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Author Ersilia Lucenteforte

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Long-Term Safety and Efficacy of Tacrolimus 0.1% in Severe Pediatric Vernal Keratoconjunctivitis.

Roberto Caputo, Elisa Marziali, Cinzia de Libero, Laura Di Grande, Gioia Danti, Gianni Virgili, Edoardo Villani, Francesca Mori, Giacomo M Bacci, Ersilia Lucenteforte, Neri Pucci,

<h4>Purpose</h4>The aim of this study was to evaluate the safety and efficacy of tacrolimus 0.1% eye drops in a large population of pediatric patients affected by a severe form of vernal keratoconjunctivitis (VKC) who responded poorly to cyclosporine eye drops.<h4>Methods</h4>This is a retrospective study based on standardized clinical charts and ... Read more >>

Cornea (Cornea)
[2021, 40(11):1395-1401]

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Letter: universal screening for hepatitis C in pregnancy, children and adolescents-authors' reply.

Giuseppe Indolfi, Ersilia Lucenteforte,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):979-980]

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Validation of algorithms for selecting rheumatoid arthritis patients in the Tuscan healthcare administrative databases.

Irma Convertino, Massimiliano Cazzato, Sabrina Giometto, Rosa Gini, Giulia Valdiserra, Emiliano Cappello, Sara Ferraro, Silvia Tillati, Claudia Bartolini, Olga Paoletti, Valentina Lorenzoni, Leopoldo Trieste, Matteo Filippi, Giuseppe Turchetti, Michele Cristofano, Corrado Blandizzi, Marta Mosca, Ersilia Lucenteforte, Marco Tuccori,

Validation of algorithms for selecting patients from healthcare administrative databases (HAD) is recommended. This PATHFINDER study section is aimed at testing algorithms to select rheumatoid arthritis (RA) patients from Tuscan HAD (THAD) and assessing RA diagnosis time interval between the medical chart date and that of THAD. A population was ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):20314]

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Large-Scale Postmarketing Surveillance of Biological Drugs for Immune-Mediated Inflammatory Diseases Through an Italian Distributed Multi-Database Healthcare Network: The VALORE Project.

Gianluca Trifirò, Valentina Isgrò, Ylenia Ingrasciotta, Valentina Ientile, Luca L'Abbate, Saveria S Foti, Valeria Belleudi, Francesca Poggi, Andrea Fontana, Ugo Moretti, Riccardo Lora, Alberto Sabaini, Ilenia Senesi, Carla Sorrentino, Maria R Puzo, Angela Padula, Mariano Fusco, Roberta Giordana, Valentina Solfrini, Aurora Puccini, Paola Rossi, Stefania Del Zotto, Olivia Leoni, Martina Zanforlini, Domenica Ancona, Vito Bavaro, Donatella Garau, Stefano Ledda, Salvatore Scondotto, Alessandra Allotta, Marco Tuccori, Rosa Gini, Giampaolo Bucaneve, David Franchini, Anna Cavazzana, Valeria Biasi, Stefania Spila Alegiani, Marco Massari, ,

<h4>Background</h4>Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings.<h4>Objective</h4>The aim of this study was to explore the potential of a large Italian multi-database distributed network for use in the postmarketing surveillance of ... Read more >>

BioDrugs (BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy)
[2021, :]

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Gender matching did not affect 2-year rejection or failure rates following DSAEK for Fuchs endothelial corneal dystrophy.

Vito Romano, Mohit Parekh, Gianni Virgili, Giulia Coco, Pia Leon, Katja Islein, Diego Ponzin, Stefano Ferrari, Adriano Fasolo, Angeli Christy Yu, Ersilia Lucenteforte, Massimo Busin, Stephen B Kaye,

<h4>Purpose</h4>To investigate if donor to recipient gender or H-Y mismatching was associated with graft rejection or failure following Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with Fuchs endothelial corneal dystrophy (FECD).<h4>Design</h4>Clinical Cohort study.<h4>Methods</h4>We used multi-center registry including patients older than 18 years who had undergone their first DSAEK for ... Read more >>

Am J Ophthalmol (American journal of ophthalmology)
[2021, :]

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Evidence-based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology.

Ilaria Girolami, Ersilia Lucenteforte, Albino Eccher, Stefano Marletta, Matteo Brunelli, Paolo Graziano, Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone, Aldo Scarpa, Tao Huang, Liron Pantanowitz,

Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and cytology samples preclude an assessment for pleural tissue invasion. Accordingly, immunohistochemical, soluble, and molecular biomarkers have been developed. The aim of this study is to provide ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2021, :]

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Association Between Visual Impairment and Depression in Patients Attending Eye Clinics: A Meta-analysis.

