Full Text Journal Articles by
Author Erol Akpinar

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Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage.

Erol Akpinar, Zerrin Kutlu, Duygu Kose, Pelin Aydin, Taha Tavaci, Zafer Bayraktutan, Tugba Nurcan Yuksel, Serkan Yildirim, Gizem Eser, Busra Dincer,

<h4>Background/aims</h4>Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple organ failure. Although much research has been conducted to illuminate sepsis's complex pathophysiology, sepsis treatment protocols are limited, and sepsis remains an important cause of mortality andmorbidity in intensive care units.Various ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2021, :1-9]

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5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.

Irfan Cinar, Busra Sirin, Zekai Halici, Saziye Sezin Palabiyik-Yucelik, Erol Akpinar, Elif Cadirci,

Prostate cancer (PCa) is one of the most common types of cancer seen among men worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation, migration, and invasion in vitro; the presence of 5-HT receptors in cancer cells; and the role of serotonin in tumor development. The most recently discovered ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(6):1205-1213]

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Effect of surfactant alkyl chain length on lyotropic uniaxial to biaxial cholesteric phase transitions.

Erol Akpinar, Nazli Uygur, Seda Uyanik, Antônio Martins Figueiredo Neto,

Some ionic surfactant-based lyotropic mixtures, exhibiting cholesteric phases, were prepared to investigate the effect of the surfactant alkyl chain length on a) uniaxial-to-biaxial phase transitions and b) stabilization of different cholesteric phases. Potassium alkanoates, KCx, (potassium undecanoate, KC11, potassium dodecanoate, KC12, and potassium tridecanoate, KC13) were chosen as the surfactant ... Read more >>

Eur Phys J E Soft Matter (The European physical journal. E, Soft matter)
[2019, 42(9):128]

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Effect of head-group size of some tetradecylalkylammonium bromide surfactants on obtaining the lyotropic biaxial nematic phase.

Erol Akpinar, Emre Guner, Oznur Demir-Ordu, Antônio Martins Figueiredo Neto,

Lyotropic quaternary mixtures of some tetradecylalkylammonium bromide surfactants were prepared to examine the effect of the size of the surfactant head group on the stabilization of different lyotropic nematic phases. The lyotropic mixtures were prepared by the addition of the tetradecylalkylammonium bromides (TTAABr) in the mixture of NaBr/decanol (DeOH)/water. The ... Read more >>

Eur Phys J E Soft Matter (The European physical journal. E, Soft matter)
[2019, 42(4):44]

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The effects of Beeswax, Olive oil and Butter impregnated bandage on burn wound healing.

Yasin Bayir, Harun Un, Rustem Anil Ugan, Erol Akpinar, Elif Cadirci, Ilknur Calik, Zekai Halici,

<h4>Background</h4>Beeswax, Olive oil and Butter (BOB) are nutritive products that could support wound healing by adsorption to bandage. This study demonstrated the therapeutic effects of BOB on second degree burn.<h4>Methods</h4>Second degree burn model was created in rats. Experimental groups were assigned to Healthy, Burn, Silver Sulfadiazine (SS) and BOB. The ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2019, 45(6):1410-1417]

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Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats.

Yasin Bayir, Harun Un, Elif Cadirci, Erol Akpinar, Busra Diyarbakir, Ilknur Calik, Zekai Halici,

Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues ... Read more >>

An Acad Bras Cienc (Anais da Academia Brasileira de Ciencias)
[2019, 91(1):e20180106]

Cited: 1 time

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Urotensin receptors as a new target for CLP induced septic lung injury in mice.

Elif Cadirci, Rustem Anil Ugan, Busra Dincer, Betul Gundogdu, Irfan Cinar, Erol Akpinar, Zekai Halici,

Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in pulmonary, cardiovascular, central nervous, renal and metabolic systems, and especially in inflammatory regions. This study aimed to investigate whether urotensin II (UII) and UII receptor (UTR) ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2019, 392(2):135-145]

Cited: 1 time

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The effects of apomorphine on paracetamol-induced hepatotoxicity in rats.

