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Author Erik Vegt

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Integrated analysis of pain, health-related quality of life, and analgesic use in patients with metastatic castration-resistant prostate cancer treated with Radium-223.

Sushil K Badrising, Rebecca D Louhanepessy, Vincent van der Noort, Jacobien Kieffer, Jules L L M Coenen, Paul Hamberg, Aart Beeker, Nils Wagenaar, Marnix Lam, Filiz Celik, Olaf J L Loosveld, Ad Oostdijk, Hanneke Zuetenhorst, Jeantine M de Feijter, Vincent O Dezentjé, Suzan Ras-van Spijk, Erik Vegt, John B Haanen, Lonneke V van de Poll-Franse, Wilbert Zwart, Andries M Bergman,

<h4>Background</h4>Radium-223 (Ra-223), an alpha-emitting radiopharmaceutical, established an improved overall survival and health-related quality of life (HRQoL) in symptomatic metastatic castration-resistant prostate cancer (mCRPC) patients. However, effects on pain were not specifically evaluated. Here we assess integrated HRQoL, pain, and opioid use in a contemporary, more extensively pretreated, symptomatic and asymptomatic ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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False positive FDG uptake in melanoma patients treated with talimogene laherparepvec (T-VEC).

Evalyn E A P Mulder, Emma H A Stahlie, Daniëlle Verver, Clara Lemstra, Lukas B Been, Antien L Mooyaart, Tessa Brabander, Erik Vegt, Frederik A Verburg, Astrid A M van der Veldt, Cornelis Verhoef, Alexander C J van Akkooi, Dirk J Grünhagen,

Talimogene laherparepvec (T-VEC) is a genetically modified herpes simplex virus-1-based oncolytic immunotherapy and has been approved for the local treatment of unresectable (stage IIIB/C and IVM1a) cutaneous melanoma. During T-VEC treatment, tumor response is often evaluated using [18F]2-fluoro-2-deoxy- d-glucose(FDG) positron emission tomography/computed tomography (PET/CT). In a Dutch cohort (n = 173), almost ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, :]

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Motion-compensated FDG PET/CT for oesophageal cancer.

Francine E M Voncken, Erik Vegt, Johanna W van Sandick, Jolanda M van Dieren, Cecile Grootscholten, Annemarieke Bartels-Rutten, Steven L Takken, Jan-Jakob Sonke, Jeroen B van de Kamer, Berthe M P Aleman,

<h4>Purpose</h4>Respiratory-induced motion of oesophageal tumours and lymph nodes can influence positron-emission tomography/computed tomography (PET/CT). The aim was to compare standard three-dimensional (3D) and motion-compensated PET/CT regarding standardized uptake value (SUV), metabolic tumour volume (MTV) and detection of lymph node metastases.<h4>Methods</h4>This prospective observational study (NCT02424864) included 37 newly diagnosed oesophageal cancer patients. ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2021, 197(9):791-801]

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F-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography Has High Diagnostic Value for Pelvic and Distant Staging in Patients with High-risk Penile Carcinoma.

Sarah R Ottenhof, Rosa S Djajadiningrat, Michelle W J Versleijen, Maarten L Donswijk, Vincent van der Noort, Oscar R Brouwer, Niels M Graafland, Erik Vegt, Simon Horenblas,

<h4>Background</h4>For penile cancer patients with pelvic metastases, multimodal treatment is advised, but pelvic lymph node metastases are often found upon surgical resection only. Early selection for multimodal treatment requires reliable noninvasive staging.<h4>Objective</h4>To evaluate the diagnostic value of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) for staging pelvic lymph nodes ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Staging 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Changes Treatment Recommendation in Invasive Bladder Cancer.

Charlotte S Voskuilen, Erik J van Gennep, Sarah M H Einerhand, Erik Vegt, Maarten L Donswijk, Annemarie Bruining, Henk G van der Poel, Simon Horenblas, Kees Hendricksen, Bas W G van Rhijn, Laura S Mertens,

Given the high risk of systemic relapse following initial therapy for muscle-invasive bladder cancer (MIBC), improved pretreatment staging is needed. We evaluated the incremental value of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after standard conventional staging, in the largest cohort of MIBC patients to date. This is a retrospective analysis ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Motion-Compensated FDG PET/CT for Oesophageal Cancer

Francine E.M. Voncken, Erik Vegt, Johana van Sandick, Jolanda van Dieren, Cecile Grootscholten, Annemarieke Bartels-Rutten, Steven Takken, Jan-Jakob Sonke, Jeroen van de Kamer, Berthe M.P. Aleman,

<h4>Purpose: </h4> Respiratory-induced motion of oesophageal tumours and lymph nodes can influence positron emission tomography/computed tomography (PET/CT). The aim was to compare standard three-dimensional (3D) and motion-compensated PET/CT regarding standardized uptake value (SUV), metabolic tumour volume (MTV) and detection of lymph node metastases. MethodsThis prospective observational study (NCT02424864) included thirty-seven ... Read more >>

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Evaluation of the Implementation of FDG-PET/CT and Staging Laparoscopy for Gastric Cancer in The Netherlands.

