Full Text Journal Articles by
Author Eric S White

Advertisement

Find full text journal articles






Hospitalizations in patients with idiopathic pulmonary fibrosis.

Hyun J Kim, Laurie D Snyder, Ayodeji Adegunsoye, Megan L Neely, Shaun Bender, Eric S White, Craig S Conoscenti, Mary E Strek, ,

<h4>Background</h4>Hospitalizations are common among patients with idiopathic pulmonary fibrosis (IPF). We investigated the impact of hospitalizations on outcomes in patients with IPF.<h4>Methods</h4>The IPF-PRO Registry is an observational US registry that enrolled patients with IPF that was diagnosed or confirmed at the enrolling center in the previous 6 months. Associations between patient ... Read more >>

Respir Res (Respiratory research)
[2021, 22(1):257]

Cited: 0 times

View full text PDF listing >>



Adoption of Antifibrotic Medications: A Closer Look at the Data.

Eric S White, Mona Nili, Sharash Shetty, Thomas B Leonard,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(10):1756-1757]

Cited: 0 times

View full text PDF listing >>



Advertisement

Adipose Stromal Cell-Secretome Counteracts Profibrotic Signals From IPF Lung Matrices.

Gwenda F Vasse, Lisette Van Os, Marina De Jager, Marnix R Jonker, Theo Borghuis, L Tim Van Den Toorn, Pytrick Jellema, Eric S White, Patrick Van Rijn, Martin C Harmsen, Irene H Heijink, Barbro N Melgert, Janette K Burgess,

<b>Introduction:</b> Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by excess deposition and altered structure of extracellular matrix (ECM) in the lungs. The fibrotic ECM is paramount in directing resident cells toward a profibrotic phenotype. Collagens, an important part of the fibrotic ECM, have been shown to be ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:669037]

Cited: 0 times

View full text PDF listing >>



Detection and Early Referral of Patients With Interstitial Lung Abnormalities: An Expert Survey Initiative.

Gary M Hunninghake, Jonathan G Goldin, Michael A Kadoch, Jonathan A Kropski, Ivan O Rosas, Athol U Wells, Ruchi Yadav, Howard M Lazarus, Fereidoun G Abtin, Tamera J Corte, Joao A de Andrade, Kerri A Johannson, Martin R Kolb, David A Lynch, Justin M Oldham, Paolo Spagnolo, Mary E Strek, Sara Tomassetti, George R Washko, Eric S White, ,

<h4>Background</h4>Interstitial lung abnormalities (ILA) may represent undiagnosed early-stage or subclinical interstitial lung disease (ILD). ILAs are often observed incidentally in patients who subsequently develop clinically overt ILD. There is limited information on consensus definitions for, and the appropriate evaluation of, ILA. Early recognition of patients with ILD remains challenging, yet ... Read more >>

Chest (Chest)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production.

Fatmah Al-Habeeb, Noof Aloufi, Hussein Traboulsi, Xingxing Liu, Parameswaran Nair, Christina Haston, Ilan Azuelos, Steven K Huang, Eric S White, Imed E Gallouzi, Sergio Di Marco, David H Eidelman, Carolyn J Baglole,

Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α-SMA-expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that promotes protein translation. Upon translocation from the nucleus to the cytoplasm, HuR functions to stabilize messenger RNA (mRNA) ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, 236(10):6836-6851]

Cited: 0 times

View full text PDF listing >>



Development and Initial Validation Analyses of the Living with Idiopathic Pulmonary Fibrosis Questionnaire.

Jeffrey J Swigris, David A Andrae, Tara Churney, Nathan Johnson, Mary Beth Scholand, Eric S White, Alison Matsui, Karina Raimundo, Christopher J Evans,

<b>Rationale:</b> Several new drugs for idiopathic pulmonary fibrosis (IPF) are in development. Tools are needed to assess whether these drugs benefit patients on outcomes that matter most to them. Health-related quality of life (HRQL) is one such outcome. It is influenced by many factors, but symptoms and their impacts are ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(12):1689-1697]

Cited: 2 times

View full text PDF listing >>



Type I Collagen Signaling Regulates Opposing Fibrotic Pathways through α2β1 Integrin.

