Full Text Journal Articles by
Author Evan M Bloch

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Blood Product (Donor) Noninfectious and Infectious Testing and Modification.

Tania Sarker, Louis M Katz, Evan M Bloch, Ruchika Goel,

Blood transfusion begins with safe donor selection and testing. In the United States, the blood supply and transfusion are highly regulated. Blood transfusion safety is multifaceted, whereby each of the elements of the blood safety value chain, spanning donor recruitment and qualification, to collection, blood processing, testing, transfusion practice, and ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):579-598]

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Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children.

Oren Gordon, Mary Katherine Brosnan, Steve Yoon, Dawoon Jung, Kirsten Littlefield, Abhinaya Ganesan, Christopher A Caputo, Maggie Li, William R Morgenlander, Stephanie N Henson, Alvaro A Ordonez, Patricia De Jesus, Elizabeth W Tucker, Nadine Peart Akindele, Zexu Ma, Jo Wilson, Camilo A Ruiz-Bedoya, M Elizabeth M Younger, Evan M Bloch, Shmuel Shoham, David Sullivan, Aaron Ar Tobian, Kenneth R Cooke, Ben Larman, Jogarao Vs Gobburu, Arturo Casadevall, Andrew Pekosz, Howard M Lederman, Sabra L Klein, Sanjay K Jain,

While most children experience mild COVID-19, high-risk children with underlying conditions may develop severe disease, requiring interventions. Kinetics of antibodies transferred via COVID-19 convalescent plasma early in disease, have not been characterized. In this study (NCT04377672), high-risk children were prospectively enrolled to receive high-titer COVID-19 convalescent plasma (>1:320 anti-spike IgG; ... Read more >>

JCI Insight (JCI insight)
[2021, :]

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Powassan virus: What is the risk to the blood supply?

Evan M Bloch, Aaron A R Tobian, Louis M Katz,

Powassan virus (POWV) is an emerging tick-borne arbovirus that is found widely in Canada, the Northeastern and Northcentral United States, and the Russian Far East. While still rare, there has been an increase in reported cases of POWV disease over the last decade; most (>90%) cases have been neuroinvasive and ... Read more >>

Transfusion (Transfusion)
[2021, :]

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Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018.

Ruchika Goel, Xianming Zhu, Eshan U Patel, Elizabeth P Crowe, Paul M Ness, Louis M Katz, Evan M Bloch, Aaron A R Tobian,

Blood transfusions are among the most common therapeutic procedures performed in hospitalized patients. This study evaluates contemporary national trends in red blood cell (RBC), plasma, platelet, and cryoprecipitate transfusions. National Inpatient Sample, the largest all-payer inpatient database representing 94% to 97% of the US population, was evaluated from the fourth ... Read more >>

Blood Adv (Blood advances)
[2021, 5(20):4179-4184]

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Preventing Transfusion-Transmitted Babesiosis.

Evan M Bloch, Peter J Krause, Laura Tonnetti,

<i>Babesia</i> are tick-borne intra-erythrocytic parasites and the causative agents of babesiosis. <i>Babesia</i>, which are readily transfusion transmissible, gained recognition as a major risk to the blood supply, particularly in the United States (US), where <i>Babesia microti</i> is endemic. Many of those infected with <i>Babesia</i> remain asymptomatic and parasitemia may persist ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2021, 10(9):]

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In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential.

Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Ya Chea Tsai, Liangmei He, Gianni Castiglione, Emily Egbert, Elia J Duh, Evan M Bloch, Aaron A R Tobian, Aaron M Milstone, Richard B S Roden, Tzyy-Choou Wu, Chien-Fu Hung,

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads, variants with enhanced virulence and transmissibility have emerged. Although in vitro systems allow rapid characterization, they do not fully recapitulate the dynamic interaction of virions and neutralizing antibodies in the airway. Here, we demonstrate that the N501Y variant permits respiratory infection in ... Read more >>

Cell Rep (Cell reports)
[2021, 37(3):109838]

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A Hemagglutination-Based Semiquantitative Test for Point-of-Care Determination of SARS-CoV-2 Antibody Levels.

