Full Text Journal Articles by
Author Erin Q Jennings

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Sirtuin 2 Regulates Protein LactoylLys Modifications.

Erin Q Jennings, Jason D Ray, Christopher J Zerio, Marissa N Trujillo, David M McDonald, Eli Chapman, David A Spiegel, James J Galligan,

Post-translational modifications (PTMs) play roles in both physiological and pathophysiological processes through the regulation of enzyme structure and function. We recently identified a novel PTM, lactoylLys, derived through a nonenzymatic mechanism from the glycolytic by-product, lactoylglutathione. Under physiologic scenarios, glyoxalase 2 prevents the accumulation of lactoylglutathione and thus lactoylLys modifications. ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2021, 22(12):2102-2106]

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Trisomy 21 impairs PGE2 production in dermal fibroblasts.

John O Marentette, Colin C Anderson, Kendra M Prutton, Erin Q Jennings, Abhishek K Rauniyar, James J Galligan, James R Roede,

The triplication of human chromosome 21 results in Down syndrome (DS), the most common genetic form of intellectual disability. This aneuploid condition also results in an enhanced risk of a spectrum of comorbid conditions, such as leukemia, early onset Alzheimer's disease, and diabetes. Individuals with DS also display an increased ... Read more >>

Prostaglandins Other Lipid Mediat (Prostaglandins & other lipid mediators)
[2021, 153:106524]

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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling.

Siennah R Miller, Xiaohong Zhang, Raymond K Hau, Joseph L Jilek, Erin Q Jennings, James J Galligan, Daniel H Foil, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington,

Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the testes with drugs that use endogenous transport pathways may lead to more effective treatments for diseases within the reproductive tract. In this study, CRISPR/CRISPR-associated protein 9 was used to generate ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, 99(2):147-162]

Cited: 2 times

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