Mariacristina Parravano, Davide Petri, Erica Maurutto, Ersilia Lucenteforte, Francesca Menchini, Paolo Lanzetta, Monica Varano, Ruth M A van Nispen, Gianni Virgili,

<h4>Importance</h4>Given that depression is treatable and some ocular diseases that cause visual loss are reversible, early identification and treatment of patients with visual impairment who are most at risk of depression may have an important influence on the well-being of these patients.<h4>Objective</h4>To conduct a meta-analysis on the prevalence of depression ... Read more >>

JAMA Ophthalmol (JAMA ophthalmology)
[2021, 139(7):753-761]

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The use of a non-biological, bridging, antiprotrusio cage in complex revision hip arthroplasty and periacetabular reconstructive oncologic surgery. Is still today a valid option?: A mid/long-term survival and complications' analysis.

Matteo Innocenti, Francesco Muratori, Giacomo Mazzei, Davide Guido, Filippo Frenos, Ersilia Lucenteforte, Rodolfo Capanna, Domenico Andrea Campanacci,

<h4>Introduction</h4>Burch-Schneider-like antiprotrusio cages (B-SlAC) still remain helpful implants to bridge severe periacetabular bone losses. The purpose of this study was to evaluate outcomes and estimate both cages' failures and complication risks in a series of B-SlAC implanted in revision of failed total hip arthroplasties (THA) or after resection of periacetabular ... Read more >>

Arch Orthop Trauma Surg (Archives of orthopaedic and trauma surgery)
[2021, :]

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Assessment of automated high-throughput serological assays for prediction of high-titer SARS-CoV-2 neutralizing antibody

Giovanna Moscato, Paola Mazzetti, Ersilia Lucenteforte, Alfredo Rosellini, Alice Cara, Paola Quaranta, Valerio Mainardi, Pietro Villa, Daniele Focosi, Maria Lanza, Irene Bianco, Alessandro Mazzoni, Marco Falcone, Francesco Menichetti, Fabrizio Maggi, Michele Lai, Giulia Freer, Mauro Pistello,

COVID19 convalescent patient plasma units with high titer neutralizing antibody can be used to treat patients with severe disease. Therefore, in order to select suitable donors, neutralizing antibody titer against SARS CoV-2 needs to be determined. Because the neutralization assay is highly demanding from several points of view, a pre-selection ... Read more >>

(Journal of Clinical Virology Plus)
[2021, 1(1):100016-100016]

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Telomere Length and Male Fertility.

Manuel Gentiluomo, Alice Luddi, Annapaola Cingolani, Marco Fornili, Laura Governini, Ersilia Lucenteforte, Laura Baglietto, Paola Piomboni, Daniele Campa,

Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters. The aim of this study ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(8):]

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Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin.

Daniele Focosi, Angelo Genoni, Ersilia Lucenteforte, Silvia Tillati, Antonio Tamborini, Pietro Giorgio Spezia, Lorenzo Azzi, Andreina Baj, Fabrizio Maggi,

Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other <i>Coronaviridae</i> for both cellular and humoral immunity. We show here that IgG against ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(4):]

Cited: 5 times

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Use of antiseizure medications and safety of branded versus generic formulations: A comparative study on Tuscan administrative databases.

Sabrina Giometto, Laura Baglietto, Marco Conte, Alfredo Vannacci, Marco Tuccori, Alessandro Mugelli, Rosa Gini, Ersilia Lucenteforte,

<h4>Purpose</h4>To assess patterns of use of antiseizure medications (ASMs) and to compare the safety of generic versus branded formulations in terms of admission to hospital or to emergency department (ED).<h4>Methods</h4>We conducted a drug utilization study with a propensity score-matched design using the administrative databases of the Italian Tuscany region. New ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2021, 117:107876]

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Association between the glyco-metabolic adverse effects of antipsychotic drugs and their chemical and pharmacological profile: a network meta-analysis and regression.

Carla Carnovale, Ersilia Lucenteforte, Vera Battini, Faizan Mazhar, Marco Fornili, Elena Invernizzi, Giulia Mosini, Michele Gringeri, Annalisa Capuano, Cristina Scavone, Maria Nobile, Chiara Vantaggiato, Simone Pisano, Carmela Bravaccio, Sonia Radice, Emilio Clementi, Marco Pozzi,

<h4>Background</h4>Glyco-metabolic deteriorations are the most limiting adverse reactions to antipsychotics in the long term. They have been incompletely investigated and the properties of antipsychotics that determine their magnitude are not clarified.To rank antipsychotics by the magnitude of glyco-metabolic alterations and to associate it to their pharmacological and chemical properties, we ... Read more >>

Psychol Med (Psychological medicine)
[2021, :1-13]

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The management of pediatric severe traumatic brain injury: Italian Guidelines.