Robert L Kruse, Yuting Huang, Alyssa Lee, Xianming Zhu, Ruchee Shrestha, Oliver Laeyendecker, Kirsten Littlefield, Andy Pekosz, Evan M Bloch, Aaron A R Tobian, Zack Z Wang,

Serologic point-of-care tests to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are an important tool in the COVID-19 pandemic. The majority of current point-of-care antibody tests developed for SARS-CoV-2 rely on lateral flow assays, but these do not offer quantitative information. To address this, we developed a ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2021, 59(12):e0118621]

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Causes of death after biannual azithromycin treatment: A community-level randomized clinical trial.

Evan M Bloch, Zakayo Mrango, Jerusha Weaver, Beatriz Munoz, Thomas M Lietman, Sheila K West,

The MORDOR study, a masked, community-level randomized clinical trial conducted in Niger, Malawi and Tanzania (2015 to 2017), showed that biannual administration of single-dose azithromycin to preschool children reduced all-cause mortality. We sought to evaluate its impact on causes of death in children aged 1-59 months in Tanzania. A random ... Read more >>

PLoS One (PloS one)
[2021, 16(9):e0250197]

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serosurveillance in Blood Donor Populations.

Eshan U Patel, Evan M Bloch, Aaron A R Tobian,

J Infect Dis (The Journal of infectious diseases)
[2021, :]

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Risk of transfusion-transmitted Babesia microti in Canada.

Sheila F O'Brien, Steven J Drews, Qi-Long Yi, Evan M Bloch, Nicholas H Ogden, Jules K Koffi, Leslie Robbin Lindsay, Yves Gregoire, Gilles Delage,

<h4>Background</h4>Babesia microti has gained a foothold in Canada as tick vectors become established in broader geographic areas. B. microti infection is associated with mild or no symptoms in healthy individuals but is transfusion-transmissible and can be fatal in immunocompromised individuals. This is the first estimate of clinically significant transfusion-transmitted babesiosis ... Read more >>

Transfusion (Transfusion)
[2021, 61(10):2958-2968]

Cited: 1 time

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Low rates of transfusion-transmitted infection screening in chronically transfused adults with sickle cell disease.

Vignesh Chidambaram, Jennifer M Jones, Parvez M Lokhandwala, Evan M Bloch, Sophie Lanzkron, Rosalyn Stewart, Lydia H Pecker,

<h4>Background</h4>Adults with sickle cell disease (SCD) on chronic transfusion therapy are exposed to a large volume of blood products, thus increasing their risk of transfusion-associated human immunodeficiency virus (HIV), hepatitis C (HCV), and hepatitis B (HBV).<h4>Methods</h4>We performed a systematic chart review of chronically transfused SCD subjects at the Johns Hopkins ... Read more >>

Transfusion (Transfusion)
[2021, 61(8):2421-2429]

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Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report.

Michelle C Nguyen, Eliza J Lee, Robin K Avery, M Veronica Dioverti-Prono, Shmuel Shoham, Aaron A R Tobian, Evan M Bloch, Ahmet Gurakar, Nicole A Rizkalla, Andrew M Cameron, Elizabeth A King, Shane Ottmann, Jacqueline M Garonzik-Wang, Russel N Wesson, Benjamin Philosophe,

Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(8):e721]

Cited: 2 times

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Blood transfusions in gunshot-wound-related emergency department visits and hospitalizations in the United States.

Ruchika Goel, Xianming Zhu, Sarah Makhani, Molly R Petersen, Cassandra D Josephson, Louis M Katz, Beth H Shaz, Richard Austin, Elizabeth P Crowe, Paul M Ness, Eric A Gehrie, Steven M Frank, Evan M Bloch, Aaron A R Tobian,

<h4>Background</h4>The United States (US) leads all high-income countries in gunshot wound (GSW) deaths. However, previous US studies have not evaluated the national blood transfusion utilization patterns in hospitalized GSW patients.<h4>Methods</h4>Data from 2016 to 2017 were analyzed from the Nationwide Emergency Department Sample (NEDS) and Nationwide Inpatient Sample (NIS), the largest ... Read more >>

Transfusion (Transfusion)
[2021, 61(8):2277-2289]

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International survey of strategies to mitigate transfusion-transmitted Trypanosoma cruzi in non-endemic countries, 2016-2018.

