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Author Esben Laugesen

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Esben Laugesen, Per L Poulsen,

J Hypertens (Journal of hypertension)
[2021, 39(5):1047-1048]

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Invasive aortic pulse pressure is not superior to cuff pulse pressure in cardiovascular risk prediction.

Esben Laugesen, Søren T Knudsen, Klavs W Hansen, Niklas B Rossen, Lisette Okkels Jensen, Michael S Hansen, Lone K Andersen, Kristian K Thomsen, Hanne Søndergaard, Morten Böttcher, Bent Raungaard, Kevin K W Olesen, Michael Mæng, Hans Erik Bøtker, Per L Poulsen,

<h4>Objective</h4>Aortic pulse pressure (PP) represents the hemodynamic cardiac and cerebral burden more directly than cuff PP. The objective of this study was to investigate whether invasively measured aortic PP confers additional prognostic value beyond cuff PP for cardiovascular events and death. With increasing age, cuff PP progressively underestimates aortic PP. ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(4):607-613]

Cited: 0 times

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Changes in vascular function during breast cancer treatment.

Stine Overvad Fredslund, Niels Henrik Buus, Cecilie Skjold, Esben Laugesen, Anders Bonde Jensen, Britt Elmedal Laursen,

<h4>Background</h4>Breast cancer (BC) survivors are at increased risk of cardiovascular disease. We evaluated whether chemotherapy induces early or late vascular dysfunction in vivo.<h4>Methods</h4>Early-stage BC patients (n=33) underwent measurements of forearm blood flow (FBF), 24-hour blood pressure, aortic pulse wave velocity (PWV) and inflammatory markers before (T0), 14 days after (T1) ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, :]

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Identifying Isolated Systolic Hypertension From Upper-Arm Cuff Blood Pressure Compared With Invasive Measurements.

Dean S Picone, Martin G Schultz, Matthew K Armstrong, J Andrew Black, Willem Jan W Bos, Chen-Huan Chen, Hao-Min Cheng, Antoine Cremer, Nathan Dwyer, Alun D Hughes, Hack-Lyoung Kim, Peter S Lacy, Esben Laugesen, Fuyou Liang, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Telmo Pereira, Giacomo Pucci, Roland E Schmieder, Manish D Sinha, George A Stouffer, Kenji Takazawa, Philip Roberts-Thomson, Ji-Guang Wang, Thomas Weber, Berend E Westerhof, Bryan Williams, James E Sharman, ,

Isolated systolic hypertension (ISH) is the most common form of hypertension and is highly prevalent in older people. We recently showed differences between upper-arm cuff and invasive blood pressure (BP) become greater with increasing age, which could influence correct identification of ISH. This study sought to determine the difference between ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, 77(2):632-639]

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Effect of 12-week continuous positive airway pressure therapy on glucose levels assessed by continuous glucose monitoring in people with type 2 diabetes and obstructive sleep apnoea; a randomized controlled trial.

Anne Margareta Banghøj, Christoffer Krogager, Peter Lommer Kristensen, Klavs Würgler Hansen, Esben Laugesen, Jesper Fleischer, Simon Lebech Cichosz, Per Løgstrup Poulsen, Martin Glymer Kirkegaard, Birger Thorsteinsson, Lise Tarnow,

<h4>Aim</h4>Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes (T2D). The aim was to investigate the effect of a 12-week treatment with continuous positive airway pressure (CPAP) on glycaemic control assessed by continuous glucose monitoring (CGM), HbA1c and fasting blood glucose in patients with T2D and newly detected OSA.<h4>Methods</h4>In ... Read more >>

Endocrinol Diabetes Metab (Endocrinology, diabetes & metabolism)
[2021, 4(2):e00148]

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Effect of 12 weeks continuous positive airway pressure on day and night arterial stiffness and blood pressure in patients with type 2 diabetes and obstructive sleep apnea: A randomized controlled trial.

Christoffer Krogager, Anne Margareta Banghøj, Per L Poulsen, Martin G Kirkegaard, Birger Thorsteinsson, Lise Tarnow, Klavs W Hansen, Esben Laugesen,

The objective of this study was to evaluate the effect of continuous positive airway pressure treatment on pulse wave velocity and blood pressure in patients with type 2 diabetes and obstructive sleep apnea. A randomized controlled study was performed, including 72 patients with type 2 diabetes and newly diagnosed obstructive ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, 29(4):e12978]

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Influence of Age on Upper Arm Cuff Blood Pressure Measurement.

