Full Text Journal Articles by
Author Etsuko Miyagi

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Effect of interventions in pregnant women with mildly impaired glucose tolerance.

Ryosuke Shindo, Shigeru Aoki, Junko Kasai, Sayuri Nakanishi, Yusuke Saigusa, Etsuko Miyagi,

<h4>Aim</h4>In 2010, the Japan Society of Obstetrics and Gynecology (JSOG) changed the diagnostic criteria for gestational diabetes mellitus (GDM) to follow the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria. As a result, many pregnant women with mildly impaired glucose tolerance (IGT) were newly diagnosed with GDM. This ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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Reply to the "Letter to the Editor: measurement of fetal parasympathetic activity during labor: a new pathway for evaluation of fetal well-being?"

Christopher A Lear, Jenny A Westgate, Michi Kasai, Michael J Beacom, Yoshiki Maeda, Shoichi Magawa, Etsuko Miyagi, Tomoaki Ikeda, Laura Bennet, Alistair J Gunn,

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2021, 320(4):R469-R470]

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Psychological stress associated with the COVID-19 pandemic in postpartum women in Yokohama, Japan.

Kazuya Hiiragi, Soichiro Obata, Toshihiro Misumi, Etsuko Miyagi, Shigeru Aoki,

<h4>Aim</h4>This study aimed to clarify how the COVID-19 pandemic impacts psychological stress levels in postpartum women in Yokohama, Japan.<h4>Methods</h4>We retrospectively compared the rates of positive screening tests for postpartum depression (Edinburgh Postnatal Depression Scale score of 9 or more or self-injury factors) and liaison/psychiatric intervention rates between pre-pandemic and pandemic ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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Impact of gestational diabetes mellitus diagnosed during the third trimester on pregnancy outcomes: a case-control study.

Ryosuke Shindo, Shigeru Aoki, Sayuri Nakanishi, Toshihiro Misumi, Etsuko Miyagi,

<h4>Background</h4>In 2010, the International Association of Diabetes and Pregnancy Study Group (IADPSG) proposed new criteria indicating that gestational diabetes mellitus (GDM) can be diagnosed if the fasting threshold of ≤92 mg/dL, 1-h threshold of ≤180 mg/dL, or 2-h threshold of ≤153 mg/dL are exceeded during the 75-g 2-h oral glucose tolerance test (OGTT) ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):246]

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Evaluating the safety of dienogest in women with adenomyosis: A retrospective analysis.

Natsumi Ono, Ryoko Asano, Koichi Nagai, Yoshinobu Sugo, Tomomi Nakamura, Etsuko Miyagi,

<h4>Aim</h4>Dienogest (DNG) is highly effective for relieving pain caused by endometriosis and adenomyosis. However, women with severe uterine swelling due to adenomyosis who take DNG usually experience metrorrhagia. This study aimed to examine the safety of DNG usage in women with adenomyosis.<h4>Methods</h4>This study included 20 women who were prescribed DNG ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, 47(4):1433-1440]

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Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women.

Manako Yamaguchi, Masayuki Sekine, Sharon J B Hanley, Risa Kudo, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Takayuki Enomoto,

In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-grade cervical disease in a Japanese population. This study investigates sexual behavior and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2898]

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Long-read whole-genome sequencing identified a partial MBD5 deletion in an exome-negative patient with neurodevelopmental disorder.

Sachiko Ohori, Rie S Tsuburaya, Masako Kinoshita, Etsuko Miyagi, Takeshi Mizuguchi, Satomi Mitsuhashi, Martin C Frith, Naomichi Matsumoto,

Whole-exome sequencing (WES) can detect not only single-nucleotide variants in causal genes, but also pathogenic copy-number variations using several methods. However, there may be overlooked pathogenic variations in the out of target genome regions of WES analysis (e.g., promoters), leaving many patients undiagnosed. Whole-genome sequencing (WGS) can potentially analyze such ... Read more >>

J Hum Genet (Journal of human genetics)
[2021, :]

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The first-round results of a population-based cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate.

Kanako Kono, Tohru Morisada, Kumiko Saika, Eiko Saitoh Aoki, Etsuko Miyagi, Kiyoshi Ito, Hirokazu Takahashi, Tomio Nakayama, Hiroshi Saito, Daisuke Aoki,

<h4>Objective</h4>In 2013, a cohort study aimed to clarify the positive and negative effects of introducing the human papillomavirus (HPV) testing for population-based cervical cancer screening has been launched in Japan. This study included four screenings during the subsequent 7-year follow-up period. We aim to describe the results of the first ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e29]

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Internet Survey of Awareness and Behavior Related to HPV Vaccination in Japan.