Leonardo Bussolin, Martina Falconi, Maria C Leo, Niccolò Parri, Salvatore DE Masi, Anna Rosati, Costanza Cecchi, Barbara Spacca, Manuela Grandoni, Alessandra Bettiol, Ersilia Lucenteforte, Riccardo Lubrano, Raffaele Falsaperla, Francesca Melosi, Rino Agostiniani, Francesca Mangiantini, Giuseppe Talamonti, Edoardo Calderini, Aldo Mancino, Marco DE Luca, Giorgio Conti, Flavia Petrini, ,

<h4>Introduction</h4>The aim of the work was to update the "Guidelines for the Management of Severe Traumatic Brain Injury" published in 2012, to reflect the new available evidence, and develop the Italian national guideline for the management of severe pediatric head injuries to reduce variation in practice and ensure optimal care ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(5):567-579]

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Systematic review on estimated rates of nephrotoxicity and neurotoxicity in patients treated with polymyxins.

Florian Wagenlehner, Ersilia Lucenteforte, Federico Pea, Alex Soriano, Lara Tavoschi, Victoria R Steele, Anne Santerre Henriksen, Christopher Longshaw, Davide Manissero, Raymond Pecini, Jason M Pogue,

<h4>Background</h4>Nephrotoxicity and neurotoxicity are commonly associated with polymyxin treatment; however, the emergence of multidrug-resistant Gram-negative bacteria with limited therapeutic options has resulted in increased use of polymyxins.<h4>Objectives</h4>To determine the rates of nephrotoxicity and neurotoxicity during polymyxin treatment and whether any factors influence these.<h4>Data sources</h4>Medline, Embase and Cochrane Library databases were ... Read more >>

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2021, :]

Cited: 1 time

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Office hysteroscopy in pre- and post-menopausal women: a predictive model.

Flavia Sorbi, Massimiliano Fambrini, Srdjan Saso, Ersilia Lucenteforte, Federica Lisi, Luigi Piciocchi, Riccardo Cioni, Felice Petraglia,

<h4>Objectives</h4>To assess the variables associated with success of office hysteroscopy (OH) in pre-menopausal and post-menopausal women and to develop a clinical model for predicting the outcome of OH.<h4>Methods</h4>This is a retrospective cohort study of consecutive patients (<i>n</i> = 3181) referred for an OH to a tertiary care university hospital between January 2018 ... Read more >>

Gynecol Endocrinol (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2021, 37(3):206-210]

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Diagnostic mesothelioma biomarkers in effusion cytology.

Albino Eccher, Ilaria Girolami, Ersilia Lucenteforte, Giancarlo Troncone, Aldo Scarpa, Liron Pantanowitz,

Malignant mesothelioma is a rare malignancy with a poor prognosis whose development is related to asbestos fiber exposure. An increasing role of genetic predisposition has been recognized recently. Pleural biopsy is the gold standard for diagnosis, in which the identification of pleural invasion by atypical mesothelial cell is a major ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2021, 129(7):506-516]

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The diagnostic accuracy of digital, infrared and mercury-in-glass thermometers in measuring body temperature: a systematic review and network meta-analysis.

Valentina Pecoraro, Davide Petri, Giorgio Costantino, Alessandro Squizzato, Lorenzo Moja, Gianni Virgili, Ersilia Lucenteforte,

Not much is known about how accurate and reproducible different thermometers are at diagnosing patients with suspected fever. The study aims at evaluating which peripheral thermometers are more accurate and reproducible. We searched Medline, Embase, Scopus, WOS, CENTRAL, and Cinahl to perform: (1) diagnostic accuracy meta-analysis (MA) using rectal mercury-in-glass ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2021, 16(4):1071-1083]

Cited: 1 time

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Quantitative MRI-Based Analysis Identifies Developmental Limbic Abnormalities in PCDH19 Encephalopathy.