Manisha Agarwal, Mitchell Goheen, Shijing Jia, Song Ling, Eric S White, Kevin K Kim,

Fibrosis is characterized by fibroblast activation, leading to matrix remodeling culminating in a stiff, type I collagen-rich fibrotic matrix. Alveolar epithelial cell (AEC) apoptosis is also a major feature of fibrogenesis, and AEC apoptosis is sufficient to initiate a robust lung fibrotic response. TGF-β (transforming growth factor-β) is a major ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2020, 63(5):613-622]

Cited: 0 times

View full text PDF listing >>



Identification of a unique temporal signature in blood and BAL associated with IPF progression.

Katy C Norman, David N O'Dwyer, Margaret L Salisbury, Katarina M DiLillo, Vibha N Lama, Meng Xia, Stephen J Gurczynski, Eric S White, Kevin R Flaherty, Fernando J Martinez, Susan Murray, Bethany B Moore, Kelly B Arnold,

Idiopathic pulmonary fibrosis (IPF) is a progressive and heterogeneous interstitial lung disease of unknown origin with a low survival rate. There are few treatment options available due to the fact that mechanisms underlying disease progression are not well understood, likely because they arise from dysregulation of complex signaling networks spanning ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12049]

Cited: 1 time

View full text PDF listing >>



Radiographic Honeycombing and Altered Lung Microbiota in Patients with Idiopathic Pulmonary Fibrosis.

Robert P Dickson, Gary B Huffnagle, Kevin R Flaherty, Eric S White, Fernando J Martinez, John R Erb-Downward, Bethany B Moore, David N O'Dwyer,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(12):1544-1547]

Cited: 9 times

View full text PDF listing >>



Biomarkers of extracellular matrix turnover in patients with idiopathic pulmonary fibrosis given nintedanib (INMARK study): a randomised, placebo-controlled study.

Toby M Maher, Susanne Stowasser, Yasuhiko Nishioka, Eric S White, Vincent Cottin, Imre Noth, Moisés Selman, Klaus B Rohr, Andreas Michael, Carina Ittrich, Claudia Diefenbach, R Gisli Jenkins, ,

<h4>Background</h4>A hallmark of idiopathic pulmonary fibrosis is the excess accumulation of extracellular matrix in the lungs. Degradation of extracellular matrix generates free-circulating protein fragments called neoepitopes. The aim of the INMARK trial was to investigate changes in neoepitopes as predictors of disease progression in patients with idiopathic pulmonary fibrosis and ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(9):771-779]

Cited: 15 times

View full text PDF listing >>



Reliability, construct validity and responsiveness to change of the PROMIS-29 in systemic sclerosis-associated interstitial lung disease.

Caitlyn J Fisher, Rajaie Namas, Daniela Seelman, Sara Jaafar, Kate Homer, Holly Wilhalme, Amber Young, Vivek Nagaraja, Eric S White, Elena Schiopu, Kevin Flaherty, Dinesh Khanna,

OBJECTIVES:PROMIS-29 is a generic health-related quality of life instrument. Our objective was to assess the reliability, construct validity, and responsiveness to change of PROMIS-29 in systemic sclerosis-associated interstitial lung disease (SSc-ILD). METHODS:Seventy-three participants with SSc-ILD were administered patient reported outcomes (PROs) at baseline and follow-up visits which included PROMIS-29 and ... Read more >>

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2019, 37 Suppl 119(4):49-56]

Cited: 0 times

View full text PDF listing >>



Prevalence, Treatment, and Outcomes of Coexistent Pulmonary Hypertension and Interstitial Lung Disease in Systemic Sclerosis.

Amber Young, Dharshan Vummidi, Scott Visovatti, Kate Homer, Holly Wilhalme, Eric S White, Kevin Flaherty, Vallerie McLaughlin, Dinesh Khanna,

<h4>Objective</h4>Systemic sclerosis (SSc) is associated with interstitial lung disease (ILD) and pulmonary hypertension (PH). This study was undertaken to determine the prevalence, characteristics, treatment, and outcomes of PH in a cohort of patients with SSc-associated ILD.<h4>Methods</h4>Patients with SSc-associated ILD on high-resolution computed tomography (HRCT) were included in a prospective observational ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2019, 71(8):1339-1349]

Cited: 11 times

View full text PDF listing >>



Routine Chest Radiography for the Evaluation of Pneumothorax Following Bronchoscopy.