Muserref Hilal Sehitoglu, Muhammet Yayla, Asli Kiraz, Rahime Ozlem Oztopuz, Yasin Bayir, Turan Karaca, Sumbul Khalid, Erol Akpinar,

It is becoming progressively more understandable that overdose of paracetamol in both humans and animals causes severe hepatotoxicity. Apomorphine is known as a neuroprotective agent. Due to the protective effect,  apomorphine had been tested in experimental studies on different models. Findings obtained through series of expriments suggested that apomorphine may ... Read more >>

Cell Mol Biol (Noisy-le-grand) (Cellular and molecular biology (Noisy-le-Grand, France))
[2017, 63(12):40-44]

Cited: 1 time

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Role of kosmotrope-chaotrope interactions at micelle surfaces on the stabilization of lyotropic nematic phases.

Erol Akpinar, Meric Turkmen, Cihan Canioz, Antônio Martins Figueiredo Neto,

Three lyotropic quaternary systems of ionic surfactants were prepared to investigate the role of kosmotrope-chaotrope interactions at the micelle surfaces on stabilizing the different nematic phases. The ionic surfactants were potassium laurate (KL), sodium dodecylsulfate (SDS) and tetradecyltrimethylammonium bromide (TDTMABr), where KL is a kosmotrope surfactant, and others are chaotrope. ... Read more >>

Eur Phys J E Soft Matter (The European physical journal. E, Soft matter)
[2016, 39(11):107]

Cited: 1 time

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Serum nesfatin-1 levels: a potential new biomarker in patients with subarachnoid hemorrhage.

Murteza Cakir, Cagatay Calikoglu, Atilla Yılmaz, Erol Akpinar, Zafer Bayraktutan, Atilla Topcu,

<h4>Background</h4>Acute subarachnoid hemorrhage (SAH) is a neurological emergency with significant potential for long-term morbidity and mortality. Nesfatin-1 is a polypeptide which is found in various regions of the brain that play role in the feeding and metabolic regulation.<h4>Objective</h4>So this study aimed to investigate if nesfatin-1 levels in patients with SAH, ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2017, 127(2):154-160]

Cited: 0 times

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The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist.

Saziye S Palabiyik, Emre Karakus, Erol Akpinar, Zekai Halici, Yasin Bayir, Muhammed Yayla, Duygu Kose,

We aimed to evaluate the possible protective effect of a UTR antagonist and to determine the effect of the antagonist on ALT and AST levels in serum, the mRNA expression level of UTR, tumour necrosis factor-alpha (TNF-α) and IL-1β and SOD activity, GSH and MDA levels in liver tissues, which ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2016, 118(2):150-159]

Cited: 5 times

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The Effects of Argan Oil in Second-degree Burn Wound Healing in Rats.

Umit Avsar, Zekai Halici, Erol Akpinar, Muhammed Yayla, Ummu Avsar, Un Harun, Un Harun, Atmaca Hasan Tarik, Zafer Bayraktutan,

Argan oil, produced from the kernels of the argan tree (Argania spinosa), has been shown to have antioxidant properties. To examine the effect of argan oil in second-degree burn wound healing, an in vivo experiment was conducted among 30 adult male Wistar rats divided into 5 equal groups: a sham ... Read more >>

Ostomy Wound Manage (Ostomy/wound management)
[2016, 62(3):26-34]

Cited: 5 times

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The Effects of RAAS Inhibition in Rate Limiting Step by Aliskiren on Testicular Torsion Injury in Rats.

Harun Un, Yasin Bayir, Zekai Halici, Erol Akpinar, Emre Karakus, Akgun Oral, Tevfik Ziypak, Jale Selli,

<h4>Purpose</h4>Testicular torsion is a urological emergency. Failure of timely intervention for this issue leads the testicles to go into necrosis. If left untreated, it can lead to loss of the reproductive organs. The aim of this study was to examine the role of aliskiren in testicular torsion and detorsion injuries.<h4>Materials ... Read more >>

J Urol (The Journal of urology)
[2015, 194(3):828-833]

Cited: 8 times

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Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study.

