Full Text Journal Articles by
Author Etienne Daguindau


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CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm.

Elodie Bôle-Richard, Maxime Fredon, Sabeha Biichlé, François Anna, Jean-Marie Certoux, Florian Renosi, Frédéric Tsé, Chloé Molimard, Séverine Valmary-Degano, Alizée Jenvrin, Walid Warda, Jean-René Pallandre, Francis Bonnefoy, Margaux Poussard, Marina Deschamps, Tony Petrella, Christophe Roumier, Elizabeth Macintyre, Frédéric Féger, Eolia Brissot, Mohamad Mohty, Kiave-Yune HoWangYin, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin, Yann Godet, Delphine Binda, Maïder Pagadoy, Eric Deconinck, Etienne Daguindau, Philippe Saas, Christophe Ferrand, Fanny Angelot-Delettre, Olivier Adotévi, Francine Garnache-Ottou,

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is associated with a remarkably poor prognosis and with no treatment consensus. The identification of relevant therapeutic targets is challenging. Here, we investigated the immune functions, antileukemia efficacy and safety of CD28/4-1BB CAR T cells targeting CD123 the interleukin (IL)-3 receptor alpha chain which ... Read more >>

Leukemia (Leukemia)
[2020, :]

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Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman.

Claire Cochet, Marion Simonet, Julie Cattin, Jean-Patrick Metz, Ana Berceanu, Eric Deconinck, Etienne Daguindau, Françoise Schillinger, Pierre Fenaux, Nicolas Mottet, Yohan Desbrosses,

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. In ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3686584]

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Correction of Severe Myelofibrosis, Impaired Platelet Functions and Abnormalities in a Patient with Gray Platelet Syndrome Successfully Treated by Stem Cell Transplantation.

Rémi Favier, Xavier Roussel, Sylvain Audia, Jean Claude Bordet, Emmanuel De Maistre, Pierre Hirsch, Anne Neuhart, Isabelle Bedgedjian, Vasiliki Gkalea, Marie Favier, Etienne Daguindau, Paquita Nurden, Eric Deconinck,

Gray platelet syndrome (GPS) is an inherited disorder. Patients harboring GPS have thrombocytopenia with large platelets lacking α-granules. A long-term complication is myelofibrosis with pancytopenia. Hematopoietic stem cell transplant (HSCT) could be a curative treatment. We report a male GPS patient with severe pancytopenia, splenomegaly and a secondary myelofibrosis needing ... Read more >>

Platelets (Platelets)
[2020, 31(4):536-540]

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Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.

Anne-Pauline Bellanger, Ana Berceanu, Emeline Scherer, Yohan Desbrosses, Etienne Daguindau, Steffi Rocchi, Laurence Millon,

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2019, 25(9):1778-1779]

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Allogeneic Stem Cell Transplantation in Therapy-Related Myelodysplasia after Autologous Transplantation for Lymphoma: A Retrospective Study of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.

Daniel Jaimes-Albornoz, Lionel Mannone, Stéphanie Nguyen-Quoc, Yves Chalandon, Patrice Chevallier, Mohamad Mohty, Mathieu Meunier, Marie Robin, Marie-Pierre Ledoux, Gaëlle Guillerm, Jacques-Olivier Bay, Xavier Poiré, Natacha Maillard, Mathieu Leclerc, Etienne Daguindau, Yves Beguin, Marie Thérèse Rubio, Emmanuel Gyan,

Therapy-related myelodysplastic syndrome (t-MDS) after autologous stem cell transplantation (ASCT) is a rare complication with no curative option. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be considered for eligible patients and has been understudied in t-MDS. We report 47 consecutive patients with t-MDS after an ASCT who underwent allo-HSCT with ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2019, 25(12):2366-2374]

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Altered thymic CD4+ T-cell recovery after allogeneic hematopoietic stem cell transplantation is critical for nocardiosis.