Christopher P Centonze, Matthew S Davenport, Eric S White, Ella A Kazerooni,

<h4>Rationale and objectives</h4>To determine the utility of routine postbronchoscopy chest radiography to detect pneumothorax.<h4>Materials and methods</h4>This retrospective quality improvement cohort study was approved by the Institutional Review Board. All outpatients (n = 1443) who underwent protocol-driven postbronchoscopy chest radiography in one health system from January 2010 to July 2017 were identified by ... Read more >>

Acad Radiol (Academic radiology)
[2019, 26(5):585-590]

Cited: 1 time

View full text PDF listing >>



The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.

Jesse Roman, Teresa R Barnes, Dolly J Kervitsky, Gregory P Cosgrove, Dennis E Doherty, Andrew M Tager, Luca Richeldi, Eric S White, David A Brenner, Lynn M Schnapp, Timothy D Hewitson, Bodh I Jugdutt, Timothy A McKinsey, John D Tosi, Stephen Crane, Kevin K Brown, ,

Am J Med Sci (The American journal of the medical sciences)
[2019, 357(5):405-410]

Cited: 0 times

View full text PDF listing >>



Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.

David N O'Dwyer, Shanna L Ashley, Stephen J Gurczynski, Meng Xia, Carol Wilke, Nicole R Falkowski, Katy C Norman, Kelly B Arnold, Gary B Huffnagle, Margaret L Salisbury, MeiLan K Han, Kevin R Flaherty, Eric S White, Fernando J Martinez, John R Erb-Downward, Susan Murray, Bethany B Moore, Robert P Dickson,

<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene expression, supporting a role for lung microbiota in IPF. However, the causal significance of altered ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 199(9):1127-1138]

Cited: 49 times

View full text PDF listing >>



Frailty and geriatric conditions in older patients with idiopathic pulmonary fibrosis.

Jamie S Sheth, Meng Xia, Susan Murray, Carlos H Martinez, Catherine A Meldrum, Elizabeth A Belloli, Margaret L Salisbury, Eric S White, Colin H Holtze, Kevin R Flaherty,

BACKGROUND:Functional status, an important predictor of health outcomes in older patients, has not been studied in an IPF population. This study aimed to determine the prevalence of frailty and geriatric conditions in older patients with IPF. METHODS:IPF patients age ≥65 years were identified prospectively at the University of Michigan. Frailty ... Read more >>

Respir Med (Respiratory medicine)
[2019, 148:6-12]

Cited: 8 times

View full text PDF listing >>



Hypersensitivity Pneumonitis: Radiologic Phenotypes Are Associated With Distinct Survival Time and Pulmonary Function Trajectory.

Margaret L Salisbury, Tian Gu, Susan Murray, Barry H Gross, Aamer Chughtai, Mohamed Sayyouh, Ella A Kazerooni, Jeffrey L Myers, Amir Lagstein, Kristine E Konopka, Elizabeth A Belloli, Jamie S Sheth, Eric S White, Colin Holtze, Fernando J Martinez, Kevin R Flaherty,

<h4>Background</h4>Hypersensitivity pneumonitis (HP) is an interstitial lung disease with a better prognosis, on average, than idiopathic pulmonary fibrosis (IPF). We compare survival time and pulmonary function trajectory in patients with HP and IPF by radiologic phenotype.<h4>Methods</h4>HP (n = 117) was diagnosed if surgical/transbronchial lung biopsy, BAL, and exposure history results suggested ... Read more >>

Chest (Chest)
[2019, 155(4):699-711]

Cited: 28 times

View full text PDF listing >>



Development and validation of a radiological diagnosis model for hypersensitivity pneumonitis.

Margaret L Salisbury, Barry H Gross, Aamer Chughtai, Mohamed Sayyouh, Ella A Kazerooni, Brian J Bartholmai, Meng Xia, Susan Murray, Jeffrey L Myers, Amir Lagstein, Kristine E Konopka, Elizabeth A Belloli, Jamie S Sheth, Eric S White, Colin Holtze, Fernando J Martinez, Kevin R Flaherty,

High-resolution computed tomography (HRCT) may be useful for diagnosing hypersensitivity pneumonitis. Here, we develop and validate a radiological diagnosis model and model-based points score.Patients with interstitial lung disease seen at the University of Michigan Health System (derivation cohort) or enrolling in the Lung Tissue Research Consortium (validation cohort) were included. ... Read more >>

Eur Respir J (The European respiratory journal)
[2018, 52(2):]

Cited: 14 times

View full text PDF listing >>



Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt.

