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Author Erpeng Zhu

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Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages.

Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng,

<i>Mycoplasma ovipneumoniae (MO)</i> is a principle causative agent of chronic respiratory disease in ruminants, including sheep, goats, and deer, posing a great threat to the ruminant industry worldwide. However, the pathogenesis of <i>MO</i> infection still remains not well understood and needs further clarification. Here we report a time-dependent apoptosis in ... Read more >>

Virulence (Virulence)
[2021, 12(1):2703-2720]

Cited: 0 times

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Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.

Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen,

Endoplasmic reticulum stress (ERS)-mediated autophagy is indispensable for modulation of replication and pathogenesis of numerous mammalian viruses. We have previously shown that classical swine fever virus (CSFV) infection induces ERS-mediated autophagy for maintaining viral replication both <i>in vivo</i> and <i>in vitro</i>, however, the underlying mechanism remains unclarified. Here we found ... Read more >>

Virulence (Virulence)
[2021, 12(1):130-149]

Cited: 1 time

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A fowl adenovirus serotype 4 (FAdV-4) Fiber2 subunit vaccine candidate provides complete protection against challenge with virulent FAdV-4 strain in chickens.

Dejing Yin, Ling He, Erpeng Zhu, Tian Fang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng,

Hypervirulent fowl adenovirus serotype 4 (FAdV-4)-induced hepatitis-hydropericardium syndrome (HHS) with high mortality causes huge economic losses to the poultry industry worldwide. However, commercially available vaccines against FAdV-4 infection remain scarce. Here, we prepared a subunit vaccine candidate derived from the bacterially expressed recombinant Fiber2 protein (termed as rFiber2 subunit vaccine) ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 263:109250]

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Recombinant pseudorabies virus with gI/gE deletion generated by overlapping polymerase chain reaction and homologous recombination technology induces protection against the PRV variant PRV-GD2013.

Wenhui Li, Dijing Zhuang, Hong Li, Mengpo Zhao, Erpeng Zhu, Baoming Xie, Jinding Chen, Mingqiu Zhao,

<h4>Background</h4>Since 2011, numerous highly virulent and antigenic variant viral strains have been reported in pigs that were vaccinated against the swine pseudorabies virus. These infections have led to substantial economic losses in the Chinese swine industry.<h4>Results</h4>This study, constructed a novel recombinant vaccine strain with gI/gE deletion (PRV-GD2013-ΔgI/gE) by overlapping PCR ... Read more >>

BMC Vet Res (BMC veterinary research)
[2021, 17(1):164]

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Corrigendum: Dual NDP52 Function in Persistent CSFV Infection.

Shuangqi Fan, Keke Wu, Chaowei Luo, Xin Li, Mengpo Zhao, Dan Song, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jun Li, Mingqiu Zhao, Jinding Chen,

[This corrects the article DOI: 10.3389/fmicb.2019.02962.]. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:673468]

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LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection.

Shuangqi Fan, Keke Wu, Mingqiu Zhao, Jin Yuan, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jinding Chen,

Cellular metabolism caters to the energy and metabolite needs of cells. Although the role of the terminal metabolic enzyme LDHB (lactate dehydrogenase B) in the glycolysis pathway has been widely studied in cancer cells, its role in viral infection is relatively unknown. In this study, we found that CSFV (classical ... Read more >>

Autophagy (Autophagy)
[2021, 17(9):2305-2324]

Cited: 3 times

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MG132 Attenuates the Replication of Classical Swine Fever Virus in vitro.

Yuming Chen, Shuangqi Fan, Mengpo Zhao, Keke Wu, Erpeng Zhu, Shengming Ma, Wencheng He, Shaofeng Deng, Hailuan Xu, Jingyuan Zhang, Hongxing Ding, Lin Yi, Mingqiu Zhao, Jinding Chen,

The 26S proteasome, in charge of intracellular protein degradation, plays significant roles in the modulation of various cellular activities as well as in the interplay between virus and host. However, studies about the relationship between 26S proteasome and classical swine fever virus (CSFV) is limited up to now. MG132 is ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:852]

Cited: 1 time

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The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections.

Shuangqi Fan, Keke Wu, Mengpo Zhao, Erpeng Zhu, Shengming Ma, Yuming Chen, Hongxing Ding, Lin Yi, Mingqiu Zhao, Jinding Chen,

Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading and recycling cellular components under stress conditions. The degradation pathway that is mediated by autophagy receptors is called selective autophagy, also named as xenophagy. Autophagy receptor NDP52 acts as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

Cited: 5 times

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Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro.

