Full Text Journal Articles by
Author Erin C. Dunn

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Cross-classified multilevel models (CCMM) in health research: A systematic review of published empirical studies and recommendations for best practices.

Kathryn M Barker, Erin C Dunn, Tracy K Richmond, Sarah Ahmed, Matthew Hawrilenko, Clare R Evans,

Recognizing that health outcomes are influenced by and occur within multiple social and physical contexts, researchers have used multilevel modeling techniques for decades to analyze hierarchical or nested data. Cross-Classified Multilevel Models (CCMM) are a statistical technique proposed in the 1990s that extend standard multilevel modeling and enable the simultaneous ... Read more >>

SSM Popul Health (SSM - population health)
[2020, 12:100661]

Cited: 0 times

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Maternal vitamin D status during pregnancy and offspring risk of childhood/adolescent depression: Results from the Avon Longitudinal Study of Parents and Children (ALSPAC).

Min-Jung Wang, Erin C Dunn, Olivia I Okereke, Peter Kraft, Yiwen Zhu, Jordan W Smoller,

BACKGROUND:Low maternal vitamin D levels [serum 25-hydroxyvitamin D (25(OH)D)] during pregnancy have been linked to offspring neuropsychiatric outcomes such as schizophrenia and autism, but studies on depression are lacking. We examined the association between maternal vitamin D status during pregnancy and offspring depression during childhood and adolescence and investigated whether ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 265:255-262]

Cited: 0 times

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

Jonathan R I Coleman, Wouter J Peyrot, Kirstin L Purves, Katrina A S Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M Lyall, Karmel W Choi, , Erin C Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J Grabe, Cathryn M Lewis, Paul F O'Reilly, Andrew M McIntosh, Daniel J Smith, Naomi R Wray, Matthew Hotopf, Thalia C Eley, Gerome Breen,

Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, 25(7):1430-1446]

Cited: 3 times

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Time-Dependent Effects of Exposure to Physical and Sexual Violence on Psychopathology Symptoms in Late Childhood: In Search of Sensitive Periods in Development.

Erin C Dunn, Kristen Nishimi, Alexander Neumann, Alice Renaud, Charlotte A M Cecil, Ezra S Susser, Henning Tiemeier,

OBJECTIVE:Exposure to interpersonal violence is a known risk factor for psychopathology. However, it is unclear whether there are sensitive periods when exposure is most deleterious. We aimed to determine whether there were time periods when physical or sexual violence exposure was associated with greater child psychopathology. METHOD:This study (N = 4,580) ... Read more >>

J Am Acad Child Adolesc Psychiatry (Journal of the American Academy of Child and Adolescent Psychiatry)
[2020, 59(2):283-295.e4]

Cited: 1 time

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Genomics and psychological resilience: a research agenda.

Karmel W Choi, Murray B Stein, Erin C Dunn, Karestan C Koenen, Jordan W Smoller,

Although exposure to adversity increases risk for poor mental health outcomes, many people exposed to adversity do not develop such outcomes. Psychological resilience, defined broadly as positive emotional and/or behavioral adaptation to adversity, may be influenced by genetic factors that have remained largely unexplored in the era of large-scale genome-wide ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2019, 24(12):1770-1778]

Cited: 2 times

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Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.

Kylie P Glanville, Jonathan R I Coleman, Ken B Hanscombe, Jack Euesden, Shing Wan Choi, Kirstin L Purves, Gerome Breen, Tracy M Air, Till F M Andlauer, Bernhard T Baune, Elisabeth B Binder, Douglas H R Blackwood, Dorret I Boomsma, Henriette N Buttenschøn, Lucía Colodro-Conde, Udo Dannlowski, Nese Direk, Erin C Dunn, Andreas J Forstner, Eco J C de Geus, Hans J Grabe, Steven P Hamilton, Ian Jones, Lisa A Jones, James A Knowles, Zoltán Kutalik, Douglas F Levinson, Glyn Lewis, Penelope A Lind, Susanne Lucae, Patrik K Magnusson, Peter McGuffin, Andrew M McIntosh, Yuri Milaneschi, Ole Mors, Sara Mostafavi, Bertram Müller-Myhsok, Nancy L Pedersen, Brenda W J H Penninx, James B Potash, Martin Preisig, Stephan Ripke, Jianxin Shi, Stanley I Shyn, Jordan W Smoller, Fabian Streit, Patrick F Sullivan, Henning Tiemeier, Rudolf Uher, Sandra Van der Auwera, Myrna M Weissman, , Paul F O'Reilly, Cathryn M Lewis,

BACKGROUND:The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2020, 87(5):419-430]

Cited: 0 times

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Association of Race/Ethnicity With Specific Glycemic Thresholds for Predicting Diabetic Retinopathy.