Risa Kudo, Masayuki Sekine, Manako Yamaguchi, Megumi Hara, Sharon J B Hanley, Yutaka Ueda, Asami Yagi, Sosuke Adachi, Megumi Kurosawa, Etsuko Miyagi, Takayuki Enomoto,

Recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears in Japan. We aimed to clarify the differences between vaccinated and unvaccinated females in their awareness, knowledge, and behaviors toward cervical cancer, HPV vaccination and sex. Questionnaires were administered online to women aged 16 to 20. We ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(2):]

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Tissue factor pathway inhibitor‑2 is specifically expressed in ovarian clear cell carcinoma tissues in the nucleus, cytoplasm and extracellular matrix.

Yukihide Ota, Shiro Koizume, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Tomoko Takahashi, Shinya Sato, Shohei Myoba, Norihisa Ohtake, Hisamori Kato, Tomoyuki Yokose, Etsuko Miyagi, Yohei Miyagi,

Tissue factor pathway inhibitor‑2 (TFPI‑2) is a promising candidate as a serum biomarker of ovarian clear cell carcinoma (OCCC), a lethal histological subtype of epithelial ovarian cancer (EOC). TFPI‑2 is a secreted serine protease inhibitor that suppresses cancer progression through the inhibition of matrix protease activities. Previous studies have also ... Read more >>

Oncol Rep (Oncology reports)
[2021, 45(3):1023-1032]

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Increased anxiety and depression in patients with gynecologic cancers during the COVID-19 pandemic: A retrospective study from Japan.

Tae Mogami, Emi Onuma, Mihoko Aoki, Natsuko Kamiya, Akiko Sukegawa, Etsuko Miyagi, Hideya Sakakibara,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 152(3):457-458]

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Factors predicting rubella vaccination among pregnant women in Japan: An interim report from the Pregnant Women Health Initiative.

Akiko Iwata, Kentaro Kurasawa, Kazumi Kubota, Yoshinobu Sugo, Mizuha Odagami, Shigeru Aoki, Mika Okuda, Takeharu Yamanaka, Etsuko Miyagi,

Following the 2018 rubella outbreak in Japan, this study aimed to assess rubella prevention measures based on the vaccination and immunization status of pregnant women in Japan. Our cohort study involved 3 local core hospitals in Yokohama City, and a total of 666 pregnant women were recruited between June 2018 ... Read more >>

Jpn J Infect Dis (Japanese journal of infectious diseases)
[2020, :]

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Outcome of Radiation Therapy for Locally Advanced Vulvar Carcinoma: Analysis of Inguinal Lymph Node.

Yuki Mukai, Izumi Koike, Tatsuya Matsunaga, Naho Ruiz Yokota, Hisashi Kaizu, Shoko Takano, Madoka Sugiura, Eiko Ito, Etsuko Miyagi, Masaharu Hata,

BACKGROUND/AIM:The aim of this study was to define the outcome of radiation therapy for vulvar carcinoma, and to investigate the effectiveness of therapeutic and prophylactic inguinal lymph node (ILN) irradiation. Because reports about the treatment of ILN were limited. PATIENTS AND METHODS:Thirty consecutive vulvar carcinoma patients were treated using external ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2020, 34(1):307-313]

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A case of incarcerated gravid uterus with a history of cesarean section was a good candidate for manual reduction: A case report.

Sayaka Suzuki, Soichiro Obata, Mariko Utsunomiya, Etsuko Miyagi, Shigeru Aoki,

Because the anterior lower uterine segment is stretched, the incarcerated gravid uterus case with a history of cesarean section is a good candidate for manual reduction. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(1):322-325]

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Spontaneous rupture of a degenerated leiomyoma causing peritonitis and ileus during pregnancy: A case report.

Mizuha Odagami, Mutsuko Makino, Etsuko Miyagi, Shigeru Aoki,

Degenerated leiomyomas can rupture during pregnancy, and leakage of the fluid causes peritonitis in rare cases. If peritonitis associated with a degenerated leiomyoma is observed, the occurrence of rupture of the leiomyoma should be considered. ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(1):491-493]

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De novo variants in CELF2 that disrupt the nuclear localization signal cause developmental and epileptic encephalopathy.