Dean S Picone, Martin G Schultz, Petr Otahal, J Andrew Black, Willem J Bos, Chen-Huan Chen, Hao-Min Cheng, Antoine Cremer, Nathan Dwyer, Ricardo Fonseca, Alun D Hughes, Hack-Lyoung Kim, Peter S Lacy, Esben Laugesen, Nobuyuki Ohte, Stefano Omboni, Christian Ott, Telmo Pereira, Giacomo Pucci, Philip Roberts-Thomson, Niklas B Rossen, Roland E Schmieder, Daisuke Sueta, Kenji Takazawa, Jiguang Wang, Thomas Weber, Berend E Westerhof, Bryan Williams, Hirotsugu Yamada, Eiichiro Yamamoto, James E Sharman, ,

Blood pressure (BP) is a leading global risk factor. Increasing age is related to changes in cardiovascular physiology that could influence cuff BP measurement, but this has never been examined systematically and was the aim of this study. Cuff BP was compared with invasive aortic BP across decades of age ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 75(3):844-850]

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Aortic Calcification Affects Noninvasive Estimates of Central Blood Pressure in Patients with Severe Chronic Kidney Disease.

Rasmus Kirkeskov Carlsen, Simon Winther, Christian D Peters, Esben Laugesen, Dinah S Khatir, Hans E Bøtker, Morten Bøttcher, Per Ivarsen, My Svensson, Niels Henrik Buus,

<h4>Background</h4>Central blood pressure (BP) assessed noninvasively considerably underestimates true invasively measured aortic BP in chronic kidney disease (CKD) patients. The difference between the estimated and the true aortic BP increases with decreasing estimated glomerular filtration rates (eGFR). The present study investigated whether aortic calcification affects noninvasive estimates of central BP.<h4>Methods</h4>Twenty-four ... Read more >>

Kidney Blood Press Res (Kidney & blood pressure research)
[2019, 44(4):704-714]

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Retinal vessel reactivity is not attenuated in patients with type 2 diabetes compared with matched controls and is associated with peripheral endothelial function in controls.

Jonathan Mathias Baier, Kristian Løkke Funck, Line Petersen, Liv Vernstrøm, Søren T Knudsen, Toke Bek, Per Løgstrup Poulsen, Esben Laugesen,

BACKGROUND AND AIMS:Attenuated retinal vasoreactivity in patients with type 2 diabetes preceding diabetic retinopathy development has been proposed to reflect local endothelial dysfunction. Whether retinal vessel reactivity is associated with peripheral endothelial dysfunction and large artery stiffness in patients with type 2 diabetes remains to be elucidated. METHODS:Twenty patients with ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2019, 33(9):641-647]

Cited: 1 time

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Volumes of coronary plaque disease in relation to body mass index, waist circumference, truncal fat mass and epicardial adipose tissue in patients with type 2 diabetes mellitus and controls.

Søren Gullaksen, Kristian Løkke Funck, Esben Laugesen, Troels Krarup Hansen, Damini Dey, Per Løgstrup Poulsen,

OBJECTIVES:Coronary atherosclerosis in patients with type 2 diabetes mellitus may be promoted by regional fat distribution. We investigated the association between anthropometric measures of obesity, truncal fat mass, epicardial adipose tissue and coronary atherosclerosis in asymptomatic patients and matched controls. METHODS:We examined 44 patients and 59 controls [mean (standard deviation) ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2019, 16(4):328-336]

Cited: 2 times

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Impaired aortic distensibility and elevated central blood pressure in Turner Syndrome: a cardiovascular magnetic resonance study.

Jan Wen, Christian Trolle, Mette H Viuff, Steffen Ringgaard, Esben Laugesen, Ephraim J Gutmark, Dhananjay Radhakrishnan Subramaniam, Philippe Backeljauw, Iris Gutmark-Little, Niels H Andersen, Kristian H Mortensen, Claus H Gravholt,

<h4>Background</h4>Women with Turner Syndrome have an increased risk for aortic dissection. Arterial stiffening is a risk factor for aortic dilatation and dissection. Here we investigate if arterial stiffening can be observed in Turner Syndrome patients and is an initial step in the development of aortic dilatation and subsequent dissection.<h4>Methods</h4>Fifty-seven women ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2018, 20(1):80]

Cited: 3 times

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Antiplatelet effect of aspirin during 24h in patients with type 2 diabetes without cardiovascular disease.

Liv Vernstrøm, Kristian Løkke Funck, Erik Lerkevang Grove, Esben Laugesen, Jonathan Mathias Baier, Anne-Mette Hvas, Per Løgstrup Poulsen,

The antiplatelet effect of low-dose aspirin in patients with type 2 diabetes (T2DM) without cardiovascular disease (CVD) has not been thoroughly explored. We investigated if platelet aggregation increased during the standard 24-hour aspirin dosing interval in patients with T2DM compared to non-diabetic controls. Furthermore, we evaluated baseline platelet aggregation, the ... Read more >>

Thromb Res (Thrombosis research)
[2018, 161:1-6]

Cited: 4 times

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Continuous glucose monitoring adds information beyond HbA1c in well-controlled diabetes patients with early cardiovascular autonomic neuropathy.