Emma C Gertsen, Alicia S Borggreve, Hylke J F Brenkman, Rob H A Verhoeven, Erik Vegt, Richard van Hillegersberg, Peter D Siersema, Jelle P Ruurda, ,

<h4>Background</h4>The role of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) and staging laparoscopy (SL) has increased in the preoperative staging of gastric cancer. Dutch national guidelines have recommended the use of FDG-PET/CT and SL for patients with locally advanced tumors since July 2016.<h4>Objective</h4>The aim of this study was to ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(4):2384-2393]

Cited: 1 time

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Clinical impact of PSMA PET/CT in primary prostate cancer compared to conventional nodal and distant staging: a retrospective single center study.

Maarten L Donswijk, Pim J van Leeuwen, Erik Vegt, Zing Cheung, Stijn W T P J Heijmink, Henk G van der Poel, Marcel P M Stokkel,

<h4>Background</h4>To evaluate the impact of Gallium-68 [<sup>68</sup>Ga] labeled prostate specific membrane antigen (PSMA) positron emission tomography (PET)/X-ray computed tomography (CT) compared with conventional imaging on staging and clinical management of men evaluated for primary prostate cancer (PCa).<h4>Methods</h4>Men with newly diagnosed biopsy-proven PCa who had been staged with a conventional staging ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):723]

Cited: 3 times

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Clinical response assessment on DW-MRI compared with FDG-PET/CT after neoadjuvant chemoradiotherapy in patients with oesophageal cancer.

Sophie E Vollenbrock, Francine E M Voncken, Doenja M J Lambregts, Monique Maas, Maarten L Donswijk, Erik Vegt, Leon C Ter Beek, Jolanda M van Dieren, Johanna W van Sandick, Berthe M P Aleman, Regina G H Beets-Tan, Annemarieke Bartels-Rutten,

<h4>Purpose</h4>In about 30% of patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgical resection for locally advanced oesophageal cancer no vital tumour is found in the resection specimen. Accurate clinical response assessment is critical if deferral from surgery is considered in complete responders. Our study aimed to compare the performance ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(1):176-185]

Cited: 1 time

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A prospective observational registry evaluating clinical outcomes of Radium-223 treatment in a nonstudy population.

Sushil K Badrising, Rebecca D Louhanepessy, Vincent van der Noort, Jules L L M Coenen, Paul Hamberg, Aart Beeker, Nils Wagenaar, Marnix G E H Lam, Filiz Celik, Olaf J L Loosveld, Ad Oostdijk, Hanneke Zuetenhorst, John B Haanen, Erik Vegt, Wilbert Zwart, Andries M Bergman, ,

The ALSYMPCA study established a 3.6 month Overall Survival (OS) benefit in metastatic Castration Resistant Prostate Cancer (mCRPC) patients treated with Radium-223 dichloride (Ra-223) over placebo. Here we report clinical outcomes of Ra-223 treatment in a nonstudy population. In this prospective registry, patients from 20 Dutch hospitals were included prior to ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 147(4):1143-1151]

Cited: 1 time

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Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial.

Bart J T Reymen, Marike W van Gisbergen, Aniek J G Even, Catharina M L Zegers, Marco Das, Erik Vegt, Joachim E Wildberger, Felix M Mottaghy, Ala Yaromina, Ludwig J Dubois, Wouter van Elmpt, Dirk De Ruysscher, Philippe Lambin,

Background:Nitroglycerin is proposed as an agent to reduce tumour hypoxia by improving tumour perfusion. We investigated the potential of nitroglycerin as a radio-sensitizer in non-small cell lung cancer (NSCLC) and the potential of functional imaging for patient selection. Material and methods:Trial NCT01210378 is a single arm phase II trial, designed ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2020, 21:49-55]

Cited: 2 times

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Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma.

Charlotte S Voskuilen, Donald Schweitzer, Jørgen Bjerggaard Jensen, Anna M Nielsen, Steven Joniau, Tim Muilwijk, Andrea Necchi, Mounsif Azizi, Philippe E Spiess, Alberto Briganti, Marco Bandini, Karolien Goffin, Kirsten Bouchelouche, Erik van Werkhoven, Shahrokh F Shariat, Evanguelos Xylinas, Nessn H Azawi, Ja Hyeon Ku, Beat Foerster, Bas W G van Rhijn, Erik Vegt, Kees Hendricksen,

<h4>Background</h4>Presence of lymph node metastases (LNM) is an important prognostic factor for cancer-specific survival (CSS) in patients with upper tract urothelial carcinoma (UTUC). In various neoplasms, <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) is an established modality for preoperative lymph node (LN) staging. In UTUC, the diagnostic value of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(1):73-79]

Cited: 3 times

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Prostate-Specific Membrane Antigen PET/CT Combined with Sentinel Node Biopsy for Primary Lymph Node Staging in Prostate Cancer.

