Full Text Journal Articles by
Author Evan S Glazer

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Implications of Conversion during Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma.

Olivia M Delozier, Zachary E Stiles, Benjamin W Deschner, Justin A Drake, Jeremiah L Deneve, Evan S Glazer, Miriam W Tsao, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Although advocated by some, minimally invasive adrenalectomy (MIA) for adrenocortical carcinoma (ACC) is controversial. Moreover, the oncologic implications for patients requiring conversion to an open procedure during attempted MIA for ACC are not extensively reported. PATIENTS AND METHODS:The National Cancer Database was queried for patients undergoing resection for ACC. Overall ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, :]

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Critical analysis of lymph node examination in patients undergoing curative-intent resection for adrenocortical carcinoma.

Benjamin W Deschner, Zachary E Stiles, Olivia M DeLozier, Justin A Drake, Miriam Tsao, Evan S Glazer, Jeremiah L Deneve, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Adrenocortical carcinoma (ACC) is a rare tumor and the role of lymph node dissection remains ill-defined. This study evaluates the effect of nodal examination on prognosis and survival in patients undergoing curative-intent resection of ACC. METHODS:The National Cancer Database (2004-2015) was queried for patients undergoing margin-negative resection for ACC. Patients ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, :]

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Primary Diffuse Large B Cell Lymphoma of the Common Bile Duct.

Denise L Wong, Benjamin W Deschner, Lauren C King, Evan S Glazer,

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2020, :]

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Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.

Matthew K Stein, Forrest W Williard, Joanne Xiu, Miriam W Tsao, Michael G Martin, Benjamin W Deschner, Paxton V Dickson, Evan S Glazer, Danny Yakoub, David Shibata, Axel F Grothey, Philip A Philip, Jimmy J Hwang, Anthony F Shields, John L Marshall, W Michael Korn, Heinz-Josef Lenz, Jeremiah L Deneve,

BACKGROUND AND OBJECTIVES:Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences are not well defined. METHODS:We compared unpaired tumor profiles of patients with pCRC and PM from Caris Life Sciences. Testing included next-generation sequencing of 592 genes, microsatellite instability (MSI) and tumor mutational ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(8):1320-1328]

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Restaging Patients with Rectal Cancer Following Neoadjuvant Chemoradiation: A Systematic Review.

Leah E Hendrick, Renee L Levesque, Nathan M Hinkle, Justin J Monroe, Evan S Glazer, Jeremiah L Deneve, Danny Yakoub, David Shibata, Paxton V Dickson,

BACKGROUND:In the USA, most patients with clinical stage II/III rectal cancer receive neoadjuvant chemoradiation (chemo/XRT) over 5-6 weeks followed by a 6-10-week break before proctectomy. As chemotherapy is delivered at radio-sensitizing doses, there is essentially a 3-month window during which potential systemic disease is untreated. Evidence regarding the utility of restaging ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(3):973-979]

Cited: 1 time

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Outcomes Following Resection of Hepatocellular Carcinoma in the Absence of Cirrhosis.

Richard H Lewis, Evan S Glazer, David M Bittenbinder, Thomas O'Brien, Jeremiah L Deneve, David Shibata, Stephen W Behrman, Jason M Vanatta, Sanjaya K Satapathy, Paxton V Dickson,

BACKGROUND:Hepatocellular carcinoma (HCC) occasionally occurs in non-cirrhotic patients; however, outcomes for these patients are not extensively documented. METHODS:We performed an institutional review of patients without cirrhosis who underwent resection for HCC. Clinical data were evaluated to identify factors impacting recurrence-free survival (RFS) and overall survival (OS). RESULTS:Forty-two patients underwent hepatectomy ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(4):808-815]

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Elevated Serum α-Fetoprotein is Associated with Abbreviated Survival for Patients with Fibrolamellar Hepatocellular Carcinoma Who Undergo a Curative Resection.

James D McDonald, Shreya Gupta, Mackenzie L Shindorf, Lauren A Gamble, Samantha M Ruff, Justin Drake, Theo Heller, Jim Y Wan, Paxton V Dickson, Evan S Glazer, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Fibrolamellar hepatocellular carcinoma (FLC) is a rare variant of hepatocellular carcinoma (HCC), with most clinical data stemming from single-institution series. The variability in the literature lends support for analysis using a large national dataset. In doing so, we sought to (1) define the characteristics and outcomes of patients with FLC; ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(6):1900-1905]

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The impact of race and socioeconomic status on the presentation, management and outcomes for gastric cancer patients: Analysis from a metropolitan area in the southeast United States.