Matteo Lenge, Carla Marini, Edoardo Canale, Antonio Napolitano, Salvatore De Masi, Marina Trivisano, Davide Mei, Daniela Longo, Maria Camilla Rossi Espagnet, Ersilia Lucenteforte, , Carmen Barba, Nicola Specchio, Renzo Guerrini,

Protocadherin-19 (PCDH19) is a calcium dependent cell-adhesion molecule involved in neuronal circuit formation with prevalent expression in the limbic structures. PCDH19-gene mutations cause a developmental encephalopathy with prominent infantile onset focal seizures, variably associated with intellectual disability and autistic features. Diagnostic neuroimaging is usually unrevealing. We used quantitative MRI to ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(11):6039-6050]

Cited: 2 times

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Systematic review with meta-analysis: the efficacy and safety of direct-acting antivirals in children and adolescents with chronic hepatitis C virus infection.

Giuseppe Indolfi, Sabrina Giometto, Daniele Serranti, Alessandra Bettiol, Elisabetta Bigagli, Salvatore De Masi, Ersilia Lucenteforte,

<h4>Background</h4>The effect of direct-acting anti-virals (DAAs) in children and adolescents with chronic hepatitis C virus (HCV) infection is difficult to determine, since few, aged between 3 and 18 years, have been enrolled in clinical trials, and some data come from observational studies.<h4>Aim</h4>To summarise the evidence on efficacy and safety of DAAs ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(7):1125-1133]

Cited: 3 times

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Utilisation patterns and clinical impact of the introduction of infliximab-biosimilar in Tuscany, Italy: real world evidence following the recommendation of switching for non-medical reasons.

Irma Convertino, Ersilia Lucenteforte, Rosa Gini, Valentina Lorenzoni, Massimiliano Cazzato, Giuseppe Turchetti, Leopoldo Trieste, Sara Ferraro, Luca Leonardi, Giuseppe Roberto, Nicoletta Luciano, Corrado Blandizzi, Marta Mosca, Marco Tuccori,

<h4>Objectives</h4>This study was aimed at assessing the impact of a non-medical recommendation on drug-utilisation patterns and clinical outcomes in a central Region of Italy (Tuscany).<h4>Methods</h4>We performed a pre-post study on data collected in Tuscan healthcare administrative databases. We included patients with diagnosis of rheumatoid arthritis, or psoriatic arthritis, or ankylosing ... Read more >>

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2021, 39(4):753-762]

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Selective Estrogen Receptor Modulators in COVID-19: A Possible Therapeutic Option?

Alba Calderone, Francesco Menichetti, Ferruccio Santini, Luciano Colangelo, Ersilia Lucenteforte, Vincenzo Calderone,

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:1085]

Cited: 1 time

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Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study.

Alessandra Vultaggio, Emanuele Vivarelli, Gianni Virgili, Ersilia Lucenteforte, Alessandro Bartoloni, Carlo Nozzoli, Alessandro Morettini, Andrea Berni, Danilo Malandrino, Oliviero Rossi, Francesca Nencini, Filippo Pieralli, Adriano Peris, Filippo Lagi, Giulia Scocchera, Michele Spinicci, Michele Trotta, Marcello Mazzetti, Paola Parronchi, Lorenzo Cosmi, Francesco Liotta, Paolo Fontanari, Alessio Mazzoni, Lorenzo Salvati, Enrico Maggi, Francesco Annunziato, Fabio Almerigogna, Andrea Matucci,

<h4>Background</h4>The early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms.<h4>Objective</h4>The aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, 8(8):2575-2581.e2]

Cited: 23 times

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The CoV-2 outbreak: how hematologists could help to fight Covid-19.

Sara Galimberti, Chiara Baldini, Claudia Baratè, Federica Ricci, Serena Balducci, Susanna Grassi, Francesco Ferro, Gabriele Buda, Edoardo Benedetti, Rita Fazzi, Laura Baglietto, Ersilia Lucenteforte, Antonello Di Paolo, Mario Petrini,

COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). ... Read more >>

Pharmacol Res (Pharmacological research)
[2020, 157:104866]

Cited: 17 times

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The development of a Consensus Conference on Pediatric Procedural Sedation in the Emergency Department in Italy: from here where to?

Idanna Sforzi, Silvia Bressan, Claudia Saffirio, Salvatore De Masi, Leonardo Bussolin, Liviana Da Dalt, Fabio De Iaco, Itai Shavit, Baruch Krauss, Egidio Barbi, ,

<h4>Background</h4>In Italy, as in many European countries, Pediatric Emergency Medicine is not formally recognized as a pediatric subspecialty, hindering nation-wide adoption of standards of care, especially in the field of procedural sedation and analgesia (PSA) in the Emergency Department (ED). For this reason PSA in Italy is mostly neglected or ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):57]

Cited: 1 time

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