Florentien J Hinsenveld, Esther M K Wit, Pim J van Leeuwen, Oscar R Brouwer, Maarten L Donswijk, Corinne N Tillier, Erik Vegt, Erik van Muilekom, Matthias N van Oosterom, Fijs W B van Leeuwen, Henk G van der Poel,

Our objective was to determine the diagnostic capabilities of combined prostate-specific membrane antigen (PSMA) PET/CT and sentinel node (SN) biopsy in PSMA PET/CT-negative patients for primary lymph node (LN) staging in prostate cancer (PCa) patients. <b>Methods:</b> Between January 2017 and March 2019, retrospectively, all consecutive patients with diagnosed intermediate- or ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2020, 61(4):540-545]

Cited: 3 times

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Integrated versus separate reading of F-18 FDG-PET/CT and MRI for abdominal malignancies - effect on staging outcomes and diagnostic confidence.

Lisa A Min, Wouter V Vogel, Max J Lahaye, Monique Maas, Maarten L Donswijk, Erik Vegt, Miranda Kusters, Henry J Zijlmans, Katarzyna Jóźwiak, Sander Roberti, Regina G H Beets-Tan, Doenja M J Lambregts,

<h4>Objective</h4>Abdominal cancer patients increasingly undergo multimodality imaging. This study evaluates effects of integrated reading of PET/CT and abdominal MRI on staging outcomes and diagnostic confidence compared to "routine" separate reading.<h4>Methods</h4>In total, N = 201 patients who underwent abdominal MRI and whole-body F-18 FDG-PET/CT within 14 days were retrospectively analyzed. Original MRI and PET/CT ... Read more >>

Eur Radiol (European radiology)
[2019, 29(12):6900-6910]

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Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease.

Joost M Blok, J Martijn Kerst, Erik Vegt, Oscar R Brouwer, Richard P Meijer, J L H Ruud Bosch, Axel Bex, Henk G van der Poel, Simon Horenblas,

<h4>Objectives</h4>To report the long-term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility.<h4>Patients and methods</h4>We conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated with an SN procedure at our tertiary ... Read more >>

BJU Int (BJU international)
[2019, 124(3):424-430]

Cited: 3 times

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Recent developments in penile cancer imaging.

Hielke M de Vries, Oscar R Brouwer, Stijn Heijmink, Simon Horenblas, Erik Vegt,

<h4>Purpose of review</h4>This review discusses new findings in penile cancer imaging in relation to the European Association of Urology and National Comprehensive Cancer Network guidelines.<h4>Recent findings</h4>For imaging in penile cancer patients who are candidates for organ-sparing primary treatment, ultrasound with Doppler seems to be the method of choice in addition ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2019, 29(2):150-155]

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Radiation-induced liver injury mimicking liver metastases on FDG-PET-CT after chemoradiotherapy for esophageal cancer : A retrospective study and literature review.

Francine E M Voncken, Berthe M P Aleman, Jolanda M van Dieren, Cecile Grootscholten, Ferry Lalezari, Johanna W van Sandick, Jeffrey D Steinberg, Erik Vegt,

<h4>Background</h4>For esophageal cancer patients treated with neoadjuvant chemoradiotherapy (nCRT), restaging using F‑18-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET-CT) following nCRT can detect interval metastases, including liver metastases, in almost 10% of patients. However, in clinical practice, focal FDG liver uptake, unrelated to liver metastases, is observed after chemoradiotherapy. This ... Read more >>

Strahlenther Onkol (Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al])
[2018, 194(2):156-163]

Cited: 4 times

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Advancements in staging and imaging for penile cancer.

Sarah R Ottenhof, Andrew R Leone, Simon Horenblas, Philippe E Spiess, Erik Vegt,

<h4>Purpose of review</h4>We review recent advancements in staging and imaging of penile cancer, including surveillance after therapy.<h4>Recent findings</h4>For cN0 patients, the sentinel lymph node biopsy is currently considered the preferred way for invasive staging. It has largely replaced other modalities such as staging inguinal lymphadenectomy. Its diagnostic value increases when ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2017, 27(6):612-620]

Cited: 2 times

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The role of PET/CT imaging in penile cancer.