Kevin J Moore, Erin C Dunn, Tulay Koru-Sengul,

JAMA Ophthalmol (JAMA ophthalmology)
[2019, 137(4):463-464]

Cited: 0 times

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Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.

Erin C Dunn, Thomas W Soare, Yiwen Zhu, Andrew J Simpkin, Matthew J Suderman, Torsten Klengel, Andrew D A C Smith, Kerry J Ressler, Caroline L Relton,

BACKGROUND:Exposure to early-life adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposure. METHODS:Using a two-stage structured life course modeling approach, we tested the hypothesis that there are ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2019, 85(10):838-849]

Cited: 7 times

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What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: recency, accumulation, or sensitive periods?

Erin C Dunn, Thomas W Soare, Miriam R Raffeld, Daniel S Busso, Katherine M Crawford, Kathryn A Davis, Virginia A Fisher, Natalie Slopen, Andrew D A C Smith, Henning Tiemeier, Ezra S Susser,

BACKGROUND:Although childhood adversity is a potent determinant of psychopathology, relatively little is known about how the characteristics of adversity exposure, including its developmental timing or duration, influence subsequent mental health outcomes. This study compared three models from life course theory (recency, accumulation, sensitive period) to determine which one(s) best explained ... Read more >>

Psychol Med (Psychological medicine)
[2018, 48(15):2562-2572]

Cited: 7 times

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Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study.

Sylvia Wassertheil-Smoller, Qibin Qi, Tushar Dave, Braxton D Mitchell, Rebecca D Jackson, Simin Liu, Ki Park, Joel Salinas, Erin C Dunn, Enrique C Leira, Huichun Xu, Kathleen Ryan, Jordan W Smoller,

BACKGROUND AND PURPOSE:Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis. METHODS:We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association ... Read more >>

Stroke (Stroke)
[2018, 49(3):543-548]

Cited: 2 times

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Does an uneven sample size distribution across settings matter in cross-classified multilevel modeling? Results of a simulation study.

Carly E Milliren, Clare R Evans, Tracy K Richmond, Erin C Dunn,

BACKGROUND:Recent advances in multilevel modeling allow for modeling non-hierarchical levels (e.g., youth in non-nested schools and neighborhoods) using cross-classified multilevel models (CCMM). Current practice is to cluster samples from one context (e.g., schools) and utilize the observations however they are distributed from the second context (e.g., neighborhoods). However, it is ... Read more >>

Health Place (Health & place)
[2018, 52:121-126]

Cited: 0 times

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Sensitive periods for the effect of childhood interpersonal violence on psychiatric disorder onset among adolescents.

Erin C Dunn, Yan Wang, Jenny Tse, Katie A McLaughlin, Garrett Fitzmaurice, Stephen E Gilman, Ezra S Susser,

BackgroundAlthough childhood adversity is a strong determinant of psychopathology, it remains unclear whether there are 'sensitive periods' when a first episode of adversity is most harmful.AimsTo examine whether variation in the developmental timing of a first episode of interpersonal violence (up to age 18) associates with risk for psychopathology.MethodUsing cross-sectional ... Read more >>

Br J Psychiatry (The British journal of psychiatry : the journal of mental science)
[2017, 211(6):365-372]

Cited: 1 time

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Exposure to childhood adversity and deficits in emotion recognition: results from a large, population-based sample.

Erin C Dunn, Katherine M Crawford, Thomas W Soare, Katherine S Button, Miriam R Raffeld, Andrew D A C Smith, Ian S Penton-Voak, Marcus R Munafò,

BACKGROUND:Emotion recognition skills are essential for social communication. Deficits in these skills have been implicated in mental disorders. Prior studies of clinical and high-risk samples have consistently shown that children exposed to adversity are more likely than their unexposed peers to have emotion recognition skills deficits. However, only one population-based ... Read more >>

J Child Psychol Psychiatry (Journal of child psychology and psychiatry, and allied disciplines)
[2018, 59(8):845-854]

Cited: 2 times

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Developmental timing of trauma exposure and emotion dysregulation in adulthood: Are there sensitive periods when trauma is most harmful?

Erin C Dunn, Kristen Nishimi, Stephanie H Gomez, Abigail Powers, Bekh Bradley,

BACKGROUND:This study aimed to determine whether there were sensitive periods when a first exposure to trauma was most associated with emotion dysregulation symptoms in adulthood. METHODS:Adult participants came from a public urban hospital in Atlanta, GA (n = 1944). Lifetime trauma exposure was assessed using the Traumatic Events Inventory (TEI). ... Read more >>

J Affect Disord (Journal of affective disorders)
[2018, 227:869-877]

Cited: 2 times

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Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos.