Tevfik Ziypak, Zekai Halici, Erdal Alkan, Erol Akpinar, Beyzagul Polat, Senol Adanur, Elif Cadirci, Irmak Ferah, Yasin Bayir, Emre Karakus, Tolga Mercantepe,

<h4>Purpose</h4>To determine the protective effect of aliskiren on ischemia-reperfusion (I/R) injury in a rat renal (I/R) model.<h4>Methods</h4>Rats were randomly divided into five groups: sham control group; sham control with aliskiren pretreatment; I/R group and I/R with two doses of aliskiren pretreatment. Rats were unilaterally nephrectomized and subjected to 45 min of ... Read more >>

Ren Fail (Renal failure)
[2015, 37(2):343-354]

Cited: 8 times

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Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain.

Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir,

Diabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non-diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)-1 in brain damage formed in a ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2015, 116(3):236-243]

Cited: 3 times

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The double-edged sword: effects of pregabalin on experimentally induced sciatic nerve transection and crush injury in rats.

Mine Celik, Ahmet Kose, Duygu Kose, Emre Karakus, Erol Akpinar, Muhammed Calik, Aysenur Dostbil, Cagatay Calikoglu, Mehmet Aksoy, Lutfu Ozel,

The aim of this study was to research the effects of pregabalin on experimentally induced peripheral nerve crush injuries in rats.Forty-two adult female Wistar albino rats were divided into seven groups: 1st group: healthy; 2nd group: axonotmesis control; 3rd group: anastomosis control; 4th group: axonotmesis+30 mg/kg of pregabalin; 5th group: axonotmesis+60 mg/kg ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2015, 125(11):845-854]

Cited: 5 times

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Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy.

Murat Saritemur, Harun Un, Elif Cadirci, Emre Karakus, Erol Akpinar, Zekai Halici, Rustem Anil Ugan, Adem Karaman, Hasan Tarik Atmaca,

Contrast medium-induced nephropathy (CIN) remains as a problem with high incidence and mortality rates. The aim of this study is to examine the roles of infliximab (INF) in the glycerol (GLY) and CIN model in rats. The rats were separated into five groups (n=8): Healthy, GLY, GLY+CM, GLY+CM+INF 5mg/kg intraperitoneally ... Read more >>

Environ Toxicol Pharmacol (Environmental toxicology and pharmacology)
[2015, 39(2):577-588]

Cited: 5 times

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New Lyotropic Mixtures with Non-Chiral N-Acylamino Acid Surfactants Presenting the Biaxial Nematic Phase Investigated by Laser Conoscopy, Polarized Optical Microscopy and X-ray Diffraction.

Erol Akpinar, Dennys Reis, Muhammet Yildirim, Antônio Martins Figueiredo Neto,

Amino acid-based surfactants were used as the main surfactants to prepare new lyotropic mixtures presenting three nematic phases. One of them is biaxial (<i>N<sub>B</sub></i>), and the two others are uniaxial, discotic (<i>N<sub>D</sub></i>) and calamitic (<i>N<sub>C</sub></i>). These surfactants were the non-chiral molecules, potassium <i>N</i>-dodecanoyl-DL-alaninate (DL-KDDA), potassium <i>N</i>-dodecanoyl-DL-serinate (DL-KDDS), disodium <i>N</i><b>-</b>dodecanoyl-DL-aspartate (DL-NaDDAs) ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2014, 7(6):4132-4147]

Cited: 0 times

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Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses.

Recep Demir, Muhammed Yayla, Erol Akpinar, Murtaza Cakir, Cagatay Calikoglu, Lutfu Ozel, Gokhan Ozdemir, Tolga Mercantepe,

<h4>Aim</h4>The present study aimed to demonstrate protective effects of alpha lipoic acid on experimental sciatic nerve crush injury model assessed with functional and electronmicroscopy analyses.<h4>Methods</h4>In this study, groups were; Group 1; sham operated, Group 2; applied only sciatic nerve crush (Control), Group 3; Sciatic nerve crush + treated ALA 25 ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2014, 124(12):935-943]

Cited: 5 times

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Anomalous behavior in the crossover between the negative and positive biaxial nematic mesophases in a lyotropic liquid crystal.