Jesper Fleischer, Esben Laugesen, Simon Lebech Cichosz, Pernille Hoeyem, Thomas Fremming Dejgaard, Per Loegstrup Poulsen, Lise Tarnow, Troels Krarup Hansen,

<h4>Aims</h4>Hyperglycemia as evaluated by HbA1c is a risk factor for the development of cardiovascular autonomic neuropathy (CAN). The aim of the present study was to investigate whether continuous glucose monitoring (CGM) may add information beyond HbA1c in patients with type 2 diabetes and CAN.<h4>Methods</h4>81 patients with type 2 diabetes (43 ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2017, 31(9):1389-1393]

Cited: 4 times

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Accuracy of Cuff-Measured Blood Pressure: Systematic Reviews and Meta-Analyses.

Dean S Picone, Martin G Schultz, Petr Otahal, Svend Aakhus, Ahmed M Al-Jumaily, J Andrew Black, Willem J Bos, John B Chambers, Chen-Huan Chen, Hao-Min Cheng, Antoine Cremer, Justin E Davies, Nathan Dwyer, Brian A Gould, Alun D Hughes, Peter S Lacy, Esben Laugesen, Fuyou Liang, Roman Melamed, Sandy Muecke, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Xiaoqing Peng, Telmo Pereira, Giacomo Pucci, Ronak Rajani, Philip Roberts-Thomson, Niklas B Rossen, Daisuke Sueta, Manish D Sinha, Roland E Schmieder, Harold Smulyan, Velandai K Srikanth, Ralph Stewart, George A Stouffer, Kenji Takazawa, Jiguang Wang, Berend E Westerhof, Franz Weber, Thomas Weber, Bryan Williams, Hirotsugu Yamada, Eiichiro Yamamoto, James E Sharman,

<h4>Background</h4>Hypertension (HTN) is the single greatest cardiovascular risk factor worldwide. HTN management is usually guided by brachial cuff blood pressure (BP), but questions have been raised regarding accuracy.<h4>Objectives</h4>This comprehensive analysis determined the accuracy of cuff BP and the consequent effect on BP classification compared with intra-arterial BP reference standards.<h4>Methods</h4>Three individual ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2017, 70(5):572-586]

Cited: 33 times

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Increased high-risk coronary plaque burden is associated with arterial stiffness in patients with type 2 diabetes without clinical signs of coronary artery disease: a computed tomography angiography study.

Kristian L Funck, Esben Laugesen, Kristian Øvrehus, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Troels K Hansen, Per L Poulsen,

<h4>Objectives</h4>Arterial stiffness and subclinical coronary atherosclerosis may yield valuable information on cardiovascular risk. We aimed to characterize coronary atherosclerosis in asymptomatic patients with type 2 diabetes and healthy controls and to investigate the association between baseline arterial stiffness and coronary plaque volumes after 5-year follow-up.<h4>Methods</h4>Data from 45 patients and 61 ... Read more >>

J Hypertens (Journal of hypertension)
[2017, 35(6):1235-1243]

Cited: 4 times

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Evaluation of interarm blood pressure differences using the Microlife WatchBP Office in a clinical setting.

Christoffer Krogager, Esben Laugesen, Niklas B Rossen, Per L Poulsen, Mogens Erlandsen, Klavs W Hansen,

<h4>Objective</h4>The aim of this study was to evaluate the usefulness of Microlife WatchBP Office and the effect of increasing the number of measurements in the clinical evaluation of systolic interarm difference (IAD).<h4>Patients and methods</h4>Office blood pressure was measured simultaneously on both arms in 339 patients (85% diabetic) using the Microlife ... Read more >>

Blood Press Monit (Blood pressure monitoring)
[2017, 22(3):161-165]

Cited: 1 time

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The Authors Reply.

Rasmus K Carlsen, Christian D Peters, Dinah S Khatir, Esben Laugesen, Hans Erik Bøtker, Simon Winther, Niels H Buus,

Kidney Int (Kidney international)
[2017, 91(1):254]

Cited: 0 times

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The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren T Knudsen, Won Y Kim, Per L Poulsen, Troels K Hansen, Mette Bjerre, Jan Frystyk,

<h4>Objective</h4>Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2017, 176(5):521-531]

Cited: 9 times

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The cardiovascular system in familial hypocalciuric hypercalcemia: a cross-sectional study on physiological effects of inactivating variants in the calcium-sensing receptor gene.

