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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Immunotherapy in genitourinary cancers: achievements and perspectives.

Evanguelos Xylinas, Mathieu Roumiguié, Paul Sargos,

World J Urol (World journal of urology)
[2021, 39(5):1317]

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Is it Worth Starting Sexual Rehabilitation Before Radical Prostatectomy? Results From a Systematic Review of the Literature.

Nadja Schoentgen, Gianluigi Califano, Celeste Manfredi, Javier Romero-Otero, Felix K H Chun, Idir Ouzaid, Jean-François Hermieu, Evanguelos Xylinas, Paolo Verze,

<b>Background and Purpose:</b> Sexual dysfunction (SD) is a frequent side effect associated with radical prostatectomy (RP) for prostate cancer (PCa). Some studies have showed the benefit associated with preoperative sexual rehabilitation (prehabilitation) and Enhanced Recovery After Surgery (ERAS) for RP, but no clear clinical recommendations are available yet. Our aim ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:648345]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Assessment of the oncological outcomes of three different bacillus Calmette-Guérin strains in patients with high-grade T1 non-muscle-invasive bladder cancer.

Łukasz Nowak, Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Sławomir Poletajew, Andrzej Tukiendorf, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Rossella Orlando, Ettore Di Trapani, Mario Alvarez-Maestro, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Objective</h4>: To determine whether there are significant differences in oncological outcomes between three different bacillus Calmette-Guérin (BCG) strains used for adjuvant intravesical immunotherapy in patients with high-grade T1 (T1HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>: Data of 590 patients with a diagnosis of primary T1HG NMIBC were retrospectively reviewed. The ... Read more >>

Arab J Urol (Arab journal of urology)
[2021, 19(1):78-85]

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A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.

Luca Afferi, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Evanguelos Xylinas, Thomas Seisen, Morgan Roupret, Chiara Lonati, Alexandre De la Taille, Benoit Peyronnet, Ekaterina Laukhtina, Benjamin Pradere, Andrea Mari, Wojciech Krajewski, Mario Alvarez-Maestro, Eiji Kikuchi, Keisuke Shigeta, Piotr Chlosta, Francesco Montorsi, Alberto Briganti, Giuseppe Simone, Paola I Ornaghi, Maria Angela Cerruto, Alessandro Antonelli, Kazumasa Matsumoto, Pierre I Karakiewicz, Livio Mordasini, Agostino Mattei, Shahrokh F Shariat, Marco Moschini,

<h4>Background</h4>Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In small uncontrolled studies, laparoscopic RNU has been suggested to be associated with better perioperative outcomes compared ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Perioperative chemotherapy for upper tract urothelial carcinoma: show me the evidence.

Benjamin Pradère, Gianluigi Califano, Evanguelos Xylinas,

Curr Opin Urol (Current opinion in urology)
[2021, 31(1):66-67]

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New immunotherapy treatments in non-muscle invasive bladder cancer.

Gianluigi Califano, Idir Ouzaid, Paolo Verze, Nadja Stivalet, Jean-François Hermieu, Evanguelos Xylinas,

Non-muscle invasive bladder cancer (NMIBC) is a highly heterogeneous disease that hides classes of patients who behave significantly differently under a favorable overall prognosis facade. Individual risk stratification and good decision making improve the patient outcomes. To date, radical cystectomy remains the treatment of choice in particularly aggressive subsets of ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2020, 73(10):945-953]

Cited: 1 time

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Comparison of the prognosis of primary vs. progressive muscle invasive bladder cancer after radical cystectomy: Results from a large multicenter study.

François-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulié, Mathieu Roumiguié, Grégory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister,

<h4>Purpose</h4>To assess whether progressive and primary muscle invasive bladder cancer (MIBC) have different prognosis after radical cystectomy or not. To date only a few data are available on this topic with conflicting results. Further studies on large cohort are needed to clarify these outcomes that may influence bladder cancer management ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):195.e1-195.e6]

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Delaying BCG immunotherapy onset after transurethral resection of non-muscle-invasive bladder cancer is associated with adverse survival outcomes.

Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen-Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy, ,

<h4>Purpose</h4>This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette-Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).<h4>Materials and methods</h4>Data on 429 ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Immune checkpoint inhibition in upper tract urothelial carcinoma.

Gianluigi Califano, Idir Ouzaid, Paolo Verze, Jean-Francois Hermieu, Vincenzo Mirone, Evanguelos Xylinas,

<h4>Introduction</h4>Immunotherapy is changing the way we think about and treat urothelial carcinoma (UC). The PD-1/PD-L1 pathway inhibition has shown robust efficacy, associated with an acceptable toxicity profile, in patients with locally advanced and metastatic unresectable disease, addressing a high decades-old unmet medical need.<h4>Material and methods</h4>Using the Pubmed database, we conducted ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1357-1367]

Cited: 3 times

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Impact of Smoking Habit on Perioperative Morbidity in Patients Treated with Radical Cystectomy for Urothelial Bladder Cancer: A Systematic Review and Meta-analysis.

Riccardo Tellini, Andrea Mari, Gianluca Muto, Giovanni Enrico Cacciamani, Matteo Ferro, Judith Stangl-Kremser, Riccardo Campi, Francesco Soria, Michael Rink, Evanguelos Xylinas, Andrea Minervini, Alberto Briganti, Francesco Montorsi, Morgan Roupret, Shahrokh F Shariat, Marco Moschini, ,

<h4>Context</h4>Smoking habit at the time of surgery is associated with higher perioperative complications and mortality across different types of surgeries. In recent years, several studies have attempted to explore the influence of smoking on perioperative outcomes following radical cystectomy (RC) for urothelial bladder cancer (UBC) with contradictory results.<h4>Objective</h4>To systematically investigate ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, :]

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review.

Thomas Seisen, Andrea Mari, Riccardo Campi, Benoit Peyronnet, Karim Bensalah, Nathalie Rioux-Leclercq, Christian Pfister, Françoise Gobet, Alexandre De La Taille, Yves Allory, Evanguelos Xylinas, Yann Neuzillet, Camelia Radulescu, Jean-Luc Descotes, Géraldine Saada-Sebag, Jacques Irani, Céline Delpech-Debiais, Pierre Bigot, Caroline Eymerit, Sebastien Crouzet, Florence Mege-Lechevallier, Alain Ruffion, Myriam Decaussin-Petrucci, Stéphane Droupy, Pascal Roger, Xavier Durand, Philippe Camparo, Olivier Cussenot, Eva Compérat, Morgan Rouprêt,

<h4>Background</h4>The current pathological tumour-node-metastasis (pTNM) classification for upper tract urothelial carcinoma (UTUC) does not include any risk stratification of pT3 renal pelvicalyceal tumours.<h4>Objective</h4>To assess the prognostic impact of pT3 subclassification in a multicentre cohort of patients with UTUC of the renal pelvicalyceal system undergoing radical nephroureterectomy (RNU).<h4>Design, setting, and participants</h4>Data ... Read more >>

Eur Urol Focus (European urology focus)
[2020, :]

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Frailty impact on postoperative complications and early mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review.

Paola I Ornaghi, Luca Afferi, Alessandro Antonelli, Maria A Cerruto, Livio Mordasini, Agostino Mattei, Philipp Baumeister, Giancarlo Marra, Wojciech Krajewski, Andrea Mari, Francesco Soria, Benjamin Pradere, Evanguelos Xylinas, Alessandro Tafuri, Marco Moschini,

<b>Objective</b>: To assess the prevalence of frailty, a status of vulnerability to stressors leading to adverse health events, in bladder cancer patients undergoing radical cystectomy (RC), and test the impact of frailty measurements on postoperative adverse outcomes. <b>Methods</b>: A systematic review of English-language articles published up to April 2020 was ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):9-23]

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Consensus Definition and Prediction of Complexity in Transurethral Resection or Bladder Endoscopic Dissection of Bladder Tumours.