Erol Akpinar, Dennys Reis, Antonio M Figueiredo Neto,

A novel quaternary lyotropic liquid-crystalline mixture of dodecyltrimethylammonium bromide (DDTMABr)/sodium bromide/1-dodecanol/water, presenting the biaxial nematic phase (NB ) in addition to two uniaxial discotic (ND) and calamitic (NC) nematic ones, was synthesized. The partial phase diagram of this new mixture was constructed as a function of the DDTMABr molar-fraction concentration. ... Read more >>

Chemphyschem (Chemphyschem : a European journal of chemical physics and physical chemistry)
[2014, 15(7):1463-1469]

Cited: 1 time

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Can early myocardial infarction-related deaths be diagnosed using postmortem urotensin receptor expression levels?

Mustafa Talip Sener, Emre Karakus, Zekai Halici, Erol Akpinar, Atilla Topcu, Ahmet Nezih Kok,

<h4>Purpose</h4>Myocardial infarction (MI) is one of the most prevalent causes of sudden adult death. It is difficult to diagnose early MI postmortem because there are no typical or characteristic changes in morphology. In this study, changes in the level of the mRNA for the urotensin receptor (UR) were investigated postmortem ... Read more >>

Forensic Sci Med Pathol (Forensic science, medicine, and pathology)
[2014, 10(3):395-400]

Cited: 1 time

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What is the role of bosentan in healing of femur fractures in a rat model?

Ali Aydin, Zekai Halici, Erol Akpinar, A Murat Aksakal, Murat Saritemur, Muhammed Yayla, C Semih Kunak, Elif Cadirci, H Tarik Atmaca, S Sena Karcioglu,

The purpose of this study was to examine the effects bosentan (which is a strong vasoconstrictor) on bone fracture pathophysiology, and investigate the roles of the nonselective endothelin 1 receptor blocker bosentan on the bone fractures formed in rats through radiographic, histopathologic, and immunohistochemical methods. The rats were divided into three ... Read more >>

J Bone Miner Metab (Journal of bone and mineral metabolism)
[2015, 33(5):496-506]

Cited: 1 time

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Protective effect of Et-1 receptor antagonist bosentan on paracetamol induced acute liver toxicity in rats.

Muhammed Yayla, Zekai Halici, Bunyami Unal, Yasin Bayir, Erol Akpinar, Fatma Gocer,

Paracetamol is one of the first rank drugs which cause hepatic damage during drug intoxications. Endothelin (ET) which is known as one of the most potent vasoactive agent has been shown to contribute in the pathophysiology of various diseases. We hypothesized that bosentan, which is a non-selective ET-1 receptor antagonist, ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2014, 726:87-95]

Cited: 17 times

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Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats.

Ali Aydin, Zekai Halici, Ayhan Akoz, Adem Karaman, Irmak Ferah, Yasin Bayir, A Murat Aksakal, Erol Akpinar, Jale Selli, Halim Kovaci,

This study investigated the fracture-healing effects of α-lipoic acid (α-LA), which was applied orally once daily in preventive treatment mode during 1 month after fracture induction. Rats were randomly divided into sham-operated group (group 1), femoral fracture control (group 2), femoral fracture + 25 mg/kg α-LA (group 3), and femoral fracture + 50 mg/kg ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2014, 387(11):1025-1036]

Cited: 7 times

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What is the role of renin inhibition during rat septic conditions: preventive effect of aliskiren on sepsis-induced lung injury.

Erol Akpinar, Zekai Halici, Elif Cadirci, Yasin Bayir, Emre Karakus, Muhammet Calik, Atilla Topcu, Beyzagul Polat,

Sepsis and sepsis-related acute lung injuries (ALIs) are one of the main causes of death among hospitalized patients. Renin-angiotensin-aldosterone system (RAAS) has been reported to have role in sepsis. However, there is no study on aliskiren, a renin inhibitor, on sepsis-induced ALI. We aimed to investigate the potential protective effects ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2014, 387(10):969-978]

Cited: 10 times

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