Francesca G Iodice, Arianna Di Molfetta, Marianna Cicenia, Caterina Rizzo, Emanuele Agolini, Fabrizio Drago, Antonio Novelli, Luca Di Chiara, Giuseppina Testa, Antonio Amodeo,

Warfarin is prescribed in patients with ventricular assist devices (VADs). Dosage depends on several factors including the underlying genotype. These include polymorphisms of genes encoding cytochrome P450 enzymes, the main ones being CYP2C9, VKORC1, and CYP4F2. The objectives of this study were to evaluate the prevalence of CY2CP9 1*2*3*, VKORC1, ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2021, 42(5):1082-1087]

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Regulatory, scientific, and ethical issues arising from institutional activity in one of the 90 Italian Research Ethics Committees.

G Benfatto, , , F Drago,

<h4>Background</h4>This paper highlights the issues that one of the 90 Italian Research Ethics Committees (RECs) might encounter during the approval phase of a clinical trial to identify corrective and preventive actions for promoting a more efficient review process and ensuring review quality. Publications on the subject from Italy and the ... Read more >>

BMC Med Ethics (BMC medical ethics)
[2021, 22(1):40]

Cited: 1 time

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An Exploratory Study of Emotional Dysregulation Dimensions in Youth With Attention Deficit Hyperactivity Disorder and/or Bipolar Spectrum Disorders.

Gabriele Masi, Gianluca Sesso, Chiara Pfanner, Elena Valente, Agnese Molesti, Francesca Placini, Silvia Boldrini, Nina Loriaux, Flavia Drago, Anna Rita Montesanto, Simone Pisano, Annarita Milone,

Emotional dysregulation (ED) is currently the most frequently used term to describe children with an impaired regulation of emotional states. Recent research studies speculate whether ED may be a neurodevelopmental disorder itself, a shared risk factor, or a common key feature of several psychiatric disorders, including, among others, attention deficit ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2021, 12:619037]

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Remember friedreich ataxia even in a toddler with apparently isolated dilated (not hypertrophic!) cardiomyopathy: revisited.

Anwar Baban, Marianna Cicenia, Lorena Travaglini, Federica Calí, Gessica Vasco, Paola Francalanci, Antonio Novelli, Rachele Adorisio, Antonio Amodeo, Bruno Dallapiccola, Enrico Bertini, Fabrizio Drago,

<h4>Background</h4>Friedreich Ataxia (FRDA) is the most common form of ataxia in late childhood. Neurological manifestations often precede cardiac involvement, presenting mainly as hypertrophic cardiomyopathy.<h4>Methods</h4>We describe a toddler with apparently isolated severe heart failure, successfully managed with heart transplant (HT). Although well described in adolescents and adults, onset of FRDA is ... Read more >>

Minerva Pediatr (Torino) (Minerva pediatrics)
[2021, :]

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The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy.

Gabrielle Norrish, Cristian Topriceanu, Chen Qu, Ella Field, Helen Walsh, Lidia Ziółkowska, Iacopo Olivotto, Silvia Passantino, Silvia Favilli, Aris Anastasakis, Vasiliki Vlagkouli, Robert Weintraub, Ingrid King, Elena Biagini, Luca Ragni, Terrence Prendiville, Sophie Duignan, Karen McLeod, Maria Ilina, Adrian Fernández, Regina Bökenkamp, Anwar Baban, Fabrizio Drago, Peter Kubuš, Piers E F Daubeney, Sian Chivers, Georgia Sarquella-Brugada, Sergi Cesar, Chiara Marrone, Constancio Medrano, Reyes Alvarez Garcia-Roves, Orhan Uzun, Ferran Gran, Fernandez J Castro, Juan R Gimeno, Roberto Barriales-Villa, Fernando Rueda, Satish Adwani, Jonathan Searle, Tara Bharucha, Ana Siles, Ana Usano, Torsten B Rasmussen, Caroline B Jones, Toru Kubo, Jens Mogensen, Zdenka Reinhardt, Elena Cervi, Perry M Elliott, Rumana Z Omar, Juan P Kaski,

<h4>Aims</h4>The 12-lead electrocardiogram (ECG) is routinely performed in children with hypertrophic cardiomyopathy (HCM). An ECG risk score has been suggested as a useful tool for risk stratification, but this has not been independently validated. This aim of this study was to describe the ECG phenotype of childhood HCM in a ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2021, :]

Cited: 1 time

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Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes.

B Di Marco, P Dell'Albani, S D'Antoni, M Spatuzza, C M Bonaccorso, S A Musumeci, F Drago, B Bardoni, M V Catania,

Fragile X syndrome (FXS) is a common form of intellectual disability and autism caused by the lack of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in RNA transport and protein synthesis. Upon cellular stress, global protein synthesis is blocked and mRNAs are recruited into stress granules (SGs), ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 154:105338]

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Identification of human immune cell subtypes most responsive to IL-1β-induced inflammatory signaling using mass cytometry.

Hema Kothari, Corey M Williams, Chantel McSkimming, Fabrizio Drago, Melissa A Marshall, James Garmey, Mythili Vigneshwar, Eli R Zunder, Coleen A McNamara,

IL-1β is a key mediator of the cytokine storm linked to high morbidity and mortality from COVID-19, and IL-1β blockade with anakinra and canakinumab during COVID-19 infection has entered clinical trials. Using mass cytometry of human peripheral blood mononuclear cells, we identified effector memory CD4<sup>+</sup> T cells and CD4<sup>-</sup>CD8<sup>low/-</sup>CD161<sup>+</sup> T ... Read more >>

Sci Signal (Science signaling)
[2021, 14(673):]

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Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta.

Veronica Zingales, Sebastiano Alfio Torrisi, Gian Marco Leggio, Claudio Bucolo, Filippo Drago, Salvatore Salomone,

Dopamine receptors (DRs) are generally considered as mediators of vasomotor functions. However, when used in pharmacological studies, dopamine and/or DR agonists may not discriminate among different DR subtypes and may even stimulate alpha1 and beta-adrenoceptors. Here, we tested the hypothesis that D2R and/or D3R may specifically induce vasoconstriction in isolated ... Read more >>

Biomolecules (Biomolecules)
[2021, 11(3):]

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