Erpeng Zhu, Wenxian Chen, Yuwei Qin, Shengming Ma, Shuangqi Fan, Keke Wu, Wenhui Li, Jindai Fan, Lin Yi, Hongxing Ding, Jinding Chen, Mingqiu Zhao,

Endoplasmic reticulum (ER) stress-mediated autophagy plays significant roles in replication and pathogenesis of many animal viruses. However, the relationship between ER stress, autophagy, and viral replication during in vivo and in vitro infection of classical swine fever virus (CSFV) remains unclear. In this study, we established a pig model for ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2545]

Cited: 4 times

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Important roles of C-terminal residues in degradation of capsid protein of classical swine fever virus.

Yuming Chen, Erpeng Zhu, Shuangqi Fan, Hongxing Ding, Shengming Ma, Mengjiao Zhu, Shaofeng Deng, Jinding Chen, Mingqiu Zhao,

BACKGROUND:Capsid (C) protein plays an important role in the replication of classical swine fever virus (CSFV). The ubiquitin proteasome system (UPS) involves in replication of many viruses via modulation of viral proteins. The relationship of CSFV with UPS is poorly understood and the impact of 26S proteasome on C protein ... Read more >>

Virol J (Virology journal)
[2019, 16(1):127]

Cited: 2 times

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Changes in the small intestine mucosal immune barrier in Muscovy ducklings infected with Muscovy duck reovirus.

Yijian Wu, Zhenni Liu, Erpeng Zhu, Minghui Li, Huihui Jiang, Yu Luo, Quanxi Wang, Xiaoping Wu, Baocheng Wu, Yifan Huang,

Muscovy duck reovirus (MDRV) causes serious immunodeficiency in the intestinal mucosa, although the underlying histopathological mechanisms remain unclear. Thus, we investigated the impact of MDRV infection on intestinal morphology using hematoxylin and eosin staining. Immune-related cells were also quantified by staining with hematoxylin and eosin, toluidine blue, and periodic acid-Schiff ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2019, 233:85-92]

Cited: 2 times

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Dual NDP52 Function in Persistent CSFV Infection.

Shuangqi Fan, Keke Wu, Chaowei Luo, Xin Li, Mengpo Zhao, Dan Song, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jun Li, Mingqiu Zhao, Jinding Chen,

Viruses have evolved many mechanisms to escape host antiviral responses. Previously, we found that classical swine fever virus (CSFV) infection induces autophagy using the autophagosome as a self-replication site, thereby evading the host immune response and promoting long-term infection. However, the underlying mechanisms used by CSFV to enter autophagosomes and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:2962]

Cited: 5 times

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Hericium erinaceus polysaccharide facilitates restoration of injured intestinal mucosal immunity in Muscovy duck reovirus-infected Muscovy ducklings.

Yijian Wu, Huihui Jiang, Erpeng Zhu, Jian Li, Quanxi Wang, Wuduo Zhou, Tao Qin, Xiaoping Wu, Baocheng Wu, Yifan Huang,

To elucidate the effect of Hericium erinaceus polysaccharide (HEP) on the intestinal mucosal immunity in normal and Muscovy duck reovirus (MDRV)-infected Muscovy ducklings, 1-day-old healthy Muscovy ducklings were pretreated with 0.2g/L HEP and/or following by MDRV infection in this study, duodenal samples were respectively collected at 1, 3, 6, 10, ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2018, 107(Pt A):1151-1161]

Cited: 6 times

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Muscovy duck reovirus σNS protein triggers autophagy enhancing virus replication.

Yijian Wu, Longping Cui, Erpeng Zhu, Wuduo Zhou, Quanxi Wang, Xiaoping Wu, Baocheng Wu, Yifan Huang, Hung-Jen Liu,

<h4>Background</h4>Muscovy duck reovirus (MDRV) causes high morbidity and mortality in Muscovy ducklings at 10 days old and can persist in an infected flock until the ducklings of 6 weeks old. It shares common physicochemical properties with avian reovirus (ARV) and differs in coding assignment and pathogenicity. The ARV p17 protein has been ... Read more >>

Virol J (Virology journal)
[2017, 14(1):53]

Cited: 7 times

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