Toshiyuki Itai, Kohei Hamanaka, Kazunori Sasaki, Matias Wagner, Urania Kotzaeridou, Ines Brösse, Markus Ries, Yu Kobayashi, Jun Tohyama, Mitsuhiro Kato, Winnie P Ong, Hui B Chew, Kavitha Rethanavelu, Emmanuelle Ranza, Xavier Blanc, Yuri Uchiyama, Naomi Tsuchida, Atsushi Fujita, Yoshiteru Azuma, Eriko Koshimizu, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake, Hidehisa Takahashi, Etsuko Miyagi, Yoshinori Tsurusaki, Hiroshi Doi, Masataka Taguri, Stylianos E Antonarakis, Mitsuko Nakashima, Hirotomo Saitsu, Satoko Miyatake, Naomichi Matsumoto,

We report heterozygous CELF2 (NM_006561.3) variants in five unrelated individuals: Individuals 1-4 exhibited developmental and epileptic encephalopathy (DEE) and Individual 5 had intellectual disability and autistic features. CELF2 encodes a nucleocytoplasmic shuttling RNA-binding protein that has multiple roles in RNA processing and is involved in the embryonic development of the ... Read more >>

Hum Mutat (Human mutation)
[2021, 42(1):66-76]

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Impact of gestational diabetes mellitus diagnosed during the third trimester on pregnancy outcomes: A case control study

Ryosuke Shindo, Shigeru Aoki, Sayuri Nakanishi, Toshihiro Misumi, Etsuko Miyagi,

<h4>Background: </h4> In 2010, the International Association of Diabetes and Pregnancy Study Group (IADPSG) proposed new criteria indicating that gestational diabetes mellitus (GDM) can be diagnosed if the fasting threshold of ≤92 mg/dL, 1-hour threshold of ≤180 mg/dL, or 2-hour threshold of ≤153 mg/dL are exceeded during the 75-g 2-hour ... Read more >>

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Are the Institute of Medicine guidelines for optimal gestational weight gain in twin pregnancies applicable to Japanese women?

Mai Shimura, Soichiro Obata, Toshihiro Misumi, Etsuko Miyagi, Shigeru Aoki,

<h4>Aims</h4>To investigate whether the Institute of Medicine (IOM) guidelines for optimal gestational weight gain (GWG) in twin pregnancies are applicable to Japanese women.<h4>Methods</h4>This was a retrospective study involving women who delivered full-term twins at our tertiary center diagnosed with a normal prepregnancy body mass index. The women were divided into ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, 47(1):337-342]

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Potential for cervical cancer incidence and death resulting from Japan's current policy of prolonged suspension of its governmental recommendation of the HPV vaccine.

Asami Yagi, Yutaka Ueda, Satoshi Nakagawa, Sayaka Ikeda, Yusuke Tanaka, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura,

In 2013, recurrent reports of diverse symptoms occurring in girls after receiving HPV vaccination appeared in Japanese media. The Ministry of Health, Labor and Welfare quickly responded by announcing a temporary suspension of its recommendation for the vaccine. The HPV vaccination rate soon fell to almost zero. In the present ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15945]

Cited: 1 time

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Japanese Mothers' Intention to HPV Vaccinate Their Daughters: How Has It Changed over Time Because of the Prolonged Suspension of the Governmental Recommendation?

Asami Yagi, Yutaka Ueda, Tatsuo Masuda, Sayaka Ikeda, Takashi Miyatake, Satoshi Nakagawa, Kei Hirai, Tomio Nakayama, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura,

The trend for cervical cancer in younger women has been increasing recently in Japan. However, as a result of the suspension of governmental recommendation, Japan's HPV (human papillomavirus) vaccination rate for girls born since 2000 has dropped sharply. We conducted an internet survey in December of 2019, 76 months after ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(3):]

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Parasympathetic activity is the key regulator of heart rate variability between decelerations during brief repeated umbilical cord occlusions in fetal sheep.

Christopher A Lear, Jenny A Westgate, Michi Kasai, Michael J Beacom, Yoshiki Maeda, Shoichi Magawa, Etsuko Miyagi, Tomoaki Ikeda, Laura Bennet, Alistair J Gunn,

Fetal heart rate variability (FHRV) is a widely used index of intrapartum well being. Both arms of the autonomic system regulate FHRV under normoxic conditions in the antenatal period. However, autonomic control of FHRV during labor when the fetus is exposed to repeated, brief hypoxemia during uterine contractions is poorly ... Read more >>

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2020, 319(5):R541-R550]

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Reply to the "Letter to the Editor: Mind the gap: epistemology of heart rate variability".