Sarah R Ottenhof, Erik Vegt,

Positron emission tomography (PET) imaging with 18F-fluorodeoxyglucose (FDG) combined with computed tomography (CT) provides functional imaging combined with anatomic information, improving diagnostic accuracy and confidence. Although virtually all primary penile tumors are FDG-avid, PET/CT is not recommended for primary tumor staging as it has limited spatial resolution and is hampered ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2017, 6(5):833-838]

Cited: 5 times

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Factors influencing brown fat activation in FDG PET/CT: a retrospective analysis of 15,000+ cases.

Jeffrey D Steinberg, Wouter Vogel, Erik Vegt,

<h4>Objective</h4>Brown fat can exhibit high uptake of fluorine-18 fludeoxyglucose (<sup>18</sup>F-FDG) on positron emission tomography (PET) and interferes with interpretation of the scan. The goal of this study was to identify factors that may influence brown adipose tissue (BAT) activation.<h4>Methods</h4>A retrospective study of <sup>18</sup>F-FDG PET scans was performed using a database ... Read more >>

Br J Radiol (The British journal of radiology)
[2017, 90(1075):20170093]

Cited: 10 times

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Sentinel Lymph Node Dissection to Select Clinically Node-negative Prostate Cancer Patients for Pelvic Radiation Therapy: Effect on Biochemical Recurrence and Systemic Progression.

Nikolaos Grivas, Esther Wit, Floris Pos, Jeroen de Jong, Erik Vegt, Axel Bex, Kees Hendricksen, Simon Horenblas, Gijs KleinJan, Bas van Rhijn, Henk van der Poel,

<h4>Purpose</h4>To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT).<h4>Methods and materials</h4>Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2017, 97(2):347-354]

Cited: 5 times

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Multimodal hybrid imaging agents for sentinel node mapping as a means to (re)connect nuclear medicine to advances made in robot-assisted surgery.

Gijs H KleinJan, Nynke S van den Berg, Jeroen de Jong, Esther M Wit, Helene Thygessen, Erik Vegt, Henk G van der Poel, Fijs W B van Leeuwen,

<h4>Purpose</h4>Radical prostatectomy and complementary extended pelvic lymph node dissection (ePLND) of sentinel lymph nodes (SNs) and non-sentinel lymph nodes (LNs) at risk of containing metastases are increasingly being performed using high-tech robot-assisted approaches. Although this technological evolution has clear advantages, the physical nature of robotic systems limits the integrated use ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2016, 43(7):1278-1287]

Cited: 14 times

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Clinical Relevance of Incidental Prostatic Lesions on FDG-Positron Emission Tomography/Computerized Tomography-Should Patients Receive Further Evaluation?

Daan J Reesink, Elisabeth E Fransen van de Putte, Erik Vegt, Jeroen De Jong, Erik van Werkhoven, Laura S Mertens, Axel Bex, Henk G van der Poel, Bas W G van Rhijn, Simon Horenblas, Richard P Meijer,

<h4>Purpose</h4>FDG ((18)F-fluoro-2-deoxy-D-glucose)-PET/CT (positron emission tomography)/(computerized tomography) is a widely used diagnostic tool for whole body imaging. Incidental prostatic uptake is often found on FDG-PET/CT. The objective of this study was to determine the clinical relevance of incidental prostatic uptake on FDG-PET/CT.<h4>Materials and methods</h4>We analyzed 108 consecutive male patients with bladder ... Read more >>

J Urol (The Journal of urology)
[2016, 195(4 Pt 1):907-912]

Cited: 2 times

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[The quality of patient information brochures can be improved: a discussion using radium-223 therapy as an example].

Wouter V Vogel, Marnix G E H Lam, Erik Vegt, Leonne Prompers, Mark J Roef,

Patients and their peers need to be adequately informed to ensure proper treatment selection, and to facilitate optimal realisation and outcome of treatment. Written patient information can contribute, but only when brochures are of sufficient quality. An evaluation of patient brochures for radium-223 therapy in the Netherlands revealed significant differences ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2015, 159:A8948]

Cited: 0 times

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Detecting interval metastases and response assessment using 18F-FDG PET/CT after neoadjuvant chemoradiotherapy for esophageal cancer.

Jurriën Stiekema, Daan Vermeulen, Erik Vegt, Francine E M Voncken, Berthe M P Aleman, Joyce Sanders, Henk Boot, Johanna W van Sandick,

<h4>Aim</h4>The aim of this study is to evaluate the potential of FDG PET/CT for the detection of interval distant metastases after neoadjuvant chemoradiotherapy (CRT) and the prediction of the pathologic response to CRT in esophageal cancer patients.<h4>Patients and methods</h4>In this retrospective study, all esophageal cancer patients for whom CRT followed ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2014, 39(10):862-867]

Cited: 23 times

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