Xavier Roussel, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Philippe Saas, Christophe Ferrand, Estelle Seilles, Fabienne Pouthier, Eric Deconinck, Fabrice Larosa,

PURPOSE OF THE STUDY:Nocardia affects immunocompromised human host exhibiting an altered cell-mediated immunity. Infectious risk after allogeneic hematopoietic cell transplantation (AHCT) is significantly correlated to the recovery status of donor-derived immune system, especially CD4+ T-cells reconstitution and thymopoiesis. The purpose of this paper is to highlight a lack of cell-mediated ... Read more >>

Curr Res Transl Med (Current research in translational medicine)
[2019, 67(4):135-143]

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[Donor Lymphocyte Infusions (DLI): Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

John De Vos, Etienne Baudoux, Jacques-Olivier Bay, Boris Calmels, Audrey Cras, Jean El Cheikh, Marie-Agnès Guerout-Verite, Marie-Noëlle Lacassagne, Sylvain Lamure, Catherine Letellier, Anne-Lise Menard, Etienne Daguindau, Xavier Poiré, Ibrahim Yakoub-Agha, Thierry Guillaume,

Donor lymphocyte infusion (DLI) can be proposed to treat or prevent the relapse of malignant hemopathies following allogeneic stem cell transplantation. The efficiency has been mainly reported in the treatment of CML and low-grade lymphomas while the anti-tumoral activity is less in forms of acute leukemia and myelodysplastic syndromes. The ... Read more >>

Bull Cancer (Bulletin du cancer)
[2019, 106(1S):S35-S39]

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CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells.

Walid Warda, Fabrice Larosa, Mathieu Neto Da Rocha, Rim Trad, Eric Deconinck, Ziad Fajloun, Cyril Faure, Denis Caillot, Marius Moldovan, Severine Valmary-Degano, Sabeha Biichle, Etienne Daguindau, Francine Garnache-Ottou, Sebastien Tabruyn, Olivier Adotevi, Marina Deschamps, Christophe Ferrand,

Chronic myeloid leukemia (CML) is a chronic disease resulting in myeloid cell expansion through expression of the BCR-ABL1 fusion transcript. Tyrosine kinase inhibitors (TKI) have significantly increased survival of patients with CML, and deep responders may consider stopping the treatment. However, more than 50% of patients relapse and restart TKI, ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(3):663-675]

Cited: 6 times

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Biologie, concepts et principes des CAR-T cells.

Marie-Thérèse Rubio, Jeanne Galaine, Christophe Borg, Étienne Daguindau,

CAR-T CELLS:BIOLOGY, CONCEPTS AND PRINCIPLES: The development of new anti-tumor immunotherapy approaches has recently dramatically increased. Progresses made in molecular biology and the development of various genetic manipulation tools allow the "reprogrammation" of T cells in order to make them express a chimeric receptor including the variable part of an ... Read more >>

Bull Cancer (Bulletin du cancer)
[2018, 105 Suppl 2:S135-S146]

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HLA-DRB3/4/5 mismatches are associated with increased risk of acute GVHD in 10/10 matched unrelated donor hematopoietic cell transplantation.

Stéphanie Ducreux, Valérie Dubois, Kahina Amokrane, Ibrahim Yakoub-Agha, Myriam Labalette, Mauricette Michallet, Marie-Thérèse Rubio, Anne Kennel, Edouard Forcade, Xavier Lafarge, Claude-Eric Bulabois, Dominique Masson, Etienne Daguindau, Anne Devys, Virginie Moalic, Erwann Quelvennec, Abdelali Boudifa, Christophe Picard, Peter Van Endert, Muriel de Matteis, Florent Delbos, Matthieu Filloux, Béatrice Pedron, Virginie Renac, Françoise Hau, Julie Bonneau, Anne Parissiadis, Marylise Fort, Anne Dormoy, Natacha Maillard, Isabelle Jollet, Patrice Chevallier, Anne Cesbron, Jacques-Olivier Bay, Fabienne Quainon, Federico Garnier, Gérard Socié, Pascale Loiseau, Raphaël Porcher, Régis Peffault de Latour, ,

Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transplant-related morbidity ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2018, :]

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Hospital end-of-life care in haematological malignancies.