Christopher A Lear, Michael J Beacom, Michi Kasai, Jenny A Westgate, Robert Galinsky, Shoichi Magawa, Etsuko Miyagi, Tomoaki Ikeda, Laura Bennet, Alistair J Gunn,

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2020, 319(3):R345-R346]

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Peripheral chemoreflex control of fetal heart rate decelerations overwhelms the baroreflex during brief umbilical cord occlusions in fetal sheep.

Christopher A Lear, Michi Kasai, Lindsea C Booth, Paul P Drury, Joanne O Davidson, Yoshiki Maeda, Shoichi Magawa, Etsuko Miyagi, Tomoaki Ikeda, Jenny A Westgate, Laura Bennet, Alistair J Gunn,

<h4>Key points</h4>The majority of intrapartum decelerations are widely believed to be mediated by the baroreflex secondary to brief umbilical cord occlusions (UCOs) but this remains unproven. We examined the responses to brief-UCOs in fetal sheep and compared these to a phenylephrine-stimulated baroreflex in a separate cohort. A further cohort was ... Read more >>

J Physiol (The Journal of physiology)
[2020, 598(20):4523-4536]

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Prenatal clinical manifestations in individuals with COL4A1/2 variants.

Toshiyuki Itai, Satoko Miyatake, Masataka Taguri, Fumihito Nozaki, Masayasu Ohta, Hitoshi Osaka, Masafumi Morimoto, Tomoko Tandou, Fumikatsu Nohara, Yuichi Takami, Fumitaka Yoshioka, Shoko Shimokawa, Jiu Okuno-Yuguchi, Mitsuo Motobayashi, Yuko Takei, Tetsuhiro Fukuyama, Satoko Kumada, Yohane Miyata, Chikako Ogawa, Yuki Maki, Noriko Togashi, Teruyuki Ishikura, Makoto Kinoshita, Yusuke Mitani, Yonehiro Kanemura, Tsuyoshi Omi, Naoki Ando, Ayako Hattori, Shinji Saitoh, Yukihiro Kitai, Satori Hirai, Hiroshi Arai, Fumihiko Ishida, Hidetoshi Taniguchi, Yasuji Kitabatake, Keiichi Ozono, Shin Nabatame, Robert Smigiel, Mitsuhiro Kato, Koichi Tanda, Yoshihiko Saito, Akihiko Ishiyama, Yushi Noguchi, Mazumi Miura, Takaaki Nakano, Keiko Hirano, Ryoko Honda, Ichiro Kuki, Jun-Ichi Takanashi, Akihito Takeuchi, Tatsuya Fukasawa, Chizuru Seiwa, Atsuko Harada, Yusuke Yachi, Hiroyuki Higashiyama, Hiroshi Terashima, Tadayuki Kumagai, Satoshi Hada, Yoshiichi Abe, Etsuko Miyagi, Yuri Uchiyama, Atsushi Fujita, Eri Imagawa, Yoshiteru Azuma, Kohei Hamanaka, Eriko Koshimizu, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake, Yoshinori Tsurusaki, Hiroshi Doi, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto,

<h4>Background</h4>Variants in the type IV collagen gene (<i>COL4A1/2</i>) cause early-onset cerebrovascular diseases. Most individuals are diagnosed postnatally, and the prenatal features of individuals with <i>COL4A1/2</i> variants remain unclear.<h4>Methods</h4>We examined <i>COL4A1/2</i> in 218 individuals with suspected <i>COL4A1</i>/2-related brain defects. Among those arising from <i>COL4A1/2</i> variants, we focused on individuals showing prenatal ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, :]

Cited: 1 time

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Survey on the use of personal protective equipment and COVID-19 testing of pregnant women in Japan.

Takeshi Umazume, Etsuko Miyagi, Yasuo Haruyama, Gen Kobashi, Shigeru Saito, Satoshi Hayakawa, Kei Kawana, Satoru Ikenoue, Ichiro Morioka, Hideto Yamada,

<h4>Aim</h4>To clarify the status of personal protective equipment (PPE) and coronavirus disease 2019 (COVID-19) tests for pregnant women, we conducted an urgent survey.<h4>Methods</h4>The survey was conducted online from April 27 to May 1, 2020. Questionnaires were sent to core facilities and affiliated hospitals of the obstetrics and gynecology training program ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, 46(10):1933-1939]

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