Miriam W Tsao, Olivia M Delozier, Zachary E Stiles, Louis J Magnotti, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, David Shibata, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Socioeconomic disparities in gastric cancer have been associated with differences in care and inferior outcomes. We evaluated the presentation, treatment, and survival for patients with gastric cancer (GC) in a metropolitan setting with a large African American population. METHODS:Retrospective cohort analysis of patients with GC (2003-2018) across a multi-hospital system ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(3):494-502]

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Rising BMI Is Associated with Increased Rate of Clinically Relevant Pancreatic Fistula after Distal Pancreatectomy for Pancreatic Adenocarcinoma.

Yixuan Zhou, Justin Drake, Jeremiah L Deneve, Stephen W Behrman, Paxton V Dickson, David Shibata, Evan S Glazer,

Clinically relevant pancreatic fistula (CR-POPF), after distal pancreatectomy (DP), remains a clinical challenge. Prior studies investigating the relationship between BMI and CR-POPF have yielded conflicting results. We hypothesized that BMI is associated with CR-POPF in patients having DP for pancreatic ductal adenocarcinoma (PDAC). Patients who underwent DP for PDAC at ... Read more >>

Am Surg (The American surgeon)
[2019, 85(12):1376-1380]

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Resection and chemotherapy is the optimal treatment approach for patients with clinically node positive intrahepatic cholangiocarcinoma.

Sean P Martin, Justin Drake, Michael M Wach, Samantha M Ruff, Laurence P Diggs, Jim Y Wan, Meghan L Good, Dana A Dominguez, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Clinically lymph node positive (cLNP) intrahepatic cholangiocarcinoma (ICC) carries a poor prognosis, without clear management guidelines for the practicing clinician. We sought to evaluate current practice patterns for cLNP ICC, including associations with survival. METHODS:The National Cancer Database was queried for patients with cLNP ICC, without extrahepatic metastases. RESULTS:We identified ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, 22(1):129-135]

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Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Zachary E Stiles, Andrew J Murphy, Doralina L Anghelescu, Christina-Lin Brown, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Michael W Bishop, Wayne L Furman, Alberto S Pappo, John T Lucas, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. METHODS:A retrospective review was performed for ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(1):171-178]

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TGF-β Inhibitors in Metastatic Pancreatic Ductal Adenocarcinoma.

Marcus A Alvarez, Júlia Pedó Freitas, S Mazher Hussain, Evan S Glazer,

BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancerrelated mortality in the USA, and the overall incidence of the disease is increasing such that it is expected to be the third leading cause of cancer-related deaths in the next decade. Minimal improvements in therapy have not changed the ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(2):207-213]

Cited: 1 time

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Molecular Alterations Associated with DNA Repair in Pancreatic Adenocarcinoma Are Associated with Sites of Recurrence.

Margaret D Ferguson, Lei Dong, Jim Wan, Jeremiah L Deneve, Paxton V Dickson, Stephen W Behrman, David Shibata, Mike G Martin, Evan S Glazer,

BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies with a rising incidence. Mutational analysis of PDAC has provided valuable information but has not yet dramatically changed the therapeutic landscape due to the number of variations detected in any one individual. The pattern of molecular alterations-gene mutations, variations in ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(2):285-291]

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Symptomatic Pancreatic Lipoma.

Benjamin Deschner, Jatin Gandhi, Jeremiah L Deneve, Paxton V Dickson, Ian Clark, Evan S Glazer,

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2019, 23(9):1942-1943]

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Laparoscopic Approach to Intrahepatic Cholangiocarcinoma is Associated with an Exacerbation of Inadequate Nodal Staging.

Sean P Martin, Justin Drake, Michael M Wach, Samantha Ruff, Laurence P Diggs, Jim Y Wan, Zachary J Brown, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

INTRODUCTION:Laparoscopic approach to liver resection is feasible and safe, though its utilization with intrahepatic cholangiocarcinoma (ICC) remains poorly documented. We sought to evaluate the use laparoscopy for ICC, and to examine adherence to oncologic standards. METHODS:The National Cancer Database was queried for patients who underwent resection for ICC. Patients were ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(6):1851-1857]

Cited: 1 time

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Hypervascular lesions of the pancreas: Think before you act.