Mathieu Roumiguié, Evanguelos Xylinas, Antonin Brisuda, Maximillian Burger, Hugh Mostafid, Marc Colombel, Marek Babjuk, Joan Palou Redorta, Fred Witjes, Bernard Malavaud,

Ten senior urologists were interrogated to develop a predictive model based on factors from which they could anticipate complex transurethral resection of bladder tumours (TURBT). Complexity was defined by consensus. Panel members then used a five-point Likert scale to grade those factors that, in their opinion, drove complexity. Consensual factors ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

Cited: 1 time

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Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit.

Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Alvarez-Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl Tully, Joanna Krajewska, Radosław Piszczek, Evanguelos Xylinas, Romuald Zdrojowy,

<h4>Background and purpose</h4>The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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Comparing oncological outcomes of laparoscopic vs open radical nephroureterectomy for the treatment of upper tract urothelial carcinoma: A propensity score-matched analysis.

Marco Moschini, Stefania Zamboni, Luca Afferi, Benjamin Pradere, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Morgan Roupret, Alexandre De la Taille, Claudio Simeone, Agostino Mattei, Romain Mathieu, Karim Bensalah, Manfred Peter Wirth, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Giuseppe Simone, Michele Gallucci, Carlo Di Bona, Giancarlo Marra, Andrea Mari, Ettore Di Trapani, Mario Alvarez Maestro, Wojciech Krajewski, Shahrokh F Shariat, Evanguelos Xylinas, Philipp Baumeister,

<h4>Objectives</h4>To compare oncological outcomes of open (ORNU) and laparoscopic radical nephroureterectomy (LRNU) after controlling for preoperative patient-derived factors.<h4>Patients and methods</h4>We evaluated a multi-institutional collaborative database composed of 3984 patients diagnosed with upper tract urothelial carcinoma (UTUC) treated with RNU between 2006 and 2018. To adjust for potential selection bias, propensity ... Read more >>

Arab J Urol (Arab journal of urology)
[2020, 19(1):31-36]

Cited: 1 time

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Incidence and preoperative predictors for major complications following radical nephroureterectomy.

Neil J Kocher, David Canes, Karim Bensalah, Morgan Roupret, Costas Lallas, Vitaly Margulis, Shahrokh Shariat, Pierre Colin, Surena Matin, Chad Tracy, Evanguelos Xylinas, Andrew Wagner, Mathieu Roumiguie, Wassim Kassouf, Tobias Klatte, Jay D Raman,

<h4>Background</h4>Radical nephroureterectomy (RNU) is the referent standard for managing bulky, invasive, or high grade upper-tract urothelial carcinoma (UTUC). The UTUC patient population, however, generally harbor medical comorbidities thereby placing them at risk of surgical complications. This study reviews a large international cohort of RNU patients to define the risk of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1786-1793]

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Impact of tumor size on the oncological outcome of high-grade nonmuscle invasive bladder cancer - examining the utility of classifying Ta bladder cancer based on size.

Karl H Tully, Marco Moschini, Friedrich-Carl E von Rundstedt, Atiqullah Aziz, Luis A Kluth, Andrea Necchi, Michael Rink, Kees Hendricksen, Paul Sargos, Malte W Vetterlein, Roland Seiler, Cedric Poyet, Wojciech Krajewski, Harun Fajkovic, Shahrokh F Shariat, Evanguelos Xylinas, Florian Roghmann,

<h4>Purpose</h4>To examine survival rates and to calculate the risk of disease recurrence, progression, overall, and cancer-specific mortality in patients diagnosed with high-risk NMIBC using a multi-institutional dataset to evaluate differences between the guidelines of the European Association of Urology and the guidelines of the National Comprehensive Cancer Network (NCCN) with ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(11):851.e19-851.e25]

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Comparison of the Comprehensive Complication Index and Clavien-Dindo systems in predicting perioperative outcomes following radical nephroureterectomy.