Yvan Beaussant, Etienne Daguindau, Adrien Chauchet, Philippe Rochigneux, Christophe Tournigand, Régis Aubry, Lucas Morin,

OBJECTIVE:To investigate patterns of care during the last months of life of hospitalised patients who died from different haematological malignancies. METHODS:Nationwide register-based study, including all hospitalised adults ≥20 years who died from haematological malignancies in France in 2010-2013. Outcomes included use of invasive cancer treatments and referral to palliative care. ... Read more >>

BMJ Support Palliat Care (BMJ supportive & palliative care)
[2018, 8(3):314-324]

Cited: 5 times

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[Preventative and therapeutic relapse strategies after allogeneic hematopoietic stem cell transplantation: Guidelines from the Francophone society of bone marrow transplantation and cellular therapy (SFGM-TC)].

Nabil Yafour, Florence Beckerich, Claude Eric Bulabois, Patrice Chevallier, Étienne Daguindau, Cécile Dumesnil, Thierry Guillaume, Anne Huynh, Stavroula Masouridi Levrat, Anne-Lise Menard, Mauricette Michallet, Cécile Pautas, Xavier Poiré, Aurelie Ravinet, Ibrahim Yakoub-Agha, Ali Bazarbachi,

Disease relapse remains the first cause of mortality of hematological malignancies after allogeneic hematopoietic stem cell transplantation (allo-HCT). The risk of recurrence is elevated in patients with high-risk cytogenetic or molecular abnormalities, as well as when allo-HCT is performed in patients with refractory disease or with persistent molecular or radiological ... Read more >>

Bull Cancer (Bulletin du cancer)
[2017, 104(12S):S84-S98]

Cited: 0 times

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Is It Time to Reconsider the Lipopolysaccharide Paradigm in Acute Graft-Versus-Host Disease?

Etienne Daguindau, Thomas Gautier, Cécile Chagué, Jean-Paul Pais de Barros, Valérie Deckert, Laurent Lagrost, Philippe Saas,

Front Immunol (Frontiers in immunology)
[2017, 8:952]

Cited: 1 time

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Metabolic Complications Precede Alloreactivity and Are Characterized by Changes in Suppression of Tumorigenicity 2 Signaling.

Romany A N Johnpulle, Sophie Paczesny, Dae Kwang Jung, Etienne Daguindau, Madan H Jagasia, Bipin N Savani, Wichai Chinratanalab, Robert F Cornell, Stacey Goodman, John P Greer, Adetola A Kassim, Salyka Sengsayadeth, Michael T Byrne, Brian G Engelhardt,

New-onset post-transplantation diabetes mellitus (PTDM) occurs commonly after allogeneic hematopoietic cell transplantation (HCT) and is associated with inferior survival. We hypothesize that PTDM and nonrelapse mortality (NRM) are related to IL-33/suppression of tumorigenicity 2 (ST2) signaling and that soluble ST2 (sST2) levels will predict PTDM diagnosis. sST2 was measured at ... Read more >>

Biol. Blood Marrow Transplant. (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2017, 23(3):529-532]

Cited: 7 times

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Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide.

Christopher G Kanakry, Giorgos Bakoyannis, Susan M Perkins, Shannon R McCurdy, Ante Vulic, Edus H Warren, Etienne Daguindau, Taylor Olmsted, Christen Mumaw, Andrea M H Towlerton, Kenneth R Cooke, Paul V O'Donnell, Heather J Symons, Sophie Paczesny, Leo Luznik,

Recent studies have suggested that plasma-derived proteins may be potential biomarkers relevant for graft-versus-host disease and/or non-relapse mortality occurring after allogeneic blood or marrow transplantation. However, none of these putative biomarkers have been assessed in patients treated either with human leukocyte antigen-haploidentical blood or marrow transplantation or with post-transplantation cyclophosphamide, ... Read more >>

Haematologica (Haematologica)
[2017, 102(5):932-940]

Cited: 12 times

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Clofarabine versus fludarabine-based reduced-intensity conditioning regimen prior to allogeneic transplantation in adults with AML/MDS.