Niels Frederik Breum Jakobsen, Esben Laugesen, Lars Rolighed, Peter H Nissen, Per Løgstrup Poulsen, Erling Bjerregaard Pedersen, Leif Mosekilde, Lars Rejnmark,

<h4>Objective</h4>Loss-of-function variants in the gene encoding the calcium-sensing receptor (CASR) result in familial hypocalciuric hypercalcemia (FHH), causing hypercalcemia with high normal or elevated parathyroid hormone levels. The CASR may also influence electrolyte and water homeostasis. It is unknown whether FHH affects cardiovascular health. We, therefore investigated whether FHH is associated ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2016, 175(4):299-309]

Cited: 5 times

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Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment: A Prospective Cohort Study.

Esben Laugesen, Søren T Knudsen, Klavs W Hansen, Niklas B Rossen, Lisette Okkels Jensen, Michael G Hansen, Henrik Munkholm, Kristian K Thomsen, Hanne Søndergaard, Morten Bøttcher, Bent Raungaard, Morten Madsen, Adam Hulman, Daniel Witte, Hans Erik Bøtker, Per L Poulsen,

Aortic systolic blood pressure (BP) represents the hemodynamic cardiac and cerebral burden more directly than office systolic BP. Whether invasively measured aortic systolic BP confers additional prognostic value beyond office BP remains debated. In this study, office systolic BP and invasively measured aortic systolic BP were recorded in 21 908 patients ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2016, 68(3):768-774]

Cited: 2 times

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Reduced Subendocardial Viability Ratio Is Associated With Unfavorable Cardiovascular Risk Profile in Women With Short Duration of Type 2 Diabetes.

Esben Laugesen, Pernille Høyem, Jesper Fleischer, Indumathi Kumarathas, Søren T Knudsen, Klavs W Hansen, Jens Sandahl Christiansen, Troels K Hansen, Per L Poulsen,

<h4>Background</h4>The pathophysiological perturbations underlying the unfavorable cardiovascular prognosis in women with type 2 diabetes (T2DM) remain elusive. Low subendocardial viability ratio (SEVR), an index of myocardial oxygen supply and demand, has been associated with intermediate cardiovascular risk markers and cardiovascular mortality in various populations. However, whether SEVR is associated with ... Read more >>

Am J Hypertens (American journal of hypertension)
[2016, 29(10):1165-1172]

Cited: 7 times

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Should There be Concern About Autoimmune Diabetes in Adults? Current Evidence and Controversies.

Jakob Appel Østergaard, Esben Laugesen, R David Leslie,

Autoimmune diabetes has a heterogeneous phenotype. Although often considered a condition starting in childhood, a substantial proportion of type 1 diabetes presents in adult life. This holds important implications for our understanding of the factors that modify the rate of progression through the disease prodrome to clinical diabetes and for ... Read more >>

Curr Diab Rep (Current diabetes reports)
[2016, 16(9):82]

Cited: 11 times

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Estimated aortic blood pressure based on radial artery tonometry underestimates directly measured aortic blood pressure in patients with advancing chronic kidney disease staging and increasing arterial stiffness.

Rasmus K Carlsen, Christian D Peters, Dinah S Khatir, Esben Laugesen, Hans Erik Bøtker, Simon Winther, Niels H Buus,

Central blood pressure (BP) can be assessed noninvasively based on radial tonometry and may potentially be a better predictor of clinical outcome than brachial BP. However, the validity of noninvasively obtained estimates has never been examined in patients with chronic kidney disease (CKD). Here we compared invasive aortic systolic BP ... Read more >>

Kidney Int (Kidney international)
[2016, 90(4):869-877]

Cited: 15 times

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Arterial Stiffness and Central Hemodynamics in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine.

Esben Laugesen, Emil Moser, Tanja Sikjaer, Per Løgstrup Poulsen, Lars Rejnmark,

<h4>Background</h4>Long-term levothyroxine (LT4) therapy targeting thyrotropin (TSH) suppression in hypothyroid patients treated for thyroid cancer has been associated with increased arterial stiffness and increased cardiovascular mortality. However, most patients with hypothyroidism receive LT4 therapy targeting TSH in the reference range. The long-term vascular effects of this strategy have never been ... Read more >>

Thyroid (Thyroid : official journal of the American Thyroid Association)
[2016, 26(6):779-784]

Cited: 2 times

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Low Physical Activity Is Associated With Increased Arterial Stiffness in Patients Recently Diagnosed With Type 2 Diabetes.

Kristian L Funck, Esben Laugesen, Pernille Høyem, Jesper Fleischer, Simon L Cichosz, Jens S Christiansen, Troels K Hansen, Per L Poulsen,

<h4>Aims</h4>Several studies have indicated that low physical activity is associated with increased risk of cardiovascular disease (CVD) and all-cause mortality among patients with diabetes. The association between physical activity and subclinical cardiovascular changes preceding clinical events remains to be elucidated. We investigated the relationship between physical activity and arterial stiffness, ... Read more >>

Am J Hypertens (American journal of hypertension)
[2016, 29(7):882-888]

Cited: 10 times

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