Full Text Journal Articles by
Author Erik D Fagerholm


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Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression.

Erik D Fagerholm, Robert Leech, Steven Williams, Carlos A Zarate, Rosalyn J Moran, Jessica R Gilbert,

The glutamatergic modulator ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant major depressive disorder (TRD). Although its mechanisms of action are not fully understood, changes in cortical excitation/inhibition (E/I) following ketamine administration are well documented in animal models and could represent a potential biomarker of ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2021, 11(1):335]

Cited: 0 times

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Neural Systems Under Change of Scale.

Erik D Fagerholm, W M C Foulkes, Yasir Gallero-Salas, Fritjof Helmchen, Karl J Friston, Robert Leech, Rosalyn J Moran,

We derive a theoretical construct that allows for the characterisation of both scalable and scale free systems within the dynamic causal modelling (DCM) framework. We define a dynamical system to be "scalable" if the same equation of motion continues to apply as the system changes in size. As an example ... Read more >>

Front Comput Neurosci (Frontiers in computational neuroscience)
[2021, 15:643148]

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

Cited: 1 time

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Neural diffusivity and pre-emptive epileptic seizure intervention.

Erik D Fagerholm, Chayanin Tangwiriyasakul, Karl J Friston, Inês R Violante, Steven Williams, David W Carmichael, Suejen Perani, Federico E Turkheimer, Rosalyn J Moran, Robert Leech, Mark P Richardson,

The propagation of epileptic seizure activity in the brain is a widespread pathophysiology that, in principle, should yield to intervention techniques guided by mathematical models of neuronal ensemble dynamics. During a seizure, neural activity will deviate from its current dynamical regime to one in which there are significant signal fluctuations. ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2020, 16(12):e1008448]

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A GABA Interneuron Deficit Model of the Art of Vincent van Gogh.

Federico E Turkheimer, Erik D Fagerholm, Miriam Vignando, Jessica Dafflon, Pedro F Da Costa, Paola Dazzan, Robert Leech,

Vincent van Gogh was one of the most influential artists of the Western world, having shaped the post-impressionist art movement by shifting its boundaries forward into abstract expressionism. His distinctive style, which was not valued by the art-buying public during his lifetime, is nowadays one of the most sought after. ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:685]

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Dynamic causal modelling of phase-amplitude interactions.

Erik D Fagerholm, Rosalyn J Moran, Inês R Violante, Robert Leech, Karl J Friston,

Models of coupled phase oscillators are used to describe a wide variety of phenomena in neuroimaging. These models typically rest on the premise that oscillator dynamics do not evolve beyond their respective limit cycles, and hence that interactions can be described purely in terms of phase differences. Whilst mathematically convenient, ... Read more >>

Neuroimage (NeuroImage)
[2020, 208:116452]

Cited: 2 times

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The characteristic patterns of neuronal avalanches in mice under anesthesia and at rest: An investigation using constrained artificial neural networks.

Erik D Fagerholm, Martin Dinov, Thomas Knöpfel, Robert Leech,

Local perturbations within complex dynamical systems can trigger cascade-like events that spread across significant portions of the system. Cascades of this type have been observed across a broad range of scales in the brain. Studies of these cascades, known as neuronal avalanches, usually report the statistics of large numbers of ... Read more >>

PLoS One (PloS one)
[2018, 13(5):e0197893]

Cited: 4 times

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Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice.

Erik D Fagerholm, Gregory Scott, Woodrow L Shew, Chenchen Song, Robert Leech, Thomas Knöpfel, David J Sharp,

Some neural circuits operate with simple dynamics characterized by one or a few well-defined spatiotemporal scales (e.g. central pattern generators). In contrast, cortical neuronal networks often exhibit richer activity patterns in which all spatiotemporal scales are represented. Such "scale-free" cortical dynamics manifest as cascades of activity with cascade sizes that ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2016, 26(10):3945-3952]

Cited: 19 times

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Novel Modeling of Task vs. Rest Brain State Predictability Using a Dynamic Time Warping Spectrum: Comparisons and Contrasts with Other Standard Measures of Brain Dynamics.

Martin Dinov, Romy Lorenz, Gregory Scott, David J Sharp, Erik D Fagerholm, Robert Leech,

Dynamic time warping, or DTW, is a powerful and domain-general sequence alignment method for computing a similarity measure. Such dynamic programming-based techniques like DTW are now the backbone and driver of most bioinformatics methods and discoveries. In neuroscience it has had far less use, though this has begun to change. ... Read more >>

Front Comput Neurosci (Frontiers in computational neuroscience)
[2016, 10:46]

Cited: 4 times

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Cascades and cognitive state: focused attention incurs subcritical dynamics.

Erik D Fagerholm, Romy Lorenz, Gregory Scott, Martin Dinov, Peter J Hellyer, Nazanin Mirzaei, Clare Leeson, David W Carmichael, David J Sharp, Woodrow L Shew, Robert Leech,

The analysis of neuronal avalanches supports the hypothesis that the human cortex operates with critical neural dynamics. Here, we investigate the relationship between cascades of activity in electroencephalogram data, cognitive state, and reaction time in humans using a multimodal approach. We recruited 18 healthy volunteers for the acquisition of simultaneous ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2015, 35(11):4626-4634]

Cited: 28 times

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Disconnection of network hubs and cognitive impairment after traumatic brain injury.

Erik D Fagerholm, Peter J Hellyer, Gregory Scott, Robert Leech, David J Sharp,

Traumatic brain injury affects brain connectivity by producing traumatic axonal injury. This disrupts the function of large-scale networks that support cognition. The best way to describe this relationship is unclear, but one elegant approach is to view networks as graphs. Brain regions become nodes in the graph, and white matter ... Read more >>

Brain (Brain : a journal of neurology)
[2015, 138(Pt 6):1696-1709]

Cited: 64 times

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Voltage imaging of waking mouse cortex reveals emergence of critical neuronal dynamics.

Gregory Scott, Erik D Fagerholm, Hiroki Mutoh, Robert Leech, David J Sharp, Woodrow L Shew, Thomas Knöpfel,

Complex cognitive processes require neuronal activity to be coordinated across multiple scales, ranging from local microcircuits to cortex-wide networks. However, multiscale cortical dynamics are not well understood because few experimental approaches have provided sufficient support for hypotheses involving multiscale interactions. To address these limitations, we used, in experiments involving mice, ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2014, 34(50):16611-16620]

Cited: 62 times

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