Erin C Dunn, Tamar Sofer, Min-Jung Wang, Thomas W Soare, Linda C Gallo, Stephanie M Gogarten, Kathleen F Kerr, Chia-Yen Chen, Murray B Stein, Robert J Ursano, Xiuqing Guo, Yucheng Jia, Jie Yao, Jerome I Rotter, Maria Argos, Jianwen Cai, Krista Perreira, , Sylvia Wassertheil-Smoller, Jordan W Smoller,

Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2018, 99:167-176]

Cited: 3 times

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Associations Between Trauma Type, Timing, and Accumulation on Current Coping Behaviors in Adolescents: Results from a Large, Population-based Sample.

Rachel A Vaughn-Coaxum, Yan Wang, Jenna Kiely, John R Weisz, Erin C Dunn,

The development of adolescents' coping in response to stress is critical for adaptive functioning; these coping strategies may be shaped by numerous environmental factors during childhood, including experiences such as exposure to trauma. Childhood trauma has been shown to undermine contemporaneous coping, but how does a history of exposure to ... Read more >>

J Youth Adolesc (Journal of youth and adolescence)
[2018, 47(4):842-858]

Cited: 0 times

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Are there sensitive periods when child maltreatment substantially elevates suicide risk? Results from a nationally representative sample of adolescents.

Stephanie H Gomez, Jenny Tse, Yan Wang, Brianna Turner, Alexander J Millner, Matthew K Nock, Erin C Dunn,

BACKGROUND:Although child maltreatment is a well documented risk factor for suicidal behavior, little is known about whether the timing of child maltreatment differentially associates with risk of suicidal ideation, suicide plans, or suicide attempts. The goal of this study was to examine whether a first exposure to physical or sexual ... Read more >>

Depress Anxiety (Depression and anxiety)
[2017, 34(8):734-741]

Cited: 4 times

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Disentangling overlapping influences of neighborhoods and schools on adolescent body mass index.

Tracy K Richmond, Erin C Dunn, Carly E Milliren, Clare Rosenfeld Evans, S V Subramanian,

To compare the simultaneous influence of schools and neighborhoods on adolescent body mass index (BMI).Analyzing data from a nationally representative sample of adolescents in grades 7 to 12 (n = 18,200), cross-classified multilevel modeling was used to examine the fixed and random effects of individuals, schools, and neighborhoods on adolescent ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2016, 24(12):2570-2577]

Cited: 4 times

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Factors Associated With New-Onset Depression Following Ischemic Stroke: The Women's Health Initiative.

Joel Salinas, Roberta M Ray, Rami Nassir, Kamakshi Lakshminarayan, Christina Dording, Jordan Smoller, Sylvia Wassertheil-Smoller, Jonathan Rosand, Erin C Dunn,

BACKGROUND:Psychosocial characteristics have a strong effect on risk of depression, and their direct treatment with behavioral interventions reduces rates of depression. Because new-onset poststroke depression (NPSD) is frequent, devastating, and often treatment-resistant, novel preventive efforts are needed. As a first step toward developing behavioral interventions for NPSD, we investigated whether ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(2):]

Cited: 1 time

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Is developmental timing of trauma exposure associated with depressive and post-traumatic stress disorder symptoms in adulthood?

Erin C Dunn, Kristen Nishimi, Abigail Powers, Bekh Bradley,

Trauma exposure is a known risk factor for psychopathology. However, the impact of the developmental timing of exposure remains unclear. This study examined the effect of age at first trauma exposure on levels of adult depressive and posttraumatic stress disorder (PTSD) symptoms.Lifetime trauma exposure (including age at first exposure and ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2017, 84:119-127]