Patrice Chevallier, Myriam Labopin, Regis Peffault de La Tour, Bruno Lioure, Claude-Eric Bulabois, Anne Huynh, Didier Blaise, Pascal Turlure, Etienne Daguindau, Natacha Maillard, Ibrahim Yakoub-Agha, Gaelle Guillerm, Jeremy Delage, Nathalie Contentin, Jacques-Olivier Bay, Florence Beckerich, Jean-Henri Bourhis, Marie Detrait, Stéphane Vigouroux, Sylvie François, Faezeh Legrand, Thierry Guillaume, Mohamad Mohty, ,

We have retrospectively compared survivals between acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) patients who received either a clofarabine/busulfan (CloB2A2) or a fludarabine/busulfan (FB2A2) RIC regimen for allogeneic stem cell transplantation. Between 2009 and 2014, 355 allotransplanted cases were identified from the SFGM-TC registry as having received either the FB2A2 (n = 316, ... Read more >>

Cancer Med (Cancer medicine)
[2016, 5(11):3068-3076]

Cited: 4 times

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Consolidation anti-CD22 fractionated radioimmunotherapy with 90Y-epratuzumab tetraxetan following R-CHOP in elderly patients with diffuse large B-cell lymphoma: a prospective, single group, phase 2 trial.

Françoise Kraeber-Bodere, Amandine Pallardy, Hervé Maisonneuve, Loïc Campion, Anne Moreau, Isabelle Soubeyran, Steven Le Gouill, Olivier Tournilhac, Etienne Daguindau, Henry Jardel, Nadine Morineau, Krimo Bouabdallah, Emmanuel Gyan, Marie-Pierre Moles, Remy Gressin, Christian Berthou, Sophie Sadot, Philippe Moreau, Bénédicte Deau, Caroline Bodet-Milin, Anne-Laure Cazeau, Etienne Garin, Pierre-Yves Salaun, Jean-Philippe Vuillez, Valérie Gouilleux-Gruart, Jacques Barbet, William A Wegener, David M Goldenberg, Thierry Lamy, Pierre Soubeyran,

Radioimmunotherapy represents a potential option as consolidation after chemoimmunotherapy in patients with diffuse large B-cell lymphoma who are not candidates for transplantation. We aimed to assess activity and toxicity of fractionated radioimmunotherapy using anti-CD22 90Y-epratuzumab tetraxetan as consolidation after front-line induction chemoimmunotherapy in untreated elderly patients with diffuse large B-cell ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2017, 4(1):e35-e45]

Cited: 4 times

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Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation.

Jan Styczynski, Gloria Tridello, Lidia Gil, Per Ljungman, Jennifer Hoek, Simona Iacobelli, Katherine N Ward, Catherine Cordonnier, Hermann Einsele, Gerard Socie, Noel Milpied, Hendrik Veelken, Patrice Chevallier, Ibrahim Yakoub-Agha, Johan Maertens, Didier Blaise, Jan Cornelissen, Mauricette Michallet, Etienne Daguindau, Eefke Petersen, Jakob Passweg, Hildegard Greinix, Rafael F Duarte, Nicolaus Kröger, Peter Dreger, Mohamad Mohty, Arnon Nagler, Simone Cesaro,

We investigated the effect of Epstein-Barr virus (EBV) serostatus on the overall outcome of allogeneic hematopoietic stem-cell transplantation (allo-HSCT).The study included 11,364 patients who underwent allogeneic peripheral-blood or bone marrow transplantation for acute leukemia between 1997 and 2012. We analyzed the impact of donor and recipient EBV serologic status on ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2016, 34(19):2212-2220]

Cited: 10 times

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Concise Review: Apoptotic Cell-Based Therapies-Rationale, Preclinical Results and Future Clinical Developments.

Philippe Saas, Etienne Daguindau, Sylvain Perruche,

The objectives of this review are to summarize the experimental data obtained using apoptotic cell-based therapies, and then to discuss future clinical developments. Indeed, apoptotic cells exhibit immunomodulatory properties that are reviewed here by focusing on more recent mechanisms. These immunomodulatory mechanisms are in particular linked to the clearance of ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2016, 34(6):1464-1473]

Cited: 16 times

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Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation.

Brian G Engelhardt, Sophie Paczesny, Dae Kwang Jung, Etienne Daguindau, Madan Jagasia, Bipin N Savani, Wichai Chinratanalab, Robert F Cornell, Stacey Goodman, John P Greer, Adetola A Kassim, Salyka Sengsayadeth, Sandra M Yoder, Michael T Rock, James E Crowe,

Haematologica (Haematologica)
[2016, 101(5):e204-8]

Cited: 0 times

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Proteomic Characterization Reveals That MMP-3 Correlates With Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Cell and Lung Transplantation.

