Full Text Journal Articles by
Author Evan I Saad

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Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function.

Rana Alaaeddine, Mohammed A W Elkhatib, Ali Mroueh, Hosny Fouad, Evan I Saad, Marwan E El-Sabban, Frances Plane, Ahmed F El-Yazbi,

Endothelial dysfunction is a hallmark of diabetic vasculopathies. Although hyperglycemia is believed to be the culprit causing endothelial damage, the mechanism underlying early endothelial insult in prediabetes remains obscure. We used a nonobese high-calorie (HC)-fed rat model with hyperinsulinemia, hypercholesterolemia, and delayed development of hyperglycemia to unravel this mechanism. Compared ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2019, 371(3):567-582]

Cited: 4 times

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Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.

Mohammed A W Elkhatib, Ali Mroueh, Rim W Rafeh, Fatima Sleiman, Hosny Fouad, Evan I Saad, Mohamed A Fouda, Ola Elgaddar, Khodr Issa, Ali H Eid, Assaad A Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2019, 214:121-143]

Cited: 4 times

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Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade.

Hanan M El-Gowelli, Evan I Saad, Abdel-Galil A Abdel-Galil, Einas R Ibrahim,

In this work, α-lipoic acid and cyclosporine demonstrated significant protection against acetic acid-induced ulcerative colitis in rats. We proposed that α-lipoic acid and cyclosporine co-administration might modulate their individual effects. Induction of ulcerative colitis in rats was performed by intra-rectal acetic acid (5% v/v) administration for 3 consecutive days. Effects ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2015, 288(3):300-312]

Cited: 10 times

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Different mechanisms for lead acetate, aluminum and cadmium sulfate in rat corpus cavernosum.

Amira M Senbel, Evan I Saad, Safaa S Taha, Hosny F Mohamed,

<h4>Introduction</h4>Some heavy metals show adverse vascular and neurological effects, however, their effect on erection is underestimated. This study aims to investigate the effect of Pb, Cd and Al on erectile function and their potential mechanism of action in rats.<h4>Methods</h4>Measurement of intracavernosal pressure/mean arterial pressure (ICP/MAP) changes elicited by electrical stimulation ... Read more >>

Toxicology (Toxicology)
[2016, 340:27-33]

Cited: 0 times

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Central estrogenic pathways protect against the depressant action of acute nicotine on reflex tachycardia in female rats.

Mahmoud M El-Mas, Mohamed A Fouda, Sahar M El-Gowilly, Evan I Saad,

We have previously shown that acute exposure of male rats to nicotine preferentially attenuates baroreceptor-mediated control of reflex tachycardia in contrast to no effect on reflex bradycardia. Here, we investigated whether female rats are as sensitive as their male counterparts to the baroreflex depressant effect of nicotine and whether this ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2012, 258(3):410-417]

Cited: 5 times

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PPARγ dependence of cyclosporine-isoprenaline renovascular interaction: roles of nitric oxide synthase and heme oxygenase.

Hanan M El-Gowelli, Khaled S Abd-Elrahman, Evan I Saad, Sahar M El-Gowilly, Abdel-Galil A Abdel-Galil, Mahmoud M El-Mas,

We previously showed that cyclosporine (CSA) impairs renal vasodilations caused by β-adrenoceptor activation. This study investigated whether the peroxisome proliferator-activated receptor gamma (PPARγ) and related nitric oxide synthase (NOS)/heme oxygenase (HO) signaling mediates the CSA-β-adrenoceptor interaction. The vasodilatory response elicited by a bolus injection of isoprenaline (1 μmole) in phenylephrine-preconstricted ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2011, 58(2):173-180]

Cited: 6 times

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Role of adenosine A2A receptor signaling in the nicotine-evoked attenuation of reflex cardiac sympathetic control.

Mahmoud M El-Mas, Sahar M El-Gowilly, Mohamed A Fouda, Evan I Saad,

Baroreflex dysfunction contributes to increased cardiovascular risk in cigarette smokers. Given the importance of adenosinergic pathways in baroreflex control, the hypothesis was tested that defective central adenosinergic modulation of cardiac autonomic activity mediates the nicotine-baroreflex interaction. Baroreflex curves relating changes in heart rate (HR) to increases or decreases in blood ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2011, 254(3):229-237]

Cited: 9 times

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Role of PPAR gamma/nitric oxide synthase signaling in the cyclosporine-induced attenuation of endothelium-dependent renovascular vasodilation.

Khaled S Abd-Elrahman, Hanan M El-Gowelli, Evan I Saad, Abdel-Galil A Abdel-Galil, Mahmoud M El-Mas,

Evidence from our laboratory and others suggests a negative effect for cyclosporine A (CSA) on renovascular reactivity. This study investigated the role of peroxisome proliferator-activated receptor gamma (PPAR gamma)/nitric oxide synthase (NOS) signaling in the CSA-induced attenuation of endothelium-dependent vasodilations in phenylephrine-preconstricted perfused kidneys of rats. Bolus injection of carbachol ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2010, 56(2):195-202]

Cited: 3 times

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Pioglitazone abrogates cyclosporine-evoked hypertension via rectifying abnormalities in vascular endothelial function.

Mahmoud M El-Mas, Hanan M El-Gowelli, Khaled S Abd-Elrahman, Evan I Saad, Abdel-Galil A Abdel-Galil, Abdel A Abdel-Rahman,

In addition to insulin sensitization, the thiazolidenedione drug pioglitazone exhibits favorable circulatory effects. Here, we hypothesized that pioglitazone protects against the hypertension and related vascular derangements caused by the immunosuppressant drug cyclosporine (CSA). Compared with vehicle (olive oil)-treated rats, chronic treatment with CSA (20mg/kg/day s.c., for 14 days) increased blood ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2011, 81(4):526-533]

Cited: 22 times

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Role of oxidative stress and nitric oxide in the protective effects of alpha-lipoic acid and aminoguanidine against isoniazid-rifampicin-induced hepatotoxicity in rats.

Evan I Saad, Sahar M El-Gowilly, Mabrouka O Sherhaa, Azza E Bistawroos,

Despite the great efficacy of isoniazid (INH) and rifampicin (RIF) combination, in the treatment of tuberculosis, hepatotoxicity is the most common serious complication. The potential protective effect of alpha-lipoic acid and aminoguanidine; against combination-induced hepatotoxicity was investigated in the present study. Administration of INH-RIF combination (50 mg/kg each for 14 ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2010, 48(7):1869-1875]

Cited: 17 times

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