Scott Geiger, Neil Kocher, Dan Illinsky, Evanguelos Xylinas, Peter Chang, Lauren Dewey, Andrew A Wagner, Firas Petros, Surena F Matin, Conrad Tobert, Chad Tracy, Pierre-Marie Patard, Mathieu Roumiguie, Leonardo Lima Monteiro, Wassim Kassouf, Jay D Raman,

<h4>Background</h4>Complications can occur following radical nephroureterectomy (RNU) in 20-40% of patients. The Comprehensive Complication Index (CCI) is an alternative grading system to the Clavien-Dindo (CD) grading system that aggregates all complications experienced by a patient on a continuous (as opposed to categorical) scale. We investigate whether the cumulative nature of ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(4):1780-1785]

Cited: 1 time

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PD-L1 expression and pattern of immune cells in pre-treatment specimens are associated with disease-free survival for HR-NMIBC undergoing BCG treatment.

Mathieu Roumiguié, Eva Compérat, Léonor Chaltiel, François Xavier Nouhaud, Gregory Verhoest, Alexandra Masson-Lecomte, Pierre Colin, François Audenet, Nadine Houédé, Stéphane Larré, Evanguelos Xylinas, Serge Brunelle, Jeanne Piana-Thomassin, Juliette Cotte, Géraldine Pignot, Yann Neuzillet, Morgan Rouprêt,

<h4>Purpose</h4>To assess the association between PD-L1 expression and disease-free survival (DFS) in High-Risk Non-Muscle Invasive Bladder Cancer (HR-NMIBC) patients treated with intravesical Bacillus Calmette-Guerin (BCG) instillations (IBI).<h4>Methods</h4>Retrospective study in five French centres between 2001 and 2015. Participants were 140 patients with histologically confirmed HR-NMIBC. All patients received induction and maintenance ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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The association of cigarette smoking and pathological response to neoadjuvant platinum-based chemotherapy in patients undergoing treatment for urinary bladder cancer - A prospective European multicenter observational study of the EAU Young Academic Urologists (YAU) urothelial carcinoma working group.

Philipp Gild, Malte W Vetterlein, Roland Seiler, Andrea Necchi, Kees Hendricksen, Laura S Mertens, Florian Roghmann, Nicolas V Landenberg, Paolo Gontero, Marcus Cumberbatch, Jakub Dobruch, Thomas Seisen, Pietro Grande, David D'Andrea, Julien Anract, Evi Comploj, Armin Pycha, Karim Saba, Cedric Poyet, Bas W van Rhijn, Aidan P Noon, Morgan Roupret, Shahrokh F Shariat, Margit Fisch, Evanguelos Xylinas, Michael Rink,

<h4>Objective</h4>To prospectively study the impact of smoking on pathological response to neoadjuvant chemotherapy (NAC) in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB).<h4>Materials & methods</h4>We collected standard clinicopathological variables, including smoking status (never, former, current) in patients undergoing NAC and RC for UCB at 12 European ... Read more >>

Surg Oncol (Surgical oncology)
[2020, 34:312-317]

Cited: 1 time

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Survival Outcomes of Patients with Pathologically Proven Positive Lymph Nodes at Time of Radical Cystectomy with or without Neoadjuvant Chemotherapy.

Guillaume Ploussard, Benjamin Pradere, Jean-Baptiste Beauval, Christine Chevreau, Christophe Almeras, Etienne Suc, Jean-Romain Gautier, Anne-Pascale Laurenty, Mathieu Roumiguié, Guillaume Loison, Christophe Tollon, Loïc Mourey, Ambroise Salin, Evanguelos Xylinas, Damien Pouessel,

<h4>Background</h4>To compare overall survival (OS) outcomes in pN1-3 disease at the time of radical cystectomy (RC) for muscle invasive bladder according to the neoadjuvant chemotherapy (NAC) status.<h4>Materials and methods</h4>This multicenter study included 450 consecutive patients undergoing RC for muscle-invasive urothelial bladder cancer with pN1-3 pM0 disease from 2010 to 2019. ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(6):]

Cited: 3 times

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