Susan M Wcislak, Zachary E Stiles, Jeremiah L Deneve, Evan S Glazer, Stephen W Behrman, Farees T Farooq, Paxton V Dickson,

BACKGROUND:The "classic" CT appearance of pancreatic neuroendocrine tumors (PNETs) is a solid, hypervascular lesion; however, non-PNET diagnoses may appear similar. In addition, some PNETs have a "non-classic" appearance. METHODS:Demographic, imaging, endoscopic ultrasound-fine needle aspiration (EUS/FNA) results, and pathology data were analyzed for patients who underwent pancreatectomy for suspected or confirmed ... Read more >>

Am. J. Surg. (American journal of surgery)
[2019, 218(2):362-367]

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Long-Term Implications of Unplanned Conversion During Laparoscopic Liver Resection for Hepatocellular Carcinoma.

Zachary E Stiles, Evan S Glazer, Jeremiah L Deneve, David Shibata, Stephen W Behrman, Paxton V Dickson,

BACKGROUND:Laparoscopic liver resection (LLR) is increasingly utilized for patients with hepatocellular carcinoma (HCC). However, long-term outcomes for patients requiring conversion to an open procedure during LLR have not been examined. METHODS:Patients undergoing attempted LLR for HCC were identified within the National Cancer Database. Patients undergoing successful LLR were compared with ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):282-289]

Cited: 1 time

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

Cited: 1 time

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Outcome and factors associated with aborted cytoreduction for peritoneal carcinomatosis.

Whitney Guerrero, Gitonga Munene, Paxton V Dickson, Zachary E Stiles, Johnathan Mays, Andrew M Davidoff, Evan S Glazer, David Shibata, Jeremiah L Deneve,

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) offers a potential cure for peritoneal carcinomatosis (PC), whereas aborted cytoreduction is associated with a poor outcome. We evaluate factors associated with aborted CRS procedures.An IRB approved retrospective review was performed from 12/2011 to 2/2016. Clinicopathologic variables and outcomes are described.Seventy-four patients underwent ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2018, 9(4):664-673]

Cited: 0 times

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The impact of unplanned conversion to an open procedure during minimally invasive pancreatectomy.

Zachary E Stiles, Paxton V Dickson, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Stephen W Behrman,

BACKGROUND:Minimally invasive pancreatic resection (MIPR) is being increasingly utilized. Outcomes for patients experiencing unplanned conversion to an open procedure during MIPR have been incompletely assessed. We sought to determine the short-term outcomes and factors associated with unplanned conversion during MIPR. METHODS:A retrospective cohort study using the American College of Surgeons ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2018, 227:168-177]

Cited: 3 times

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Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma.

Zachary E Stiles, Paxton V Dickson, Evan S Glazer, Andrew J Murphy, Andrew M Davidoff, Stephen W Behrman, Michael W Bishop, Michael G Martin, Jeremiah L Deneve,

Desmoplastic small round cell tumor (DSRCT) is a rare peritoneal surface malignancy. Current research is limited by the scarcity of this disease.Patients with DSRCT were identified in the 2004-2014 NCDB. Factors affecting overall survival (OS) were assessed. Additionally, trends were examined based on the volume of cases treated at individual ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2018, 117(8):1759-1767]

Cited: 3 times

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IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma.

S Mazher Hussain, Leighton F Reed, Bradley A Krasnick, Gustavo Miranda-Carboni, Ryan C Fields, Ye Bi, Abul Elahi, Abidemi Ajidahun, Paxton V Dickson, Jeremiah L Deneve, William G Hawkins, David Shibata, Evan S Glazer,

The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-ß expression in PDAC. We hypothesized ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):5808]

Cited: 2 times

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Early experience with cytoreduction and hyperthermic intraperitoneal chemotherapy at a newly developed center for peritoneal malignancy.

Whitney L Guerrero, Gitonga Munene, Paxton V Dickson, Dina Darby, Andrew M Davidoff, Michael G Martin, Evan S Glazer, David Shibata, Jeremiah L Deneve,

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). We present our experience from a newly developed peritoneal surface malignancy program.An IRB approved retrospective review was performed for the first 50 patients treated with CRS/HIPEC with clinicopathologic data described.Patients treated with CRS/HIPEC were ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2018, 9(2):338-347]

Cited: 0 times

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Ampullary adenocarcinoma: Defining predictors of survival and the impact of adjuvant therapy following surgical resection for stage I disease.

Zachary E Stiles, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Michael G Martin, Paxton V Dickson,

Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT.The NCDB was queried for stage I AAC patients undergoing resection. We evaluated variables influencing the administration of AT and ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2018, 117(7):1500-1508]

Cited: 4 times

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