X Liu, Z Yue, J Yu, E Daguindau, K Kushekhar, Q Zhang, Y Ogata, P R Gafken, Y Inamoto, A Gracon, D S Wilkes, J A Hansen, S J Lee, J Y Chen, S Paczesny,

Improved diagnostic methods are needed for bronchiolitis obliterans syndrome (BOS), a serious complication after allogeneic hematopoietic cell transplantation (HCT) and lung transplantation. For protein candidate discovery, we compared plasma pools from HCT transplantation recipients with BOS at onset (n = 12), pulmonary infection (n = 16), chronic graft-versus-host disease without ... Read more >>

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2016, 16(8):2342-2351]

Cited: 10 times

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Does bendamustine impact the mobilization of peripheral blood stem cells? A multicenter retrospective study of 23 cases.

Anne-Claire Gac, Nabih Azar, Etienne Daguindau, Guillaume Cartron, Luc M Fornecker, Emmanuel Gyan, Florence Broussais-Guillaumot, Reda Garidi, Bachra Choufi, Sylvain P Chantepie, Marie-Christine Béné, Romain Guiéze, Fontanet Bijou, Remy Gressin, Sandy Amorim, Gandhi Damaj,

Bendamustine is used in the treatment of different relapsing or refractory subtypes of lymphoma. Its impact on the yield of peripheral blood stem cells is not well known. Twenty three patients who received bendamustine followed immediately or after another chemotherapy by stem cell mobilization (SCM) were included. The patients were ... Read more >>

Leuk. Lymphoma (Leukemia & lymphoma)
[2016, 57(5):1149-1153]

Cited: 3 times

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Cerebral venous thrombosis in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma during induction chemotherapy with l-asparaginase: The GRAALL experience.

Marie-Anne Couturier, Françoise Huguet, Patrice Chevallier, Felipe Suarez, Xavier Thomas, Martine Escoffre-Barbe, Victoria Cacheux, Jean-Michel Pignon, Caroline Bonmati, Laurence Sanhes, Pierre Bories, Etienne Daguindau, Véronique Dorvaux, Oumedaly Reman, Jamile Frayfer, Corentin Orvain, Véronique Lhéritier, Norbert Ifrah, Hervé Dombret, Mathilde Hunault-Berger, Aline Tanguy-Schmidt,

Central nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP). Data on risk factors and clinical evolution is still lacking in adult patients. We report on the clinical evolution of 22 CNS venous thrombosis cases occurring in ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2015, 90(11):986-991]

Cited: 8 times

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Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation.

Christoph Schmid, Myriam Labopin, Gerard Socié, Etienne Daguindau, Liisa Volin, Anne Huynh, Jean Henri Bourhis, Noel Milpied, Jan Cornelissen, Patrice Chevallier, Johan Maertens, Pavel Jindra, Didier Blaise, Stig Lenhoff, Norbert Ifrah, Frédéric Baron, Fabio Ciceri, Claude Gorin, Bipin Savani, Sebastian Giebel, Emmanuelle Polge, Jordi Esteve, Arnon Nagler, Mohamad Mohty, ,

To analyze the influence of distinct combinations of molecular aberrations on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for cytogenetically normal acute myeloid leukemia (CN-AML), a retrospective registry analysis was performed on 702 adults undergoing HSCT in first complete remission (CR). Patients were grouped according to presence or absence ... Read more >>

Blood (Blood)
[2015, 126(17):2062-2069]

Cited: 43 times

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Allogeneic hematopoietic cell transplantation in acute myeloid leukemia with normal karyotype and isolated Nucleophosmin-1 (NPM1) mutation: outcome strongly correlates with disease status.

Ali Bazarbachi, Myriam Labopin, Mohamed A Kharfan-Dabaja, Rainer Schwerdtfeger, Liisa Volin, Jean Henri Bourhis, Gérard Socié, Etienne Daguindau, Tobias Gedde-Dahl, Alessandro Rambaldi, Michal Karas, Günter Schlimok, Didier Blaise, Patrice Chevallier, Florent Malard, Christoph Schmid, Jordi Esteve, Arnon Nagler, Mohamad Mohty,

Haematologica (Haematologica)
[2016, 101(1):e34-7]

Cited: 4 times

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