Lauren A Crowder, Silvano Wendel, Evan M Bloch, Sheila F O'Brien, Gilles Delage, Silvia Sauleda, David A Leiby, ,

<h4>Background and objectives</h4>Chagas disease, caused by Trypanosoma cruzi, is endemic to Mexico, Central and South America. While initially limited to the Americas, emigration of infected persons triggered geographically broader blood safety challenges. To mitigate transfusion-transmitted Chagas (TTC), transfusion services implemented approaches including risk factor questions and serologic testing. We sought ... Read more >>

Vox Sang (Vox sanguinis)
[2021, :]

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Sequential dosing of convalescent COVID-19 plasma with significant temporal clinical improvements in a persistently SARS-COV-2 positive patient.

Noupama Mirihagalle, Priyanka Parajuli, Vidya Sundareshan, Debadoot Saha, Arpan Shah, Francine Chua, Sana Waqar, Vidhya Prakash, Aaron A R Tobian, Evan M Bloch, Louis M Katz, Ruchika Goel,

The current global pandemic, SARS-CoV-2 infection, is still extending across the world affecting millions of lives to the date. While new successful vaccines are available with promising outcomes to minimize the spread and to reduce the severity of the disease, optimal therapeutic options still remain elusive. COVID-19 convalescent plasma (CCP) ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2021, 60(5):103180]

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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.

Elizabeth A Thompson, Katherine Cascino, Alvaro A Ordonez, Weiqiang Zhou, Ajay Vaghasia, Anne Hamacher-Brady, Nathan R Brady, Im-Hong Sun, Rulin Wang, Avi Z Rosenberg, Michael Delannoy, Richard Rothman, Katherine Fenstermacher, Lauren Sauer, Kathyrn Shaw-Saliba, Evan M Bloch, Andrew D Redd, Aaron A R Tobian, Maureen Horton, Kellie Smith, Andrew Pekosz, Franco R D'Alessio, Srinivasan Yegnasubramanian, Hongkai Ji, Andrea L Cox, Jonathan D Powell,

It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells in severe and recovered coronavirus disease 2019 (COVID-19) patients compared with other viral infections, we identify a unique population of T cells. These T cells express increased Voltage-Dependent Anion Channel ... Read more >>

Cell Rep (Cell reports)
[2021, 34(11):108863]

Cited: 14 times

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Kinetics of SARS-CoV-2 antibody responses pre-COVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case-control study.

Matthew N Klein, Elizabeth Wenqian Wang, Paul Zimand, Heather Beauchamp, Caitlin Donis, Matthew D Ward, Aidaelis Martinez-Hernandez, Ali Tabatabai, John W Baddley, Evan M Bloch, Kristin E Mullins, Magali J Fontaine,

<h4>Aims</h4>While the SARS-CoV-2 pandemic may be contained through vaccination, transfusion of convalescent plasma (CCP) from individuals who recovered from COVID-19 (CCP) is considered an alternative treatment. We investigate if CCP transfusion in patients with severe respiratory failure increases plasma titres of SARS-CoV-2 antibodies and improves clinical outcomes.<h4>Methods</h4>Patients with COVID-19 (n=34) ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2021, :]

Cited: 4 times

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Lessons learned in the collection of convalescent plasma during the COVID-19 pandemic.

Silvano Wendel, Kevin Land, Dana V Devine, James Daly, Renée Bazin, Pierre Tiberghien, Cheuk-Kwong Lee, Satyam Arora, Gopal K Patidar, Kamini Khillan, Willem Martin Smid, Hans Vrielink, Adaeze Oreh, Arwa Z Al-Riyami, Salwa Hindawi, Marion Vermeulen, Vernon Louw, Thierry Burnouf, Evan M Bloch, Ruchika Goel, Mary Townsend, Cynthia So-Osman,

<h4>Background</h4>The lack of definitive treatment or preventative options for COVID-19 led many clinicians early on to consider convalescent plasma (CCP) as potentially therapeutic. Regulators, blood centres and hospitals worldwide worked quickly to get CCP to the bedside. Although response was admirable, several areas have been identified to help improve future ... Read more >>

Vox Sang (Vox sanguinis)
[2021, 116(8):872-879]

Cited: 1 time

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CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants.