Shijing Jia, Manisha Agarwal, Jibing Yang, Jeffrey C Horowitz, Eric S White, Kevin K Kim,

Progressive fibrosis is a complication of many chronic diseases, and collectively, organ fibrosis is the leading cause of death in the United States. Fibrosis is characterized by accumulation of activated fibroblasts and excessive deposition of extracellular matrix proteins, especially type I collagen. Extensive research has supported a role for matrix ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2018, 59(3):295-305]

Cited: 12 times

View full text PDF listing >>



Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF: design of the randomised placebo-controlled INMARK®trial.

Toby M Maher, Susanne Stowasser, Yasuhiko Nishioka, Eric S White, Vincent Cottin, Imre Noth, Moisés Selman, Zuzana Blahova, Daniel Wachtlin, Claudia Diefenbach, R Gisli Jenkins,

<h4>Introduction</h4>A feature of the pathogenesis of idiopathic pulmonary fibrosis (IPF) is the excess accumulation of extracellular matrix (ECM) in the lungs. Cleavage of the ECM by metalloproteinases (MMPs) generates free-circulating protein fragments known as neoepitopes. The PROFILE study suggested that changes in ECM turnover proteins may be of value as ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2018, 5(1):e000325]

Cited: 7 times

View full text PDF listing >>



Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Vishwaraj Sontake, Rajesh K Kasam, Debora Sinner, Thomas R Korfhagen, Geereddy B Reddy, Eric S White, Anil G Jegga, Satish K Madala,

Wilms' tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during lung development but is downregulated in postnatal stages and adult lungs. We recently showed that WT1 is upregulated in both mesothelial cells and mesenchymal cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a fatal fibrotic lung ... Read more >>

JCI Insight (JCI insight)
[2018, 3(16):]

Cited: 9 times

View full text PDF listing >>



Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation.

Anne M Scruggs, Hailey B Koh, Priya Tripathi, Nicholas J Leeper, Eric S White, Steven K Huang,

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease characterized by excessive scarring and fibroblast activation. We previously showed that fibroblasts from patients with IPF are hypermethylated at the CDKN2B gene locus, resulting in decreased CDKN2B expression. Here, we examine how diminished CDKN2B expression in normal and IPF fibroblasts affect ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2018, 59(2):200-214]

Cited: 5 times

View full text PDF listing >>



FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.

Loka R Penke, Jennifer M Speth, Vijaya L Dommeti, Eric S White, Ingrid L Bergin, Marc Peters-Golden,

While the transcription factor forkhead box M1 (FOXM1) is well known as a proto-oncogene, its potential role in lung fibroblast activation has never been explored. Here, we show that FOXM1 is more highly expressed in fibrotic than in normal lung fibroblasts in humans and mice. FOXM1 was required not only ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2018, 128(6):2389-2405]

Cited: 28 times

View full text PDF listing >>



Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis.

Bart de Brouwer, Marjolein Drent, Jody M W van den Ouweland, Petal A Wijnen, Coline H M van Moorsel, Otto Bekers, Jan C Grutters, Eric S White, Rob Janssen,

Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have been suggested in both lung diseases. Emphysema is caused by an elastase/anti-elastase imbalance leading to accelerated elastin degradation. Elastinolysis is however, also accelerated in the ... Read more >>

Respir Res (Respiratory research)
[2018, 19(1):45]

Cited: 1 time

View full text PDF listing >>



The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix.

Franco Klingberg, Grace Chau, Marielle Walraven, Stellar Boo, Anne Koehler, Melissa L Chow, Abby L Olsen, Michelle Im, Monika Lodyga, Rebecca G Wells, Eric S White, Boris Hinz,

Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stores TGF-β1 in the ECM. Because the ED-A fibronectin splice variant is prominently expressed during fibrosis and supports myofibroblast activation, we investigated ... Read more >>

J Cell Sci (Journal of cell science)
[2018, 131(5):]

Cited: 30 times

View full text PDF listing >>



Advertisement


Disclaimer

1.0974 s