Cited: 21 times

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An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Nese Direk, Stephanie Williams, Jennifer A Smith, Stephan Ripke, Tracy Air, Azmeraw T Amare, Najaf Amin, Bernhard T Baune, David A Bennett, Douglas H R Blackwood, Dorret Boomsma, Gerome Breen, Henriette N Buttenschøn, Enda M Byrne, Anders D Børglum, Enrique Castelao, Sven Cichon, Toni-Kim Clarke, Marilyn C Cornelis, Udo Dannlowski, Philip L De Jager, Ayse Demirkan, Enrico Domenici, Cornelia M van Duijn, Erin C Dunn, Johan G Eriksson, Tonu Esko, Jessica D Faul, Luigi Ferrucci, Myriam Fornage, Eco de Geus, Michael Gill, Scott D Gordon, Hans Jörgen Grabe, Gerard van Grootheest, Steven P Hamilton, Catharina A Hartman, Andrew C Heath, Karin Hek, Albert Hofman, Georg Homuth, Carsten Horn, Jouke Jan Hottenga, Sharon L R Kardia, Stefan Kloiber, Karestan Koenen, Zoltán Kutalik, Karl-Heinz Ladwig, Jari Lahti, Douglas F Levinson, Cathryn M Lewis, Glyn Lewis, Qingqin S Li, David J Llewellyn, Susanne Lucae, Kathryn L Lunetta, Donald J MacIntyre, Pamela Madden, Nicholas G Martin, Andrew M McIntosh, Andres Metspalu, Yuri Milaneschi, Grant W Montgomery, Ole Mors, Thomas H Mosley, Joanne M Murabito, Bertram Müller-Myhsok, Markus M Nöthen, Dale R Nyholt, Michael C O'Donovan, Brenda W Penninx, Michele L Pergadia, Roy Perlis, James B Potash, Martin Preisig, Shaun M Purcell, Jorge A Quiroz, Katri Räikkönen, John P Rice, Marcella Rietschel, Margarita Rivera, Thomas G Schulze, Jianxin Shi, Stanley Shyn, Grant C Sinnamon, Johannes H Smit, Jordan W Smoller, Harold Snieder, Toshiko Tanaka, Katherine E Tansey, Alexander Teumer, Rudolf Uher, Daniel Umbricht, Sandra Van der Auwera, Erin B Ware, David R Weir, Myrna M Weissman, Gonneke Willemsen, Jingyun Yang, Wei Zhao, Henning Tiemeier, Patrick F Sullivan,

BACKGROUND:The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2017, 82(5):322-329]

Cited: 24 times

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Factors Associated With New-Onset Depression After Stroke.

Joel Salinas, Alexa Beiser, Jayandra J Himali, Jonathan Rosand, Sudha Seshadri, Erin C Dunn,

To better identify stroke survivors at risk for depression who may benefit from early prevention through targeted strategies in the acute-subacute poststroke period, we examined 118 Framingham Heart Study stroke survivors with longitudinal prestroke depression assessments. Among those who developed poststroke depression, most lacked a history of depressive symptoms 5 ... Read more >>

J Neuropsychiatry Clin Neurosci (The Journal of neuropsychiatry and clinical neurosciences)
[2016, 28(4):286-291]

Cited: 0 times

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Childhood Trauma and Illicit Drug Use in Adolescence: A Population-Based National Comorbidity Survey Replication-Adolescent Supplement Study.

Hannah Carliner, Katherine M Keyes, Katie A McLaughlin, Jacquelyn L Meyers, Erin C Dunn, Silvia S Martins,

Although potentially traumatic events (PTEs) are established risk factors for substance use disorders among adults, little is known about associations with drug use during adolescence, an important developmental stage for drug use prevention. We examined whether childhood PTEs were associated with illicit drug use among a representative sample of US ... Read more >>

J Am Acad Child Adolesc Psychiatry (Journal of the American Academy of Child and Adolescent Psychiatry)
[2016, 55(8):701-708]

Cited: 11 times

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Childhood adversity and insomnia in adolescence.

Yan Wang, Miriam R Raffeld, Natalie Slopen, Lauren Hale, Erin C Dunn,

The study aims to evaluate the association between exposure to childhood adversity and insomnia, with an emphasis on the role of adversity type, timing, and accumulation (i.e., the number of specific types of adversities the child reported being exposed to).Our analytic sample comprised 9582 adolescents from the National Comorbidity Survey ... Read more >>

Sleep Med (Sleep medicine)
[2016, 21:12-18]

Cited: 12 times

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Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.

Erin C Dunn, Tamar Sofer, Linda C Gallo, Stephanie M Gogarten, Kathleen F Kerr, Chia-Yen Chen, Murray B Stein, Robert J Ursano, Xiuqing Guo, Yucheng Jia, Qibin Qi, Jerome I Rotter, Maria Argos, Jianwen Cai, Frank J Penedo, Krista Perreira, Sylvia Wassertheil-Smoller, Jordan W Smoller,

Although generalized anxiety disorder (GAD) is heritable and aggregates in families, no genomic loci associated with GAD have been reported. We aimed to discover potential loci by conducting a genome-wide analysis of GAD symptoms in a large, population-based sample of Hispanic/Latino adults. Data came from 12,282 participants (aged 18-74) in ... Read more >>

Am J Med Genet B Neuropsychiatr Genet (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics)
[2017, 174(2):132-143]

Cited: 6 times

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