Andrew D Redd, Alessandra Nardin, Hassen Kared, Evan M Bloch, Andrew Pekosz, Oliver Laeyendecker, Brian Abel, Michael Fehlings, Thomas C Quinn, Aaron A R Tobian,

This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(7):ofab143]

Cited: 11 times

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Coronavirus Disease 2019 Convalescent Plasma and the Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Titer.

Evan M Bloch, Elizabeth P Crowe, Aaron A R Tobian,

J Infect Dis (The Journal of infectious diseases)
[2021, 223(5):740-742]

Cited: 1 time

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Bacterial contamination of blood products in Africa.

Yembur Ahmad, Anne-Sophie Heroes, Heather A Hume, Mohammed Farouk, Alex Owusu-Ofori, Eric A Gehrie, Ruchika Goel, Paul M Ness, Aaron A R Tobian, Evan M Bloch,

<h4>Background</h4>Bacterial contamination of blood components (notably platelets) remains a leading infectious risk to the blood supply. There has been extensive research in high-income countries to characterize the risk of bacterial contamination along with adoption of strategies to mitigate that risk. By contrast, related data in Africa are lacking.<h4>Study design and ... Read more >>

Transfusion (Transfusion)
[2021, 61(3):767-780]

Cited: 1 time

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SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.

Hassen Kared, Andrew D Redd, Evan M Bloch, Tania S Bonny, Hermi Sumatoh, Faris Kairi, Daniel Carbajo, Brian Abel, Evan W Newell, Maria P Bettinotti, Sarah E Benner, Eshan U Patel, Kirsten Littlefield, Oliver Laeyendecker, Shmuel Shoham, David Sullivan, Arturo Casadevall, Andrew Pekosz, Alessandra Nardin, Michael Fehlings, Aaron Ar Tobian, Thomas C Quinn,

Characterization of the T cell response in individuals who recover from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-sectional sample ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(5):]

Cited: 41 times

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ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group.

Ruchika Goel, Evan M Bloch, France Pirenne, Arwa Z Al-Riyami, Elizabeth Crowe, Laetitia Dau, Kevin Land, Mary Townsend, Thachil Jecko, Naomi Rahimi-Levene, Gopal Patidar, Cassandra D Josephson, Satyam Arora, Marion Vermeulen, Hans Vrielink, Celina Montemayor, Adaeze Oreh, Salwa Hindawi, Karin van den Berg, Katherine Serrano, Cynthia So-Osman, Erica Wood, Dana V Devine, Steven L Spitalnik, ,

Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. The level of evidence supporting an association between ABO type ... Read more >>

Vox Sang (Vox sanguinis)
[2021, 116(8):849-861]

Cited: 13 times

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CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

Andrew Redd, Alessandra Nardin, Hassen Kared, Evan Bloch, Andrew Pekosz, Oliver Laeyendecker, Brian Abel, Michael Fehlings, Thomas Quinn, Aaron AR Tobian,

This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants. ... Read more >>

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Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point-of-Care Testing.

Steven E Conklin, Kathryn Martin, Yukari C Manabe, Haley A Schmidt, Jernelle Miller, Morgan Keruly, Ethan Klock, Charles S Kirby, Owen R Baker, Reinaldo E Fernandez, Yolanda J Eby, Justin Hardick, Kathryn Shaw-Saliba, Richard E Rothman, Patrizio P Caturegli, Andrew D Redd, Aaron A R Tobian, Evan M Bloch, H Benjamin Larman, Thomas C Quinn, William Clarke, Oliver Laeyendecker,

Rapid point-of-care tests (POCTs) for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies vary in performance. A critical need exists to perform head-to-head comparisons of these assays. The performances of 15 different lateral flow POCTs for the detection of SARS-CoV-2-specific antibodies were compared on a well-characterized set of ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2021, 59(2):]

Cited: 20 times

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